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Hepatoma Research 2019年第10期5卷 42-52页

作者： Ishan Garg Scott m.thompson Shannon P.Sheedy taofic mounajjed Ashish Khandelwal Eric C.Ehman Candice A.Bookwalter Sudhakar K.Venkatesh Department of Radiology Mayo Clinic College of MedicineRochesterMN 55905USA Department of Laboratory medicine and Pathology Mayo Clinic College of MedicineRochesterMN 55905USA

Aim:to determine the computed tomography(Ct)features of non-alcoholic fatty liver disease(NAFLD)associated hepatocellular carcinoma(HCC).methods:In this institutional review board approved study,we reviewed 38 patients with NAFLD(68.4%male;mean age 63 years)with histology confirmed HCC and triphasic liver *** images were independently reviewed by four readers blinded to clinical and pathology *** reviewers assessed HCC for arterial phase hyper enhancement(APHE),portal venous phase washout(PVWO),delayed phase washout(DPWO),and enhancing *** of cirrhotic morphology and portal hypertension(PH)were also *** final Ct features were determined by majority and a fifth reader reviewed cases lacking ***-rater agreement was determined by prevalence-adjusted ***:mean HCC size was 3.6±2.8 cm(range,1.1-16.0 cm).the HCCs showed APHE in 92.1%,PVWO in 55.3%,DPWO in 81.6%,and enhancing capsule in 44.7%.Cirrhotic morphology was present in 65.8%and PH in 63.2%.Inter-rater agreement was moderate to almost perfect for APHE(0.74-1.0),cirrhosis(0.79-0.89),and PH(0.79-0.95),weak to perfect for DPWO(0.47-0.95)and poor for PVWO(0-0.42). ;Conclusion:NAFLD associated HCC demonstrate less frequent portal venous washout on Ct which may affect their imaging diagnosis.

关键词： Hepatocellular carcinoma computed tomography fatty liver inter-rater agreement non-alcoholic fatty liver disease

modern atmospheric environmental records in Guliya Ice Cap of Qinghai-Xizang Plateau

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Chinese Science Bulletin 1995年第10期40卷 874-876页

作者：李忠勤姚檀栋谢自楚 L. G. thompson J. Dai Institute of Glaciology and Geocryology Chinese Academy of Sciences Lanzhou 730000 China Byrd Polar Research Center Ohio State University USA

Carrying dry and wet deposition records of aerosols in the mid-to upper-troposphereabove northwestern Qinghai-Xizang Plateau, the Guliya Ice Core extracted in 1992 at the el-evation of 6 400m on Guliya Ice Cap of western Kunlun mt. has provided a uniqueopportunity to improve our understanding of atmospheric emvironment in this area. Onthe basis of studies on firn-ice transition of the ice cap, depositional processes

关键词： Ca modern atmospheric environmental records in Guliya Ice Cap of Qinghai-Xizang Plateau

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Application of activated biomass waste as an adsorbent for the removal of lead(II)ion from wastewater

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Emerging Contaminants 2020年第1期6卷 259-267页

作者： Chime O.thompson Agu O.Ndukwe Christian O.Asadu Department of Chemical Engineering Enugu State University of Science and TechnologyEnuguNigeria Department of Chemical Engineering Gregory UniversityUturu P.M.B1012Abia StateNigeria

this work focuses on the application of activated biomass as an alternative to conventional adsorbents for the removal of Pb^2+from *** biomass was carbonized at 800℃before chemical *** Electron microscope(SEm)and UV/VIS Spectrophotometer were used in characterizing the *** adsorption studies were carried out to determine the effect of process conditions on the percentage *** kinetic studies were carried out using Pseudo-first order,Pseudo-second order,Elovich and Weber morris kinetic models while the thermodynamics studies were carried out using Gibbs free energy *** characterization revealed that micro porous space on the surface of the adsorbents(biomass wastes)increased significantly after *** composites maintained high surface area after chemical *** of point zero charge revealed negative charge predominance on the surface of the adsorbents and adsorption was found to be very fast due to strong electrostatic force between Pb^2+and ion diffusion on the biomass *** peel demonstrated highest potential for lead(II)ion removal from solution with 96.83%removal after 80 min with 50 mg/l lead concentration and adsorbent/liquid ratio of 0.3 g/30 ml at 60℃and pH of *** highest adsorption capacities recorded with cassava peels,groundnut shell and yam peel at initial concentration of 50 mg/g were 50.1 mg g,46.6 mg/g and 38.5 mg/g DH,DS and R2 values for the adsorption with cassava peels are:12762 J/mol,67.2 J/kmol.K and 0.945;for groundnut shell adsorbent,the DH,DS and R2 values are;36756 J/mol,130 J/mol.K and 0.997;while for yam peels adsorbent,the DH,DS and R2 values are 12163 J/mol,46 J/mol.K and ***,the sorption process was feasible,spontaneous and *** of Pb^2+was rapid and showed high kinetic *** experimental data were well fitted with pseudo second order kinetic ***,the present approach has the advantage of simplicity,less tim

关键词： Biomass Adsorption Lead(II) Wastewater

No association between phosphatase and tensin homolog genetic polymorphisms and colon cancer

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World Journal of Gastroenterology 2009年第30期15卷 3771-3775页

作者： Lynette S Phillips Cheryl L thompson Alona merkulova Sarah J Plummer thomas C tucker Graham Case Li Li Department of Epidemiology and Biostatistics and Case Comprehensive Cancer Center Case Western Reserve University Cleveland OH 44106-7136 United States Departments of Family medicine and Epidemiology and Biostatistics Case Center for Transdisciplinary Research on Energetics and Cancer Case Comprehensive Cancer Center Case Western Reserve University Cleveland OH 44106-7136m United States Department of Cancer Biology Cleveland Clinic Foundation Cleveland OH 44195-0001 United States Graham Casey Department of Preventive Medicine University of Southern California Los Angeles CA 90033-1006 United States assisted with patient referrals recruitment and reviewed the manuscript coordinated the lab work and reviewed the manuscript Li L led the study design data collection and assisted with the manuscript preparation

AIm: to investigate the association between single nucleotide polymorphisms (SNPs) in the phosphatase and tensin homolog (PtEN) tumor suppressor gene and risk of colon cancer. mEtHODS: We utilized a population-based casecontrol study of incident colon cancer individuals (n= 421) and controls (n = 483) aged ≥ 30 years to conduct a comprehensive tagSNP association analysis of the PtEN gene. RESULtS: None of the PtEN SNPs were statistically significantly associated with colon cancer when controlled for age, gender, and race, or when additionally adjusted for other known risk factors (P > 0.05). Haplotype analyses similarly showed no association between the PtEN gene and colon cancer. CONCLUSION: Our study does not support PtEN as a colon cancer susceptibility gene.

关键词： Colon cancer Phosphatase and tensinhomolog Candidate gene Genetic polymorphisms Single nucleotide polymorphism association

Using Pharmacokinetic modeling and Electronic Health Record Data to Predict Clinical and Safety Outcomes after methylprednisolone Exposure during Cardiopulmonary Bypass in Neonates

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Congenital Heart Disease 2023年第3期18卷 295-313页

作者： Henry P.Foote Huali Wu Stephen J.Balevic Elizabeth J.thompson Kevin D.Hill Eric m.Graham Christoph P.Hornik Karan R.Kumar Department of Pediatrics Duke UniversityDurhamUSA Duke Clinical Research Institute DurhamUSA Department of Pediatrics Medical University of South CarolinaCharlestonUSA

Background:Infants undergoing cardiac surgery with cardiopulmonary bypass(CPB)frequently receive intraoperative methylprednisolone(mP)to suppress CPB-related inflammation;however,the optimal dosing strategy and efficacy of mP remain ***:We retrospectively analyzed all infants under 90 days-old who received intra-operative mP for cardiac surgery with CPB from 2014–2017 at our *** combined real-world dosing data from the electronic health record(EHR)and two previously developed population pharmacokinetic/pharmacodynamic models to simulate peak concentration(Cmax)and area under the concentration-time curve for 24 h(AUC24)for mP and the inflammatory cytokines interleukin-6(IL-6)and interleukin-10(IL-10).We evaluated the relationships between post-operative,safety,and other clinical outcomes obtained from the EHR with each predicted exposure using non-parametric ***:A total of 142 infants with median post-natal age 8(interquartile range[IQR]:5,37)days received a total dose of 30(19,49)mg/kg of ***(8%)died,37(26%)met the composite post-operative outcome,114(80%)met the composite safety outcome,and 23(16%)had a major *** median Cmax and AUC24 IL-6 exposure was significantly higher for infants meeting the composite post-operative outcome and those with major *** median Cmax and AUC24 mP exposure was significantly higher for infants requiring *** exposure was associated with death or other safety ***:Pro-inflammatory IL-6,but not mP exposure,was associated with post-operative organ dysfunction,suggesting current mP dosing may not adequately suppress IL-6 or increase IL-10 to impact clinical *** study will be required to define the optimal exposure-efficacy and exposure-safety profiles in these infants.

关键词： Neonates cardiopulmonary bypass methylprednisolone exposure

近500年来喜马拉雅山达索普冰芯中尘埃含量变化与西、南亚及北非干旱化趋势

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第四纪研究 2012年第1期32卷 53-58页

作者：王宁练姚檀栋 L.G.thompson m.E.Davis 中国科学院寒区旱区环境与工程研究所冰冻圈科学国家重点实验室兰州730000 中国科学院青藏高原研究所北京100085 俄亥俄州立大学伯德极地研究中心美国哥伦布市43210

本文重建了近500年来喜马拉雅山中段达索普冰芯中尘埃浓度与尘埃沉积通量的变化历史,谱分析结果表明它们的变化均存在较显著的12.3年、9.8年、7.4年、6.1年和5.3年周期。该冰芯中尘埃含量与净积累量之间不存在任何相关性,说明其尘埃可... 详细信息

本文重建了近500年来喜马拉雅山中段达索普冰芯中尘埃浓度与尘埃沉积通量的变化历史,谱分析结果表明它们的变化均存在较显著的12.3年、9.8年、7.4年、6.1年和5.3年周期。该冰芯中尘埃含量与净积累量之间不存在任何相关性,说明其尘埃可能主要来源于上风方向的远源地区。基于后向轨迹法,并结合该地区附近已有的气溶胶研究结果,认为西、南亚甚至北非地区可能是该冰芯中尘埃物质的主要源区。近500年来达索普冰芯中尘埃沉积通量的增加趋势,反映了其源区干旱程度的加重趋势。

关键词：达索普冰芯尘埃干旱化气候变化

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the Role of the NIIt in the Formulation of *** Policy

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The Role of the NIIT in the Formulation of *** Policy

用电感耦合等离子体—氢化物法同时测定水中的砷、锑、铋、硒和碲

1996 International Conference on Information Infrastructure(ICII’96)

作者： Joe m.thompson thomas R.Burke Information technology Service U.S.General Services Administration Affiliate member National Information Infrastructure Testbed(NIIT)1517 Blake Street Office of Information Security U.S.General Services Administration Affiliate member National Information Infrastructure Testbed(NIIT)1517 Blake Street

＜正＞this paper highlights the role of the National Information Infrastructure testbed（NIIt） in the formulation of *** policy related to the National Information Infrastructure （NII）.Vice President Gore has stated "the private sector will build,own,and operate the NII." the private sector includes industry,academia,and *** is a view of the US Government and the need for private sector assistance in the development of policies, operational concepts and standards for the NII and broader implementation and interface with the Global Information Infrastructure.

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来源： cnki会议评论

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环境科学与管理 1984年第4期 38-43页

作者： m.thompson BPahlavanpourL.t.thorne 聂艳梅伦敦帝国大学地质系应用地球化学研究组伦敦帝国大学地质系应用地球化学研究组天津市环保所

导言用各种分析技术测定处理过的水和天然水中的砷、锑、铋、硒和碲的方法已做过报导(wauchope, 1976; Ohta和Suzuki, 1978; Crecelies, 1978)。这些方法虽然非常灵敏,但是一次只能测定一种元素。本文的目的在于报告一种探索性研究方法... 详细信息

导言用各种分析技术测定处理过的水和天然水中的砷、锑、铋、硒和碲的方法已做过报导(wauchope, 1976; Ohta和Suzuki, 1978; Crecelies, 1978)。这些方法虽然非常灵敏,但是一次只能测定一种元素。本文的目的在于报告一种探索性研究方法,用这种方法可以同时快速

关键词：氢化物发生器氧化态精密度分析物直接分析法盐酸溶液预浓缩同时测定电感藕合相对标准偏差电感祸合硼氢化物硼烷浓缩法原子吸收法等离子体水样

A Generic Workflow for the Data FAIRification Process

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Data Intelligence 2020年第1期2卷 56-65页

作者： Annika Jacobsen Rajaram Kaliyaperumal Luiz Olavo Bonino da Silva Santos Barend mons Erik Schultes marco Roos mark thompson Leiden University medical Center Leiden2333 ZAThe Netherlands GO FAIR International Support&Coordination Office(GFISCO) LeidenThe Netherlands

the FAIR guiding principles aim to enhance the Findability,Accessibility,Interoperability and Reusability of digital resources such as data,for both humans and *** process of making data FAIR(“FAIRification”)can be described in multiple *** this paper,we describe a generic step-by-step FAIRification workflow to be performed in a multidisciplinary team guided by FAIR data *** FAIRification workflow should be applicable to any type of data and has been developed and used for“Bring Your Own Data”(BYOD)workshops,as well as for the FAIRification of e.g.,rare diseases *** steps are:1)identify the FAIRification objective,2)analyze data,3)analyze metadata,4)define semantic model for data(4a)and metadata(4b),5)make data(5a)and metadata(5b)linkable,6)host FAIR data,and 7)assess FAIR *** each step we describe how the data are processed,what expertise is required,which procedures and tools can be used,and which FAIR principles they relate to.

关键词： FAIR data FAIRification workflow FAIR data stewardship Hands-on FAIRification FAIR dissemination

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On the mechanistic origins of maximum strength in nanocrystalline metals

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npj Computational materials 2020年第1期6卷 393-404页

作者： Ankit Gupta Jacob Gruber Satish S.Rajaram Gregory B.thompson David L.mcDowell Garritt J.tucker Colorado School of mines Mechanical EngineeringGoldenCO 80401USA Department of mechanical Engineering Drexel UniversityPhiladelphiaPA 19104USA Department of metallurgical and materials Engineering University of AlabamaTuscaloosaAL 35487USA Department of mechanical Engineering Georgia Institute of TechnologyAtlantaGA 30332USA

the maximum strength of polycrystalline metals/alloys has been suggested to occur at nanoscale grain sizes where the governing deformation mechanism transitions from dislocation plasticity to grain boundary mediated *** tremendous progress recently uncovering links between transitions in nanoscale mechanisms and peak strength,the scientific literature is mostly devoid of any quantitative support,owing to the difficulty in measuring the resolved contribution of individual mechanisms to microstructural strain *** this study,the contribution of individual nanoscale mechanisms to the overall deformation of nanocrystalline Ni is calculated from atomistic simulations leveraging continuum-based kinematic metrics to compute mechanistic contributions to microstructural strain.

关键词： strength deformation grain