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Morphological Change in the Northern Red River Delta,Vietnam

Journal of Ocean University of China 2018年第6期17卷 1272-1280页

作者： BUI Vuong van FAN Daidu NGUYEN Dac Ve TRAN Dinh Lan TRAN Duc Thanh HOANG van Long NGUYEN Thi Hong Hanh Institute of Marine Environment and Resources Vietnam Academy of Science and TechnologyHaiphong 18000Vietnam State Key Laboratory of Marine Geology Tongji UniversityShanghai 200092China Hanoi University of Mining and Geology Hanoi 10000Vietnam Graduate University of Science and Technology Vietnam Academy of Science and TechnologyHanoi 10000Vietnam

Coastal erosion has become a worldwide concern, typically in the densely populated Asian mega-river deltas. Severe coastal erosion in the southern Red River Delta(RRD) has been intensively studied. Coastal morphological change in the northern RRD was examined in detail through DEM(Digital Elevation Model) analysis based on time series of bathymetrical maps(1965–2004) and Landsat images(1975–2015) in this study. The results show that the northern RRD is featured by rapid coastal accretion in the past few decades, although suspended sediment flux has dropped by roughly 60% after the completeness of Hoa Binh dam(HBD) in 1988 and relative sea level rose at 1.9 mm yr^(-1). However, accretion at the outer part of subtidal shoals and platforms was observed to slow down quickly or even turned into erosion in the last two decades. The resuspended sediments from the erosion zone can be transported landward to replenish the inner coastal zone, keeping the latter accretion in the near future to compensate for the sediment discharge decrease from the river. However, this lag effect should be terminated soon if other adverse effects go worse, e.g., damming rivers, sea-level rising, strengthening storms, land reclamation and other poor-designed coastal engineering. Coastal planners and managers should pay full attention to these changes.

关键词： Morphological change DEM coastal erosion coastal engineering coastal management tide-dominated Red River Delta

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Real-life multi-center retrospective analysis on nivolumab in difficult-to-treat patients with advanced hepatocellular carcinoma

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World Journal of Hepatology 2022年第8期14卷 1608-1620页

作者： Nika De Wilde Luisa Vonghia Sven Francque thomas De Somer Ali Bagdadi Eva Staub Jasper Lambrechts Ana-Maria Bucalau Gontran Verset Christophe van Steenkiste Department of Internal Medicine University Hospital GhentGhent 9000Belgium Department of Gastroenterology and Hepatology University Hospital AntwerpAntwerp 2650Belgium Department of Gastroenterology and Hepatology Maria Middelares HospitalGhent 9000Belgium Department of Psychiatry UniversitéLibre de BruxellesBrussels 1050Belgium Department of Orthopedics University of GhentGhent 9000Belgium Department of Gastroenterology Hepatopancreatology and Digestive OncologyCUB Erasme HospitalUniversitéLibre de BruxellesBrussels 1070Belgium Department of Gastroenterology AZ Maria MiddelaresGhent 9000Belgium Department of Gastroenterology University AntwerpAntwerp 2650Belgium

BACKGROUND Hepatocellular carcinoma(HCC)is one of the leading causes of cancer-related death *** landscape of the systemic treatment for advanced HCC is changing quickly,and recently,the standard of care became either atezolizumab plus bevacizumab or tremelimumab plus durvalumab in the single tremelimumab regular interval durvalumab *** monotherapy has proven to be effective sometimes for advanced HCC and could be a valuable treatment option for patients outside current treatment indications and reimbursement criteria for the standard of *** is a particular population of *** To evaluate the real-world effectiveness of nivolumab monotherapy in patients with advanced HCC who are not eligible for other *** We conducted a retrospective,multicentric study including 29 patients with advanced HCC from 3 Belgian tertiary *** patients had had prior chemotherapy or were intolerant or ineligible for *** study subjects received nivolumab 3 mg/kg in monotherapy,administered once every two weeks *** continued until disease progression,severe adverse events or *** were retrieved from patients'medical *** outcome parameters such as radiological response according to response evaluation criteria in solid tumors(RECIST)criteria,the biological response through the evolution of the alpha-fetoprotein(AFP)level,and clinical response considering both the Child–Pugh(CP)score and the World Health Organization(WHO)performance status(PS)were reported.A safety profile was also *** analysis was performed using the SPSS Statistics 27 statistical software *** The radiological overall response rate(defined as complete or partial response according to the immune RECIST and modified RECIST criteria)to nivolumab monotherapy was 24.1%.The biological overall response rate(defined as a decrease of≥25%in AFP blood level)was 20.7%.Radiological and biological responses w

关键词： Advanced hepatocellular carcinoma Systemic treatment Immunotherapy Nivolumab Difficult-to-treat patients Real-life setting

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Diagnostic evaluation of dot-binding assays for circulating cathodic antigen (CCA) and anti-CCA determinations in schistosomiasis japonica using defined biotinylated conjugates

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中华医学杂志(英文版) 1993年第8期106卷 592-592页

作者： Qian Zong-li G. J. van dam A. M. Deelder Department of Parasitology SHanghai Second Medical University Shanghai 200025 Laboratory for Parasitology State University Leiden Leiden RC 2300 The Netherlands

Using an affinity purified circulating cathodic antigen (CCA) preparation and an anti-CCA monoclonal IgM antibody, we modified dot-binding assays for anti-CCA and CCA detections with biotinylated conjugates. A study on 3 groups of 138 schistosomiasis japonica patients and 105 healthy individuals demonstrated a high predictive rate of over 95% in both assays, highly comparable to those of circumoral precipitin test (COPT). A blind test in 342 samples of various groups revealed higher detection rates in Ab-binding assay with both acute and chronic case groups (over 90%), but comparatively lower rates in Ag-binding assay with chronic groups (50%-76%). Distinct reductions of either GMRT and dot-indexes were found in 48 praziquantel treated patients whose sera were collected 9 months after chemotherapy. The major target molecules detected by the two binding assays were proved to be the protein incorporated moieties readily precipitated by trichloroacetic acid (TCA), ammonium sulphate and higher concentration of polyethylene glycol (PEG) suggestive of pathological, specific immunoglobulins in the free or complex forms. Non-specific dot reactions were found in some acute and chronic patients with non-relevant bovine serum albumin (BSA) conjugated peroxidase and streptavidin-PO controls, and also in normal sera with the McAb peroxidase conjugate or when working concentration of the biotinylated McAb was not properly titrated. The reliability and proper management of the dot binding assay as an immunodiagnostic tool were discussed.

关键词： ELISA IMMUNOASSAY ANTIBODIES

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Systems biology approach for quality control of Traditional Chinese Medicine(TCM)

Systems biology approach for quality control of Traditional ...

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第十五次全国色谱学术报告会

作者： Wen-Te Chang thomas Hankemeier Jan van der Greef TNO Systems Biology and SU Biomedicine P．O.Box 360 3700 AJ Zeist．The Netherlands and Center for Medical Systems Biology／Leiden University 2300 RA Leidenthe Netherlands

Indigenous herbs are very important concept for traditional Chinese medicine (TCM) materials medica production. This means that the highest quality herbs will come from the most suitable areas. For this reason certain areas are known for their specific herbs. A number of factors determine the quality of herbs and have to be taken into consideration in the production of material medica. For instance, the geographical source, including the climate and earth factors which can influence the growth of herbal plants absolutely. In addition, the Processing of TCM materials medica is also a very important part which has a history as long as traditional Chinese herbal medicine itself. It underlines the importance of processing for the clinical effects and the quality of herbs.

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胚胎内耳葡萄糖胺聚糖的组织化学观察

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中华耳鼻咽喉头颈外科杂志 1990年第2期25卷 113-113,129页

作者：苏鸿禧 thomas R. van De Water 北京市耳鼻咽喉科研究所美国爱因斯坦医学院耳发育生物学实验室

葡萄糖胺聚糖(Glycosaminoglycan)是胚胎细胞外基质的主要成分,是细胞繁殖、移行、发育和分化的重要因素。哺乳动物内耳发育的早期,听泡的神经外胚层被头部中胚层的疏松间充质所包裹,之后间充质发生一系列变化,包括细胞的聚集,细胞外基... 详细信息

葡萄糖胺聚糖(Glycosaminoglycan)是胚胎细胞外基质的主要成分,是细胞繁殖、移行、发育和分化的重要因素。哺乳动物内耳发育的早期,听泡的神经外胚层被头部中胚层的疏松间充质所包裹,之后间充质发生一系列变化,包括细胞的聚集,细胞外基质和耳囊软骨的形成。这些变化对软骨性耳囊作为骨迷路形成的模板和在成年骨迷路中残留软骨结构将起重要的作用。细胞外基质硫酸化葡萄糖胺聚糖的合成与耳囊

关键词：胚胎内耳葡萄糖胺聚糖

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Hypoxia Is a Developmental Regulator in Plant Meristems

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Molecular Plant 2019年第11期12卷 1422-1424页

作者： Anne-Laure Le Gac thomas Laux Signalling Research Centres BIOSS and CIBSS Faculty of BiologyUniversity of FreiburgSchanzlestrasse 179104 FreiburgGermany Sino-German Joint Research Center on Agricultural Biology Shandong Agricultural UniversityTai'anShandongChina

Despite the presence of about 21%O2 in the atmosphere,organs of plants and mammals are inevitably subject to lower O2 tensions(pO2)due to high O2 demand in metabolic active cells and limited O2 transport *** humans,for example,the p O2 decreases from the ambient 21%(160 mm Hg)of the inhaled air to 2%-9%in the internal organs(Brahimi-Horn and Pouyssegur,2007).To cope with this limited oxygen supply,aerobic organisms have developed a variety of adaptive responses at cellular,tissue,and organismal levels(Bailey-Serres et al.,2012).Although low O2 tensions are the normal conditions for organs,the ambient 21%O2 is usually referred to as normoxia and the lower internal concentrations as hypoxia(van Dongen and Licausi,2015).

关键词： Hypoxia Developmental Regulator ambient Plant Meristems

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SOME RECURRENCE FORMULAS FOR BOX SPLINES AND CONE SPLINES

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Analysis in Theory and Applications 2004年第4期20卷 297-306页

作者： Patrick J. van Fleet Department of Mathematics University of St. thomas St. Paul MN 55105 USA

A degree elevation formula for multivariate simplex splines was given by Micchelli and extended to hold for multivariate Dirichlet splines in [8]. We report similar formulae for multivariate cone splines and box splines. To this end, we utilize a relation due to Dahmen and Micchelli that connects box splines and cone splines and a degree reduction formula given by Cohen, Lyche, and Riesenfeld in [2].

关键词： box spline cone spline degree elevation

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Diverse organic carbon activates soil microbiome functioning via niche modulation

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Soil Ecology Letters 2023年第4期5卷 5-7页

作者： thomas Pommier UMR INRAE 1418 Ecologie Microbienne UniversitéClaude Bernard Lyon 1F-69622 VilleurbanneFrance

Considering the“One Health”framework,the soil microbial community is essential for plant,animal,and ultimately to human health(Banerjee and van der Heijden,2023).Similar to the microbiome in human gut(Berendsen et al.,2012),the plant-associated microbiota drives key functions in agroecosystems,such as supporting nutrient uptake,suppressing plant pathogens,or improving host stress tolerance(Hartmann and Six,2023).However,continuous mono-cropping run in intensified agroecosystems often leads to the loss of soil biodiversity,reduces resistance to plant pathogens,and ultimately causes the outbreak of soil-borne diseases(Tsiafouli et al.,2015;Raaijmakers and Mazzola,2016).This represents a major threat to global food security and sustainable development in agriculture(Strange and Scott,2005;Butler,2013).Accordingly,soil microbiome engineering is widely recognized as a promising approach to promote plant health and agricultural sustainability(Raaijmakers and Mazzola,2016;Hartman et al.,2018).

关键词： soil intensified supporting

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前十字韧带在维持膝关节稳定性上的重要性

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中华骨科杂志 2007年第11期27卷 875-880页

作者： Samuel K. van de Velde thomas J. Gill 李国安美国马萨诸塞州总医院/哈佛医学院矫形外科系生物力学实验室

前十字韧带（anterior cruciate ligament，ACL）是膝关节的四条主要韧带之一，其功能是与膝关节内部及周围的其他解剖结构共同维持膝关节的静态和动态平衡。ACL具有复杂的三维结构，传统上将ACL分为两束，前内侧束和后外侧束…，是以... 详细信息

前十字韧带（anterior cruciate ligament，ACL）是膝关节的四条主要韧带之一，其功能是与膝关节内部及周围的其他解剖结构共同维持膝关节的静态和动态平衡。ACL具有复杂的三维结构，传统上将ACL分为两束，前内侧束和后外侧束…，是以韧带在胫骨上的插入方向命名的（图1）。ACL起始于胫骨髁间隆起的前区，延伸至股骨髁间窝后外侧。

关键词：膝关节稳定性前十字韧带胫骨髁间隆起股骨髁间窝 ACL 解剖结构膝关节内三维结构

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超高效液相色谱-飞行时间质谱快速分析人参根中的皂甙化合物

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色谱 2011年第6期29卷 488-494页

作者：胡春秀孔宏伟朱超魏恒 thomas HANKEMEIER Jan van der GREEF 王梅许国旺中国科学院大连化学物理研究所中国科学院分离分析化学重点实验室辽宁大连116023 荷兰莱顿大学分析生物科学部莱顿/阿姆斯特丹药物研究中心荷兰莱顿2333CC 荷兰SU生物医药有限公司及荷兰应用科学研究机构荷兰载斯特3700AJ 华东理工大学药学院上海200237

建立了超高效液相色谱-飞行时间质谱快速分析人参根部提取物中的皂甙类化合物的方法。色谱柱为HSST3超高效液相色谱柱(100 mm×2.1 mm,1.8μm);以15 mmol/L甲酸铵水溶液-乙腈为流动相,采用二元梯度洗脱的方式对人参主根的皂甙提取物进... 详细信息

建立了超高效液相色谱-飞行时间质谱快速分析人参根部提取物中的皂甙类化合物的方法。色谱柱为HSST3超高效液相色谱柱(100 mm×2.1 mm,1.8μm);以15 mmol/L甲酸铵水溶液-乙腈为流动相,采用二元梯度洗脱的方式对人参主根的皂甙提取物进行分离。基于待测目标物的多级质谱碎片离子、精确质量等信息,结合9种人参皂甙标准化合物的多级质谱碎片离子质谱图,共鉴定出人参主根提取物中27种皂甙类化合物。在确定的条件下,以9种人参皂甙标样为研究对象,进行了全面的方法学考察,发现它们的线性范围分别为0.33～9.00 mg/L(Rg1),0.11～9.00 mg/L(Re),0.02～2.00 mg/L(Rf),0.07～6.00 mg/L(Rg2),0.04～3.00 mg/L(Rb1,Rb3),0.22～6.00 mg/L(Rc),0.04～9.00 mg/L(Rb2,Rd);在中等加标浓度时,经内标物峰面积校正的9种皂甙标准化合物的峰面积的相对标准偏差(RSD)不高于11.3%;低、中、高3个质量浓度加标水平的回收率范围分别为90%～100%、98%～104%及96%～103%;最低检出限为3.5～18.5μg/L。该方法具有高分辨、快捷、简便、可靠等特点,并成功地应用于分析同一产地、不同生长时间的人参干燥主根中皂甙的差异。可以预计此方法可进一步应用于各种人参原料和制品中皂甙的快速测定。

关键词：超高效液相色谱质谱人参皂甙人参

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