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The miracle transplantation of a black leg by the surgeon saints Cosmas and damian

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Hepatobiliary Surgery and Nutrition 2024年第1期13卷 1-2页

作者： thomas M.van Gulik Department of Surgery Amsterdam University Medical CenterUniversity of AmsterdamAmsterdamThe Netherlands

The miracle of the saints Cosmas and damian refers to transplantation of a black leg onto a white man that took place in medieval Rome(Figure 1)(1).A sexton of a church in Rome was seriously affected by cancer in his right *** into a delirious fever,he dreamed that the holy surgeons,saint Cosmas and saint damian,visited him and skilled as they were,decided to remove the affected leg and replace it with a healthy *** went to the grave of a recently deceased Ethiopian man and retrieved the right leg of this black man and took it to the *** sick leg of the sexton was amputated and they transplanted onto him the leg of the black *** their miracle operation,Cosmas and damian have been elevated to patron saints of the surgical profession and many surgical societies have adopted their names in honor of them.

关键词： black Figure replace

James Hogarth Pringle and his time-honored maneuver

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Hepatobiliary Surgery and Nutrition 2024年第3期13卷 391-392页

作者： thomas M.van Gulik Department of Surgery Amsterdam University Medical CenterUniversity of AmsterdamAmsterdamThe Netherlands

The classical method to control blood loss during parenchymal transection of the liver is the Pringle *** his landmark article in the Annals of Surgery in 1908,James Hogarth Pringle occluded the afferent vessels to the liver by compressing the hepatoduodenal ligament between his thumb and index finger(1).He applied this maneuver in eight patients who required emergency laparotomy for major hemorrhage after severe liver *** he succeeded in controlling blood loss,the eight patients he described unfortunately all *** outcome did not prevent the Annals of Surgery from publishing his report after which James Hogarth Pringle was ready to enter the‘Hall of Fame’.Vascular inflow occlusion,applied in a continuous or intermittent fashion,became the mainstay technique for reducing blood loss during liver transection,and has remained so in the present era of laparoscopic and robotic liver resection(2).

关键词： Pringle Surgery patients

Rethinking Global Context in Crowd Counting

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Machine Intelligence Research 2024年第4期21卷 640-651页

作者： Guolei Sun Yun Liu thomas Probst Danda Pani Paudel Nikola Popovic Luc van Gool Computer Vision Lab ETH ZürichZürich 8092Switzerland Institute for Infocomm Research A*STARSingapore 138632Singapore Magic Leap Zürich 8050Switzerland

This paper investigates the role of global context for crowd ***,a pure transformer is used to extract features with global information from overlapping image *** by classification,we add a context token to the input sequence,to facilitate information exchange with tokens corresponding to image patches throughout transformer *** to the fact that transformers do not explicitly model the tried-and-true channel-wise interactions,we propose a token-attention module(TAM)to recalibrate encoded features through channel-wise attention informed by the context *** that,it is adopted to predict the total person count of the image through regression-token module(RTM).Extensive experiments on various datasets,including ShanghaiTech,UCFQNRF,JHU-CROWD++and NWPU,demonstrate that the proposed context extraction techniques can significantly improve the performanceover the baselines.

关键词： Crowd counting vision transformer global context attention density map.

Single-emitter super-resolved imaging of radiative decay rate enhancement in dielectric gap nanoantennas

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Light(Science & Applications) 2024年第1期13卷 47-54页

作者： R.Margoth Córdova-Castro Bart van dam Alberto Lauri Stefan A.Maier Riccardo Sapienza Yannick De Wilde Ignacio Izeddin Valentina Krachmalnicoff Institut Langevin ESPCI ParisPSL UniversityCNRSParisFrance The Blackett Laboratory Department of PhysicsImperial College LondonLondonUK School of Physics and Astronomy Monash UniversityClaytonVictoriaAustralia Chair in Hybrid Nanosystems Ludwig-Maximilians Universität MünchenMuenchenGermany Department of Physics University of OttawaOttawaONCanada

High refractive index dielectric nanoantennas strongly modify the decay rate via the Purcell effect through the design of radiative *** to their dielectric nature,the field is mainly confined inside the nanostructure and in the gap,which is hard to probe with scanning probe *** we use single-molecule fluorescence lifetime imaging microscopy(smFLIM)to map the decay rate enhancement in dielectric GaP nanoantenna dimers with a median localization precision of 14 *** measure,in the gap of the nanoantenna,decay rates that are almost 30 times larger than on a glass *** comparing experimental results with numerical simulations we show that this large enhancement is essentially radiative,contrary to the case of plasmonic nanoantennas,and therefore has great potential for applications such as quantum optics and biosensing.

关键词： dielectric decay radiative

The lymphatic vessels of the liver observed by Frederik Ruysch

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Hepatobiliary Surgery and Nutrition 2024年第5期13卷 757-758页

作者： thomas M.van Gulik Department of Surgery Amsterdam University Medical CenterUniversity of AmsterdamAmsterdamThe Netherlands

The Dutch physician and anatomist Frederik Ruysch[1638-1731]was back in the 17th century,one of the first to discover the lymphatic vessels and associated lymph *** exposed the inguinal lymph nodes during dissection of a human cadaver;however,most of his observations were based on anatomical dissections of living animals(1).He had a wide reputation for his exceptional anatomical dissection *** performed an anatomical dissection of a horse three hours after the animal had eaten,and noted‘white vessels’with a milky content in the mesentery of the *** prepared these lymphatic vessels and after tying off on two sides,he filled a vessel with air using a fine *** observed‘crescent-shaped’valves in the lymphatic vessels and concluded that the flow of lymph was directed into one direction(2).

关键词： Dutch white exceptional

Oral transforming growth factor-beta receptor 1 inhibitor vactosertib promotes osteosarcoma regression by targeting tumor proliferation and enhancing anti-tumor immunity

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Cancer Communications 2024年第8期44卷 884-888页

作者： Sung Hee Choi Jay thomas Myers Suzanne Louise Tomchuck Melissa Bonner Saada Eid Daniel Tyler Kingsley Kristen Ashley van Heyst Seong-Jin Kim Byung-Gyu Kim Alex Yee-Chen Huang Department of Pediatrics CaseWestern Reserve University School of MedicineClevelandOhioUSA Case Comprehensive Cancer Center CaseWestern Reserve University School of MedicineClevelandOhioUSA Department of Pathology CaseWestern Reserve University School of MedicineClevelandOhioUSA MedPacto Inc. SeoulRepublic of Korea Center for Pediatric Immunotherapy Angie Fowler AYA Cancer InstituteUH Rainbow Babies and Children’s HospitalClevelandOhioUSA

Osteosarcoma is an aggressive malignant bone sarcoma common among children,adolescents,and young *** 20%of patients present with pulmonary metastasis,and an additional 40%develop pulmonary osteosarcoma *** survival ou... 详细信息

关键词： osteosarcoma immunity patients

Metabolic syndrome and the urinary microbiome of patients undergoing percutaneous nephrolithotomy

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Asian Journal of Urology 2024年第2期11卷 316-323页

作者： Ryan A.Dornbier Chirag P.Doshi Shalin C.Desai Petar Bajic Michelle van Kuiken Mark Khemmani Ahmer V.Farooq Larissa Bresler thomas M.T.Turk Alan J.Wolfe Kristin G.Baldea Loyola University Medical Center Department of UrologyMaywoodILUSA Loyola University Chicago Department of Microbiology and ImmunologyMaywoodILUSA

Objective:To identify possible stone-promoting microbes,we compared the profiles of microbes grown from stones of patients with and without metabolic syndrome(MetS).The association between MetS and urinary stone disease is well established,but the exact pathophysiologic relationship remains *** evidence suggests urinary tract dysbiosis may lead to increased nephrolithiasis ***:At the time of percutaneous nephrolithotomy,bladder urine and stone fragments were collected from patients with and without *** sample types were subjected to expanded quantitative urine culture(EQUC)and 16 S ribosomal RNA gene ***:Fifty-seven patients included 12 controls(21.1%)and 45 MetS patients(78.9%).Both cohorts were similar with respect to demographics and non-MetS *** controls had uric acid stone *** EQUC,bacteria were detected more frequently in MetS stones(42.2%)compared to controls(8.3%)(p=0.041).Bacteria also were more abundant in stones of MetS patients compared to *** validate our EQUC results,we performed 16 S ribosomal RNA gene *** 12/16(75.0%)sequence-positive stones,EQUC reliably isolated at least one species of the sequenced *** were detected in both“infectious”and“non-infectious”stone ***:Bacteria are more common and more abundant in MetS stones than control *** findings support a role for bacteria in urinary stone disease for patients with MetS regardless of stone composition.

关键词： Nephrolithiasis Urolithiasis Metabolic syndrome Urinary microbiome Percutaneous nephrolithotomy

Balanced Monitoring of Flow Phenomena in Moving Mesh Methods

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Communications in Computational Physics 2010年第1期7卷 138-170页

作者： A.van dam P.A.Zegeling Department of Mathematics Utrecht UniversityP.O.Box 80.0103508 TA UtrechtThe Netherlands

Adaptive moving mesh research usually focuses either on analytical deriva-tions for prescribed solutions or on pragmatic solvers with challenging physical appli-cations. In the latter case, the monitor functions that steer mesh adaptation are oftendefined in an ad-hoc way. In this paper we generalize our previously used moni-tor function to a balanced sum of any number of monitor components. This avoidsthe trial-and-error parameter fine-tuning that is often used in monitor functions. Thekey reason for the new balancing method is that the ratio between the maximum andaverage value of a monitor component should ideally be equal for all *** as a monitor component is a good motivating example for this. Entropy alsoturns out to be a very informative monitor component. We incorporate the monitorfunction in an adaptive moving mesh higher-order finite volume solver with HLLCfluxes, which is suitable for nonlinear hyperbolic systems of conservation laws. Whenapplied to compressible gas flow it produces very sharp results for shocks and otherdiscontinuities. Moreover, it captures small instabilities (Richtmyer-Meshkov, Kelvin-Helmholtz). Thus showing the rich nature of the example problems and the effective-ness of the new monitor balancing.

关键词： Moving mesh method conservative interpolation balanced monitor function direc-tional adaptation hydrodynamics implosion problem

Effects of turbulence on carbon emission in shallow lakes

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Journal of Environmental Sciences 2018年第7期30卷 166-172页

作者： Lin Zhu Boqiang Qin Jian Zhou Bryce van dam Wenqing Shi Taihu Lake Laboratory Ecosystem Station State Key Laboratory of Lake Science and Environment Nanjing Institute of Geography and Limnology Chinese Academy of Sciences Institute of Marine Sciences University of North Carolina at Chapel Hill Center for Eco-Environmental Research Nanjing Hydraulics Research Institute

Turbulent mixing is enhanced in shallow lakes. As a result, exchanges across the air–water and sediment–water interfaces are increased, causing these systems to be large sources of greenhouse gases. This study investigated the effects of turbulence on carbon dioxide（CO2）and methane（CH4） emissions in shallow lakes using simulated mesocosm *** demonstrated that turbulence increased CO2 emissions, while simultaneously decreasing CH4 emissions by altering microbial processes. Under turbulent conditions, a greater fraction of organic carbon was recycled as CO2 instead of CH4, potentially reducing the net global warming effect because of the lower global warming potential of CO2 relative to CH4. The CH4/CO2 flux ratio was approximately 0.006 under turbulent conditions, but reached 0.078 in the control. The real-time quantitative PCR analysis indicated that methanogen abundance decreased and methanotroph abundance increased under turbulent conditions, inhibiting CH4 production and favoring the oxidation of CH4 to *** findings suggest that turbulence may play an important role in the global carbon cycle by limiting CH4 emissions, thereby reducing the net global warming effect of shallow lakes.

关键词： Turbulence Carbon dioxide Methane Methanogen Methanotroph