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Tuning beneficial calcineurin phosphatase activation to counterα-synuclein toxicity in a yeast model of parkinson’s disease

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Neural Regeneration Research 2025年第1期20卷 199-200页

作者： Srishti Chawla Mikael Molin thomas Nystrom Institute for Biomedicine Sahlgrenska AcademyCentre for Ageing and Health-AgeCapUniversity of GothenburgGothenburgSweden Department of Life Sciences Chalmers University of TechnologyGothenburgSweden

Calcineurin(CN)is a calcium-and calmodulindependent serine/threonine that has been studied in many model organisms including yeast,filamentous fungi,plants,and *** biological functions range from ion homeostasis and virulence in lower eukaryotes to T-cell activation in humans by human nuclear factors of activated *** is a heterodimeric protein consisting of a catalytic subunit,calcineurin A(Cna1p),which contains an active site with a dinuclear metal center,and a regulatory Ca^(2+) binding subunit called calcineurin B(Cnb1p)required to activate *** calcineurin B subunit has been highly conserved through evolution:For example,the mammalian calcineurin B shows 54%identity with calcineurin B from Saccharomyces cerevisiae.

关键词： activation dinuclear conserved

Compressional origin of the Aegean Orogeny,Greece

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Geoscience Frontiers 2022年第2期13卷 383-404页

作者： Michael p.Searle thomas N.Lamont Dept Earth Sciences Oxford UniversitySouth Parks RoadOxfordOX13ANUK School of Earth and Environmental Sciences University of St AndrewsSt AndrewsKY169ALUK

The Aegean Sea area is thought to be an actively extending back-arc region,north of the present day Hellenic volcanic arc and north-dipping subduction zone in the Eastern *** area shows extensive normal faulting,ductile‘extensional’shear zones and extensional S-C fabrics throughout the islands that have previously been related to regional Aegean extension associated with slab rollback on the Hellenic Subduction *** this paper,we question this interpretation,and suggest the Cenozoic geodynamic evolution of the Aegean region is associated with a Late Cretaceous-Eocene NE-dipping subduction zone that was responsible for continentcontinent collision between Eurasia and Adria-Apulia/*** of eclogite and blueschist facies rocks in the Cyclades and kyanite-sillimanite grade gneisses in the Naxos core complex have pressures that are far greater than could be accounted for purely by lithospheric extension and isostatic *** identify four stages of crustal shortening that affected the region prior to regional lithospheric extension,herein called the Aegean *** orogeny followed a classic Wilson cycle from early ophiolite obduction(ca.74 Ma)onto a previously passive continental margin,to attempted crustal subduction with Hp eclogite and blueschist facies metamorphism(ca.54-45 Ma),through crustal thickening and regional kyanite-sillimanite grade Barroviantype metamorphism(ca.22-14 Ma),to orogenic collapse(periods of‘extensional’fabrics relate to:(1)Exhumation of blueschists and eclogite facies rocks showing tight-isoclinal folds and top-NE,base-SW fabrics,recording return flow along a subduction channel in a compressional tectonic setting(ca.50-35 Ma).(2)Extensional fabrics within the core complexes formed by exhumation of kyanite-and sillimanite gneisses showing thrust-related fabrics at the base and‘extensional’fabrics along the top(ca.18.5-14 Ma).(3)Regional ductile-brittle‘extensional’fabrics and low-angle

关键词： Cyclades Ophiolite High-pressure metamorphism Core complex Compressional tectonics

Assessment of soil erosion in a tropical mountain river basin of the southern Western Ghats,India using RUSLE and GIS

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Geoscience Frontiers 2018年第3期9卷 893-906页

作者： Jobin thomas Sabu Joseph K.p.Thrivikramji EWRE Department of Civil EngineeringIndian Institute of Technology MadrasChennai600036Tamil NaduIndia Department of Environmental Sciences University of KeralaThiruvananthapuram695581KeralaIndia Center for Environment and Development Thiruvananthapuram695013KeralaIndia

Revised Universal Soil Loss Equation(RUSLE) model coupled with transport limited sediment delivery(TLSD) function was used to predict the longtime average annual soil loss, and to identify the critical erosion-/deposition-prone areas in a tropical mountain river basin, viz., Muthirapuzha River Basin(MRB; area=271.75 km^2), in the southern Western Ghats, India. Mean gross soil erosion in MRB is 14.36 t ha^(-1) yr^(-1), whereas mean net soil erosion(i.e., gross erosion-deposition) is only 3.60 t ha^(-1) yr^(-1)(i.e., roughly 25% of the gross erosion). Majority of the basin area(~86%) experiences only slight erosion(positional environment for the eroded sediments(e.g., the terraces of stream reaches, the gentle plains as well as the foot slopes of the plateau scarps and the terrain with concordant summits). Although mean gross soil erosion rates in the natural vegetation belts are relatively higher, compared to agriculture, settlement/built-up areas and tea plantation, the sediment transport efficiency in agricultural areas and tea plantation is significantly high,reflecting the role of human activities on accelerated soil erosion. In MRB, on a mean basis, 0.42 t of soil organic carbon(SOC) content is being eroded per hectare annually, and SOC loss from the 4th order subbasins shows considerable differences, mainly due to the spatial variability in the gross soil erosion rates among the sub-basins. The quantitative results, on soil erosion and deposition, modelled using RUSLE and TLSD, are expected to be beneficial while formulating comprehensive land management strategies for reducing the extent of soil degradation in tropical mountain river basins.

关键词： Soil erosion RUSLE Transport limited sediment delivery Muthirapuzha river basin Western Ghats Kerala

Dikaryotization seems essential for hypha formation and infection of coccid in the life-cycle of Auriculoscypha anacardiicola

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Studies in Fungi 2020年第1期5卷 66-72页

作者： thomas A and Manimohan p Department of Botany University of CalicutKerala673635India

Auriculoscypha,a monotypic basidiomycetous genus with *** as the only known species,is endemic to southwest India where it is seen in triple symbioses with a coccid and anacardiaceous trees involving interactions between three trophic *** present study was an attempt to verify the hypothesis that dikaryotization is a prerequisite for hypha formation and coccid-infection in the life-cycle of ***-microscopic observations using Giemsa staining and fluorescent microscopic observations of DApI-stained material were made to determine the number of nuclei in cells/hyphal compartments at various stages in the life-cycle of the *** studies revealed that while the basidiospores were consistently unicellular and uninucleate at the time of discharge,the hyphae of *** were consistently *** with the observed inability of a single basidiospore to establish a mycelium,our study indicates that dikaryotization is essential for hypha formation and infection of the coccid in the life-cycle of ***.

关键词： Fungus-insect-symbiosis pucciniomycotina Septobasidiaceae scale-insect yeast-stage

Load carrying capacity of a heterogeneous surface bearing

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Friction 2015年第4期3卷 287-293页

作者： Evan thomas Mircea D pASCOVICI Romeo p GLOVNEA Tribology Laboratory Department of Engineering and DesignUniversity of SussexUnited Kingdom Machine Elements and Tribology Division Politehnica University of BucharestBucharestRomania

It has been shown before that liquids can slip at a solid boundary,which prompted the idea that parallel-surfaces bearings can be achieved just by alternating slip and non-slip regions in the direction of fluid *** amount of slip at the wall depends on the surface tension at the liquid-solid interface,which in turn depends on the chemical state of the surface and its *** the present study a heterogeneous surface was obtained by coating half of a circular glass disc with a coating repellant to glycerol.A rotating glass disc was placed at a known/calibrated distance and the gap was filled with *** the mobile surface moving from the direction of slip to non-slip region it can be theoretically shown that a pressure build up can be *** pressure gradient in the two regions is constant,similar to that in a Rayleigh step bearing,with the maximum pressure at the separation *** heterogeneous disc was placed on a holder supported by a load cell thus the force generated by this pressure increase can be measured *** were carried out at different sliding speeds and gaps and the load carried was measured and subsequently compared with theoretical *** allowed the slip coefficient to be evaluated.

关键词： bearing slip heterogeneous load

Morphometric aspects of a small tropical mountain river system,the southern Western Ghats,India

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International Journal of Digital Earth 2010年第2期3卷 135-156页

作者： Jobin thomas Sabu Joseph K.p.Thrivikramaji Department of Environmental Sciences University of KeralaThiruvananthapuram 695581KeralaIndia Department of Geology University of KeralaThiruvananthapuram 695581KeralaIndia

The Muthirapuzha watershed(MW)is one among the major tributaries of periyarthe longest west flowing river in Kerala,India.A morphometric analysis was carried out to determine the spatial variations in the drainage characteristics of MW and its 14 fourth order sub-watersheds(SW1SW14)using Survey of India topographic maps and Landsat ETM*** study revealed that the watershed includes a sixth order stream and lower order streams dominate the *** did indicate that rainfall has a significant role in the drainage development whereas structure and relief of rocks dictate the drainage *** asymmetry in the drainage distribution is correlated with the tectonic history of the Munnar plateau in the late paleocene *** watershed is moderate to well-drained and exhibited a geomorphic maturity in its physiographic *** shape parameters revealed the elongated nature of MW and drainage network development in the ***,the analysis provided significant insight into the terrain *** study strongly brings to light,(a)the tendency of the watershed to soil loss and(b)the hydrological makeup of the subwatersheds,which combined helped to formulate a comprehensive watershed management plan.

关键词： morphometry digital earth Muthirapuzha watershed Western Ghats India

Kinematic and Dynamic Analysis of a 3-■US Spatial parallel Manipulator

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Chinese Journal of Mechanical Engineering 2020年第1期33卷 114-130页

作者： Mervin Joe thomas M.L.Joy A.p.Sudheer Mechatronics/Robotics Lab Department of Mechanical EngineeringNational Institute of Technology CalicutKozhikodeIndia

parallel Kinematic Machines(pKMs)are being widely used for precise applications to achieve complex motions and variable poses for the end effector *** are found in medical,assembly and manufacturing industries where accuracy is *** is often desired to have a compact and simple architecture for the robotic *** this paper,the kinematic and dynamic analysis of a novel 3-pRUS(p:prismatic joint,R:revolute joint,U:universal joint,S:spherical joint)parallel manipulator with a mobile platform having 6 Degree of Freedom(Do F)is *** kinematic equations for the proposed spatial parallel mechanism are formulated using the Modified Denavit-Hartenberg(DH)technique considering both active and passive *** kinematic equations are used to derive the Jacobian matrix of the mechanism to identify the singular points within the workspace.A Jacobian based sti ness analysis is done to understand the variations in sti ness for different poses of the mobile platform and further,it is used to decide trajectories for the end effector within the singularity free *** analytical model of the robot dynamics is presented using the Euler-Lagrangian approach with Lagrangian multipliers to include the system *** gravity and inertial forces of all links are considered in the mathematical *** analytical results of the dynamic model are compared with ADAMS simulation results for a pre-defined trajectory of the end effector.

关键词： parallel manipulator Kinematic modelling Workspace analysis Euler-Lagrangian modelling Singularity analysis Stiffness analysis

Decarbonising energy: The developing international activity in hydrogen technologies and fuel cells

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Journal of Energy Chemistry 2020年第12期29卷 405-415页

作者： John Meurig thomas peter p.Edwards peter J.Dobson Gari p.Owend Department of Materials Science&Metallurgy University of CambridgeCambridge CB30FSUK King Abdulaziz City for Science and Technology(KACST)-Oxford Centre of Excellence in petrochemicals and Inorganic Chemistry Laboratory University of OxfordOxford OX13QRUK The Queen’s College University of OxfordOxford OX14AWUK Annwvyn Solutions(Independent Consultant) BromleyKent BR13DWUK

Hydrogen technologies and fuel cells offer an alternative and improved solution for a decarbonised energy *** cells are electrochemical converters;transforming hydrogen (or energy sources containing hydrogen) and oxygen directly into *** hydrogen fuel cell,invented in 1839,permits the generation of electrical energy with high efficiency through a non-combustion,electrochemical process and,importantly,without the emission ofits point of ***,despite numerous efforts to exploit the obvious attractions of hydrogen technologies and hydrogen fuel cells,various challenges have been encountered,some of which are reviewed ***,however,given the exigent need to urgently seek low-carbon paths for humankind’s energy future,numerous countries are advancing the deployment of hydrogen technologies and hydrogen fuel cells not only for transport,but also as a means of the storage of excess renewable energy from,for example,wind and solar ***,hydrogen is also being blended into the natural gas supplies used in domestic heating and targeted in the decarbonisation of critical,large-scale industrial processes such as steel *** briefly review specific examples in countries such as Japan,South Korea and the people’s Republic of China,as well as selected examples from Europe and North America in the utilization of hydrogen technologies and hydrogen fuel cells.

关键词： Decarbonisation Hydrogen Energy Hydrogen Economy Fuel cells Environment Sustainability

On Huppert＇s Conjecture for Alternating Groups of Low Degrees

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Algebra Colloquium 2015年第2期22卷 293-308页

作者： Hung Ngoc Nguyen Hung p. Tong-Viet thomas p. Wakefield Department of Mathematics The University of Akron Akron Ohio 44325 USA School of Mathematical Sciences. North-West University (Mafikeng Campus) Mmabatho 2735 South Africa Department of Mathematics and Statistics Youngstown State University One University Plaza Youngstown Ohio 44555 USA

Bertram Huppert conjectured in the late 1990s that the nonabelian simple groups are determined up to an abelian direct factor by the set of their character degrees. Although the conjecture has been established for various simple groups of Lie type and simple sporadic groups, it is expected to be difficult for alternating groups. In [5], Hup- pert verified the conjecture for the simple alternating groups AN of degree up to 11. In this paper, we continue his work and verify the conjecture for the alternating groups of degrees 12 and 13.

关键词： alternating groups character degrees