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Nature Insp.red Hay Fever Therap.

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Journal of Bionic Engineering 2008年第4期5卷 335-339页

作者： Andrei p. sommer Institute of Micro and Nanomaterials University of Ulm

The survival oriented adap.ation of evolved biosystems to variations in their environment is a selective op.imization p.ocess. recognizing the op.imised end p.oduct and its functionality is the classical arena of bionic engineering. In a p.imordial world, however, the molecular organization and functions of p.ebiotic systems were solely defined by formative p.ocesses in their p.ysical and chemical environment, for instance, the interp.ay between interfacial water layers on surfaces and solar light. The formative p.tential of the interp.ay between light （laser light） and interfacial water layers on surfaces was recently exp.oited in the formation of sup.rcubane carbon nanocrystals. In evolved biosystems the formative p.tential of interracial water layers can still be activated by light. Here we rep.rt a case of hay fever, which was successfully treated in the course of a facial rejuvenation p.ogram starting in November 2007. Targeting p.imarily interfacial water layers on elastin fibres in the wrinkled areas, we p.esumably also activated mast cells in the nasal mucosa, rep.rted to p.ogressively decrease in the nasal mucosa of the rabbit, when frequently irradiated. Hay fever is induced by the release of mediators, esp.cially histamine, a p.ocess associated with the degranulation of mast cells. Decrease in mast cells numbers imp.ies a decrease in the release of histamine. To the best of our knowledge this is the first rep.rt on the treatment of hay fever with visible light. This ap.roach was insp.red by bionic thinking, and could help.ameliorating the condition of millions of p.op.e suffering from hay fever world wide.

关键词： allergic rhinitis biomimetic triangle crystalline interracial water layers light diamond elastin

Body Building on Diamonds

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Journal of Bionic Engineering 2009年第1期6卷 14-17页

作者： Andrei p. sommer Tim Scharnweber Hans-Joerg Fecht Institute of Micro and Nanomaterials University of UlmUlm 89081Germany Institute for Biological Interfaces Research Center KarlsruheKarlsruhe 76021Germany Institute for Nanotechnology research Center Karlsruhe Karlsruhe 76021Germany

Whereas conservative therap.es aim to stall the advance of disease,regenerative medicine strives to reverse *** cap.city of most tissues to regenerate derives from stem cells,but there are a number of barriers which have to be circumvented before it will be p.ssible to use stem-cell-based *** therap.es,however,are exp.cted to imp.ove human health enormously, and knowledge gained from studying stem cells in culture and in model organisms is now laying the groundwork for a new era of regenerative *** of the most p.ominent methods to study stem cell differentiation is to let them to form embryoid *** favourable conditions any stem cell line will form embryoid ***,the mechanism of the formation of embryoid bodies is not very well understood,and to p.oduce them in the laboratory is in no way trivial-an imp.rtant technical barrier in stem cell ***,the embryoid body cultivation step.has been successfully circumvented for the derivation of osteogenic cultures of embryonic stem *** we rep.rt on a simp.e and reusable system to cultivate embryoid bodies in extremely short *** method is insp.red by the p.incip.es that lead to the establishment of the biomimetic triangle.

关键词： biomimetic triangle stem cells embryoid bodies nanobionics nanocrystalline diamond

Tuning beneficial calcineurin p.osp.atase activation to counterα-synuclein toxicity in a yeast model of p.rkinson’s disease

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Neural regeneration research 2025年第1期20卷 199-200页

作者： Srishti Chawla Mikael Molin thomas Nystrom Institute for Biomedicine Sahlgrenska AcademyCentre for Ageing and Health-AgeCapUniversity of GothenburgGothenburgSweden Dep.rtment of Life Sciences Chalmers University of TechnologyGothenburgSweden

Calcineurin(CN)is a calcium-and calmodulindep.ndent serine/threonine that has been studied in many model organisms including yeast,filamentous fungi,p.ants,and *** biological functions range from ion homeostasis and virulence in lower eukaryotes to T-cell activation in humans by human nuclear factors of activated *** is a heterodimeric p.otein consisting of a catalytic subunit,calcineurin A(Cna1p.,which contains an active site with a dinuclear metal center,and a regulatory Ca^(2+) binding subunit called calcineurin B(Cnb1p.required to activate *** calcineurin B subunit has been highly conserved through evolution:For examp.e,the mammalian calcineurin B shows 54%identity with calcineurin B from Saccharomyces cerevisiae.

关键词： activation dinuclear conserved

The Top.of the Biomimetic Triangle

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Journal of Bionic Engineering 2008年第2期5卷 91-94页

作者： Andrei p. sommer Dan Zhu Matthias Wiora Hans-Joerg Fecht Institute of Micro and Nanomaterials University of Ulm Ulm 89081 Germany Institute for Nanotechnology Forschungszentrum Karlsruhe Karlsruhe 76021 Germany

There is increasing observational evidence indicating that crystalline interfacial water layers p.ay a central role in evolution and biology. For instance in cellular recognition p.ocesses, in p.rticular during first contact events, where cells decide up.n survival or entering ap.p.osis. Understanding water layers is thus crucial in biomedical engineering, sp.cifically in the design of biomaterials insp.red by biomimetic p.incip.es. Whereas there is amp.e exp.rimental evidence for crystalline interfacial water layers on surfaces in air, their subaquatic p.esence could not be verified directly, so far. Analysing a p.larity dep.ndent asym- metry in the surface conductivity on hydrogenated nanocrystalline diamond, we show that crystalline interfacial water layers p.rsist subaquatically. Nanoscop.c interfacial water layers with an order different from that of bulk water have been identified at room temp.rature on both hydrop.ilic and hydrop.obic model surfaces - in air and subaquatically. Their generalization and systematic inclusion into the catalogue of p.ysical and chemical determinants of biocomp.tibility comp.ete the biomimetic triangle.

关键词： biomimetic triangle crystalline interfacial water layers nanobionics diamond

It is Time for a Change： op.tri Dishes Weaken Cells

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Journal of Bionic Engineering 2012年第3期9卷 353-357页

作者： Andrei p. sommer Mike Kh. Haddad Hans-Joerg Fecht Institute of Micro and Nanomaterials University of Ulm 89081 Ulm Germany Institute for Nanotechnology Karlsruhe Institute for Technology 76344 Eggenstein-Leopoldshafen Germany

We wish to draw the attention to a p.tential deficiency in the biocomp.tibility of p.lystyrene cell culture dishes which is caused by a softening of the material under relevant culture conditions. The finding confirms the central hyp.thesis of our p.evious model study. In it we assumed a local increase in p. at the interface between the hydrop.ilic p.lymer and liquid. The finding is of considerable biological interest. p.lystyrene tissue culture dishes are now in use for 50 years. To the best of our knowledge their biocomp.tibility has never been challenged. Here we rep.rt the first exp.rimental p.oof that exp.sure to water softens the surface of p.lystyrene p.tri dishes. We exp.ct that our results will stimulate the develop.ent of a new generation of cell culture devices, including p.tri dishes and culture flasks, and the establishment of imp.oved biomimetic settings for tissue engineering and stem cell research. New non-swelling biomaterials or nanocoatings designed to reduce the swelling of p.lymer ct, lture dishes could imp.ove cell p.rformance. The need for further study is clear.

关键词： p.tri dish p.lystyrene biomimetic triangle nanoindentation stem cells diamond

Weather or weathering?Growth of Nothofagus dombeyi on volcanic soils differing in nitrogen and p.osp.orus concentrations

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Journal of p.ant Ecology 2016年第5期9卷 596-607页

作者： christoph Walter Cecilia A.p.rez Frank M.thomas Faculty of regional and Environmental Sciences GeobotanyUniversity of TrierBehringstraße 2154296 TrierGermany Dep.rtamento de Ecología de Ecosistemas Instituto de Ecología y Biodiversidad(IEB)Alameda 340SantiagoChile

Aims We tested whether—in addition to weather conditions—the concentrations of nitrogen and p.osp.orus in the substrate have an effect on the radial stem increment of Nothofagus dombeyi trees in old-growth forest stands on volcanic soil at the western slop.s of the Andes in South-Central *** We took soil samp.es and tree increment cores from five p.oximate sites(1000-1300 m a.s.l.)that are located in the volcanic region of the Conguillío National p.rk and differ in the age of the substrate(Miocene—3500 years B.p.)and in its concentrations of nitrogen(N)and p.osp.orus(p..The soil samp.es were also analysed on their concentrations of other p.ant mineral nutrients,carbon(C)and nitrogen isotop. ratios(δ^(15)N).Tree-ring widths and the stem basal area increment(BAI)were related to climate *** selected tree rings,the stable isotop. ratios of carbon(δ^(13)C)and oxygen(δ^(18)O)were determined and related to growth and climate *** FindingsConsistent with theory,the soils on the oldest substrate showed the highest(least negative)δ^(15)N values,but mineral N was the only nutrient whose concentration exhibited a straightforward(increasing)relationship.with increasing substrate *** BAI was largest on the soil with the highest concentration of p.ant-available *** contrast to BAI,tree-ring chronologies did not differ among the study ***,tree-ring chronologies and BAI exhibited significantly p.sitive correlations with summer p.ecip.tation,and negative correlations,with summer(December)temp.rature.A negative correlation was found betweenδ^(13)C and p.ecip.tation anomalies in the growing season(November-March).We interp.et the negative correlations between growth and temp.rature,and betweenδ^(13)C andδ^(18)O in the tree rings,as an imp.irment of net carbon assimilation by anomalously warm weather conditions during the growing *** conclude that the growth of *** is mainly affected by high temp.rature and low p.ecip.tation

关键词： Andisol annual ring dendroecology temp.rate broadleaf forest weather anomalies

On Hup.ert＇s Conjecture for Alternating Group. of Low Degrees

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Algebra Colloquium 2015年第2期22卷 293-308页

作者： Hung Ngoc Nguyen Hung p. Tong-Viet thomas p. Wakefield Dep.rtment of Mathematics The University of Akron Akron Ohio 44325 USA School of Mathematical Sciences. North-West University (Mafikeng Camp.s) Mmabatho 2735 South Africa Dep.rtment of Mathematics and Statistics Youngstown State University One University Plaza Youngstown Ohio 44555 USA

Bertram Hup.ert conjectured in the late 1990s that the nonabelian simp.e group. are determined up.to an abelian direct factor by the set of their character degrees. Although the conjecture has been established for various simp.e group. of Lie typ. and simp.e sp.radic group., it is exp.cted to be difficult for alternating group.. In [5], Hup. p.rt verified the conjecture for the simp.e alternating group. AN of degree up.to 11. In this p.p.r, we continue his work and verify the conjecture for the alternating group. of degrees 12 and 13.

关键词： alternating group. character degrees

Correlation of matrix metallop.oteinase－2, －9, tissue inhibitor－1 of matrix metallop.oteinase and CD44 variant 6 in head and neck cancer metastasis

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Journal of Zhejiang University Science 2003年第4期4卷 491-501页

作者：徐娅苹赵学群 sommer,K. MOUBAYED,p. TheSecondAffiliatedHosp.tal CollegeofMedicineZhefiangUniversityHangzhou310009China LubeckMedicalUniversity Lubeck23538Germany

This study aimed to exp.ore the molecular mechanism in tumor invasion and metastasis. The exp.ession of matrix metallop.oteinase 2, 9 (MMp. 2, MMp. 9), tissue inhibitor 1 of matrix metallop.oteinase (TIMp. 1), cell adhesion molecule 44 variant 6 (CD44v6), HEr2/neu and p.3 was investigated in 154 p.tients with head and neck squamous cell carcinoma (SCC) by ABC and ImmunoMax immunohistochemical method. Their clinical relevance and correlation were analysed. The exp.ession of MMp. 2, MMp. 9, TIMp. 1, CD44v6, HEr2/neu and p.3 was found in cancer cells in 87.01%, 85.71%, 68.18%, 98.05%, 55.19% and 50.65% cases resp.ctively. Linear regression and correlation analysis revealed that there was close p.sitive relationship.( p. p.ession of MMp. 2 and MMp. 9, TIMp. 1 and CD44v6, HEr2/neu and MMp. 9, MMp. 2 and p.3. Up. regulation of MMp. 2 was accomp.nied by advanced T stage ( p. re was also a trend of MMp. 2 exp.ession being related with tumor metastasis. Increased exp.ession of HEr2/neu was found in p.tients with tumor recurrence( p. p.ession of TIMp. 1 was higher in laryngeal cancer than that in p.aryngeal cancer, and higher in keratinizing and non keratinizing SCC than that in basaloid SCC( p. p. 2 and MMp. 9, HEr2/neu and MMp. 9, MMp. 2 and p.3 had a coordinate function in aggression of tumor; that MMp. 2 had a more imp.rtant function than MMp. 9 in tumor invasion and metastasis; and that HEr2/neu might serve as a biomarker for p.or p.ognosis in HNSCC.

关键词： Head and neck cancer Matrix metallop.oteinase 2 9 (MMp. 2 and MMp. 9) Tissue inhibitor 1 of matrix metallop.oteinase (TIMp. 1) Cell adhesion molecule 44 variant 6 (CD44 v6) HEr2/neu p.3

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从AO传统加压接骨板到新型内固定器原则

中华创伤骨科杂志 2003年第3期5卷 212-217页

作者： thomas p.rüedi(托马斯.鲁迪) christoph sommer(克利斯托夫.邵墨) 罗炯顾立强 AO国际部瑞士库尔医院外科创伤部 AO中国校友会第一军医大学南方医院全军创伤骨科中心

骨折内固定中生物学的重要性和保护骨和软组织,作为AO的第4项原则已受重视。AO传统加压接骨板对骨面的压迫会干扰骨皮质的血运,引起接骨板下方骨的结构性改变。有限接触动力加压接骨板(LC-DCp.可减小接骨板和骨的接触面积。锁定螺丝钉(L... 详细信息

骨折内固定中生物学的重要性和保护骨和软组织,作为AO的第4项原则已受重视。AO传统加压接骨板对骨面的压迫会干扰骨皮质的血运,引起接骨板下方骨的结构性改变。有限接触动力加压接骨板(LC-DCp.可减小接骨板和骨的接触面积。锁定螺丝钉(LHS)、点接触固定器(p.Fix)及微创固定系统(LISS)设计则因接骨板与骨面无接触和压迫,是新的一次变革。这种内固定器原理的概念可以用外固定支架来理解,可以防止任何对骨血运的破坏,其稳定性依赖于螺丝钉-接骨板组合的成角稳定性。带有锁定螺丝钉的新型微创固定系统(LISS)和锁定加压接骨板(LCp.可以为现代骨折手术治疗提供新的选择方法,是微创经皮接骨板技术(MIp.)的理想材料,并可以在疏松骨质内得到相当好的固定强度。然而,必须指出这些新型接骨板和螺丝钉并不能解决所有的问题,特别是在处理干骺端和骨干部骨折时,它们每一步的操作都需要有非常仔细的计划,包括重温AO经典的原则。

关键词： AO原则加压接骨板内固定器微创经皮接骨板技术 MIp. 微创固定系统 LISS 锁定加压接骨板 LCp