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PEComa of the colon resistant to sirolimus but responsive to doxorubicin/ifosfamide

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World Journal of Gastroenterology 2013年第10期19卷 1657-1660页

作者： Wolfgang Scheppach Nikolaus Reissmann thomas Sprinz Ekkehard Schippers Bjoern Schoettker Justus G mueller Department of Medicine Juliusspital WuerzburgD-97070 WuerzburgGermany Department of Surgery Juliusspital WuerzburgD-97070 WuerzburgGermany Onkologische Schwerpunktpraxis D-97070 WuerzburgGermany Department of Pathology University of Wuerzburg97070 WürzburgGermany

A 23-year-old male presented with a three-week-history of crampy abdominal pain and *** revealed a friable mass filling the entire lumen of the cecum;histologically,it was classified as perivascular epithelioid cell tumor(PEComa).An magnetic resonance imaging scan showed,in addition to the primary tumor,two large mesenteric lymph node metastases and four metastatic lesions in the *** patient underwent right hemicolectomy and left hemihepatectomy combined with wedge resections of metastases in the right lobe of the liver,the resection status was ***,the patient was treated with *** 4 mo of adjuvant mammalian target of rapamycin inhibition he developed two new liver metastases and a local pelvic *** visible tumor formations were again excised surgically,this time the resection status was R2 with regard to the pelvic *** patient was treated with 12 cycles of doxorubicin and ifosfamide under which the disease was stable for 9 *** clinical course was then determined by rapid tumor growth in the pelvic *** line chemotherapy with gemcitabine and docetaxel was ineffective,and the patient died 23 mo after the onset of *** case report adds evidence that,in malignant PEComa,the mainstay of treatment is curative *** not achievable,the effects of adjuvant or palliative chemotherapy are unpredictable.

关键词： Perivascular epithelioid cell tumor Colon Liver metastases Mammalian target of rapamycin inhibitor Sirolimus Chemotherapy Doxorubicin Ifosfamide

Meta-Analysis to Determine the Diagnostic Value of 2-<sup>18</sup>Fluoro-2-Deoxy-D-Glucose Positron Emission Tomography in Assessing Residual Tumors after Systemic Therapy for Metastatic Seminoma

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Open Journal of Urology 2011年第3期1卷 50-55页

作者： Johannes mueller thomas Schnoeller Friedemann Zengerling Sandra Waalkes Andreas Al Ghazal Florian Jentzmik Mark Schrader Andres Jan Schrader 不详

Background: A meta-analysis was performed to determine the value of 2-18fluoro-2-deoxy-D-glucose positron emission tomography (FDG-PET) for assessing viable tumor residuals after chemotherapy in patients with pure seminoma. Materials and methods: This review included five studies published between 1999 and 2010 with a total of 130 patients who underwent both computed tomography (CT) and FDG-PET scanning for residual tumor detection after systemic therapy. We compared the sensitivity and specificity of FDG-PET and CT (tumor size ≤ or > 3 cm) in identifying vital tumor tissue. Results: On the average, FDG-PET had higher specificity (92% vs. 59%) and sensitivity (72% vs. 63%) as well as a higher positive predictive value (PPV) than the solely size-based CT assessment of residual tumors (70% vs. 28%). PEt also tended to have a higher negative predictive value (93% vs. 86%). Conclusion: The present evaluation of currently available data indicates that FDG-PET is superior to CT in detecting viable tumor residuals after chemotherapy in patients with metastatic seminoma. Its application can thus be recommended.

关键词： FDG-PET Seminoma Testicular Cancer Diagnosis Residual Disease

从天然提取物或分离部位中以碳酸酐酶II为靶点的抗骨质疏松活性筛选(英文)

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云南植物研究 2003年第6期25卷 724-729页

作者：付祥谭宁华姜立花贾锐锐嵇长久 LANDRO James FEKETE Alexander mueller Hartwig HENKEL thomas 中国科学院昆明植物研究所植物化学与西部植物资源持续利用国家重点实验室云南昆明650204 Bayer Corporation IRT Bayer AG PH-R-EU

目的是以碳酸酐酶II (CAII)为靶点筛选其抑制剂 ,以期寻找抗骨质疏松活性样品。实验是在 96孔酶标板上对来源于 1 78个科、 60 8个属、 1 0 2 0种动植物 2 91 9个提取物或分离部位样品在CA II模型上进行了批量筛选。结果表明在 1 0 μg... 详细信息

目的是以碳酸酐酶II (CAII)为靶点筛选其抑制剂 ,以期寻找抗骨质疏松活性样品。实验是在 96孔酶标板上对来源于 1 78个科、 60 8个属、 1 0 2 0种动植物 2 91 9个提取物或分离部位样品在CA II模型上进行了批量筛选。结果表明在 1 0 μg ml浓度下发现了来源于 40个科、61个属、72个种的 1 0 0个样品有活性 ,其中 5个样品的IC50 小于 2 50 μg ml,2 2个样品的IC50 在 2 51～ 5 0 0 μg ml范围 ,73个样品的IC50 在 5 0 1～1 0 0 0 μg ml范围。通过以上工作我们认为以碳酸酐酶II为分子靶点的体外筛选方法稳定、方便、快速、微量、有效 ,特别适用于天然产物的抗骨质疏松活性筛选。

关键词：抗骨质疏松活性筛选碳酸酐酶Ⅱ 天然产物提取物分离部位

Effect of Supplemental Sericea Lespedeza Pellets on Internal Parasite Infection and Nutritional Status of Grazing Goats

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Journal of Agricultural Science and Technology(A) 2017年第5期7卷 334-344页

作者： Tiffani Hamilton thomas Tenill Dill Sandeep Kommuru: Aqiyla Rivers Jorge Mosjidis James Miller Chris Drake Irene mueller-Harvey Joan Burke Agricultural Research Station Fort Valley State University Fort Valley GA 31030 USA Department of Agronomy and Soils Auburn University Auburn AL 36849 USA Department of Pathobiological Sciences Louisiana State University Baton Rouge LA 70803 USA School of Agriculture Policy and Development University of Reading Reading RG6 6AT UK United States Department of Agriculture Agricultural Research Service Booneville AR 72927 USA

Is <sup>18</sup>F-FDG-PET/CT a Valid Non-Invasive Predictor for Regression Grade after Neoadjuvant Treatment in Patients with NSCLC Stage III?

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Journal of Cancer Therapy 2014年第6期5卷 531-541页

作者： Natalie Desiree Klass Richard P. Baum Michael Schmuecking Norbert Presselt Klaus-Michael mueller thomas G. Wendt Reiner Bonnet Department of Nuclear Medicine Zentralklinik Bad Berka Bad Berka Germany Department of Pneumology Zentralklinik Bad Berka Bad Berka Germany Department of Radiation Oncology University of Jena Jena Germany Department of Radiation-Oncology Inselspital Bern University Hospital and University of Bern Bern Switzerland Department of Thoracic Surgery Zentralklinik Bad Berka Bad Berka Germany Institute of Pathology University of Münster Münster Germany

Introduction: CT alone cannot provide sufficient information referring to response after neoadjuvant therapy in a timely manner. To evaluate the role of 18F-FDG-PET after neoadjuvant chemoradiation as a valid, non-invasive predictor for early therapy response and its effect on survival as compared to histopathologic tumor response, data of 32 of 210 randomized patients with NSCLC stage IIIA/IIIB, who were treated in a?prospective randomized controlled multicenter trial (LUCAS- MD), were re-evaluated. Material and Methods: For 32 patients with NSCLC stage IIIA (44%) IIIB (56%) neoadjuvant treatment consisted of two to three cycles of chemotherapy (225 mg/m2 paclitaxel and carboplatin AUC 6 d1q22) and concomitant chemoradiation (50 mg/m2 paclitaxel and carboplatin AUC 2 d1, d8, d15;1.5 Gy b.i.d. up to 45 Gy). Documentation of involved lymph node stations as detected by 18F-FDG-PET/CT and lymph node sampling during surgery according to the IASLC lymph node mapping (2009). Evaluation of histological regression grade (RG) according to Junker et al. (2001) and correlation with?18F-FDG-PET/CT for primary tumor and each lymph node station. Calculation of disease free survival using Kaplan-Meier estimates and log rank tests. Results: Actuarial tumor specific survival for the 32 patients with concomitant chemoradiation plus?chemotherapy: complete vs. incomplete metabolic remission prior to surgery after 60 months:?40% vs. 24% (p?= 0.018). RG III/IIb (no/less than 10% of vital tumor cells) vs. RG IIa/I (more than 10% vital tumor cells) after 60 months: 46% vs. 15% (p?= 0.006). 18/32 (56%) patients had RG III/IIb, 8/32 (25%) patients had regression grade III. 1/8 pts. with RG III were in the 18F-FDG- PET/CT false positive, 10 pts. with RG IIb (i.e. all pts. with RG IIb) were in the 18F-FDG-PET/CT false negative. One patient with RG IIa was in the 18F-FDG-PET/CT false negative. Hence, the cut-off level in detecting vital tumor cells by 18F-FDG-PET/CT after neoadjuvant chemoradia

关键词： NSCLC 1818F-FDG-PET Neoadjuvant Treatment Non-Invasive Predictor

从天然提取物或分离部位中以烯醇式丙酮酸转移酶为靶点的抗细菌活性筛选(英文)

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云南植物研究 2003年第1期25卷 90-94页

作者：姜立花谭宁华杨亚滨汪俊松付祥 Lars JOHANNSEN Hartwig mueller thomas HENKEL 中国科学院昆明植物研究所植物化学与西部植物资源持续利用国家重点实验室云南昆明650204 Bayer AG PH-R-EU

目的是以烯醇式丙酮酸转移酶 (EPT)为靶点筛选其抑制剂 ,以期寻找抗细菌活性样品。实验是在 96孔酶标板上对来源于 16 9个科、 5 6 0个属、 916种动植物 2 4 90个提取物或分离部位样品在EPT模型上进行了批量筛选。结果表明在 96 15 μg... 详细信息

目的是以烯醇式丙酮酸转移酶 (EPT)为靶点筛选其抑制剂 ,以期寻找抗细菌活性样品。实验是在 96孔酶标板上对来源于 16 9个科、 5 6 0个属、 916种动植物 2 4 90个提取物或分离部位样品在EPT模型上进行了批量筛选。结果表明在 96 15 μg/ml浓度下发现了来源于 80个科、 16 9个属、 2 18个种的 30 9个样品有活性 ,其中 14个样品的IC50 小于 10 0 0 μg/ml,4 0个样品的IC50 在 10 0 1～ 30 0 0 μg/ml范围 ,83个样品的IC50 在 30 0 1～ 5 0 0 0 μg/ml范围 ,172个样品的IC50 在 5 0 0 1～ 96 15 μg/ml范围。通过以上工作我们认为以烯醇式丙酮酸转移酶为分子靶点的体外筛选方法稳定、方便、快速、微量、有效。

关键词：烯醇式丙酮酸转移酶抑制剂抗细菌活性天然产物天然提取物分离部位体外筛选

Pathologic Q Waves and Prolonged QTc Time in Preoperative ECG Are Predictive for Perioperative Cardiovascular Events

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World Journal of Cardiovascular Diseases 2014年第10期4卷 498-509页

作者： thomas Wolters Michael Weber thomas Neumann Hans-Georg Strauß Andreas Luchner Manfred Seeberger Christian mueller Christoph Liebetrau Svetlana Apostolovic Radmilo Jankovic Dragic Bankovic Marina Jovic Vesselin Mitrovic Holger Nef Helge Mollmann Karl Werdan Christian W. Hamm Axel Schlitt Department of Medicine III University Clinic Halle (Saale) Halle Germany Department of Medicine Clinic Grabs Grabs Switzerland Department of Cardiology Kerckhoff Heart and Thorax Center Bad Nauheim Germany Department of Medicine II Clinic Gro&szlig -Umstadt Gro&szlig -Umstadt Germany Department of Medicine II University of Regensburg Regensburg Germany Department of Cardiology University of Basel Basel Switzerland University Cardiology Clinic Ni&scaron Serbia Department of Mathematical Sciences University of Kragujevac Kragujevac Serbia Department of Medicine I University Clinic of Gie&szlig en and Marburg Gie&szlig en Germany Department of Medicine I Paracelsus-Harz-Clinic Bad Suderode Quedlinburg Germany

Aims: The value of ECG in the perioperative risk stratification under modern treatment options is uncertain. The main objective of the present analysis was to determine the usefulness of a pre-operative ECG derivation for evaluating the risk of perioperative morbidity and mortality. Methods: We performed a secondary analysis of the prospective, international, multicenter, observational “No-Risk” Study (N-terminal B-type natriuretic peptide [NT-proBNP] for the assessment of the perioperative cardiac risk after major noncardiac surgery) to determine the prognostic value of 12-lead ECG. Inclusion criteria were age >55 years and at least one of the following cardiovascular risk factors: arterial hypertension, diabetes mellitus, dyslipidemia, active smoking, and family history positive for coronary heart disease. The combined primary endpoint included total mortality, acute myocardial infarction (NSTEMI and STEMI), cardiopulmonary resuscitation, heart failure, and asystole or ventricular fibrillation during hospitalization. ECGs from 616 patients enrolled from 2006 to 2009 prior to noncardiac surgery in the No-Risk Study were analyzed. Results: The mean age was 67.6 (±8.1) years;300 (48.7%) patients were male. Fourteen (2.3%) patients suffered from the combined primary endpoint while in the hospital. In Kaplan-Meier analyses, a pathologic Q wave and QTc > 500 ms were significantly related to the incidence of the primary endpoint (p p = 0.042, respectively), whereas other ECG parameters such as LBBB, RBBB, PQ interval, QRS interval, and others were not related to worse in-hospital outcome. Conclusion: The 12-lead ECG is still an important diagnostic tool for perioperative risk assessment of cardiovascular events in noncardiac surgery in patients at risk.

关键词： ECG Perioperative Risk Cardiovascular Risk

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小型飞行器空气动力学

力学进展 2004年第2期34卷 270-279页

作者： thomas J.Muller nd.edu James D.Delaurier utias.utoronto.ca 于鑫孙茂 Hessert Center for Aerospace Research Department of Aerospace and Mechanical EngineeringUniversity of Notre DameNotre DameIndiana 46556 email:mueller.1 Institute for Aerospace Studies University of TorontoDownsviewOntarioCanada M3H 5T6 email:jdd 北京航空航天大学流体所

对小型飞行器设计中涉及的空气动力学问题进行了综述。描述了雷诺数和展弦比对固定翼飞行器的设计以及飞行性能的影响。在低雷诺数飞行范围。翼型上边界层的特性对飞行器的设计尤为关键。本文讨论了大量有关层流边界层(包括层流分离泡影... 详细信息

对小型飞行器设计中涉及的空气动力学问题进行了综述。描述了雷诺数和展弦比对固定翼飞行器的设计以及飞行性能的影响。在低雷诺数飞行范围。翼型上边界层的特性对飞行器的设计尤为关键。本文讨论了大量有关层流边界层(包括层流分离泡影响)的实验,作为例子,列举了几个此飞行雷诺数范围的小型低空无人驾驶飞行器(UAVs)。此外,对扑动翼推进的理论模型进行了简述;其范围涵盖了早期的准定常附着流模型,以及后来计及非定常尾涡、流动分离以及气动弹性等效应的模型。文中还介绍了那些与理论互补并最终导致扑翼机设计成功的实验。

关键词：空气动力学雷诺数固定翼扑翼小型无人驾驶飞行器飞行器设计

Abstracts from the 15th International Myopia Conference

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Eye and Vision 2016年第1期3卷 211-221页

作者： Alexandra Benavente-Perez Ann Nour Tobin Ansel Kathleen Abarr Luying Yan Keisha Roden David Troilo Chanyi Lu Miaozhen Pan Min Zheng Jia Qu Xiangtian Zhou Christine F. Wildsoet Fan Lu Jie Chen Jinhua Bao Liang Hu Qinmei Wang Zibing Jin Frances Rucker Stephanie Britton Stephan Hanowsky Molly Spatcher Hui-Ying Kuo Ching-Hsiu Ke I-Hsin Kuo Chien-Chun Peng Han-Yin Sun Ian G. Morgan Jeremy A. Guggenheim Rupal L. Shah Cathy Williams Jinglei Yang Peter S. Reinach Sen Zhang Wenfeng Sun Bo Liu Fen Li Xiaoqing Li Aihua Zhao Tianlu Chen Wei Jia Jun Jiang Haoran Wu Kazuo Tsubota Hiroko Ozawa Hidemasa Torii Shigemasa Takamizawa Toshihide Kurihara Kazuno Negishi Klaus Graef Daniel Rathbun Frank Schaeffel Ladan Ghodsi William K. Stell Machelle T. Pardue Ranjay Chakraborty Han na Park Curran S. Sidhu P. Michael Iuvone Michael J Collins Nethrajeith Srinvasalu Sally A. McFadden Paul N. Baird Pablo Artal Pauline Cho SW Cheung Pei-Chang Wu Quan V. Hoang Duk C. Lee Erica G. Landis Michael A. Bergen Curran Sidhu Samer Hattar Richard A. Stone Ravi Metlapally Ruiqin Li Qinglin Xu Hong Zhong Chenglin Pan Weizhong Lan Xiaoning Li Ling Chen Zhikuan Yang Scott A. Read Seang-Mei Saw Shi-Jun Weng Xiao-Hua Wu Kang-Wei Qian Yun-Yun Li Guo-Zhong Xu Furong Huang Xiong-Li Yang Yong-Mei Zhong Earl L Smith, III Baskar Arumugam Li-Fang Hung Lisa A. Ostrin Klaus Trier Monica Jong Brien A. Holden thomas Chuen Lam Samantha Shan Bing Zuo Dennis Yan-yin Tse Jingfang Bian King-Kit Li Quan Liu Chi-ho To Timothy J. Gawne John T. Siegwart, Jr. Alexander H. Ward thomas T. Norton Yan Zhang Yue Liu Carol Ho Eileen Phan Abraham Hang Emily Eng Christine Wildsoet Department of Biological Sciences SUNY College of Optometry New York NY 10036 USA School of Optometry and Ophthalmology and Eye Hospital Wenzhou Medical University Wenzhou Zhejiang 325027 China Center for Eye Disease & Development School of Optometry & Vision Science Program University of California Berkeley Berkeley CA 94720-2020 USA Wenzhou Medical University Wenzhou Zhejiang 325027 China Biomedical Science and Disease New England College of Optom Boston MA USA School of Optometry Chung Shan Medical University Taichung City 402 Taiwan Institute of Medicine Chung Shan Medical University Taichung City 402 Taiwan Division of Biochemistry and Molecular Biology Research School of Biology Australian National University Canberra Australia State Key Laboratory of Ophthalmology and Division of Preventive Ophthalmology Zhongshan Ophthalmic Center Sun Yat-Sen University Guangzhou China School of Optometry & Vision Sciences Cardiff University Cardiff UK School of Social and Community Medicine University of Bristol Bristol UK School of and Eye Hospital Wenzhou Medical University Wenzhou Zhejiang 325027 China State Key Laboratory Cultivation Base and Key Laboratory of Vision Science Ministry of Health and Zhejiang Provincial Key Laboratory of Ophthalmology and Optometry Wenzhou Zhejiang 325027 People’s Republic of China Shanghai Key Laboratory of Diabetes Mellitus and Center for Translational Medicine Shanghai Jiao Tong University Affiliated Sixth People’s Hospital Shanghai 200233 China Eye Hospital of Wenzhou Medical University Wenzhou Zhejiang 325027 China Department of Ophthalmology Keio University School of Medicine Shinjuku-ku Tokyo 160-8582 Japan General Medicine Ichikawa Medical Center Urayasu City Chiba 279-0001 Japan Ophthalmic Research Institute University of Tuebingen 72076 Tuebingen Germany Bernstein Center for Computational Neuroscience Tuebingen 72076 Tuebingen Germany Werner Reichardt Centre for Integrative Neuroscience Otfried-Mueller-Straße 25 Tueb

To assess the peripheral refractive changes that occur when eye growth decelerates in *** We measured peripheral refraction and on-axis vitreous chamber depth on a total of 53 marmosets;36 treated monocularly for 12 weeks 9 hrs/day(26 with-5 D contact lenses,10 with+5 D)and 17 untreated *** the 26 marmosets treated with-5 D,10 wore contact lenses 9 hrs/day without interruptions and were mea-sured at the end of 10 weeks of treatment(T10)and after 4 weeks of recovery(R14).Eight had both contact lenses removed for 30 mins twice/day(mid-morning and mid-afternoon)during the first four weeks of treatment(early interruption group)and eight had the lenses removed during the second four weeks of treatment(late interruption group).The two interruption groups were measured after 4,8 and 12 weeks of treatment only(T4,T8,T12).

关键词： removed treatment untreated