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Stroke & Vascular Neurology 2019年第4期4卷 198-205页

作者： Mark R Etherton Ona Wu Pedro Cougo Svetlana Lorenzano Hua Li Lisa Cloonan Mark J R J Bouts Arne lauer Ken Arai Eng H Lo Steve K Feske Karen L Furie Natalia S Rost Department of Neurology Massachusetts General Hospital and Harvard Medical SchoolBostonMassachusettsUSA Martinos Center for Biomedical Imaging Massachusetts General HospitalCharlestownMAUnited States Department of Radiology Massachusetts General Hospital and Harvard Medical SchoolBostonMAUnited States Medical School of Ribeirao Preto University of Sao PauloSao PauloBrazil Department of Human Neurosciences Sapienza University of RomeRomeItaly Institute of Psychology Leiden UniversityLeidenNetherlands Department of Neuroradiology Goethe-Universitat Frankfurt am MainFrankfurtGermany Department of Neurology Brigham and Women’s Hospital and Harvard Medical SchoolBostonMAUnited States Department of Neurology Warren Alpert Medical School of Brown UniversityProvidenceRhode IslandUSA

background and purpose Functional outcomes after ischaemic stroke are worse in women,despite adjusting for differences in comorbidities and treatment *** matter microvascular integrity represents one risk factor for poor long-term functional outcomes after ischaemic *** aim of the study is to characterise sex-specific differences in microvascular integrity in individuals with acute ischaemic *** A retrospective analysis of subjects with acute ischaemic stroke and brain MRI with diffusion-weighted(DWI)and dynamic-susceptibility contrast-enhanced(DSC)perfusion-weighted imaging obtained within 9 hours of last known well was *** the hemisphere contralateral to the acute infarct,normal-appearing white matter(NAWM)microvascular integrity was measured using the K_(2) coefficient and apparent diffusion coefficient(ADC)*** analyses for predictors of K_(2) coefficient,DWI volume and good outcome(90-day modified Rankin scale(mRS)score<2)were *** 105 men and 79 women met inclusion criteria for *** no difference in age,women had increased NAWM K_(2) coefficient(1027.4 vs 692.7×10^(-6)/s;p=0.006).In women,atrial fibrillation(β=583.6;p=0.04)and increasing NAWM ADC(β=4.4;p=0.02)were associated with increased NAWM K_(2) *** multivariable regression analysis,the K_(2) coefficient was an independent predictor of DWI volume in women(β=0.007;p=0.01)but not *** In women with acute ischaemic stroke,increased NAWM K_(2) coefficient is associated with increased infarct volume and chronic white matter structural *** studies investigating sex-specific differences in white matter microvascular integrity are needed.

关键词： microvascular white coefficient

Expression liver-directed genes by employing synthetic transcriptional control units

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World Journal of Gastroenterology 2005年第34期11卷 5295-5302页

作者： Marie-Luise Lemken Wolfgang A.Wybranietz Ulrike Schmidt Florian Graepler Sorin Armeanu Michael Bitzer Ulrich M.lauer Department of Internal Medicine I University Clinic Tübingen D-72076 Tübingen Germany

AIM： To generate and characcerize the synthetic transoiptional control units for transcriptional targeting of the liver, thereby compensating for the lack of specificity of currently available gene therapeutic vector systems. METHODS： Synthetic transcriptional control unit constructs were generated and analyzed for transcriptional activities in different cell types by FACS quantification, semi-quantitative RT-PCR, and Western blotting. RESULTS： A new bifunctionally-enhanced green fluorescent protein （EGFP）/neor fusion gene cassette was generated, and could flexibly be used both for transcript quantification and for selection of stable cell clones. Then, numerous synthetic transcriptional control units consisting of a minimal promoter linked to “naturally” derived composite enhancer elements from liver-specific expressed genes or binding sites of liver-specific transcription factors were inserted upstream of this reporter cassette. Following liposome-mediated transfection, EGFP reporter protein quantification by FACS analysis identified constructs encoding multimerized composite elements of the apolipoprotein B100 （APOB） promoter or the ornithin transcarbamoylase （OTC） enhancer to exhibit maximum transcriptional activities in liver originating cell lines, but only background levels in non-liver originating cell lines. In contrast, constructs encoding only singular binding sites of liver-specific transcription factors, namely hepatocyte nuclear factor （HNF）, HNF3, HNF4, HNF5, or CAAT/enhancer binding protein （C/EBP） only achieved background levels of EGFP expression. Finally, both semi-quantitative RT-PCR and Western blotting analysis of Hep3B cells demonstrated maximum transcriptional activities for a multimeric 4xAPOB cassette construct, which fully complied with the dataobtained by initial FACS analysis CONCLUSION： Synthetic transcriptional control unit constructs not only exhibit a superb degree of structural compactness, but also provide new means for liver

关键词： Liver gene therapy Hepatoma gene therapy Liver-directed gene expression Synthetic liver-specific promoters

高炉热风炉燃烧的分布控制系统软件和控制策略

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科技译丛（重庆） 1997年第1期 46-55页

作者： lauer,GF 熊熊重庆钢铁高等专科学校炼铁教研室

美国／神户钢铁公司利用一个炉子总体控制系统使其３号高炉实现现代化，借助于该系统，一个操作员就可以从中心控制室来监视整个高炉设备。重建项目包括安装全集成式自动控制系统结构，一个分布控制系统和一个可编程序逻辑控制器。

关键词：热风炉燃烧控制分布控制系统高炉

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你是哪种领袖？

空中英语教室（高级版．彭蒙惠英语） 2010年第7期 12-13,40,41页

作者： Chris lauer

策略专家麦可·柏兰与道格拉斯·熊恩近来致力于了解成功的领袖所拥有的内在特质。在广泛研究后发现，这种人能在自己的领域里出类拔萃，是因为他们拥有强烈的个人冲劲、行事坚定不懈，并且具备自知之明，深知自己是什么样的人，想要追... 详细信息

策略专家麦可·柏兰与道格拉斯·熊恩近来致力于了解成功的领袖所拥有的内在特质。在广泛研究后发现，这种人能在自己的领域里出类拔萃，是因为他们拥有强烈的个人冲劲、行事坚定不懈，并且具备自知之明，深知自己是什么样的人，想要追求什么样的目标。柏兰和熊恩访问了当今最成功的部分人士，结果发现成功会降临在那些充分了解自己的人身上。

关键词：领袖内在特质道格拉斯成功

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千禧桥的教训

空中英语教室（高级版．彭蒙惠英语） 2010年第8期 34-36,47,48页

作者： Chris lauer

即便是直觉最准确的人，偶尔也会做出愚蠢的决策。作家暨投资策略专家麦可·莫布新在《别让直觉作决定》（暂译）一书里指出，“睿智”或“聪明”的特质并不足以让人免疫于错误的决定。他写道，即便是《上当大全：上当的原因及避免之道... 详细信息

即便是直觉最准确的人，偶尔也会做出愚蠢的决策。作家暨投资策略专家麦可·莫布新在《别让直觉作决定》（暂译）一书里指出，“睿智”或“聪明”的特质并不足以让人免疫于错误的决定。他写道，即便是《上当大全：上当的原因及避免之道》（暂译）的作者史蒂芬·格林斯潘，

关键词：投资策略格林斯潘直觉

Development and Evaluation of a Model-based Usability Assessment Tool for Interactive CAS-Systems

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Development and Evaluation of a Model-based Usability Assess...

纳米聚合物粒子组合物及其在防微生物涂料中的应用

第十七届国际工效学大会暨中国人类工效学会成立20周年庆祝大会

作者： A.Jan B W.lauer K.Radermacher Helmholtz-Institute for Biomedical Engineering Chair of Medical EngineeringRWTH Aachen University

Technological progress in the field of Computer-Assisted Surgery(CAS) not only leads to an enhancement in efficiency and effectiveness concerning therapeutic results but also to a change of the Human-Computer-Interaction characteristics in the operating room(OR).Deficiencies in the use process of CAS systems bring along high potential for hazardous human-induced failures implicating higher risk for patients and physicians during surgical *** enhance safety and reliability in modern surgical work systems the design of the user interfaces has to be not only "ergonomic"-usability and reliability are major characteristics to be taken into consideration for the approval as well as for routine application of medical *** experimental and criteria-oriented usability-evaluation of interactive systems are receiving increasing attention from manufacturers of medical devices,the design engineer has to examine and determine the usability of an envisioned system already in a very early developmental *** this context the presented mAIXuse method as well as a corresponding software tool have been developed and are currently being evaluated in order to support the application of prospective usability assessment for complex medical *** from two model-based methods,the Concur Task Tree methodology and the CPM-GOMS approach,the software tool uses formal,normative models to predict user and system behaviour in order to estimate the usability of a new or re-designed *** developed prospective usability investigation approach has already been evaluated in comparison to conventional risk assessment and usability evaluation methods and the corresponding software tool has been evaluated in cooperation with medical and industrial *** aim of the presented work is to support especially small and medium sized enterprises developing and manufacturing medical devices,taking into account the required usability engineering and risk management pr

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涂料技术与文摘 2005年第4期26卷 11-21页

作者： lauer Rosemarie palmer

本发明涉及一种可以用于防止涂层表面微生物污染的组合物,该组合物含有平均粒径1～50 nm的纳米聚合物粒子.纳米聚合物粒子可以官能化以提供其他的性能,改善涂膜的表面性能,减少粒子附着于涂层表面.

关键词：聚合物粒子组合物纳米应用涂料涂层表面微生物污染平均粒径表面性能官能化涂膜

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职场脑力聪明用

空中英语教室（高级版．彭蒙惠英语） 2010年第10期 28-30,45,46页

作者： Chris lauer

身为商业顾问、领导学指导教练、作家及研究者，大卫·洛克对职场脑力的运用多少有所涉猎。虽然他不是神经科学家，但多年来一直在研究脑部，并了解脑科学的新发展如何能协助人们改进工作表现。他的新书《职场脑力聪明用》（暂译）是历... 详细信息

身为商业顾问、领导学指导教练、作家及研究者，大卫·洛克对职场脑力的运用多少有所涉猎。虽然他不是神经科学家，但多年来一直在研究脑部，并了解脑科学的新发展如何能协助人们改进工作表现。他的新书《职场脑力聪明用》（暂译）是历经许多研讨会、调查以及访谈数十位顶尖神经科学家的成果。洛克在书中阐释脑部运作与神经科学领域最新发现之间的深层关连，而大家可以充分运用这些新发现让职场表现更有效益与效率.

关键词：职场脑力明用工作表现科学领域科学家领导学研究者

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谐波过滤器实现节能环保

现代制造 2009年第34期 32-33页

作者： Andreas lauer

在从发电厂到居民楼,最终直至家用电器的电网中,电器设备常常在工作时出现电流反馈,并带来明显的电噪声。 Block变压器厂明确地将降低电流反馈与电噪声作为自身的任务。

关键词：节能环保过滤器谐波电流反馈家用电器电器设备变压器厂电噪声