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Cardiac catheterisation in nonagenarians： Single center experience

Journal of Geriatric Cardiology 2012年第2期9卷 148-152页

作者： Marc-Alexander Ohlow Aly Hassan Ulrich Lotze Bemward lauer Department of Cardiology Zentralklinik Bad Berka Robert Koch-Allee 9 99437 Bad Berka Germany Department of Cardiology Faculty of Medicine Alexandria University El-Guish Road El-Shatby Alexandria 21526 Egypt Department of Internal Medicine DRK Krankenhaus Sonderhausen Hospitalstrasse 2 99706 Sondershausen Germany

Objective To explore the treatment, procedure related risks, and outcomes of patients older than 90 years of age undergoing cardiac catheterization. Methods We retrospectively studied 32 patients ≥ 90 years （93.0 ± 1.2 years） who underwent cardiac catheterisation in a tertiary specialist hospital （0.2% of 14,892 procedures during three years）. The results were compared to a patient cohort younger than 90 years of age. Results Baseline characteristics revealed a higher prevalence of diabetes （P 〈 0.001）, chronic obstructive pulmonary disease （P 〈 0.04）, previous myocardial infarction （P 〈 0.02）, and complex coronary anatomy （SYNTAX score 33 vs. 19） in nonagenarians. Patients 〈 90 years of age showed more hyperlipidemia （P 〈 0.01） and previous percutaneous coronary interventions （P 〈 0.015）. Nonagenarians underwent coronary angiography more often for acute coronary syndrome （ACS）（P 〈 0.003）, were presented more often in cardiogenic shock （P 〈 0.003）, and were transferred faster to coronary angiography in cases ofACS （P 〈 0.0001）. The observed in-hospital mortality rate （13% study group vs. 1% control group; P 〈 0.003） in nonagenarians was lower than the calculated rate of thrombolysis in myocardial infarction （TIMI） and global registry of acute cardiac events （GRACE） mortality and strongly influenced by the severity of clinical presentation and the presence of co-morbidities. Conclusion Despite the common scepticism that cardiac catheterisation exposes patients 〉 90 years to an unwarranted risk, our data demonstrate an acceptable incidence of complications and mortality in this group of patients.

关键词： Nonagenarian Acute coronary syndrome Complications Coronary angiography

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网上购物：真的是“淘宝”吗?

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疯狂英语（初中天地） 2007年第11期 16-19页

作者： Matt lauer 朱敏姬

在"快餐式"社会里,单纯的"快"已经不能满足人们的要求。除了快,还要便捷,要什么就有什么。网上购物为我们提供了一种方便、快捷的新型购物方式。许多人说,谁都不能打败网上购物带来的便利——足不出户便可将所有东西轻松收入囊中。然而... 详细信息

在"快餐式"社会里,单纯的"快"已经不能满足人们的要求。除了快,还要便捷,要什么就有什么。网上购物为我们提供了一种方便、快捷的新型购物方式。许多人说,谁都不能打败网上购物带来的便利——足不出户便可将所有东西轻松收入囊中。然而,在网上淘宝的同时,你是否想过,网上购物是不是真的那么划算呢?

关键词：网上购物网上订购

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Surface roughness of zirconia for full-contour crowns after clinically simulated grinding and polishing

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International Journal of Oral Science 2014年第4期6卷 241-246页

作者： Rim Hmaidouch Wolf-Dieter Mller Hans-Christoph lauer Paul Weigl Department of Prosthodontics and Geriatric Dentistry Faculty of Oral and Dental Medicine at Johann Wolfgang Goethe-University Department of Prosthodontics and Geriatric Dentistry University of Medicine Charite Department of Postgraduate Education Faculty of Oral and Dental Medicine at Johann Wolfgang Goethe-University

The aim of this study was to evaluate the effect of controlled intraoral grinding and polishing on the roughness of full-contour zirconia compared to classical veneered zirconia. Thirty bar-shaped zirconia specimens were fabricated and divided into two groups（n515）. Fifteen specimens（group 1） were glazed and 15 specimens（group 2） were veneered with feldspathic ceramic and then glazed. Prior to grinding,maximum roughness depth（Rmax） values were measured using a profilometer, 5 times per specimen. Simulated clinical grinding and polishing were performed on the specimens under water coolant for 15 s and 2 N pressure. For grinding, NTI diamonds burs with grain sizes of 20 mm, 10 mm, and 7.5 mm were used sequentially. The ground surfaces were polished using NTI kits with coarse, medium and fine polishers. After each step, Rmaxvalues were determined. Differences between groups were examined using one-way analysis of variance（ANOVA）. The roughness of group 1 was significantly lower than that of group 2. The roughness increased significantly after coarse grinding in both groups. The results after glazing were similar to those obtained after fine grinding for non-veneered zirconia. However, fine-ground veneered zirconia had significantly higher roughness than venerred, glazed zirconia. No significant difference was found between fine-polished and glazed zirconia, but after the fine polishing of veneered zirconia, the roughness was significantly higher than after *** can be concluded that for full-contour zirconia, fewer defects and lower roughness values resulted after grinding and polishing compared to veneered zirconia. After polishing zirconia, lower roughness values were achieved compared to glazing; more interesting was that the grinding of glazed zirconia using the NTI three-step system could deliver smooth surfaces comparable to untreated glazed zirconia surfaces.

关键词： full-contour zirconia grinding polishing roughness veneering porcelain

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Social problems and the quality of life 8th ed.

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2002年

作者： Robert H. lauer Jeanette C. lauer.

来源：畅想之星图书光盘版（南... 评论

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Clinical profile of patients with advanced age and inflammatoric dilated cardiomyopathy on endomyocardial biopsy

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Journal of Geriatric Cardiology 2015年第6期12卷 605-612页

作者： Marc-Alexander Ohlow Ting-Hui Chen Andreas Schmidt Joerg Saenger Bemward lauer Department of Cardiology Zentralklinik Bad Berka Germany Institute of Pathology Zentralklinik Bad Berka Germany

Background Endomyocardial biopsy （EMB） is an important tool when patients with inflammatoric cardiomyopathy （DCMi） are evaluated. We aimed to assess the clinical profile of elderly patients with DCMi on EMB. Methods Retrospective study of all consecutive patients hospitalized from January 2007 to December 2011 with clinical suspicion of DCMi undergoing EMB. Patients with evidence of DCMi on EMB （Group 1 〉 70 years, n = 85; Group 3 〈 70 years; n = 418） were compared to patients of the same age group without evi- dence of DCMi on EMB （Group 2 〉 70 years, n = 45; Group 4 〈 70 years; n = 147）. Results Among 24,275 patients treated at our institu- tion during the study period, 695 had clinical suspicion of DCMi and underwent EMB; 503 （2.1%） patients had DCMi on EMB. There were more male patients in Group 1, mean age was 74 ~ 2.8 years, mean ejection fraction was 38% q- 14%. On presentation, signs of hemody- namic compromise （NYHA functional class IIUIV, low cardiac output/index, and low cardiac power index） were more frequent in Group 1. EMB revealed viral genome in 78% of the patients, parvovirus B 19 （PVB） was frequently encountered in both age groups （Group 1： 69.4% vs. Group 2： 59.6%）; detection of more than one viral genome was more frequent in Group 1 （21.2% vs. 11.2%; P = 0.02） whereas the extent of immune response was significantly lower in individuals with advanced age. Conclusions In patients 〉 70 years with DCMi on EMB signs of hemodynamic compromise, detection of multiple viral genomes together with an overall lower extent of immune response were more frequently observed.

关键词： Advanced age Clinical profile Dilated cardiomyopathy Endomyocardial biopsy Inflammation factors

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Program & faculty evaluation

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Annals of Eye Science 2017年第1期2卷 220-228页

作者： Andreas K.lauer Casey Eye Institute Oregon Health and Science UniversityPortland OregonUSA

Graduate medical education(GME)has shifted its curricula from process-oriented approach to outcomes-oriented *** and faculty evaluation are methods by which educational curricula may adjust the teaching and learning environment to meet the needs and fills the gaps in *** measurement of educational outcomes is an essential for assessing teaching effectiveness in a shifting health care *** addition to trainee,program,and faculty evaluations,annual program review(APR)and evaluation and navigational changes made by the program education committee are essential to maintain effectiveness of an educational curriculum in a contemporary graduate medical training program.

关键词： Program evaluation faculty evaluation program evaluation committee(PEC) annual program review(APR) graduate medical education(GME)

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Unmanned Aerial Vehicles in Environmental Monitoring——An Efficient Way for Remote Sensing

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Journal of Environmental Science and Engineering(A) 2015年第2期4卷 85-91页

作者： Tamas Frater Tatjana Juzsakova Janos lauer Laszlo Diossy Akos Redey Direetorate of Plant Protection National Food Chain Safety Office Soil Conservation and Agri-environment Pesticide A nalytieal Laboratory Velence 2481 Hungary University of Pannonia Veszprem 8200 Hungary Fire-Moon Ltd. Papa 8500 Hungary Chianti 3D Ltd. Veszprem 8200 Hungary

Airborne photographs can be expediently used in environmental monitoring; e.g., in the surveillance of the state of natural reserve areas, such as wetlands; or in the measurement and mapping of pollutants, such as oil spills on a lake or sea. A new and cost-effective platform of airborne remote sensing is the UAV （unmanned aerial vehicle） or drone. In this experimental work, aerial photos were made in Bakony Mountains using three UAVs equipped with small HD （high definition） cameras; resolution： 1,280 ~ 720 pixels. Within the framework of this work, a small lake was photographed, where the beginning of eutrophication was detected. This hardly can be observed from ground, however, it is visible on the aerial photos. The airborne surveillance of areas of ragweed （Ambrosia sp.） populations was also investigated. It was found that both UAVs are feasible for these tasks, and the application of these platforms for environmental monitoring is advantageous, especially in case of natural reserve areas since those are very silent and--contrary to big aircrafts and helicopters---do not disturb the ecology even in natural reserve areas and the people living there. Moreover, those could be operated in a very flexible and economic way, and the aerial photos taken are highly informative.

关键词： Remote sensing UAV aerial photographing eutrophication ragweed.

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Technology Trends in Commercial Vehicle Base Engine Development

Technology Trends in Commercial Vehicle Base Engine Developm...

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2014中国汽车工程学会年会

作者： M Neitz A Wiartalla S lauer P Methfessel FEV GmbH RWTH Aachen University

Commercial vehicles will have to meet increasing requirements in the future with regard to further reductions in emissions and fuel consumption.A holistic view of the subjects thermodynamics/after- treatment of exhaust gases and base engine design/mechanics is essentially necessary in order to achieve an optimum condition with regard to product and operating *** the following report,FEV presents some examples that show,which potentials can still be exploited in the further development of the basic engines of commercial vehicles,one of the more progressive examples being the reduction of the number of cylinders for heavy- duty truck engines from 6 to 4.

关键词： heavy-duty downsizing number of cylinders cylinder liner high-pressure injection cylinder head peak firing pressure.

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Bifunctional chimeric SuperCD suicide gene -YCD: YUPRT fusion is highly effective in a rat hepatoma model

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World Journal of Gastroenterology 2005年第44期11卷 6910-6919页

作者： Florian Graepler Marie-Luise Lemken Wolfgang A Wybranietz Ulrike Schmidt Irina Smirnow Christine D GroB Martin Spiegel Andrea Schenk Schenk Hansj(o|¨)rg Graf Ulrike A lauer Reinhard Vonthein Michael Gregor Sorin Armeanu Michael Bitzer Ulrich M.lauer Department of Internal Medicine Ⅰ Section of Experimental Radiology Department of Medical Biometry

AIM： To investigate the effects of catalytically superior gene-directed enzyme prodrug therapy systems on a rat hepatoma model. METHODS： To increase hepatoma cell chemosensitivity for the prodrug 5-fluorocytosine （5-FC）, we generated a chimeric bifunctional SuperCD suicide gene, a fusion of the yeast cytosine deaminase （YCD） and the yeast uracil phosphoribosyltransferase （YUPRT） gene. RESULTS： In vitro stably transduced Morris rat hepatoma cells （MH） expressing the bifunctional SuperCD suicide gene （MH SuperCD） showed a clearly marked enhancement in cell killing when incubated with 5-FC as compared with MH cells stably expressing YCD solely （MH YCD） or the cytosine deaminase gene of bacterial origin （MH BCD）, respectively. In vivo, MH SuperCD tumors implanted both subcutaneously as well as orthotopically into the livers of syngeneic ACI rats demonstrated significant tumor regressions （P〈0.01） under both high dose as well as low dose systemic 5-FC application, whereas MH tumors without transgene expression （MH naive） showed rapid progression. For the first time, an order of in vivo suicide gene effectiveness （SuperCD〉〉 YCD〉〉BCD〉〉〉negative control） was defined as a result of a direct in vivo comparison of all three suicide genes. CONCLUSION： Bifunctional SuperCD suicide gene expression is highly effective in a rat hepatoma model, thereby significantly improving both the therapeutic index and the efficacy of hepatocellular carcinoma killing by fluorocytosine.

关键词： YCD/YUPRT fusion Cytosine deaminase GDEPT Suicide gene therapy Hepatoma therapy

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Patients ≥ 75 years with acute coronary syndrome but without critical epicardial coronary disease： prevalence, characteristics, and outcome

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Journal of Geriatric Cardiology 2015年第1期12卷 11-16页

作者： Vincent Wong Ahmed Farah Hubertus von Korn Nedim Memisevic Stefan Richter KetevanTukhiashvili Bernward lauer Marc-Alexander Ohlow Cardiology Clinic Zentralklinik Bad Berka Robert-Koch-Allee 9 99437 Bad Berka Germany

Objective Absence of significant epicardial coronary artery disease （CAD） in patients with acute onset of chest pain and elevation of myocardial necrosis markers is occasionally observed. The aim of this study was to analyse the clinical characteristics and outcome of such patients with advanced age. Methods We retrospectively analysed 4,311 patients with acute onset of chest pain plus necrosis marker elevation. Two hundred and seventy two patients without CAD on angiogram （6.3%） were identified. Out of them, 50 （1.2%） patients 〉 75 years （Group Ⅰ） were compared with （1） 222 acute coronary syndrome （ACS） patients without CAD on angiogram 〈 75 years （Group Ⅱ）, and （2） 610 consecutive patients ≥ 75 years with Non-ST-elevation Myocardial Infarction （NSTEMI） undergoing percutaneous coronary intervention （Group Ⅲ）. Results Group 1 compared to Group III patients made up for more females （64.0% vs. 49.2%; P 〈 0.0001）, and had more severe anginal symptoms on presentation [Canadian Cardiovascular Society （CCS） class Ⅰ/Ⅱ, 26.0% vs. 49.8%; P = 0.02]. Group I patients also had lower troponin levels （0.62 ± 0.8 ng/mL vs. 27 ± 74 ng/mL; P 〈 0.02）, lower leukocyte count （9.4 ± 3.13 × 10^9 vs. 12 ± 5.1 × 10^9; P = 0.001 ） and better preserved left ventricular function （56.7% ± 14.3 % vs. 45% ± 1 1%; P 〈 0.0001 ）. Event-free survival （cardiac death, myocardial infarction, recurrent angina, and re-hospitalisation） was more frequent in Group Ⅰ and Ⅱ patients compared to Group III patients （64.9%, 66.7%, and 41.6%, respectively; P 〈 0.0001）. Conclusions ACS in patients 〉 75 years without CAD is very infrequent, associated with a （1） similar outcome compared to ACS patients 〈 75 years without CAD, and （2） significant better outcome compared to NSTEMI patients 〉 75 years.

关键词： Acute coronary syndrome Angina Biological markers Coronary stenosis Myocarditis Syndrome

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