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发生于东部英吉利海峡的多格海岸痒病:古老疾病的新地域分布

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世界核心医学期刊文摘（皮肤病学分册） 2006年第2期2卷 41-41页

作者： Pathmanaban O.N. Porter j.S. White I.R. 潘敏 St. john' s Institute of Dermatology St. Thomas' HospitalLondon SE1 7EH United KingdomDr.

Dogger Bank itch is an allergic contact dermatitis to the (2- hydroxyethyl) Dimethyl sulphoxonium ion, a metabolite produced by the marine Bryozoan Alcyonidium diaphanum. The condition may become disabling in affected individuals, who are chiefly fishermen and dock labourers. It involves regions of skin directly exposed to sea water and areas where water may course. As A. diaphanum is common in the coastal waters of Britain, Ireland and neighbouringmainland Europe, it is important for dermatologists to be aware of Dogger Bank itch. Data published in 1966 suggested that 7% of trawler- men at the UK port of Lowestoft had the condition. The current epidemiology is unknown, but the disease still occurs despite shrinkage of the fishing industry, and the condition is not confined to North Sea trawler- men as had been thought previously. It has been reported in trawler- men from Le Havre and shell fishermen from Cornwall, and we report it here in a fisherman using fixed nets in the eastern English Channel.

关键词：痒病皮肤科医师羟乙基二甲基硫码头工人沿海水域病主氧离子弗尔洛斯

异丁子香酚及其衍生物接触致敏:过敏原置换问题

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世界核心医学期刊文摘（皮肤病学分册） 2005年第5期1卷 25-25页

作者： Tanaka S. Royds C. Buckley D. j.P. McFadden 崔荣 St. john's Institute of Dermatology St. Thomas'Hospital London SE17EH United Kingdom

A total of 2261 (808 male, 1453 female) consecutive patients attending contact dermatitis clinics were patch tested to isoeugenol and its derivatives listed i n the EUInventory of Fragrance Ingredients. Positive reactions were found to iso eugenol in 40, transisoeugenol in 40, isoeugenyl acetate in 19, isoeugenyl benzo ate in 4, isoeugenyl phenylacetate in 16, isoeugenyl methyl ether in 6 and benzy l isoeugenyl ether in 2 patients. There was a concomitant reaction to isoeugenol in 36/40 of those positive to transisoeugenol, 13/19 of those to isoeugenyl ace tate, 3/4 of those to isoeugenyl benzoate and 15/16 of those to isoeugenyl pheny lacetate but in none of those 6 positive to isoeugenyl methyl ether and in neith er of those 2 positive to benzylisoeugenyl ether. Concomitant contact allergy be tween isoeugenol and its derivatives may occur through chemical cross-reactivit y or local skin metabolism of the derivatives. It is more commonly observed with the esters rather than the ethers. Isoeugenyl acetate has been proposed as an a lternative to isoeugenol, but there is a high degree of concomit an treactivity with isoeugenol.

关键词：异丁子香酚丁子香斑贴试验致敏安息香酸乙酸苯酯反应者阳性反应皮肤代谢醚类

评价“胸痛三联排除”的CT冠状动脉血管成像扫描方法在疑有低到中度急性冠状动脉综合征危险的急诊病人64层CT检查中的应用

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国际医学放射学杂志 2008年第5期31卷 400-400页

作者： K.M. Takakuwa E.j. Halpern. 邱建星（译）唐光健（校） Department of Radiology Thomas Jefferson University Hospital 132 S 10th St Philadelphia PA 19107-5244USA. 不详

目的利用冠状动脉CT血管成像“胸痛三联排除”扫描对临床表现提示为急性冠状动脉综合征（ACS）的急诊（ED）病人进行评估，以确定其是否有助于确定这些病人可出院并在30d内预后良好。方法本研究得到了机构审查委员会的批准。病人在人组... 详细信息

目的利用冠状动脉CT血管成像“胸痛三联排除”扫描对临床表现提示为急性冠状动脉综合征（ACS）的急诊（ED）病人进行评估，以确定其是否有助于确定这些病人可出院并在30d内预后良好。方法本研究得到了机构审查委员会的批准。病人在人组前均签署知情同意书。共201例有轻至中度ACS患病风险的病人接受了CT冠状动脉血管成像检查。采用一种排除胸痛三联的扫描方法评估冠心病、肺动脉栓塞、主动脉夹层和其他胸部疾病。由于技术问题，

关键词：急性冠状动脉综合征 CT检查冠状动脉血管成像急诊病人扫描三联胸痛 CT血管成像

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慢性肺病婴儿的一氧化氮呼出水平

世界核心医学期刊文摘（儿科学分册） 2005年第2期1卷 38-38页

作者： Leiplj.A. Williams O. Sreekumar S. A.Greenough 郭战宏 Department of Child HealthGuy's King's/St. Thomas'Sch.MedKing's College HospitalSE5 9PJ LondonUnited Kingdom

慢性肺病(CLD)为一炎症性疾病,在其他炎症性疾病时患者的一氧化氮(NO)呼出水平升高,本研究的目的是验证患有CLD的早产儿与未患CLD的早产儿及健康足月产儿相比其NO呼出水平升高的假说。

关键词：呼出慢性肺病足月产儿鼻部出生后口唇部监测方法

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嗜表皮的转移胰腺癌

世界核心医学期刊文摘（皮肤病学分册） 2006年第12期2卷 45-页

作者： Ambro C.M. Humphreys T.R. Lee j.B. 李晓莉 Department of Dermatology and Cutaneous Biology Thomas Jefferson University Hospital 833 Chestnut Street Phi-ladelphia PAUnited States Dr.

We describe an epidermotropically metastatic pancreatic mucinous ductal adenocarcinoma on the scalp. Neoplastic glandular structures that varied in size and shape containing abundant mucin within the lumens and in the neoplastic cells were present within a seborrheic keratosis and adjacent normal epidermis. Similar neoplastic glandular structures were present in the dermis, some within adnexal epithelium and lymphatic vessels. The patient’s history of pancreatic mucinous ductal adenocarcinoma and immunohistochemical staining pattern of carbohydrate antigen 19-9 (CA 19-9) confirmed the diagnosis.

关键词：表皮皮肤管状腺癌腺体结构

伴发乳头状肾细胞癌的家族性多发性皮肤和子宫平滑肌瘤

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世界核心医学期刊文摘（皮肤病学分册） 2005年第5期1卷 61-61页

作者： Chan I. Wong T. Martinez-Mir A. j.A. McGrath 张宪旗 Genetic Skin Disease Group St. John's Institute of Dermatolog y Guy's King's/St. Thomas'Med. Sch. London United Kingdom

Multiple cutaneous and uterine leiomyomas is an autosomal dominant condition t hat results in benign smooth muscle tumours of the skin and, in females, uterine fibroids. This syndrome overlaps with hereditary leiomyomatosis and renal cell cancer syndrome in which affected individuals may develop the rare type II papil lary renal cell cancer, in addition to skin leiomyomas. Recently, heterozygous m utations in the gene encoding fumarate hydratase have been found to underlie bot h conditions. Fumarate hydratase is an enzyme that catalyses the conversion of f umarate to malate in the Kreb’s cycle and may also function as a tumour suppres sor gene. We report a family with multiple leiomyomas, uterine fibroids and papi llary renal cell cancer. The proband is a 77-year-old Polish woman who develop ed multiple cutaneous leiomyomas on her right upper arm in her thirties and subs equently underwent a hysterectomy for uterine fibroids in her forties. She has f our offspring: her eldest daughter also has skin and uterine leiomyomas with a s imilar onset; her son has multiple skin leiomyomas and in addition was diagnosed with metastatic papillary renal cell cancer at the age of 50 years; the two you ngest daughters are unaffected. DNA sequencing in all the affected individuals d isclosed a heterozygous G ?úC substitution at nucleotide 173 ofthefumaratehydra tasegene,thatconvertsanarginineresidue (CGA) to proline (CCA). This missense mut ation has not been reported previously and is designated R58P. Interestingly, th e clinically asymptomatic 20-year-old son of the individual with renal cancer was also found to be heterozygous for R58P. It is likely that he will develop sk in leiomyomas in the future but the risk of renal cancer is difficult to predict . Nevertheless, detection of this mutation has important implications for screen ing and genetic counselling in this and other family members.

关键词：乳头状肾细胞癌子宫平滑肌瘤族性多发性平滑肌瘤良性平滑肌瘤延胡索酸水合酶基因杂合性抑制功能子宫切除术先证者

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当代化学家小传——T.C.沃丁顿传略

世界科学 1982年第12期 59-59页

作者： j.A.S.史密斯 W.K.R.穆斯格莱夫燕诒

1981年5月7日,德黑姆大学无机化学教授托马斯·卡德沃斯·沃丁顿(thomas Cudworth Wad-dington)年仅五十岁便令人痛惜地永别了人世。沃丁顿教授于1930年9月16日出生于布莱克里。在利物浦学院受教育。继而进入剑桥市的贡维尔和凯乌斯学院... 详细信息

1981年5月7日,德黑姆大学无机化学教授托马斯·卡德沃斯·沃丁顿(thomas Cudworth Wad-dington)年仅五十岁便令人痛惜地永别了人世。沃丁顿教授于1930年9月16日出生于布莱克里。在利物浦学院受教育。继而进入剑桥市的贡维尔和凯乌斯学院,在那里他先后被委任为研究员(1956)、化学教师(1957)和讲师(1962)。在1957至1958年间,他还担任剑桥市英国化学工业公司研究员。

关键词：沃丁顿托马斯化学家 T.C

与斑贴试验反应强度有关的副-苯二胺过敏患者的分析

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世界核心医学期刊文摘（皮肤病学分册） 2005年第11期1卷 35-35页

作者： Ho S.G.Y. Basketter D.A. jefferies D. j.P. Mcfadden 刘艳 Dr. Contact Dermatitis Clinic St. John's Institute of Dermatology St. Thomas'Hospital Lambeth Palace Rd London SE1 7EH United Kingdom

Background: Despite having a positive patch test reaction to para-phenylenediamine (PPD), some patients continue to dye their hair, while others are forced to give up or abandon this practice. This difference in patient behaviour could be due to the degree of sensitization. Objectives: To establish whether the ability to continue dyeing hair in PPD allergic patients is related to the strength of patch test reaction. To note differences in other clinical features in relation to the strength of patch test reaction. Methods We analysed retrospectively the patch test records of 400 sequential PPD-positive patients for the strength of patch test reaction (+, ++, +++) and different clinical features. Data were analysed using Cochran-Mantel-Haenszel χ2 tests. Results: There was a strong linear relationship between the strength of patch test reaction and continuation with hair dyeing. Patients were more likely to report a history of hair dye reaction with increasing strength of patch test reaction. There was no difference in strength of patch test reaction in relation to age, site of rash, occupation (hairdressing) or history of atopic eczema. Overall concomitant reactivity with related aromatic amine allergens (benzocaine,N-isopropyl-Nphenyl-para-phenylenediamine, para-aminobenzoic acid) was infrequent. Conclusions: Patients with stronger patch test reactions (++, +++) are more likely to have a clear history of reacting to hair dye and are less likely to still be dyeing their hair.

关键词：斑贴试验过敏患者苯二胺反应强度特应性皮炎发疹苯佐卡因 Cochran 线性关系数据分析

阿达木单抗成功治疗严重型银屑病和银屑病关节炎

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世界核心医学期刊文摘（皮肤病学分册） 2005年第2期1卷 28-28页

作者： Chew A.-L. Bennett A. Smith C.H. j.Barker 田中伟 Skin Therapy Research Unit St. John's Institute of Dermatology St. Thomas'Hospital London SE1 7EH United Kingdom Prof.

Adalimumab, a fully human-derived recombinant monoclonal antibody against tumour necrosis factor-α, has been shown to be effective for the treatment of patients with moderately to severely active rheumatoid arthritis. We report two patients with long-standing recalcitrant psoriasis and psoriatic arthritis who, after multiple treatment failures with conventional and experimental antipsoriatic medications, both responded to treatment with adalimumab. Significant clinical improvement was noted in both skin and joint disease in the two patients after several weeks of treatment with adalimumab. We are unaware of previous published reports of adalimumab therapy in patients with psoriasis and psoriatic arthritis.

关键词：银屑病关节炎严重型达木抗银屑病药物肿瘤坏死因子人源性单克隆抗体关节症状