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除了缺乏以外:增加维生素K摄入量对骨和血管健康的潜在益处

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营养健康新观察 2009年第1期 14-19页

作者： Cees Vermeer Martin j.Shearer Armin Zittermann Caroline Bolton-Smith Pawel Szulc Stephen Hodges Paul Walter Walter Rambeck Elisabeth Stcklin.Peter Weber 王劲 Maastricht大学生化系 St.thomas医院德国波恩大学 MRC Human Nutrition Research INSERM S.Hodges大学伦敦学院巴塞尔大学慕尼黑大学 Roche维生素有限公司

维生素K以其合成许多血凝因子的作用而著名。最近几年发现维生素K依赖性蛋白对骨和血管的健康有极其重要作用。膳食维生素K推荐摄入量是以肝脏合成血凝因子需要量为基础制定的。积累的证据提示用于其他功能的需要量比用于血凝的需要量... 详细信息

维生素K以其合成许多血凝因子的作用而著名。最近几年发现维生素K依赖性蛋白对骨和血管的健康有极其重要作用。膳食维生素K推荐摄入量是以肝脏合成血凝因子需要量为基础制定的。积累的证据提示用于其他功能的需要量比用于血凝的需要量可能要高。本文是一个封闭专题讨论会的结果,会上许多欧洲维生素K专家回顾了现有的资料并阐明了他们在膳食维生素K推荐摄入量和使用含维生素K补充剂的立场。

关键词：维生素K γ-羧基谷氨酸骨质疏松症骨矿物质密度心血管病

晚发型VitK缺乏性出血高发区孕妇及新生儿VitK状况的研究

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中国妇幼保健 2001年第10期16卷 630-632页

作者：张会丰王小康李伟李芳李根山贾俊娟吕志华林秀芝李华忠刘秀萍 Shearer Mj Harvey j 河北医科大学第二医院儿科 050000 山东省栖霞县妇幼保健院山西省泽州县妇幼保健院 The Vitamin K Units St Thomas'Hospital UK

研究晚发型VitK缺乏性出血高发地区孕妇及其新生儿的VitK营养状况。山东省栖霞县是迄今为止晚发型VitK缺乏性出血发病率最高的地区。采用凝血酶原前体蛋白（PIVKA-Ⅱ）的ＥＬＩＳＡ法测定了栖霞县７６名健康孕妇及其新生儿血清凝血酶... 详细信息

研究晚发型VitK缺乏性出血高发地区孕妇及其新生儿的VitK营养状况。山东省栖霞县是迄今为止晚发型VitK缺乏性出血发病率最高的地区。采用凝血酶原前体蛋白（PIVKA-Ⅱ）的ＥＬＩＳＡ法测定了栖霞县７６名健康孕妇及其新生儿血清凝血酶原前体蛋白（PIVKA－Ⅱ）水平。结果显示：孕妇凝血酶原前体蛋白阳性率为３１．５８％;新生儿为５５．２６％。凝血酶原前体蛋白阳性孕妇，其新生儿凝血酶原前体蛋白阳性的几率为７０．８３％。凝血酶原前体蛋白同时阳性的１７例孕妇及其新生儿中，孕妇和新生儿水平有相关性（相关系数为０．５２６，Ｐ＜０．０５）。母亲凝血酶原前体蛋白阴性，其新生儿阳性的几率为４８．０８％。提示：当孕妇有亚临床VitK缺乏时，其分娩的新生儿大部分将发生VitK缺乏。孕妇VitK 缺乏会导致新生儿VitK缺乏。即使孕产妇不存在亚临床VitK缺乏，由于胎盘屏障的作用，仍有４８．０８％的新生儿会发生亚临床VitK缺乏。

关键词：孕妇新生儿凝血酶原前体蛋白晚发性维生素K缺乏性出血 VKDB

非同卵双生胎儿Herlitz结合性大疱性表皮松解症的产前诊断

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世界核心医学期刊文摘（皮肤病学分册） 2005年第7期1卷 46-46页

作者： FassihiH. Ashton G.H.S. Denyer j. j.A.McGrath 王琼 Genetic Skin Disease Group St. John' s Institute of Dermatology St. Thomas' Hospital Lambeth Palace Road London SE17EH United Kingdom

Advances in molecular diagnostics have led to the feasibility of DNA-based prenatal testing in families at risk for recurrence of severe forms of both dystrophic and junctional epidermolysis bullosa. In this report, we describe prenatal testing in a woman who previously had a child affected with Herlitz junctional epidermolysis bullosa. However, in her second pregnancy, she was found to have dichorionic diamniotic twins. DNA analysis of a pathogenic mutation and informative intragenic polymorphisms (LAMB3 gene) predicted one fetus to be affected and the other unaffected. Selective termination of the affected fetus was performed, and pregnancy with the unaffected fetus was continued, leading to full term delivery of a healthy girl with no skin blisters. This is the first reported case of DNA analysis in a twin pregnancy at risk of Herlitz junctional epidermolysis bullosa, with successful diagnosis and selective termination of one affected twin.

关键词：产前诊断 Herlitz 同卵双生结合性产前检测羊膜腔营养不良性足月分娩双胎妊娠首例报道

人类小肠IgA反应在集结的肠黏膜相关淋巴组织中产生,并非在固有膜中产生

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世界核心医学期刊文摘（胃肠病学分册） 2005年第10期1卷 28-28页

作者： Boursier L. Gordon j.N. Thiagamoorthy S. j. Spencer 王铮 Department of Immunobiology GKT Medical School New Guy's House St. Thomas Street London SE1 9RT United Kingdom Dr.

Background &Aims: The intestinal lamina propria has traditionally been viewed as the effector site of mucosal immune responses. However, this view has been challenged with the identification, in the murine lamina propria, of an in situ class switch DNA recombination pathway to IgA. In this study, we tested the hypothesis that in situ class switching occurs in the human lamina propria. Methods: Immunohistochemistry was used to analyze tissue microenvironments and RT-PCR to look for molecular evidence of Ig class switching and to track clonally related cells of B lineage. Results: We found no evidence of proliferation of either lamina propria CD20+or CD19+cells or evidence of activation-induced cytidine deaminase mRNA expression outside the organized gut-associated lymphoid tissue, although Iα-Cαimmunoglobulin germ-line gene transcript expression could be identified in the lamina propria. We identified clonally related cells, including IgA and IgM isotype-switched variants, in multiple samples known to be free of activation-induced cytidine deaminase, organized lymphoid tissue, or cellular proliferation. For 4 groups of cells, the patterns of somatic mutations on the rearranged IgVH5 gene segment were more similar between cells from distant sites than from their immediate neighbors, implying dissemination of cells from a common set of precursors. Conclusions: Our data are inconsistent with a model in which precursors of human IgA-secreting plasma cells are induced or expanded in the lamina propria. The human lamina propria is therefore likely to solely be an effector site of intestinal secretory IgA responses that originate from the organized gut-associated lymphoid tissues.

关键词：固有膜 IgA 类别转换固有层组织微环境黏膜免疫免疫组化技术免疫球蛋白分子学胞嘧啶核苷

Decline in subarachnoid haemorrhage volumes associated with the first wave of the COVID- 19 pandemic

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Stroke & Vascular Neurology 2021年第4期6卷 542-552,I0026-I0032页

作者： Thanh N Nguyen Diogo C Haussen Muhammad M Qureshi Hiroshi Yamagami Toshiyuki Fujinaka Ossama Y Mansour Mohamad Abdalkader Michael Frankel Zhongming Qiu Allan Taylor Pedro Lylyk Omer F Eker Laura Mechtouff Michel Piotin Fabricio Oliveira Lima Francisco Mont'Alverne Wazim Izzath Nobuyuki Sakai Mahmoud Mohammaden Alhamza R Al-Bayati Leonardo Renieri Salvatore Mangiafico David Ozretic Vanessa Chalumeau Saima Ahmad Umair Rashid Syed Irteza Hussain Seby john Emma Griffin john Thornton jose Antonio Fiorot Rodrigo Rivera Nadia Hammami Anna M Cervantes-Arslanian Hormuzdiyar H Dasenbrock Huynh Le Vu Viet Quy Nguyen Steven Hetts Romain Bourcier Romain Guile Melanie Walker Malveeka Sharma Don Frei Pascal jabbour Nabeel Herial Fawaz Al-Mufti Atilla Ozcan Ozdemir Ozlem Aykac Dheeraj Gandhi Chandril Chugh Charles Matouk Pascale Lavoie Randall Edgell Andre Beer-Furlan Michael Chen Monika Killer-Oberpfalzer Vitor Mendes Pereira Patrick Nicholson Vikram Huded Nobuyuki Ohara Daisuke Watanabe Dong Hun Shin Pedro SC Magalhaes Raghid Kikano Santiago Ortega-Gutierrez Mudassir Farooqui Amal Abou-Hamden Tatsuo Amano Ryoo Yamamoto Adrienne Weeks Elena A Cora Rotem Sivan-Hoffmann Roberto Crosa Markus Möhlenbruch Simon Nagel Hosam Al-jehani Sunil A Sheth Victor S Lopez Rivera james E Siegler Achmad Fidaus Sani Ajit S Puri Anna Luisa Kuhn Gianmarco Bernava Paolo Machi Daniel G Abud Octavio M Pontes-Neto Ajay K Wakhloo Barbara Voetsch Eytan Raz Shadi Yaghi Brijesh P Mehta Naoto Kimura Mamoru Murakami jin Soo Lee ji Man Hong Robert Fahed Gregory Walker Eiji Hagashi Steve M Cordina Hong Gee Roh Ken Wong juan F Arenillas Mario Martinez-Galdamez jordi Blasco Alejandro Rodriguez Vasquez Luisa Fonseca M Luis Silva Teddy Y Wu Simon john Alex Brehm Marios Psychogios William j Mack Matthew Tenser Tatemi Todaka Miki Fujimura Roberta Novakovic jun Deguchi Yuri Sugiura Hiroshi Tokimura Rakesh Khatri Michael Kelly Lissa Peeling Yuichi Murayama Hugh Stephen Winters johnny Wong Mohamed Teleb jeremy Payne Hiroki Fukuda Kosuke Miyake junsuke Shimbo Yusuke Sug Neurology RadiologyBoston Medical CenterBostonMassachusettsUSA Neurology Marcus Stroke&Neuroscience CenterGrady Memorial HospitalEmory University School of MedicineAtlantaGAUSA Radiology Radiation OncologyBoston University School of MedicineBostonMassachusettsUSA Neurology National Hospital Organization Osaka National HospitalOsakaJapan Neurosurgery National Hospital Organization Osaka National HospitalOsakaJapan Neurology Alexandria UniversityAlexandriaEgypt Radiology Boston Medical CenterBostonMassachusettsUSA Department of Neurology Xinqiao HospitalChongqingChina Neurosurgery University of Cape TownRondeboschWestern CapeSouth Africa Neurosurgery Interventional NeuroradiologyClinica La Sagrada FamiliaBuenos AiresArgentina Neuroradiologie Neurologie VasculaireHospices Civils de LyonLyonAuvergne-Rhône AlpesFrance Neurologie Vasculaire Hospices Civils de LyonLyonAuvergne-Rhône AlpesFrance Interventional Neuroradiology Fondation Ophtalmologique Adolphe de RothschildParisÎle-de FranceFrance Neurology Hospital Geral de FortalezaFortalezaBrazil Interventional Neuroradiology Hospital Geral de FortalezaFortalezaBrazil Neuroradiology Nottingham University Hospitals NHS TrustNottinghamUK Department of Neurosurgery Kobe City Medical Center General HospitalKobeHyogoJapan Interventional Neurovascular Unit University Hospital CareggiFirenzeToscanaItaly Neuroradiology University Hospital Centre ZagrebZagrebCroatia Interventional Neuroradiology Hopital BicetreLe Kremlin-BicetreFrance Stroke and Interventional Neuroradiology Lahore General HospitalLahorePakistan Neurological Institute Cleveland Clinic Abu DhabiAbu DhabiUAE Department of Radiology Beaumont HospitalDublinIreland Neurology Stroke UnitHospital-Estadual CentralVitoriaBrazil Neuroradiology Instituto de Neurocirugia Dr AsengoSantiagoChile Interventional Neuroradiology Institut National de NeurologieTunisTunisia Neurology Boston Medical CenterBostonMassachusettsUSA Neurosurgery Boston Medical Center

Background During the COVID-19 pandemic,decreased volumes of stroke admissions and mechanical thrombectomy were *** study’s objective was to examine whether subarachnoid haemorrhage(SAH)hospitalisations and ruptured aneurysm coiling interventions demonstrated similar *** We conducted a cross-sectional,retrospective,observational study across 6 continents,37 countries and 140 comprehensive stroke *** with the diagnosis of SAH,aneurysmal SAH,ruptured aneurysm coiling interventions and COVID-19 were identified by prospective aneurysm databases or by International Classification of Diseases,10th Revision,*** 3-month cumulative volume,monthly volumes for SAH hospitalisations and ruptured aneurysm coiling procedures were compared for the period before(1 year and immediately before)and during the pandemic,defined as 1 March-31 May *** prior 1-year control period(1 March-31 May 2019)was obtained to account for seasonal *** There was a significant decline in SAH hospitalisations,with 2044 admissions in the 3 months immediately before and 1585 admissions during the pandemic,representing a relative decline of 22.5%(95%CI−24.3%to−20.7%,p<0.0001).Embolisation of ruptured aneurysms declined with 1170-1035 procedures,respectively,representing an 11.5%(95%CI−13.5%to−9.8%,p=0.002)relative *** analysis was noted for aneurysmal SAH hospitalisation decline from 834 to 626 hospitalisations,a 24.9%relative decline(95%CI−28.0%to−22.1%,p<0.0001).A relative increase in ruptured aneurysm coiling was noted in low coiling volume hospitals of 41.1%(95%CI 32.3%to 50.6%,p=0.008)despite a decrease in SAH admissions in this *** There was a relative decrease in the volume of SAH hospitalisations,aneurysmal SAH hospitalisations and ruptured aneurysm embolisations during the COVID-19 *** findings in SAH are consistent with a decrease in other emergencies,such as stroke and myocardial infarction.

关键词： diagnosis representing subarachnoid

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青皮苹果

国外农学(果树) 1983年第3期 16-16页

作者： Ballard j. 顾敏芬

Granny Smith起源于澳大利亚的一株自然实生苗。是该地分布广泛的一个苹果品种。早在1864年,该品种因由英籍果树栽培家thomas S—mith的夫人Granny Smith发现而定名。一百多年来,该品种以产量高、品质好而闻名世界。在七十年代,美国巳... 详细信息

Granny Smith起源于澳大利亚的一株自然实生苗。是该地分布广泛的一个苹果品种。早在1864年,该品种因由英籍果树栽培家thomas S—mith的夫人Granny Smith发现而定名。一百多年来,该品种以产量高、品质好而闻名世界。在七十年代,美国巳开始大规模栽植。此后,世界各地许多国家也纷纷引种栽培。目前,它的产量仅次于金冠和红元帅,跃居世界第三位。

关键词：苹果砧木台木嫁接材料

慢性肝病:肝静脉压力梯度的无创性次谐波辅助压力评估

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国际医学放射学杂志 2013年第5期 487-487页

作者： j.R.Eisenbrey j.K.Dave V.G.Halldorsdottir D.A.Merton C.Miller j.M.Gonzalez 董帜 Department of Radiology Thomas Jefferson University

摘要目的在经颈静脉肝活检的慢性肝病病人中比较次谐波辅助压力估算法(subharmonic aided pressure estimation,SHAPE)与导管测压法测定肝静脉压力。方法本研究符合HIPAA规定并获得美国食品与药物管理局审核批准,取得所有病人的知情同意... 详细信息

摘要目的在经颈静脉肝活检的慢性肝病病人中比较次谐波辅助压力估算法(subharmonic aided pressure estimation,SHAPE)与导管测压法测定肝静脉压力。方法本研究符合HIPAA规定并获得美国食品与药物管理局审核批准,取得所有病人的知情同意。2010年12月—2011年12月共45例慢性肝病者参与完成本研究。采用改装的能够采集SHAPE数据的临床超声扫描仪。45例病人按标准治疗行经颈静脉肝活检,同时测量血管压力。再接受输注超声对比剂微泡和生理盐水,采集门静脉及肝静脉的SHAPE数据,并与

关键词：肝静脉压力梯度慢性肝病门静脉高压门脉高血压次谐波

除了缺乏以外:增加维生素K摄入量对骨和血管健康的潜在益处

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除了缺乏以外:增加维生素K摄入量对骨和血管健康的潜在益处

作者： Cees Vermeer Martin j.Shearer Armin Zittermann Caroline Bolton-Smith Pawel Szulc Stephen Hodges Paul Walter Walter Rambeck Elisabeth StLcklin·Peter Weber 王劲 Maastricht大学生化系 St thomas医院德国波恩大学 MRC Human Nutrition Research

关键词：维生素K γ-羧基谷氨酸骨质疏松症骨矿物质密度心血管病

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催产素帮助人类撩开羞怯面纱?

中国处方药 2008年第8期7卷 11-11页

作者： M.j.STEPHEY 姚立新

在临床上广泛用于控制子宫平滑肌收缩的药物——催产素,最新的研究表明,其在促进人类社交方面也同样起到关键作用。

关键词：催产素人类子宫平滑肌收缩羞怯 thomas 拉丁文英文名愿望