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Python Server Page Perf.rmance Analysis and Modeling

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Communications and Network 2024年第1期16卷 1-30页

作者： Razaf.ndraibe Marolahy Alix Randrianomenjanahary Lala f.rdinand Raf.mantanantsoa f.ntaine Mahatody thomas f. Angelo Raherinirina University of.f.anarantsoa Fianarantsoa Madagascar

Today, in the f.eld of.computer networks, new services have been developed on the Internet or intranets, including the mail server, database management, sounds, videos and the web server itself.Apache. The number of.solutions f.r this server is theref.re growing continuously, these services are becoming more and more complex and expensive, without being able to f.lf.ll the needs of.the users. The absence of.benchmarks f.r websites with dynamic content is the major obstacle to research in this area. These users place high demands on the speed of.access to inf.rmation on the Internet. This is why the perf.rmance of.the web server is critically important. Several f.ctors inf.uence perf.rmance, such as server execution speed, network saturation on the internet or intranet, increased response time, and throughputs. By measuring these f.ctors, we propose a perf.rmance evaluation strategy f.r servers that allows us to determine the actual perf.rmance of.dif.erent servers in terms of.user satisf.ction. f.rthermore, we identif.ed perf.rmance characteristics such as throughput, resource utilization, and response time of.a system through measurement and modeling by simulation. f.nally, we present a simple queue model of.an Apache web server, which reasonably represents the behavior of.a saturated web server using the Simulink model in Matlab (Matrix Laboratory) and also incorporates sporadic incoming traf.ic. We obtain server perf.rmance metrics such as average response time and throughput through simulations. Compared to other models, our model is conceptually straightf.rward. The model has been validated through measurements and simulations during the tests that we conducted.

关键词： Perf.rmance Analysis Queue Perf.rmance Model Web Server Internet World Wide Web Web Server Perf.rmance

Enhanced diagnostic workup increases pathological f.ndings in patients with acute ischaemic stroke:results of.the prospective HEBRAS study

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Stroke & Vascular Neurology 2024年第2期9卷 145-152,I0414-I0425页

作者： Simon Hellwig thomas Krause Jan f.Scheitz Juliane Herm Ulrike Grittner Nadja Jauert Jochen B f.ebach Mario Kasner Wolf.am Doehner Matthias Endres Rolf.Wachter thomas Elgeti Christian H Nolte Karl Georg Haeusler Department of.Neurology with Experimental Neurology Charité-Universitätsmedizin Berlincorporate member of Freie Universität Berlin and Humboldt-Universität zu BerlinBerlinGermany Center f.r Stroke Research Berlin BerlinGermany Berlin Institute of.Health at Charité–Universitätsmedizin Berlin BIH Biomedical Innovation AcademyBerlinGermany Department of.Neurology Jüdisches Krankenhaus BerlinBerlinGermany German Center f.r Cardiovascular Diseases(DZHK) Partner Site BerlinBerlinGermany Institute of.Biometry and Clinical Epidemiology Charité-Universitätsmedizin BerlinBerlinGermany BIH Center f.r Regenerative Therapies(BCRT) Berlin Institute of Health at Charité–Universitätsmedizin BerlinBerlinGermany Department of.Cardiology Charité-Universitätsmedizin BerlinBerlinGermany Department of.Cardiology Campus Benjamin FranklinCharité-Universitätsmedizin BerlinBerlinGermany German Center f.r Neurodegenerative Diseases(DZNE) Partner Site BerlinBerlinGermany Department of.Cardiology University Hospital LeipzigLeipzigGermany Department of.Radiology Charité-Universitätsmedizin BerlinBerlinGermany Department of.Neurology University Hospital WürzburgWürzburgGermany

Background Stroke aetiology remains cryptogenic in a relevant proportion of.patients with acute ischaemic stroke(AIS).We assessed whether enhanced diagnostic workup af.er AIS yields a higher rate of.prespecif.ed pathological f.ndings compared with routine diagnostic care *** Hospitalised patients with AIS were prospectively enrolled in the investigator-initiated observational HEart and BRain Interf.ces in Acute Ischaemic Stroke(HEBRAS)study at the Charité,Berlin,*** with AIS without known atrial f.brillation(Af.underwent cardiovascular MR imaging(CMR),MR-angiography of.the aortic arch and prolonged Holter-ECG monitoring on top of.routine diagnostic *** Among 356 patients with AIS(mean age 66 years,37.6%f.male),enhanced workup yielded a higher rate of.prespecif.ed pathological f.ndings compared with routine care(17.7%vs 5.3%;pf.wer patients were classif.ed as cryptogenic af.er enhanced diagnostic workup(38.5%vs 45.5%,pf.lly perf.rmed in 292(82.0%)patients and revealed more of.en a prespecif.ed pathological f.nding compared with routine echocardiography(16.1%vs 5.3%).f.rthermore,study-related ECG monitoring(median duration 162 hours(IQR 98–210))detected Af.in 16(4.5%)patients,while routine monitoring(median duration 51 hours(IQR 34–74))detected Af.in seven(2.0%)*** Enhanced diagnostic workup revealed a higher rate of.prespecif.ed pathological f.ndings in patients with AIS compared with routine diagnostic care and signif.cantly reduced the proportion of.patients with cryptogenic *** registration number NCT02142413.

关键词： routine patients prospective

Circulating microRNA expression and nonalcoholic f.tty liver disease in adolescents with severe obesity

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World Journal of.Gastroenterology 2024年第4期30卷 332-345页

作者： Yi-Jie Li Brittney O baumert Nikos Stratakis Jesse A Goodrich Hao-Tian Wu Jing-Xuan He Yin-Qi Zhao Max T Aung Hong-Xu Wang Sandrah P Eckel Douglas I Walker Damaskini Valvi Michele A La Merrill Justin R Ryder thomas H Inge Todd Jenkins Stephanie Sisley Rohit Kohli Stavra A Xanthakos Andrea A Baccarelli Rob McConnell David V Conti Lida Chatzi Department of.Population and Public Health Sciences Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCA 90032United States Barcelona Institute of.Global Health Barcelona Institute of Global HealthBarcelona 08036Spain Department of.Environmental Health Sciences Mailman School of Public HealthColumbia UniversityNew YorkNY 10032United States Gangarosa Department of.Environmental Health Rollins School of Public HealthEmory UniversityAtlantaGA 30329United States Department of.Environmental Medicine and Public Health Icahn School of Medicine at Mount SinaiNew YorkNY 10029United States Department of.Environmental Toxicology University of CaliforniaDavisCA 95616United States Department of.Surgery Lurie Children’s Hospital of ChicagoChicagoIL 60611United States Northwestern University f.inberg School of.Medicine Northwestern UniversityChicagoIL 60611United States Division of.Biostatistics and Epidemiology Cincinnati Children's Hospital Medical CenterCincinnatiOH 45229United States Department of.Pediatrics University of Cincinnati College of MedicineCincinnatiOH 45229United States Department of.Pediatrics Children’s Nutrition Research Center USDA/ARSBaylor College of MedicineHoustonTX 77030United States Department of.Gastroenterology Children’s Hospital Los AngelesLos AngelesCA 90027United States Division of.Gastroenterology Hepatology and NutritionCincinnati Children's Hospital Medical CenterCincinnatiOH 45229United States

BACKGROUND Nonalcoholic f.tty liver disease(NAf.D)is one of.the most common chronic liver diseases in children and *** ranges in severity f.om isolated hepatic steatosis to nonalcoholic steatohepatitis(NASH),wherein hepatocellular inf.ammation and/or f.brosis coexist with *** microRNA(miRNA)levels have been suggested to be altered in NAf.D,but the extent to which miRNA are related to NAf.D f.atures remains *** analysis tested the hypothesis that plasma miRNAs are signif.cantly associated with histological f.atures of.NAf.D in *** To investigate the relationship between plasma miRNA expression and NAf.D f.atures among adolescents with *** This study included 81 adolescents diagnosed with NAf.D and 54 adolescents without NAf.D f.om the Teen-Longitudinal Assessment of.Bariatric Surgery ***-operative core liver biopsies were collected f.om participants and used to characterize histological f.atures of.*** samples were collected during surgery f.r miRNA prof.ling.A total of.843 plasma miRNAs were prof.led using the HTG EdgeSeq *** examined associations of.plasma miRNAs and NAf.D f.atures using logistic regression af.er adjusting f.r age,sex,race,and other key *** Pathways Analysis was used to identif. biological f.nctions of.miRNAs that were associated with multiple histological f.atures of.*** We identif.ed 16 upregulated plasma miRNAs,including miR-193a-5p and miR-193b-5p,and 22 downregulated plasma miRNAs,including miR-1282 and miR-6734-5p,in adolescents with ***,52,16,15,and 9 plasma miRNAs were associated with NASH,f.brosis,ballooning degeneration,and lobular inf.ammation,***,16 miRNAs were associated with two or more histological f.atures of.*** those miRNAs,miR-411-5p was downregulated in NASH,ballooning,and f.brosis,while miR-122-5p,miR-1343-5p,miR-193a-5p,miR-193b-5p,and miR-7845-5p were consistently and posi

关键词： MicroRNA Nonalcoholic f.tty liver disease Non-alcoholic steatohepatitis Liver f.brosis Lobular inf.ammation Ballooning degeneration

Spatiotemporal characteristics of.cultivated land use eco-ef.iciency and its inf.uencing f.ctors in China f.om 2000 to 2020

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Journal of.Arid Land 2024年第3期16卷 396-414页

作者： LI Shaoting MU Na REN Yanjun thomas GLAUBEN College of.Economics and Management Northwest A&F UniversityYangling 712100China Sino-German Center f.r Agricultural and f.od Economics Northwest A&F UniversityYangling 712100China Leibniz Institute of.Agricultural Development in Transition Economies(IAMO) Halle 06120Germany

Improving cultivated land use eco-ef.iciency(CLUE)can ef.ectively promote agricultural sustainability,particularly in developing countries where CLUE is generally *** study used provincial-level data f.om China to evaluate the spatiotemporal evolution of.CLUE f.om 2000 to 2020 and identif.ed the inf.uencing f.ctors of.CLUE by using a panel Tobit *** addition,given the undesirable outputs of.agricultural production,we incorporated carbon emissions and nonpoint source pollution into the global benchmark-undesirable output-super ef.iciency-slacks-based measure(GB-US-SBM)model,which combines global benchmark technology,undesirable output,super ef.iciency,and slacks-based *** results indicated that there was an upward trend in CLUE in China f.om 2000 to 2020,with an increase rate of.2.62%.The temporal evolution of.CLUE in China could be classif.ed into three distinct stages:a period of.f.uctuating decrease(2000-2007),a phase of.gradual increase(2008-2014),and a period of.rapid growth(2015-2020).The major grain-producing areas(MPAs)had a lower CLUE than their counterparts,namely,non-major grain-production areas(non-MPAs).The spatial agglomeration ef.ect f.llowed a northeast-southwest strip distribution;and the movement path of.barycentre revealed a"P"shape,with Luoyang City,Henan Province,as the *** terms of.inf.uencing f.ctors of.CLUE,investment in science and technology played the most vital role in improving CLUE,while irrigation index had the most negative *** should be noted that these two inf.uencing f.ctors had dif.erent impacts on MPAs and ***,relevant departments should f.rmulate policies to enhance the level of.science and technology,improve irrigation condition,and promote sustainable utilization of.cultivated land.

关键词： cultivated land use eco-ef.iciency(CLUE) slacks-based measure(SBM)model barycentre model standard deviation ellipse(SDE) panel Tobit model carbon emissions nonpoint source pollution

EZH2 inhibitors promote β-like cell regeneration in young and adult type 1 diabetes donors

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Signal Transduction and Targeted Therapy 2024年第2期9卷 679-692页

作者： Keith Al-Hasani Saf.ya Naina Marikar Harikrishnan Kaipananickal Scott Maxwell Jun Okabe Ishant Khurana thomas Karagiannis Julia J.Liang Lina Mariana thomas Loudovaris thomas Kay Assam El-Osta Epigenetics in Human Health and Disease Program Baker Heart and Diabetes Institute75 Commercial RoadMelbourne 3004 VICAustralia Department of.Diabetes Central Clinical SchoolMonash UniversityMelbourne 3004 VICAustralia Epigenetics in Human Health and Disease Laboratory Central Clinical SchoolMonash UniversityMelbourne 3004 VICAustralia School of.Science STEM CollegeRMIT UniversityMelbourne 3001 VICAustralia Immunology and Diabetes Unit St Vincent’s Institute of Medical ResearchFitzroy 3065 VICAustralia Department of.Medicine and Therapeutics The Chinese University of Hong KongSha TinHong Kong SAR Hong Kong Institute of.Diabetes and Obesity Prince of Wales HospitalThe Chinese University of Hong Kong3/F Lui Che Woo Clinical Sciences Building30-32-Ngan Shing StreetSha TinHong Kong SAR Li Ka Shing Institute of.Health Sciences The Chinese University of Hong KongSha TinHong Kong SAR Biomedical Laboratory Science Department of TechnologyFaculty of HealthUniversity College CopenhagenCopenhagenDenmark

β-cells are a type of.endocrine cell f.und in pancreatic islets that synthesize,store and release *** type 1 diabetes(T1D),T-cells of.the immune system selectively destroy the insulin-producingβ-*** of.these cells leads to a lif.long dependence on exogenous insulin administration f.r ***,there is an urgent need to identif. novel therapies that stimulateβ-cell growth and induceβ-cell *** and others have shown that pancreatic ductal progenitor cells are a promising source f.r regeneratingβ-cells f.r T1D owing to their inherent dif.erentiation *** transcriptional suppression is ref.actory to exocrine reaction and tightly controls the regenerative potential by the EZH2 *** the present study,we show that transient stimulation of.exocrine cells,derived f.om juvenile and adult T1D donors to the f.Aapproved EZH2 inhibitors GSK126 and Tazemetostat(Taz)inf.uence a phenotypic shif. towards aβ-like cell *** transition f.om repressed to permissive chromatin states are dependent on bivalent H3K27me3 and H3K4me3 chromatin *** EZH2 is f.ndamental toβ-cell regenerative *** pancreatic ductal cells exhibit insulin production and secretion in response to a physiological glucose challenge ex *** pre-clinical studies underscore the potential of.small molecule inhibitors as novel modulators of.ductal progenitor dif.erentiation and a promising new approach f.r the restoration of.-like cell f.nction.

关键词： EZH2 struction inhibitors

B-cell and antibody responses to SARS-CoV-2:inf.ction,vaccination,and hybrid immunity

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Cellular & Molecular Immunology 2024年第2期21卷 144-158页

作者： Dennis Lapuente thomas H.Winkler Matthias Tenbusch Institut f.r klinische und molekulare Virologie Universitätsklinikum Erlangen und Friedrich-Alexander-Universität(FAU)Erlangen-NürnbergSchlossgarten 491054 ErlangenGermany Department of.Biology Division of GeneticsNikolaus-Fiebiger-Center for Molecular MedicineFriedrich-Alexander-Universität Erlangen-Nürnberg(FAU)ErlangenGermany Medical Immunology Campus Erlangen Friedrich-Alexander-Universität(FAU)Erlangen-NürnbergSchlossplatz 191054 ErlangenGermany

The emergence of.severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)in 2019 prompted scientif.c,medical,and biotech communities to investigate inf.ction-and vaccine-induced immune responses in the context of.this pathogen.B-cell and antibody responses are at the center of.these investigations,as neutralizing antibodies(nAbs)are an important correlate of.protection(COP)f.om inf.ction and the primary target of.SARS-CoV-2 vaccine *** addition to absolute levels,nAb longevity,neutralization breadth,immunoglobulin isotype and subtype composition,and presence at mucosal sites have become important topics f.r scientists and health policy *** recent pandemic was and still is a unique setting in which to study de novo and memory B-cell(MBC)and antibody responses in the dynamic interplay of.inf.ction-and vaccine-induced *** also provided an opportunity to explore new vaccine platf.rms,such as mRNA or adenoviral vector vaccines,in unprecedented cohort *** with the technological advances of.recent years,this situation has provided detailed mechanistic insights into the development of.B-cell and antibody responses but also revealed some unexpected *** this review,we summarize the key f.ndings of.the last 2.5 years regarding inf.ction-and vaccine-induced B-cell immunity,which we believe are of.signif.cant value not only in the context of.SARS-CoV-2 but also f.r f.ture vaccination approaches in endemic and pandemic settings.

关键词： SARS-CoV-2 neutralizing antibodies memory responses vaccines IgG4

The impact of.demographic dynamics on f.od consumption and its environmental outcomes:Evidence f.om China

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Journal of.Integrative Agriculture 2024年第2期23卷 414-429页

作者： Shaoting Li Xuan Chen Yanjun Ren thomas Glauben College of.Economics and Management Northwest A&F UniversityYangling 712100China Leibniz Institute of.Agricultural Development in Transition Economies(IAMO) Halle(Saale)06120Germany Sino-German Center f.r Agricultural and f.od Economics Northwest A&F UniversityYangling 712100China

With increasing population and changing demographics,f.od consumption has experienced a signif.cant transition in quantity and ***,a dearth of.knowledge remains regarding its environmental impacts and how it responds to demographic dynamics,particularly in emerging economies like *** the two-stage Quadratic Almost Demand System(QUAIDS)model,this study empirically examines the impact of.demographic dynamics on f.od consumption and its environmental outcomes based on the provincial data f.om 2000 to 2020 in *** various scenarios,according to changes in demographics,we extend our analysis to project the long-term trend of.f.od consumption and its environmental impacts,including greenhouse gas(GHG)emissions,water f.otprint(Wf.,and land appropriation(LA).The results reveal that an increase in the proportion of.senior people signif.cantly decreases the consumption of.grain and livestock meat and increases the consumption of.poultry,egg,and aquatic products,particularly f.r urban ***,an increase in the proportion of.males in the population leads to higher consumption of.poultry and aquatic ***,in the current scenario of.an increased aging population and sex ratio,it is anticipated that GHG emissions,Wf.and LA are likely to decrease by 1.37,2.52,and 3.56%,*** importantly,in the scenario adhering to the standards of.nutritional intake according to the Dietary Guidelines f.r Chinese Residents in 2022,GHG emissions,Wf.and LA in urban areas would increase by 12.78,20.94,and 18.32%,*** f.ndings suggest that changing demographics should be considered when designing policies to mitigate the diet-environment-health trilemma and achieve sustainable f.od consumption.

关键词： demographic dynamics f.od consumption environmental impacts nutrition intakes

Pathogenesis of.hepatitis B virus inf.ction

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World Journal of.Gastroenterology 2007年第1期13卷 82-90页

作者： thomas f.baumert Robert Thimme f.itz von Weizscker Department of.Medicine II University of Freiburg Freiburg Germany INSERM U748 Université Louis Pasteur Strasbourg France Department of.Medicine II University of Freiburg Freiburg Germany Department of.Medicine II University of Freiburg Freiburg Germany Schlosspark-Klinik Charité Humboldt University Berlin Germany

Inf.ction with hepatitis B virus (HBV) leads to a wide spectrum of.clinical presentations ranging f.om an asymptomatic carrier state to self.limited acute or f.lminant hepatitis to chronic hepatitis with progression to cirrhosis and hepatocellular carcinoma. Inf.ction with HBV is one of.the most common viral diseases af.ecting man. Both viral f.ctors as well as the host immune response have been implicated in the pathogenesis and clinical outcome of.HBV inf.ction. In this review, we will discuss the impact of.virus-host interactions f.r the pathogenesis of.HBV inf.ction and liver disease. These interactions include the relevance of.naturally occurring viral variants f.r clinical disease, the role of.virus-induced apoptosis f.r HBV-induced liver cell injury and the impact of.antiviral immune responses f.r outcome of.inf.ction.

关键词： Host response Viral hepatitis Mutants Pathogenesis Resistance

Modelling of.the elastoplastic behaviour of.the bio-cemented soils using an extended Modif.ed Cam Clay model

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Journal of.Rock Mechanics and Geotechnical Engineering 2024年第6期16卷 2184-2197页

作者： Xuerui Wang Christian B.Silbermann thomas Nagel Udo Nackenhorst Institute of.Mechanics and Computational Mechanics Leibniz UniversitätHannoverAppelstr.9aHannover30167Germany Gesellschaf. f.r Anlagen-und Reaktorsicherheit(GRS)gGmbH Theodor-Heuss-Straße 4Braunschweig38122Germany Geotechnical Institute Technische Universität BergakademieFreibergGustav-Zeuner-Str.1Freiberg09599Germany

An elastoplastic constitutive model based on the Modif.ed Cam Clay(MCC)model is developed to describe the mechanical behaviour of.soils cemented via microbially induced calcite precipitation(MICP).It considers the increase of.the elastic stif.ness,the change of.the yield surf.ce due to MICP cementation and the degradation of.calcium carbonate bonds during ***,to capture the typical contraction-dilation transition in MICP soils,the original volumetric hardening rule in the MCC model is modif.ed to a combined deviatoric and volumetric hardening *** model could reproduce a series of.drained triaxial tests on MICP-treated soils with dif.erent calcium carbonate ***,we carry out a parametric study and observe numerical instability in some *** combination with an analytical analysis,our numerical modelling has identif.ed the benef.ts and limitations of.using MCCbased models in the simulation of.MICP-cemented soils,leading to suggestions f.r f.rther model development.

关键词： Microbially induced calcite precipitation(MICP) Elastoplasticity Modif.ed cam clay(MCC) OpenGeoSys Mf.ont Contraction-dilation transition