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MutL homolog 1 methylation and microsatellite instability in sporadic colorectal tumors among Filipinos

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World Journal of Gastrointestinal Oncology 2021年第12期13卷 2101-2113页

作者： Loraine Kay d Cabral Cynthia A Mapua Filipinas F Natividad Caecilia H C Sukowati Edgardo R Cortez Ma Luisa d Enriquez Research and Biotechnology Group St.Luke's Medical CenterQuezon City 1112Philippines Centro Studi Fegato Fondazione Italiana Fegato ONLUSTrieste 34149Italy department of Surgery St.Luke's Medical CenterQuezon City 1112Philippines Center for Natural Science and Environmental Research De La Salle UniversityManila 1004Philippines

BACKGROUNd Colorectal cancer(CRC)ranks third in terms of incidence and second in mortality *** CRC,the silencing of mismatch repair genes,including the mutL homolog 1(hMLH1)has been linked to microsatellite instability(MSI),the lengthening or shortening of microsatellite *** limited data have been presented so far on the link of hMLH1 methylation and MSI in Southeast Asia populations with sporadic CRC,and on its clinical *** To investigate the significance of the MSI status and hMLH1 methylation in CRC Filipino *** Fifty-four sporadic CRC patients with complete clinical data were included in this *** dNA from CRC tumor biopsies and their normal tissue counterparts were profiled for MSI by high resolution melting(HRM)analysis using the Bethesda Panel of Markers(BAT25,BAT26,d2S123,d5S346,and d17S250).hMLH1 methylation screening was performed using bisulfite conversion and methylation specific polymerase chain *** analysis was conducted to calculate their associations to clinicopathological characteristics and survival relevance(Kaplan-Meier curves and the log-rank test).RESULTS hMLH1 methylation was observed in 9%and 35%of CRC and normal samples,*** incidence of consistently methylated hMLH1 found in both normal and CRC was noticed for relation to location of tumor(Pd2S123 the most common unstable microsatellite and MSI-high(MSIH)was the most common MSI profile,counted for 46%and 50%of normal and CRC tissues,*** presence of MSI-low(MSI-L)and microsatellite stable(MSS)was 43%and 11%for normal,and 31%and 19%for CRC *** mean month of patients’survival was shorter in patients whose normal and tumor tissues had methylated compared to those with unmethylated hMLH1 and with MSI-H compared to those with MSI-L/MSS(Pd by significant difference in Kaplan-Meier with log-rank *** data indicated that hMLH1 methylation

关键词： Sporadic colorectal cancer dNA methylation Microsatellite instability Population genetic Colorectal cancer

Cycling of antibiotics for the prophylaxis of recurrent spontaneous bacterial peritonitis in a cirrhotic patient

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World Journal of Gastroenterology 2005年第41期11卷 6407-6408页

作者： N Assy S Schlesinger d Miron O Hussein department of Internal Medicine A Sieff Government Hospital SafedIsraelTechnion InstituteHaifaIsrael

More than 80% of cirrhotic patients who have been treated successfully for spontaneous bacterial peritonitis （SBP） experience a recurrence. Long-term prophylaxis with single daily oral antibiotic has been shown to be cost effective in delaying a recurrence but only for a short time. What has never been tested in this population is the cycling of antibiotics. We report the beneficial use of antibiotic cycling for 36 weeks in a 74-year-old woman with cryptogenic cirrhosis and recurrent SBE

关键词： Aged Anti-Bacterial Agents dosage Bacterial Infections control Female Humans Liver Cirrhosis Peritonitis Recurrence

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氮化硅晶界玻璃相结晶化的研究

硅酸盐学报 1982年第1期 1-8页

作者： d.A.Jefferson,温树林,J.M.thomas 英国剑桥大学物理化学系中国科学院上海硅酸盐研究所英国剑桥大学物理化学系

三种经过不同温度下热处理的热压氮化硅样品（含5wt％Y2O3和2wt％Al2O3添加物）,用X射线衍射、X射线微量分析和高分辨率电子显微镜进行了研究。结果表明在热处理后晶界区产生相变化。晶界玻璃相由于热处理而结晶化。

关键词：晶界玻璃相结晶化氮化硅四氮化三硅氮化物晶格像

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比较法的新旧使命

法律方法

法律方法 2024年第2期 209-223页

作者： [德]海因·克茨成峥(译) 刘浩波(校) 不详德国帕绍大学兰州理工大学法学院

比较法在当下德国的立法、法学教育和司法领域均发挥着重要价值。一方面,辅助立法,为法官续造国内法律制度提供建议,是比较法尚未充分实现的旧使命。另一方面,欧洲共同民法的发展向比较法提出了新使命:构建欧洲共同民法的学术基础。此外... 详细信息

比较法在当下德国的立法、法学教育和司法领域均发挥着重要价值。一方面,辅助立法,为法官续造国内法律制度提供建议,是比较法尚未充分实现的旧使命。另一方面,欧洲共同民法的发展向比较法提出了新使命:构建欧洲共同民法的学术基础。此外,法律全球化或跨国化进程扩展了比较法的研究对象,要求其关注国内法律制度之外的其他规范,并促使比较法的研究方法进行转变:借助经济学分析说明应如何设计法规,以激励其对象采取有效行为,经济节约地利用稀缺资源。比较法的功能方法离不开社会学的事实知识。比较法不应局限于比较法律制度,还应对法律文化进行比较。

关键词：比较法欧洲共同民法法规的经济学分析法社会学法律文化比较

The biological stress of early weaned piglets

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Journal of Animal Science and Biotechnology 2013年第2期4卷 124-127页

作者： Joy M Campbell Joe d Crenshaw Javier Polo APC Inc. 2425 SE Oak Tree CourtAnkenyIA USA

Pigs experience biological stress such as physiological, environmental, and social challenges when weaned from the sow. The process of weaning is one of the most stressful events in the pig＇s life that can contribute to intestinal and immune system dysfunctions that result in reduced pig health, growth, and feed intake, particularly during the first week after weaning. Technological improvements in housing, nutrition, health, and management have been used to minimize some of the adverse effects of weaning stress, but a greater understanding of the biological impact of stress is needed to improve strategies to overcome weaning stress. The focus of this review paper is to briefly describe how the biological stress associated with weaning impacts intestinal morphology, structure, physiology, and intestinal immune responses that can impact subsequent production efficiencies such as growth, intake, morbidity, and mortality.

关键词： Biological stress Intestine Pig Weaning

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时效气体软氮化低碳钢的疲劳特性

热处理技术与装备 1981年第3期 39-43+2页

作者： d.H.thomas T.Bell 严心仪

铁素体的软氮化工艺现在被广泛用来改善低碳钢的摩擦性能和疲劳性能。已有报道,除显著改善耐磨性以外,疲劳强度可增加到140％。气体软氮化是作为代替有毒的盐浴软氮化而发展起来的。典型情况是在570℃处理

关键词：时效材料疲劳周期数疲劳过程气体软氮化盐浴软氮化疲劳特性低碳钢碳素钢

In an interconnected world: joint research priorities for the environment, agriculture and infectious disease

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Infectious diseases of Poverty 2014年第1期3卷 15-17页

作者： Bianca Brijnath Colin d Butler Anthony J McMichael department of General Practice School of Primary Health CareMonash UniversityBuilding 1270 Ferntree Gully RoadNotting HillVictoria 3168Australia Faculty of Health University of CanberraCanberraAustralia National Centre for Epidemiology and Population Health Australian National UniversityCanberraAustralia

In 2008 the UNICEF/UNdP/World Bank/WHO Special Programme for Research and Training in Tropical diseases(TdR)commissioned ten think-tanks to work on disease-specific and thematic reference groups to identify top research priorities that would advance the research agenda on infectious diseases of poverty,thus contributing to improvements in human *** first of the thematic reference group reports-on environment,agriculture and infectious diseases of poverty-was recently *** this article we review,from an insider perspective,the strengths and weaknesses of this thematic reference group report and highlight key messages for policy-makers,funders and researchers.

关键词： Agriculture Environment Infectious disease Research priorities TdR

Remodeling neuroscience education in medical student training:how early exposure and mentorship are promoting student interest in neurology and neurosurgery

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Neural Regeneration Research 2016年第7期11卷 1064-1066页

作者： Andrew d.Tieniber William J.Readdy Rutgers Robert Wood Johnson Medical School New BrunswickNew Jersey NJ USA

Exposure to clinical neurology is an essential aspect of a young clinician＇s training. Neuroscience forms the cornerstone of a wide variety of clinical pathologies and many believe it is currently under represented in medical education. This phenomenon persists as the rapidly aging population places an increasing burden on neuromedical specialists. This demographic change, compounded by the expected 19% shortage in clinical neurologists by 2025, makes it imperative to reexamine specific aspects of neuro- medical education （dall et al., 2013）. These aspects include the timing of pre-clinical neuroscience education, the presence of faculty supported interest groups, the existence of formal mentorship programs, and the availability of neurology and neurosurgical clerkships to 3rd year medical students. Given the increasing importance of neuromedi- cal training, several recent studies have examined the state of neurology training in modern medical education and its impact on medical graduates.

关键词： neuroscience neurosurgery Neuroscience clinician exposure currently burden match publications profession

Thymic carcinoma:review and update

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Journal of Cancer Metastasis and Treatment 2022年第1期8卷 476-487页

作者： Kirill Karlin Phillip d.Michaels department of Pathology Beth Israel Deaconess Medical CenterBostonMA 02115USA

Thymic carcinoma(TC)is a rare thymic epithelial neoplasm with an aggressive clinical *** are many recognized histologic subtypes as described by the fifth edition of the World Health Organization(WHO)Classification of Thoracic Tumors;however,given the rarity of this tumor group,diagnosis remains a challenge,especially on limited tissue ***,rare variants of TC are continuing to be established,particularly in the era of molecular ***,histologic subtypes are described as the rare subtypes of TC in the context of their immunoprofile,cytogenetic or molecular features,clinical presentation,and ensuing challenges.

关键词： Thymic carcinoma NUT carcinoma thymus KIT thymoma