检索结果-南通市图书馆

Genetic association and epistatic interaction of the interleukin-10 signaling pathway in pediatric inflammatory bowel disease

引用

World Journal of Gastroenterology 2017年第27期23卷 4897-4909页

作者： Zhenwu Lin Zhong Wang John P Hegarty Tony R Lin Yunhua Wang Sue deiling Rongling Wu Neal J thomas Joanna Floros CHILd Research Department of Pediatricsthe Pennsylvania State UniversityCollege of Medicine department of Radiology University of Pennsylvania Perelman School of Medicine division of Biostatistics Department of Public Health Sciencethe Pennsylvania State UniversityCollege of Medicine department of Surgery the Pennsylvania State UniversityCollege of Medicine department of Obstetrics and Gynecology the Pennsylvania State UniversityCollege of Medicine

To study the genetic association and epistatic interaction of the interleukin (IL)-10 and IL-10/STAT3 pathways in pediatric inflammatory bowel disease (IBd). METHOdSA total of 159 pediatric inflammatory IBd patients (Crohn’s disease, n = 136; ulcerative colitis, n = 23) and 129 matched controls were studied for genetic association of selected single nucleotide polymorphisms (SNPs) of the IL-10 gene and the genes IL10RA, IL10RB, STAT3, and HO1, from the IL-10/STAT3 signaling pathway. As interactions between SNPs from different loci may significantly affect the associated risk for disease, additive (a) and dominant (d) modeling of SNP interactions was also performed to examine high-order epistasis between combinations of the individual SNPs. RESULTSThe results showed that IL-10 rs304496 was associated with pediatric IBd (P = 0.022), but no association was found for two other IL-10 SNPs, rs1800872 and rs2034498, or for SNPs in genes IL10RA, IL10RB, STAT3, and HO1. However, analysis of epistatic interaction among these genes showed significant interactions: (1) between two IL-10 SNPs rs1800872 and rs3024496 (additive-additive P = 0.00015, Bonferroni P value (Bp) = 0.003); (2) between IL-10RB rs2834167 and HO1 rs2071746 (dominant-additive, P = 0.0018, Bp = 0.039); and (3) among IL-10 rs1800872, IL10RB rs2834167, and HO1 rs2071746 (additive-dominant-additive, P = 0.00015, Bp = 0.005), as well as weak interactions among IL-10 rs1800872, IL-10 rs3024496, and IL-10RA (additive-additive-additive, P = 0.003; Bp = 0.099), and among IL10RA, IL10RB, and HO1 genes (additive-dominant-additive, P = 0.008, Bp = 0.287). CONCLUSIONThese results indicate that both the IL-10 gene itself, and through epistatic interaction with genes within the IL-10/STAT3 signaling pathway, contribute to the risk of pediatric IBd.

关键词： Pediatric inflammatory bowel disease Interleukin-10 HO1 Single nucleotide polymorphism IL10-STAT3 pathway Epistatic interaction

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

On a Shallow Water Model for the Simulation of Turbidity Currents

引用

Communications in Computational Physics 2009年第9期6卷 848-882页

作者： T.Morales de Luna M.J.Castro dıaz C.Pares Madronal E.d.Fernandez Nieto Analisis Matematico Facultad de Ciencias–Univ.MalagaCampus de Teatinoss/n29071-MalagaSpain dpto.Matematica Aplicada I ETS Arquitectura–Univ.SevillaAvda.Reina Mercedes N.241012-SevillaSpain

We present a model for hyperpycnal plumes or turbidity currents that takes into account the interaction between the turbidity current and the bottom,considering deposition and erosion effects as well as solid transport of particles at the bed load due to the *** entrainment from the ambient water in which the turbidity current plunges is also *** of ambient water is neglected and the rigid lid assumption is *** model is obtained as a depth-average system of equations under the shallow water hypothesis describing the balance of fluid mass,sediment mass and mean *** character of the system is analyzed and numerical simulations are carried out using finite volume schemes and path-conservative Roe schemes.

关键词： Turbidity currents hyperbolic systems finite volume methods path-conservative schemes numerical modeling

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Information Fusion for Process Acquisition in the Operating Room

引用

Open Journal of Applied Sciences 2012年第4期2卷 195-198页

作者： thomas Neumuth Christian Meiвner Innovation Center Computer Assisted Surgery(ICCAS)University of Leipzig Leipzig Germany

The recognition of surgical processes in the operating room is an emerging research field in medical engineering. We present the design and implementation of a instrument localization system that is based on information fusion strategies to enhance its recognition power. The system was implemented using RFId technology. It monitored the presence of surgical tools in the interventional site and the instrument tray and combined the measured information by applying redundant, complementary, and cooperative information fusion strategy to achieve a more comprehensive model of the current situation. An evaluation study was performed that showed a correct classification rate of 97% for the system.

关键词： surgical procedure workflow proces modeling operating room computer-assisted surgery information fusion

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

detection of canine echinococcosis by coproantigen ELISA

引用

Asian Pacific Journal of Tropical Medicine 2010年第7期3卷 519-522页

作者： de S Pan d Bera AK Sreevatsava V das SK das S Rana T Bandyopadhyay S Bhattacharya d Indian Veterinary Research Institute Eastern Regional Station37 Belgachia Road.Kolkata-700037India NRC on Yak DirangArunachal PradeshIndia Indian Veterinary Research Institute.Eastern Regional Station.37 Belgachia Road Kolkata-700037India

Objective:To study the canine echinococcosis by coproantigen ELISA ***:during the present investigation experimental infection was established using evaginated worms of Echinococcus granulosus(***).To check cross reactivity two pups were infected with Taenia hydatigena(***).In order to detect the presence of antigen,hyperimmune sera were raised against excretory-secretory products of adult worms *** granulosus. Faecal sample collected either from experimentally infected pups or from other sources were heated at 70℃to detect heat stable soluble ***:Pups harbouring less than 104 worms showed negative *** collected from 14 days onwards from experimentally infected animals harbouring more than 104 worms showed positive *** maximum positive samples were detected in samples collected from in and around slaughter house and the least number of samples were detected positive maintained by dog ***:The affinity purified IgG exhibited promising results for detection of canine echinococcosis by indirect ELISA.

关键词： Echinococcus granulosus Coproantigen ELISA Canine

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

GALT Protein database, a Bioinformatics Resource for the Management and Analysis of Structural Features of a Galactosemia-related Protein and Its Mutants

引用

Genomics, Proteomics & Bioinformatics 2009年第1期7卷 71-76页

作者： Antonio d’Acierno Angelo Facchiano Anna Marabotti Laboratory of Bioinformatics and Computational Biology Institute of Food Science Italian National Research Council (CNR)

We describe the GALT-Prot database and its related web-based application that have been developed to collect information about the structural and functional effects of mutations on the human enzyme galactose-l-phosphate uridyltransferase （GALT） involved in the genetic disease named galactosemia type I. Besides a list of missense mutations at gene and protein sequence levels, GALT-Prot reports the analysis results of mutant GALT structures. In addition to the structural information about the wild-type enzyme, the database also includes structures of over 100 single point mutants simulated by means of a computational procedure, and the analysis to each mutant was made with several bioinformatics programs in order to investigate the effect of the mutations. The web-based interface allows querying of the database, and several links are also provided in order to guarantee a high integration with other resources already present on the web. Moreover, the architecture of the database and the web application is flexible and can be easily adapted to store data related to other proteins with point mutations. GALT-Prot is freely available at http：//***/GALT/.

关键词： database mutation homology modeling galactosemia GALT enzyme

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Simulation of Spherulite Growth Using a Comprehensive Approach to Modeling the First-Order Isotropic/Smectic-A Mesophase Transition

引用

Communications in Computational Physics 2010年第2期7卷 301-316页

作者： Nasser Mohieddin Abukhdeir Alejandro d.Rey department of Chemical Engineering McGill UniversityMontrealQuebec H3A 2B2Canada

A comprehensive modeling and simulation study of the first-orderisotropic/smectic-A transition is presented and applied to phase diagram computationand two-dimensional spherulite growth. An approach based on nonlinear optimiza-tion, that incorporates experimental data (from 12CB, dodecyl-cyanobiphenyl), is usedto determine physically realistic model parameters. These parameters are then used inconjunction with an optimized phase diagram computation method. Additionally, atime-dependent formulation is presented and applied to the study of two-dimensionalsmectic-A spherulite growth. These results show the growth kinetics and defect dy-namics of nanoscale smectic-A spherulite growth in an isotropic phase with an initiallyradial layer configuration.

关键词： Liquid crystals simulation phase transitions

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Background story of the cover picture

引用

Hepatobiliary Surgery and Nutrition 2021年第2期10卷 153-153页

作者： thomas van Gulik department of Surgery Amsterdam University Medical CentersUniversity of AmsterdamAmsterdamThe Netherlands

The cover image shows the anatomy lesson of *** Ruysch(1638-1731),one of the pioneers in disclosing the anatomy of the lymphatic *** painting was made by Adriaen Backer in 1670 in Amsterdam,depicting Ruysch(third from the left)during an anatomical demonstration of the inguinal lymph *** was the first to show these nodes and also the valves in the lymphatic *** is surrounded by surgeon-governors of the Amsterdam Surgical Guild,who had commissioned the artist to make this painting of themselves as a group portrait,while attending the anatomy *** corpse was of a criminal who was sentenced to death and after the execution,was handed over to the surgeons for this anatomy *** Ruysch was a famous dutch,17th century physician and anatomist who was appointed by the city council to teach anatomy to the members of the Surgical *** was internationally renowned for his great anatomical skills and his innovative techniques to preserve anatomical *** his work on visualization of the lymphatic system,he contributed to the early history of‘lymphatic anatomy’.

关键词： anatomy lesson Amsterdam

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

工作流程解决方案的比较

引用

印刷技术 2001年第28期 29-30页

作者： thomas Wanka 郝继皋

在所有印前解决方案中,无论是CTF(计算机到胶片)、CTP(计算机到印版),还是CTPrint(计算机到印刷),数字式数据交换都是它们的共性.胶片作为数据交换形式的全盛时期已经过去,如何处理"数字式数据"就成为工作过程中的一个核心问题.

关键词：印刷印前解决方案 PostScript工作流程专用工作流程位图工作流程

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

ZnO nanorefrigerant in R152a refrigeration system for energy conservation and green environment

引用

Frontiers of Mechanical Engineering 2014年第1期9卷 75-80页

作者： d. SENdIL KUMAR R. ELANSEZHIAN department of Mechanical Engineering Pondicherry EngineeringCollege Puducherry 605014 India

In this paper the reliability and performance of a vapour compression refrigeration system with ZnO nanoparticles in the working fluid was investigated experimentally. Nanorefrigerant was synthesized on the basis of the concept of the nanofluids, which was prepared by mixing ZnO nanoparticles with R152a refrigerant. The conventional refrigerant R134a has a global warming potential （GWP） of 1300 whereas R152a has a significant reduced value of GWP of 140 only. An experimental test rig is designed and fabricated indigenously in the laboratory to carry out the investigations. ZnO nanopar- ticles with refrigerant mixture were used in HFC R152a refrigeration system. The system performance with nanoparticles was then investigated. The concentration of nano ZnO ranges in the order of 0.1% v, 0.3% v and 0.5%v with particle size of 50nm and 150g of R152a was charged and tests were conducted. The compressor suction pressure, discharge pressure and evaporator temperature were measured. The results indicated that ZnO nanore- frigerant works normally and safely in the system. The ZnO nanoparticle concentration is an important factor considered for heat transfer enhancement in the refrigera- tion system. The performance of the system was significantly improved with 21% less energy consumption when 0.5%v ZnO-R152a refrigerant. Both the suction pressure and discharge pressure were lowered by 10.5% when nanorefrigerant was used. The evaporator tempera- ture was reduced by 6% with the use of nanorefrigerant. Hence ZnO nanoparticles could be used in refrigeration system to considerably reduce energy consumption. The usage of R 152a with zero ozone depleting potential （OdP） and very less GWP and thus provides a green and clean environment. The complete experimental results and their analysis are reported in the main paper.

关键词： ZnO nanorefrigerant reduced GWP COP,pressure ratio green energy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cigarette Smoking,Psychopathology,Cognitive Function and Medication Side Effects in Chinese Male Schizophrenia:A Case-control Study

Cigarette Smoking,Psychopathology,Cognitive Function and Med...

引用

自主创新与持续增长第十一届中国科协年会

作者： thomas R KOSTEN The Menninger department of Psychiatry and Behavioral Sciences Baylor College of Medicine

Objective: Cigarette smoking rates are 3-4 times higher among American and European schizophrenics than community controls, and are associated with reduced negative and extrapyramidal symptoms and improved cognitive functioning. The aims of the present study were to examine these clinical associations in Chinese schizophrenics. Methods: We compared 776 male schizophrenics to 560 male community controls on the Fagerstrom Test for Nicotine dependence (FTNd) and on the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS). Patients also were administered the Positive and Negative Symptom Scale (PANSS), the Simpson and Angus Extrapyramidal Symptom Rating Scale (SAES), and the Abnormal Involuntary Movement Scale (AIMS). Results: Lifetime smoking was higher for the schizophrenics than community controls(79% vs 63%), and heavy smoking showed a greater difference from controls (61% vs 31%). The PANSS negative symptom and SAES Parkinsonism scores were lower in current smokers than non-smokers. Cognitive functioning on the RBANS was worst for smoking schizophrenics, then better for non-smoking schizophrenics, then smoking controls, and then non- smoking controls, who scored best. Conclusions: Smoking rates in China are modestly higher among schizophrenics than community controls, but nicotine dependence rates show the large differences between schizophrenics and controls that are found in America. Smoking is associated with lower negative symptoms and less parkinsonism, suggesting self-medication. However, smoking in both schizophrenics and controls was associated with significant cognitive impairments.

关键词： schizophrenia smoking psychopathology cognition side effects nicotine

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：