检索结果-南通市图书馆

Tuning beneficial calcineurin phosphatase activation to counterα-synuclein toxicity in a yeast model of Parkinson’s disease

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第1期20卷 199-200页

作者： Srishti Chawla mikael molin thomas Nystrom Institute for Biomedicine Sahlgrenska AcademyCentre for Ageing and Health-AgeCapUniversity of GothenburgGothenburgSweden Department of Life Sciences Chalmers University of TechnologyGothenburgSweden

Calcineurin(CN)is a calcium-and calmodulindependent serine/threonine that has been studied in many model organisms including yeast,filamentous fungi,plants,and *** biological functions range from ion homeostasis and virulence in lower eukaryotes to T-cell activation in humans by human nuclear factors of activated *** is a heterodimeric protein consisting of a catalytic subunit,calcineurin A(Cna1p),which contains an active site with a dinuclear metal center,and a regulatory Ca^(2+) binding subunit called calcineurin B(Cnb1p)required to activate *** calcineurin B subunit has been highly conserved through evolution:For example,the mammalian calcineurin B shows 54%identity with calcineurin B from Saccharomyces cerevisiae.

关键词： activation dinuclear conserved

microglia:a promising therapeutic target in spinal cord injury

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第2期20卷 454-463页

作者： Xiaowei Zha Guoli Zheng thomas Skutella Karl Kiening Andreas Unterberg Alexander Younsi Department of Neurosurgery Heidelberg University HospitalHeidelbergGermany Department of Neuroanatomy Institute for Anatomy and Cell BiologyHeidelberg UniversityHeidelbergGermany

microglia are present throughout the central nervous system and are vital in neural repair,nutrition,phagocytosis,immunological regulation,and maintaining neuronal *** a healthy spinal cord,microglia are accountable for immune surveillance,however,when a spinal cord injury occurs,the microenvironment drastically changes,leading to glial scars and failed axonal *** this context,microglia vary their gene and protein expression during activation,and proliferation in reaction to the injury,influencing injury responses both favorably and unfavorably.A dynamic and multifaceted injury response is mediated by microglia,which interact directly with neurons,astrocytes,oligodendrocytes,and neural stem/progenitor *** a clear understanding of their essential nature and origin,the mechanisms of action and new functions of microglia in spinal cord injury require extensive *** review summarizes current studies on microglial genesis,physiological function,and pathological state,highlights their crucial roles in spinal cord injury,and proposes microglia as a therapeutic target.

关键词： astrocytes cytokines functional recovery immune regulation m1/m2 activation macrophages microglia neuroinflammation spinal cord injury therapy

在线全文

学校读者我要写书评

暂无评论

受控的空气污染物暴露与心律失常风险

环境与职业医学 2014年第10期31卷 787-787页

作者： Jeremy P.Langrish Simon J.Watts Amanda J.Hunter Anoop S.V.Shah Jenny A.Bosson Jon Unosson Stefan Barath magnus Lundbck Flemming R.Cassee Ken Donaldson thomas sandstrm Anders Blomberg David E.Newby Nicholas L.mills

[背景]流行病学研究报道了空气污染暴露与心血管疾病发病率和死亡率增加之间的关联。空气污染物暴露可以影响心脏自主神经节律并降低心率变异性,可能增加心律失常的风险,特别是在敏感的患者群体中。[目的]研究在可控制的空气污染物暴露... 详细信息

[背景]流行病学研究报道了空气污染暴露与心血管疾病发病率和死亡率增加之间的关联。空气污染物暴露可以影响心脏自主神经节律并降低心率变异性,可能增加心律失常的风险,特别是在敏感的患者群体中。[目的]研究在可控制的空气污染物暴露期间和之后,统计分析了健康志愿者和冠状动脉心脏疾病患者的心律失常发生率。[方法]分析数据来自13个随机双盲交叉研究,包括282名参加者(140名健康志愿者和142例稳定性冠状动脉心脏疾病患者)的连续心电图记录。记录研究人群每次暴露时发生心律失常的情况。[结果]在稀释的柴油车尾气、木材烟雾、臭氧、浓缩的环境颗粒物、工程碳纳米颗粒或空气污染高环境水平的暴露期间或者之后,无论在健康志愿者或冠状动脉心脏疾病患者中,任何形式心律失常的发生均没有增加。[结论]急性、可控制的空气污染物暴露不增加受试者发生心律失常的短期风险。研究中所采用的这些技术,对于确定涉及空气污染不利影响的重要病理生理途径依然至关重要,并且在为环境和公共卫生政策决策提供信息中也起着重要的作用。

关键词：空气污染物心律失常短期风险健康志愿者患者群体摘要心脏自主神经心脏疾病

The embryology of persistent cloaca and urogenital sinus malformations

在线全文

学校读者我要写书评

暂无评论

Asian Journal of Andrology 2020年第2期22卷 124-128页

作者： David F m thomas University of Leeds LeedsWest Yorkshire LS29JTUK

Cloacal malformations are characterized by the confluence of the lower urinary tract,the female reproductive tract,and the rectum to create a common channel with a single opening on the *** presence of a cloaca is a normal phase of early human embryological *** the 4^th and 7^th weeks of gestation,the cloaca undergoes subdivision to form the hindgut and urogenital *** of this process results in the congenital anomaly termed persistent cloaca(PC).The term urorectal septum malformation sequence(URSmS)is also used to describe this *** classic description of this process which is still cited in many standard textbooks dates from the 19th ***,this has been increasingly called into question by the findings of studies using modern scientific *** sinus anomalies are defined by the confluence of the urethra and vagina to form a common channel of varying length with a single perineal *** this condition,the anorectal canal opens separately on the *** presence of a urogenital sinus represents a transient phase of the normal development of the lower genital tract in the female ***,the form of urogenital sinus most commonly encountered in the developed world is a feature of disordered sexual differentiation and does not arise simply from the persistence of the anatomical structure which is a feature of normal fetal development.

关键词： cloaca embryology urogenital sinus

Theory and practice of runoff space-time distribution

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China(Technological Sciences) 2004年第Z1期47卷 90-105页

作者： thomas m. Over Department of Geology/Geography Eastern Illinois University Charleston IL 61920 USA

Based on the domestic and foreign concerning researches, this paper submits the runoff space-time distribution theory which shows evident scientific significances and powerful practical functions. On the basis of digital basin unit cell deriving from the digital elevation model (DEm) and assumption of linear confluence, this theory has been applied successfully to the runoff correlation researches in humid regions. In order to prove the adaptability of the theory in arid and semi-drought regions, this paper is used to the runoff correlation analysis in Wuding River basin——a tributary of Yellow River Basin, and has gained preliminary effective verification.

关键词： runoff space-time distribution, theory, the Wuding River, correlation coefficient, practice.

machine learning in solid organ transplantation:Charting the evolving landscape

在线全文

学校读者我要写书评

暂无评论

World Journal of Transplantation 2025年第1期15卷 165-177页

作者： Badi Rawashdeh Haneen Al-abdallat Emre Arpali Beje thomas Ty B Dunn matthew Cooper Division of Transplant Surgery Medical College of WisconsinMilwaukeeWI 53202United States Department of medicine Jordan University HospitalAmman 11263Jordan Department of Nephrology Medical College of WisconsinMilwaukeeWI 53226United States

BACKGROUND machine learning(mL),a major branch of artificial intelligence,has not only demonstrated the potential to significantly improve numerous sectors of healthcare but has also made significant contributions to the field of solid organ *** provides revolutionary opportunities in areas such as donorrecipient matching,post-transplant monitoring,and patient care by automatically analyzing large amounts of data,identifying patterns,and forecasting *** To conduct a comprehensive bibliometric analysis of publications on the use of mL in transplantation to understand current research trends and their *** On July 18,a thorough search strategy was used with the Web of Science *** and transplantation-related keywords were *** the aid of the VOS viewer application,the identified articles were subjected to bibliometric variable analysis in order to determine publication counts,citation counts,contributing countries,and institutions,among other *** Of the 529 articles that were first identified,427 were deemed relevant for bibliometric analysis.A surge in publications was observed over the last four years,especially after 2018,signifying growing interest in this *** 209 publications,the United States emerged as the top ***,the"Journal of Heart and Lung Transplantation"and the"American Journal of Transplantation"emerged as the leading journals,publishing the highest number of relevant *** keyword searches revealed that patient survival,mortality,outcomes,allocation,and risk assessment were significant themes of *** The growing body of pertinent publications highlights mL's growing presence in the field of solid organ *** bibliometric analysis highlights the growing importance of mL in transplant research and highlights its exciting potential to change medical practices and enhance patient *** collaboration between signific

关键词： machine learning Artificial Intelligence Solid organ transplantation Bibliometric analysis

Applied biodiversity science in China in the global context

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

National Science Review 2021年第7期8卷 62-65页

作者： thomas m.Brooks Xinsheng Zhang International Union for Conservation of Nature

In 2021, the city of Kunming in Yunnan Province, China,will host the fifteenth meeting of Conference of Parties of the Convention on Biological Diversity. The meeting is expected to be the pivotal moment at which the world’s governments agree on a new ‘Post-2020 Global Biodiversity Framework’(https://***/conferences/post2020). The framework is anticipated to be structured around a small number of outcome goals for 2050—a compelling case has been made that these should include explicit goals for ecosystems, species,genetic diversity and the contributions which nature makes to people [1].

关键词：

Real world studies are essential for drug therapy in Parkinson's disease

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2018年第9期13卷 1544-1545页

作者： thomas müller Department of Neurology St.Joseph Hospital Berlin-Wei?ensee

Prospective real-world data from large patient samples, which re- port on the long-term effectiveness of the employed different drug therapies, are rare in Parkinson＇s disease （PD）. The non interven- tional ＂Transdermal Rotigotine User Surveillance Study＂（TRUST） trial represents such a real-world study. It investigated long-term treatment with different dopamine substituting treatment regimens in 2195 PD patients （mfiller et al., 2018）. Participation in TRUST meant that the treating neurologists were only asked to document and modify the dopaminergic drug regimen without any prior PD patient selection criteria. Thus this unique trial design reflects the real world of patient maintenance.

关键词： RCT Real world studies are essential for drug therapy in Parkinson’s disease PDQ

Do we need a new levodopa?

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2016年第5期11卷 731-732页

作者： thomas müller Department of Neurology St.Joseph Hospital Berlin-Wei?ensee

Idiopathic Parkinson＇s disease（PD）is classified as a chronic progressive neurodegenerative *** each other complementing,still hypothetical aetiologies describe the predominant dopaminergic neuronal *** include gene... 详细信息

关键词： RGma COmT Do we need a new levodopa PLP GSH