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Dual-ratiometric magnetic resonance tunable nanoprobe with acidic-microenvironment-responsive property to enhance the visualization of early tumor pathological changes

引用

Nano Research 2023年第7期16卷 10034-10046页

作者： Rong Cao Ning Tang Yi Zhu An Chen Yumeng Li Renbin Ge Yuan Li Zhongyi Huang Jiajing Guo Jiali Deng Hongwei Lu Ziwei Lu Helen Forgham thomas pdavis Ruirui Qiao Zhongling Wang Department of Radiology Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai 200080China School of food science Nanjing Xiaozhuang UniversityNanjing 211171China School of Health Science and Engineering University of Shanghai for Science and TechnologyShanghai 200093China Department of Neurology School of MedicineNew York UniversityNew York 10016USA Department of Biomedical Engineering College of EngineeringShantou UniversityShantou 515063China Department of Radiology The First Affiliated Hospital of Soochow UniversitySuzhou 215006China Australian Institute for Bioengineering and Nanotechnology The University of QueenslandBrisbane QLD 4072Australia

The development of microenvironment-responsive nanoprobes has shown great promise for use in magnetic resonance imaging(MRI),with the advantage of significantly improved specificity and good ***,the clinical application of responsive probes is hampered by a lack of biological sensitivity for early molecular diagnostics and visualizing microenvionment of metabolism reprogramming in tumor ***,we report on a dual-ratiometric magnetic resonance tunable(DMRT)nanoprobe designed by crosslinking different ratios of transferrin chelating gadolinium and superparamagnetic nanoparticles,complexed to a pH responsive biocompatible *** dually activatable nanoprobe enables pH-dependent tumor microenvironment visualization,providing exceptional quantitative pathophysiological information in vitro and in *** used in combination with dual-contrast enhancement triple subtraction imaging technique(DETSI),this smart nanoprobe guarantees the diagnosis of early-stage *** envisage that this novel integrated nanoplatform will provide a new paradigm for the clinical translation of robust DMRT nanoprobes for early disease detection and staging,as well as microenvironment visualization and disease progression monitoring.

关键词： ratiometric nanoprobe dually activatable microenvironment visualization early diagnosis pathological changes

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