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Helicobacter pylori:High dose amoxicillin does not improve primary or secondary eradication rates in an Irish cohort

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World Journal of Clinical Cases 2024年第16期12卷 2773-2779页

作者： Conor Costigan Aoife m O'Sullivan Jim O'Connell Shreyashee Sengupta thomas Butler Stephen molloy Fintan John O'Hara Barbara Ryan Niall Breslin Sarah O'Donnell Anthony O'Connor Sinead Smith Deirdre mcNamara Trinity Academic Gastroenterology Group School of Medicine-Trinity College DublinDublin D2Ireland Department of Gastroenterology Tallaght University HospitalDublin D24 NR0AIreland

BACKGROUND Helicobacter pylori(***)eradication rates have fallen globally,likely in large part due to increasing antibiotic resistance to traditional *** areas of high clarithromycin and metronidazole resistance such as ours,maastricht VI guidelines suggest high dose amoxicillin dual therapy(HDADT)can be considered,subject to evidence for local *** this study we assess efficacy of HDADT therapy for *** eradication in an Irish *** To assess the efficacy of HDADT therapy for *** eradication in an Irish cohort as both first line,and subsequent therapy for patients diagnosed with *** All patients testing positive for *** in a tertiary centre were treated prospectively with HDADT(amoxicillin 1 g tid and esomeprazole 40 mg bid×14 d)over a period of 8 *** was confirmed with Urea Breath Test at least 4 wk after cessation of therapy.A delta-over-baseline>4%was considered *** demographics and treatment outcomes were recorded,analysed and controlled for basic demographics and prior *** *** One hundred and ninety-eight patients were identified with *** infection,10 patients were excluded due to penicillin allergy and 38 patients refused follow up *** all 139 were included in the analysis,55%(n=76)were female,mean age was 46.6 ***,93(67%)of patients were treatment-naïve and 46(33%)had received at least one previous course of *** groups were statistically ***-reported compliance with HDADT was 97%,mild side-effects occurred in 7%.There were no serious adverse drug *** the eradication rate for our cohort was 56%(78/139).Eradication rates were worse for those with previous treatment[43%(20/46)vs 62%(58/93),P=0.0458,odds ratio=2.15].Age and Gender had no effect on eradication *** Overall eradication rates with HDADT were *** being a simple and possibly better tolerated regime,these results do not

关键词： Helicobacter pylori eradication Helicobacter pylori High dose amoxicillin High dose amoxicillin dual therapy Triple therapy

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褶皱-冲断层带中盐的作用

地震地质译丛

地震地质译丛 1987年第1期 27-33页

作者： Dan m.davis Terry Engelder 远声

自从对大观模的水平仰冲断层识别以来,仰冲作用的力学一直是一争论的主题。构造地质学上通常能碰到的棘手问题来自这一事实:下伏板块中的岩石太软因而不可能运动时其内部不产生破裂。考虑冲断作用时存在的超孔隙流体压力的作用则能部分... 详细信息

自从对大观模的水平仰冲断层识别以来,仰冲作用的力学一直是一争论的主题。构造地质学上通常能碰到的棘手问题来自这一事实:下伏板块中的岩石太软因而不可能运动时其内部不产生破裂。考虑冲断作用时存在的超孔隙流体压力的作用则能部分解答这种"充满矛盾

关键词：褶皱带地槽带构造带冲断层盐层

Nanoscale inhibition of polymorphic and ambidextrous lAPP amyloid aggregation with small molecules

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Nano Research 2018年第7期11卷 3636-3647页

作者： Aleksandr Kakinen Jozef Adamcik Bo Wang Xinwei Ge Raffaele mezzenga thomas P. davis Feng Ding Pu Chun Ke ARC Centre of Excellence in Convergent Bio-Nano Science and Technology Monash Institute of Pharmaceutical Sciences Monash University 381 Royal Parade Parkville VIC 3052 Australia Food & Soft materials Department of Health Sciences & Technology ETH Zurich Schmelzbergstrasse 9 LFO E23 8092 Zurich Switzerland Department of Physics andAstronomy Clemson University Clemson SC29634 USA Department of Chemistry Warwick University Gibbet Hill Coventry CV4 7AL UK

Understanding how small molecules interface with amyloid fibrils at the nanoscale is of importance for developing therapeutic treatments against amyloid-based diseases. Here, we show for the first time that human islet amyloid polypeptides （LAPP） in the fibrillar form are polymorphic, ambidextrous, and possess multiple periodicities. Upon interfacing with the small molecule epigallocatechin gallate （EGCG）, IAPP aggregation was rendered off-pathway and assumed a form with soft and disordered clusters, while mature IAPP fibrils displayed kinks and branching but conserved the twisted fibril morphology. These nanoscale phenomena resulted from competitive interactions between EGCG and the IAPP amyloidogenic region, as well as end capping of the fibrils by the small molecule. This information is crucial in delineating IAPP toxicity implicated in type 2 diabetes and for developing new inhibitors against amyloidogenesis.

关键词： islet amyloid polypeptides(LAPP) fibriUization persistence length small molecule discrete moleculardynamics (DmD)simulations inhibition

Applied biodiversity science in China in the global context

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National Science Review 2021年第7期8卷 62-65页

作者： thomas m.Brooks Xinsheng Zhang International Union for Conservation of Nature

In 2021, the city of Kunming in Yunnan Province, China,will host the fifteenth meeting of Conference of Parties of the Convention on Biological Diversity. The meeting is expected to be the pivotal moment at which the world’s governments agree on a new ‘Post-2020 Global Biodiversity Framework’(https://***/conferences/post2020). The framework is anticipated to be structured around a small number of outcome goals for 2050—a compelling case has been made that these should include explicit goals for ecosystems, species,genetic diversity and the contributions which nature makes to people [1].

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中国湖北钉螺(腹足纲:圆口螺科)分类现状

海洋科学集刊 1997年第2期 89-95页

作者： George m.davis 张仪郭源华 Christina Spolsky 美国费城自然科学院中国预防医学科学院寄生蟲病研究所

本文对采自中国境内不同水域、不问螺壳类型的14个螺群的同工酶数据进行了遗传分化研究,探讨中国湖北钉螺的分类现状。结果表明,中国钉螺存在重要的遗传分化及与避传分化相关的可分辨的类型。对此进行研究后还发现了县城交叉传播和亚种... 详细信息

本文对采自中国境内不同水域、不问螺壳类型的14个螺群的同工酶数据进行了遗传分化研究,探讨中国湖北钉螺的分类现状。结果表明,中国钉螺存在重要的遗传分化及与避传分化相关的可分辨的类型。对此进行研究后还发现了县城交叉传播和亚种间可能存在3个例外杂合螺群的依据;此外。螺群遗传分化类型与地理分布、螺壳刻纹和形态特征相一致。以此为基础,湖北钉螺(Oncomelania hupensis)再分成3个独立的亚种:滇川亚种(***)、福建亚种(***)和湖北亚种(***)。

关键词：湖北钉螺分类遗传分化

中国大陆钉螺分子遗传学研究Ⅰ多位点酶电泳初步分析

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中国大陆钉螺分子遗传学研究Ⅰ多位点酶电泳初步分析

Real world studies are essential for drug therapy in Parkinson's disease

中国动物学会、中国海洋湖沼学会贝类学分会第四次代表大会暨第五次学术讨论会

作者：张仪冯婷 George m.davis 中国预防医学科学院寄生虫病研究所中国预防医学科学院寄生虫病研究所美国费城自然科学院

本文对中国大陆安徽、云南、四川、江苏、浙江五省6地的代表性钉螺螺群进行多态位点酶的初步分析,检测了24种同工酶的38个基因位点。结果显示 AAT、AK、APH、CK、EST、 GPI、GDH、G6PD、HBD、LAP、mPI、NADD、OCT、6PGD、PGm、SDH 16个... 详细信息

本文对中国大陆安徽、云南、四川、江苏、浙江五省6地的代表性钉螺螺群进行多态位点酶的初步分析,检测了24种同工酶的38个基因位点。结果显示 AAT、AK、APH、CK、EST、 GPI、GDH、G6PD、HBD、LAP、mPI、NADD、OCT、6PGD、PGm、SDH 16个酶为多态位点酶。多态位点酶的比例为67％,初步说明在中国大陆境内钉螺螺群存在遗传多态现象。同时发现 PGm 酶是中国大陆钉螺及日本血吸虫共有的多态位点酶。

关键词：钉螺多态位点遗传多态

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Neural Regeneration Research 2018年第9期13卷 1544-1545页

作者： thomas müller Department of Neurology St.Joseph Hospital Berlin-Wei?ensee

Prospective real-world data from large patient samples, which re- port on the long-term effectiveness of the employed different drug therapies, are rare in Parkinson＇s disease （PD）. The non interven- tional ＂Transdermal Rotigotine User Surveillance Study＂（TRUST） trial represents such a real-world study. It investigated long-term treatment with different dopamine substituting treatment regimens in 2195 PD patients （mfiller et al., 2018）. Participation in TRUST meant that the treating neurologists were only asked to document and modify the dopaminergic drug regimen without any prior PD patient selection criteria. Thus this unique trial design reflects the real world of patient maintenance.

关键词： RCT Real world studies are essential for drug therapy in Parkinson’s disease PDQ

Do we need a new levodopa?

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Neural Regeneration Research 2016年第5期11卷 731-732页

作者： thomas müller Department of Neurology St.Joseph Hospital Berlin-Wei?ensee

Idiopathic Parkinson＇s disease（PD）is classified as a chronic progressive neurodegenerative *** each other complementing,still hypothetical aetiologies describe the predominant dopaminergic neuronal *** include gene... 详细信息

关键词： RGma COmT Do we need a new levodopa PLP GSH

EFFICIENT SIXTH ORDER P-STABLE mETHODS WITH mINImAL LOCAL TRUNCATION ERROR FOR y"=f(x,y)

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Journal of Computational mathematics 2002年第2期20卷 175-184页

作者： Kai-li Xiang R.m.thomas Department of Computer Science Southwest Petroleum InstituteNanchong 637001China Department of mathematics UMISTManchesterM60 1 QDUK

A family of symmetric (hybrid) two step sixth P-stable methods for the accurate numerical integration of second order periodic initial value problems have been considered in this paper. These methods, which require only three (new) function evaluation per iteration and per step integration. These methods have minimal local truncation error (LTE) and smaller phase-lag of sixth order than some sixth orders P-stable methods in [1-3,10-11]. The theoretical and numerical results show that these methods in this paper are more accurate and efficient than some methods proposed in [1-3,10].

关键词： second order periodic initial value problems P-stable phase-lag local truncation error