检索结果-南通市图书馆

Comparison of the demographic characteristics of pediatric and adult colorectal cancer patients: a national inpatient sample based analysis

引用

World Journal of Pediatrics 2019年第1期15卷 37-41页

作者： thomas m.attard Caitlin E.Lawson University of missouri Kansas City Kansas CityMOUSA Pediatric Gastroenterology Children's Mercy Hospital2401Gillham RdKansas CityMO 64108USA Division of Genetics Children's Mercy HospitalKansas CityMOUSA

Background Colorectal cancer in children is rare,but characterized by late presentation,unfavorable histology and poor *** factors for colorectal cancer in children overlap with those for adults with greater influence of hereditary *** epidemiology of colon cancer in children is poorly understood;the aim of this study was to characterize and compare the demographics and relevant clinical characteristics of pediatric and adult colon cancer,using a national inpatient *** The AHRQ online resource HCUPnet/KID database was queried for children,under the age of 18 admitted with ICD 9 Cm diagnoses relating to colorectal cancer,at the time of *** comparison,the corresponding diagnoses in adult patients were queried for each successive *** demographics including residential type and median income by zip-code,tumor localization;if recorded,and mean hospital charges were all accrued and *** Inpatient admissions for pediatric colorectal cancer were more likely male (54%),in the 15-17 years age bracket (57%).They were significantly more likely from Southwestern regions of the Unites States,and were significantly more likely from residential zip-codes identified as at or below the lowest income quartile than adult CRC patients or pediatric patients as a *** charges have more than quadrupled over the time period studied (1997-2012).Conclusions Pediatric colorectal cancer is the most common primary gastrointestinal malignancy in *** understanding associated risk factors including those associated with gender,geographic region and social economic status may contribute to future prevention or early detection strategies.

关键词： Colorectal cancer Colorectal neoplasms Demography International classification of diseases Pediatric risk factors

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Sleep as a window to understand and regulate Alzheimer's disease:emerging roles of thalamic reticular nucleus

引用

Neural Regeneration Research 2025年第6期20卷 1711-1712页

作者： Haoqi Sun Shiqian Shen Robert J.thomas m.Brandon Westover Can Zhang Department of Neurology Beth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA Center for Translational Pain Research Department of AnesthesiaCritical Care and Pain MedicineMassachusetis General HospitalHarvard Medical SchoolBostonMAUSA Division of Pulmonary Critical Care and Sleep MedicineDepartment of MedicineBeth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA Genetics and Aging Research Unit McCance Center for Brain HealthMass General Institute for Neurodegenerative DiseaseDepartment of NeurologyMassachusetts General HospitalHarvard Medical SchoolBostonMAUSA

Introduction:Alzheimer 's disease(AD) is a common neurodegenerative disorder and the primary cause of dementia. Considerable evidence supports the “amyloid hypothesis,” stating that the pathogenesis of AD is primarily caused by the deposition of amyloid-β(Aβ), which drives tau phosphorylation, neuroinflammation, and neurodegeneration in the brain. The amyloid hypothesis is strengthened by the significant and moderate benefit of lecanemab, a humanized antibody through an anti-amyloid mechanism,showing slowed clinical decline(van Dyck et al.,2023). The recent positive results of anti-amyloid trials have brought back focus on the amyloid hypothesis through biochemical, genetic, and pharmacological approaches(Zhang, 2023).

关键词： Alzheimer inflammation hypothesis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Synergistic effect of nitrocellulose coating on structural and reactivity stabilization of ammonium nitrate oxidizer

引用

Defence Technology(防务技术) 2025年第1期43卷 35-43页

作者： Amir Abdelaziz Djalal Trache Ahmed Fouzi Tarchoun Hani Boukeciat Yash Pal Sourbh Thakur Weiqiang Pang thomas m.Klapötke Energetic materials Laboratory(EmLab) Teaching and Research Unit of Energetic ProcessesEcole Militaire PolytechniqueBP 17 Bordj El-BahriAlgiers 16046Algeria School of Aeronautical Science Hindustan Institute of Technology and ScienceChennai 603103India Department of Organic Chemistry Bioorganic Chemistry and BiotechnologySilesian University of TechnologyB.Krzywoustego 4Gliwice 44–100Poland Xi'an modern Chemistry Research Institute 168 Zhangba Rd.EastXi'an 710065China Energetic materials Research Department of ChemistryLudwig-Maximilian UniversityMunich Butenandtstrasse 5-13(D)Munich D-81377Germany

The present work aims to stabilize the room temperature allotropic transition of ammonium nitrate(AN)particles utilizing a microencapsulation technique,which involves solvent/non-solvent in which nitrocellulose(NC)has been employed as a coating *** SEm micrographs revealed distinct features of both pure AN and NC,contrasting with the irregular granular surface topography of the coated AN particles,demonstrating the adherence of NC on the AN *** analysis via infrared spectroscopy(IR)demonstrated a successful association of AN and NC,with slight shifts observed in IR bands indicating interfacial *** X-ray Diffraction(PXRD)analysis further elucidated the structural changes induced by the coating process,revealing that the NC coating altered the crystallization pattern of its pure *** analysis demonstrates distinct profiles for pure and coated AN,for which the coated sample exhibits a temperature increase and an enthalpy decrease of the room temperature allotropic transition by 6℃,and 36%,***,the presence of NC coating alters the intermolecular forces within the composite system,leading to a reduction in melting enthalpy of coated AN by~39%compared to pure *** thermal decomposition analysis shows a two-step thermolysis process for coated AN,with a significant increase in the released heat by about 78%accompanied by an increase in the activation barrier of NC and AN thermolysis,demonstrating a stabilized reactivity of the AN-NC *** findings highlight the synergistic effect of NC coating on AN particles,which contributed to a structural and reactive stabilization of both AN and NC,proving the potential application of NC-coated AN as a strategically advantageous oxidizer in composite solid propellant formulations.

关键词： Ammonium nitrate Nitrocellulose Stabilization Coating Thermolysis kinetics

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

microglia:a promising therapeutic target in spinal cord injury

引用

Neural Regeneration Research 2025年第2期20卷 454-463页

作者： Xiaowei Zha Guoli Zheng thomas Skutella Karl Kiening Andreas Unterberg Alexander Younsi Department of Neurosurgery Heidelberg University HospitalHeidelbergGermany Department of Neuroanatomy Institute for Anatomy and Cell BiologyHeidelberg UniversityHeidelbergGermany

microglia are present throughout the central nervous system and are vital in neural repair,nutrition,phagocytosis,immunological regulation,and maintaining neuronal *** a healthy spinal cord,microglia are accountable for immune surveillance,however,when a spinal cord injury occurs,the microenvironment drastically changes,leading to glial scars and failed axonal *** this context,microglia vary their gene and protein expression during activation,and proliferation in reaction to the injury,influencing injury responses both favorably and unfavorably.A dynamic and multifaceted injury response is mediated by microglia,which interact directly with neurons,astrocytes,oligodendrocytes,and neural stem/progenitor *** a clear understanding of their essential nature and origin,the mechanisms of action and new functions of microglia in spinal cord injury require extensive *** review summarizes current studies on microglial genesis,physiological function,and pathological state,highlights their crucial roles in spinal cord injury,and proposes microglia as a therapeutic target.

关键词： astrocytes cytokines functional recovery immune regulation m1/m2 activation macrophages microglia neuroinflammation spinal cord injury therapy

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

mortality associated with gastrointestinal bleeding in children: A retrospective cohort study

引用

World Journal of Gastroenterology 2017年第9期23卷 1608-1617页

作者： thomas m.attard mikaela miller Chaitanya Pant Ashwath Kumar mike Thomson Department of Gastroenterology Children’s Mercy Hospital Clinical Decision Support Children’s Mercy Hospital Department of Gastroenterology The University of Kansas Hospital University of missouri medical School Sheffield Children’s Hospital Western Bank

To determine the clinical characteristics of children with gastrointestinal bleeding (GIB) who died during the course of their *** interrogated the Pediatric Hospital Information System database, including International Classification of Diseases, Current Procedural Terminology and Clinical Transaction Classification coding from 47 pediatric tertiary centers extracting the population of patients (1-21 years of age) admitted (inpatient or observation) with acute, upper or indeterminate GIB (1/2007-9/2015). Descriptive statistics, unadjusted univariate and adjusted multivariate analysis of the associations between patient characteristics and treatment course with mortality was performed with mortality as primary and endoscopy a secondary outcome of interest. All analyses were performed using the R statistical package, *** population with GIB was 19528; 54.6% were male, overall mortality was 2.07%; (0.37% in patients with the principal diagnosis of GIB). When considering only the mortalities in which GIB was the principal diagnosis, 48% (12 of 25 principal diagnosis GIB mortalities) died within the first 3 d of admission, whereas 19.8% of secondary diagnosis GIB patients died with 3 d of admission. Patients who died were more likely to have received octreotide (19.8% c.f. 4.04%) but tended to have not received proton pump inhibitor therapy in the first 48 h, and far less likely to have undergone endoscopy during their admission (OR = 0.489, P mortalities were significantly more likely to have multiple complex chronic *** associated mortality in children is highest within 7 d of admission. multiple comorbidities are a risk factor whereas early endoscopy during the admission is protective.

关键词： Pediatrics Gastrointestinal hemorrhage Endoscopy Proton pump inhibitors mortality Liver disease Hospital Information Systems Octreotide

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Platinum modification of metallic cobalt defect sites for efficient electrocatalytic oxidation of 5-hydroxymethylfurfural

引用

Journal of Energy Chemistry 2025年第2期101卷 463-473页

作者： Haoyu Zhan Baixue Cheng Yankun Lu Danning Xing Xingshuai Lv Huining Huang thomas Frauenheim Tao Wang Peng Zhou State Key Laboratory of Bio-fibers and Eco-textiles College of Materials Science and Engineering Collaborative Innovation Center of Shandong Marine Biobased Fibers and Ecological Textiles Institute of Marine Biobased Materials Qingdao University Shandong Institute of Advanced Technology College of Chemistry and Chemical Engineering Ocean University of China Tianjin Key Laboratory of Advanced Functional Porous materials Institute for New Energy Materials & Low-Carbon Technologies School of Materials Science and EngineeringTianjin University of Technology School of Science Constructor University Beijing Computational Science Research Center College of Chemistry and molecular Engineering Qingdao University of Science and Technology

Co3O4possesses both direct and indirect oxidation effects and is considered as a promising catalyst for the oxidation of 5-hydroxymethylfurfural（HmF）.However,the enrichment and activation effects of Co3O4on OH-and HmF are weak,which limits its further *** defect engineering can regulate the electronic structure,optimize the adsorption of intermediates,and improve the catalytic activity by breaking the symmetry of the material,which is rarely involved in the upgrading of *** this work,we prepare Co3O4with metal defects and load the precious metal platinum at the defect sites（PtVco）.The results of in-situ characterizatio ns,electrochemical measurements,and theoretical calculations indicate that the reduction of Co-Co coordination number and the formation of Pt-Co bond induce the decrease of electron filling in the antibonding orbitals of Co *** resulting upward shift of the d-band center of Co combined with the characteristic adsorption of Pt species synergically enhances the enrichment and activation of organic molecules and OH species,thus exhibiting excellent HmF oxidation activity(including a lower onset potential（1.14 V） and 19 times higher current density than pure Co3O4at 1.35 V).In summary,this work explores the adsorption enhancement mechanism of metal defect sites modified by precious metal in detail,provides a new option for improving the HmF oxidation activity of cobalt-based materials,broadens the application field of metal defect based materials,and gives an innovative guidance for the functional utilization of metal defect sites in biomass conversion.

关键词： Adsorption enhancement Biomass upgrading Coordination environment Electrocatalysis metallic defect

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Clinical outcome of pediatric collagenous gastritis: Case series and review of literature

引用

World Journal of Gastroenterology 2013年第9期19卷 1478-1484页

作者： Nadia mazen Hijaz Seth Steven Septer James Degaetano thomas mario attard Section of Pediatric Gastroenterology Children's Mercy Hospital Kansas MO 64108 United States Department of Pathology Mater Dei Hospital Malta Mater Dei Hospital MSD 2090 Msida Malta Department of Pediatrics Mater Dei Hospital Malta Mater Dei Hospital MSD 2090 Msida Malta

Collagenous gastritis (CG) is characterized by patchy subepithelial collagen bands. Effective treatment and the clinical and histological outcome of CG in children are poorly defined. The aim of this study is to summarize the published literature on the clinical outcome and response to therapy of pediatric CG including two new cases. We performed a search in Pubmed, OVID for related terms; articles including management and clinical and/or endo-histologic follow up information were included and abstracted. Reported findings were pooled in a dedicated database including the corresponding data extracted from chart review in our patients with CG. Twenty-four patients were included (17 females) with a mean age of 11.7 years. The clinical presentation included iron deficiency anemia and dyspepsia. The reported duration of follow up (in 18 patients) ranged between 0.2-14 years. Despite most subjects presenting with anemia including one requiring blood transfusion, oral iron therapy was only documented in 12 patients. Other treatment modalities were antisecretory measures in 13 patients; proton pump inhibitors (12), or histamine-2 blockers (3), sucralfate (5), prednisolone (6), oral budesonide in 3 patients where one received it in fish oil and triple therapy (3). Three (13%) patients showed no clinical improvement despite therapy; conversely 19 out of 22 were reported with improved symptoms including 8 with complete symptom resolution. Spontaneous clinical resolution without antisecretory, anti-inflammatory or gastroprotective agents was noted in 5 patients (4 received only supplemental iron). Follow up endohistopathologic data (17 patients) included persistent collagen band and stable mononuclear cell infiltrate in 12 patients with histopathologic improvement in 5 patients. Neither collagen band thickness nor mononuclear cell infiltrate correlated with clinical course. Intestinal metaplasia and endocrine cell hyperplasia were reported (1) raising the concern of long term

关键词： Collagenous gastritis Pediatric Gastritis Collagenous colitis Lymphocytic gastritis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Aggressive juvenile polyposis in children with chromosome 10q23 deletion

引用

World Journal of Gastroenterology 2013年第14期19卷 2286-2292页

作者： Seth Septer Lei Zhang Caitlin E Lawson Jose Cocjin thomas attard Holly H Ardinger Department of Gastroenterology and Hepatology Children's Mercy Hospital and ClinicsKansas CityMO 64108United States Division of Cytogenetics Department of Pathology Children's Mercy Hospital and ClinicsKansas CityMO 64108 United States Division of Clinical Genetics Department of PediatricsChildren's Mercy Hospitals and Clinics and University of MissouriKansas City School of MedicineKansas CityMO 64108United States

Juvenile polyps are relatively common findings in children,while juvenile polyposis syndrome(JPS) is a rare hereditary syndrome entailing an increased risk of colorectal *** in BmPR1A or SmAD4 are found in roughly half of patients diagnosed with *** in PTEN gene are also found in patients with juvenile polyps and in Bannayan-Riley-Ruvalcaba syndrome and Cowden *** previous reports have described microdeletions in chromosome 10q23 encompassing both PTEN and BmPR1A causing aggressive polyposis and malignancy in *** reports have also described extra-intestinal findings in most cases including cardiac anomalies,developmental delay and *** this report we describe a boy with a 5.75 mb deletion of chromosome 10q23 and a 1.03 mb deletion within chromosome band 1p31.3who displayed aggressive juvenile polyposis and multiple extra-intestinal anomalies including macrocephaly,developmental delay,short stature,hypothyroidism,atrial septal defect,ventricular septal defect and *** required colectomy at six years of age,and early colectomy was a common outcome in other children with similar *** to the aggressive polyposis and reports of dysplasia and even malignancy at a young age,we propose aggressive gastrointestinal surveillance in children with 10q23 microdeletions encompassing the BmPR1A and PTEN genes to include both the upper and lower gastrointestinal tracts,and also include a flowchart for an effective genetic testing strategy in children with juvenile polyposis.

关键词： Polyposis Genetics Cancer Endoscopy pediatric

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Comparison of the use of wireless capsule endoscopy with magnetic resonance enterography in children with inflammatory bowel disease

引用

World Journal of Gastroenterology 2019年第28期25卷 3808-3822页

作者： Nadia mazen Hijaz thomas mario attard Jennifer marie Colombo Neil Joseph mardis Craig Alan Friesen Division of Gastroenterology Hepatology and Nutrition University of Missouri Kansas City Children’s Mercy Hospital Kansas City

BACKGROUND magnetic resonance enterography (mRE) and wireless capsule endoscopy (WCE) are equally accepted modalities for noninvasive screening of small bowel involvement (SBI) in children with Crohn’s disease (CD) and indeterminate colitis (IC) albeit there is a paucity of data comparing the two and thereby guiding the clinician in selecting the ideal diagnostic approach. Therefore, the goal of this study is to provide additional evidence for capsule endoscopy role in the evaluation of established Crohn’s disease exacerbation compared to mRE in relation to Pediatric Crohn's Disease Activity Index (PCDAI), and histological indices. AIm To prospectively compare the findings of mRE and WCE and their agreement with PCDAI or histology in children with CD or IC. mETHODS Consecutive patients diagnosed with CD and IC were screened for inclusion. After informed consent, patient’s demographic and clinical data was abstracted. The current pediatric disease activity index (PCDAI) and endoscopic findings were included. Patients underwent mRE and WCE including preprocedural patency capsule within a maximum of 7 d of each other. Pathological presence of active small bowel disease in ileal and duodenal biopsies were collected if the endoscopy was performed within 2 mo of the WCE study. Patients who failed to pass the PC were excluded from the study. WCE was read by two different experienced gastroenterologists (attard Tm and Colombo Jm) blinded to each other's findings and to the findings on mRE (mardis NJ). Agreement between WCE reviewers, WCE and mRE findings and concordance between positive PCDAI and SBI based on mRE compared with WCE was computed. RESULTS Forty-five patients were included in the study, 18 withdrew and 27 (20 males and 20 CD), mean age (standard deviation) 13.46 (2.4) years, completed the study protocol. There were no instances of capsule retention. Concordance between gastroenterologist reviewers was excellent for the diagnosis of small intestinal CD with good

关键词： Crohn’s disease Wireless capsule endoscopy Inflammatory bowel disease magnetic resonance enterography Small bowel involvement Small bowel disease Indeterminate colitis Pediatric Children

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Intraseasonal Variability of 2020 Temperature over Tanzania during the October-November-December (OND) Season

引用

Atmospheric and Climate Sciences 2025年第1期15卷 126-146页

作者： Godfrey thomas Assenga Chabaga Chabaga Daudi Ndabagenga Daniel Gibson mwageni Key Laboratory of meteorological Disasters of ministry of Education Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters Nanjing University of Information Science and Technology Nanjing China Tanzania meteorological Authority Dodoma Tanzania

Intraseasonal Oscillation (ISO) which is the eastward-propagating disturbance with a period of 10 - 60 days has been the topic of interest since its discovery by madden-Julian in 1972. many researchers have published their work on ISO, yet they all agree that there is no clear understanding of this matter. By using daily observed surface temperature (T2m), this study reveals the presence of significant biweekly ISO over Tanzania, a period shorter than the anticipated madden-Julian Oscillation (mJO) period of 30 to 60 days. It also reveals significant changes in wind direction when comparing the cold phase to the warm phase, highlighting a distinct atmospheric circulation pattern associated with each phase. Furthermore, the analysis reveals the presence of mJO-like eastward movement of pressure systems in the Subtropical High region, which is associated with this variability. This study presents a new analysis by providing a detailed analysis of the intraseasonal variability (ISV) of temperature over Tanzania, focusing on understanding the 2020 spatial-temporal patterns within the October-November-December (OND) season that may play a role in weather forecasting, agricultural planning, climate adaptation, reducing heat-related illnesses and contributing to the international effort to refine climate models and predictability.

关键词： Intraseasonal Variability mascarene high Biweekly Oscillation OND Season

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：