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Role of soluble triggering receptor expressed on myeloid cells in inflammatory bowel disease

World journal of Gastroenterology 2006年第21期12卷 3416-3419页

作者： Michalis Tzivras Vassilios Koussoulas Evangelos j Giamarellos-Bourboulis Dimitrios Tzivras thomas Tsaganos Pantelis Koutoukas Helen Giamarellou Athanasios Archimandritis Department of Pathophysiology Gastroenterology Section University of AthensMedical SchoolGreece 4th Department of Internal Medicine University of Athens Medical SchoolGreece

AIM： To investigate the probable role of soluble triggering receptor expressed on myeloid cells-1 （sTREM-1） in the pathogenesis of inflammatory bowel disease （IBD）.METHODS： Fifty-eight patients were enrolled; nineteen healthy volunteers served as controls; 8 patients were diagnosed with Crohn＇s disease, and 31 with ulcerative colitis, Clinical and endoscopic activity indexes of patients with Crohn＇s disease and ulcerative colitis respectively were estimated, Upon admission blood was sampled; sTREM-1 and TNFα were measured by an immunoassay and malondialdehyde （IDA） by the thiobarbitourate assay, after passage through an HPLC system,RESULTS： Median ± SE of TNFα of controls, patients with Crohn＇s disease and patients with ulcerative colitis were 6.02 ± 3.94, 7.98 ± 5.08 （P = NS vs controls）, and 8.45 ± 4.15 ng/L （P = 0.018 vs controls） respectively. Respective values of sTREM-1 were 53.31 ± 32.93, 735.10 ± 197.17 （P = 0.008 vs controls） and 435.82 ± 279.71 ng/L （P = 0.049 vs controls）, sTREM-1 was positively correlated with Crohn＇s disease activity index and clinical and endoscopic activity indexes of ulcerative colitis （P = 0.002, 0.001 and 0.009, respectively）, sTREM-1 of patients with ulcerative colitis was positively correlated with TNFα （P = 0.001）.CONCLUSION： sTREM-1 seems to behave as a novel mediator in IBD in correlation with the degree of the intlammatory reaction of the intestinal mucosa.

关键词： sTREM-1 Pro-inflammatory cytokines Malondialdehyde Inflammatory bowel disease

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No association between phosphatase and tensin homolog genetic polymorphisms and colon cancer

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World journal of Gastroenterology 2009年第30期15卷 3771-3775页

作者： Lynette S Phillips Cheryl L Thompson Alona Merkulova Sarah j Plummer thomas C Tucker Graham Case Li Li Department of Epidemiology and Biostatistics and Case Comprehensive Cancer Center Case Western Reserve University Cleveland OH 44106-7136 United States Departments of Family Medicine and Epidemiology and Biostatistics Case Center for Transdisciplinary Research on Energetics and Cancer Case Comprehensive Cancer Center Case Western Reserve University Cleveland OH 44106-7136m United States Department of Cancer Biology Cleveland Clinic Foundation Cleveland OH 44195-0001 United States Graham Casey Department of Preventive Medicine University of Southern California Los Angeles CA 90033-1006 United States assisted with patient referrals recruitment and reviewed the manuscript coordinated the lab work and reviewed the manuscript Li L led the study design data collection and assisted with the manuscript preparation

AIM: To investigate the association between single nucleotide polymorphisms (SNPs) in the phosphatase and tensin homolog (PTEN) tumor suppressor gene and risk of colon cancer. METHODS: We utilized a population-based casecontrol study of incident colon cancer individuals (n= 421) and controls (n = 483) aged ≥ 30 years to conduct a comprehensive tagSNP association analysis of the PTEN gene. RESULTS: None of the PTEN SNPs were statistically significantly associated with colon cancer when controlled for age, gender, and race, or when additionally adjusted for other known risk factors (P > 0.05). Haplotype analyses similarly showed no association between the PTEN gene and colon cancer. CONCLUSION: Our study does not support PTEN as a colon cancer susceptibility gene.

关键词： Colon cancer Phosphatase and tensinhomolog Candidate gene Genetic polymorphisms Single nucleotide polymorphism association

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Clinical laboratory and imaging evidence for effectiveness of agarose-agarose macrobeads containing stem-like cells derived from a mouse renal adenocarcinoma cell population (RMBs) in treatment-resistant, advanced metastatic colorectal cancer:Evaluation of

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Chinese journal of Cancer Research 2018年第1期30卷 72-83页

作者： Barry H.Smith Lawrence S.Gazda thomas j.Fahey Angelica Nazarian Melissa A.Laramore Prithy Martis Zoe P.Andrada joanne thomas Tapan Parikh Sudipta Sureshbabu Nathaniel Berman Allyson j.Ocean Richard D.Hall David j.Wolf The Rogosin Institute New York NY 10021 USA The Rogosin Institute-Xenia Division Xenia OH 45385 USA New York Presbyterian-Weill Cornell Medical Center New York NY 10021 USA Bob Evans Farms Inc. New Albany OH 43054 USA

Objective： The complexity, heterogeneity and capacity of malignant neoplastic cells and tumors for rapid change and evolution suggest that living-cell-based biological-systems approaches to cancer treatment are merited. Testing this hypothesis, the tumor marker, metabolic activity, and overall survival（OS） responses, to the use of one such system, implantable macrobeads [RENCA macrobeads（RMBs）], in phase I and IIa clinical trials in advanced,treatment-resistant metastatic colorectal cancer（m CRC） are described ***： Forty-eight m CRC patients（30 females; 18 males）, who had failed all available, approved treatments,underwent RMB implantation（8 RMB/kg body weight） up to 4 times in phase I and phase IIa open-label ***, labs [tumor and inflammation markers, lactate dehydrogenase（LDH）] and positron emission tomography-computed tomography（PET-CT） imaging to measure number/volume and metabolic activity of the tumors were performed pre-and 3-month-post-implantation to evaluate safety and initial efficacy（as defined by biological responses）. PET-CT maximum standard uptake value（SUVmax）（baseline and d 90; SUVmax ≥2.5）, LDH,and carcinoembryonic antigen（CEA） and/or cancer antigen 19-9（CA 19-9） response（baseline, d 30 and/or d 60）were assessed and compared to ***： Responses after implantation were characterized by an at least 20% decrease in CEA and/or CA 19-9 in75% of patients. Fluorodeoxyglucose（FDG）-positive lesions（phase I, 39; 2 a, 82） were detected in 37/48 evaluable patients, with 35% stable volume and stable or decreased SUV（10） plus four with necrosis; 10, increased tumor volume, SUV. LDH levels remained stable and low in Responders（R）（d 0–60, 290.4–333.9）, but increased steadily in Non-responders（NR）（d 0–60, 382.8–1,278.5）（d 60, P=0.050）. Responders to RMBs, indicated by the changes in the above markers, correlated with OS（R mean OS=10.76 months; NR mean OS=4.9 months; P=0.0006）.Conclusions： The correlations of the tumor marker, tumor volume

关键词： Clinical trial systems-biology RENCA macrobeads metastatic colorectal cancer colon cancer

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Isolation of farnesylhydroquinones from the basidiomycete Ganoderma pfeifferi

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Natural Products and Bioprospecting 2013年第4期3卷 137-140页

作者： Timo H.j.NIEDERMEYER thomas jIRA Michael LALK Ulrike LINDEQUIST Institute of Pharmacy Ernst-Moritz-Arndt-UniversityFriedrich-Ludwig-Jahn-Straße 1717487 GreifswaldGermany Institute of Biochemistry Ernst-Moritz-Arndt-UniversityFelix-Hausdorffstraße 417487 GreifswaldGermany

Two farnesylhydroquinones were isolated from the fruiting bodies of Ganoderma pfeifferi,farnesylhydroquinone(1)and the new compound ganomycin K(2),(5S)-3-[(E)-7,8-dihydroxy-4,8-dimethylnon-3-enyl]-5-(2,5-dihydroxyphenyl)-furan-2(5H)-*** structures of 1 and 2 were determined on the basis of mass spectrometric and NMR spectroscopic *** antibacterial activity of the isolated compounds was neglectable.

关键词： Ganoderma pfeifferi farnesylhydroquinone ganomycin

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Common sense and other writings

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作者： thomas Paine edited by j. M. Opal.

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Diagnostic accuracy of tests for Helicobacter pylori in an Alaska Native population

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World journal of Gastroenterology 2011年第42期17卷 4682-4688页

作者： Dana L Bruden Michael G Bruce Karen M Miernyk julie Morris Debby Hurlburt thomas W Hennessy Helen Peters Frank Sacco Alan j Parkinson Brian j McMahon Arctic Investigations Program Division of Preparedness and Emerging InfectionsNational Center for Emerging Zoonoses and Infectious DiseasesCenters for Disease Control and Prevention Alaska Native Tribal Health Consortium Anchorage

AIM： TO evaluate the accuracy of two non-invasive tests in a population of Alaska Native persons. High rates of Helicobacter pylori （H. pylon] infection, H. pyIori treatment failure, and gastric cancer in this population necessitate documentation of infection status at multiple time points over a patient＇s *** test, 13C urea breath test （UBT）, and immunoglobulin G antibodies to H. pylori in serum. The performances of 13C-UBT and antibody test were compared to a gold standard defined by a positive H. pylori test by culture or, in case of a negative culture result, by positive histology and a positive rapid urease test.RESULTS： The sensitivity and specificity of the 13C- UBT were 93% and 88%, respectively, relative to the gold standard. The antibody test had an equivalent sensitivity of 93% with a reduced specificity of 68%. The false positive results for the antibody test were associated with previous treatment for an H. pylorlinfection [relative risk （RR） = 2.8]. High levels of antibodies to H. py/or/were associated with chronic gastritis and male gender, while high scores in the 13C-UBT test were associated with older age and with theH. pylori bacteria load on histological examination （RR = 4.4）. CONCLUSION： The 13C-UBT outperformed the antibody test for H. pylori and could be used when a noninvasive test is clinically necessary to document treatment outcome or when monitoring for reinfection.

关键词： Urea breath test Antibody test Sensitivity Specificity

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Microcrack Formation During Gas Metal Arc Welding of High-Strength Fine-Grained Structural Steel

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Acta Metallurgica Sinica(English Letters) 2014年第1期27卷 140-148页

作者： Christoph Heinze thomas Michael Andreas Pittner Michael Rethmeier Division 9.3 "Welding Technology" BAM Federal Institute for Materials Research and TestingUnter den Eichen 8712205 BerlinGermany joining and Coating Technology Fraunhofer-Institute for Production Systems and Design Technology IPKPascalstraβe 8-910587 BerlinGermany

The recent development of high-performance-modified spray arc processes in gas metal arc welding due to modern digital control technology and inverter power sources enables a focused spray arc, which results in higher penetration depths and welding speed. However, rnicrocracks occurred in the weld metal while approaching the process limits of the modified spray arc, represented by a 20-mm double layer DV-groove butt-weld, These cracks were detected in structural steel exhibiting a yield strength level of up to 960 MPa and are neither dependent on the used weld power source nor a consequence of the modified spray arc process itself. The metallographic and fractographic investigations of the rather exceptional fracture surface lead to the classification of the microcracks as hot cracks, The effects of certain welding parameters on the crack probability are clarified using a statistical design of experiment. However, these microcracks do not impact the design specification for toughness in the Charpy V-notch test （absorbed energy at -40 ℃ for the present material is 30 j）.

关键词： High-strength low-alloy steel Welding Fracture Design of experiments Microcracking

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Dynamic Modeling, Testing, and Stability Analysis of an Ornithoptic Blimp

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journal of Bionic Engineering 2011年第4期8卷 375-386页

作者： john Dietl thomas Herrmann Gregory Reich Ephrahim Garcia Sibley School of Mechanical and Aerospace Engineering Cornell University Ithaca New York USA Air Force Research Laboratory Wright-Patterson AFB OH 45433-7542 USA

In order to study omithopter flight and to improve a dynamic model of flapping propulsion, a series 0f tests are conducted on a flapping-wing blimp. The blimp is designed and constructed from mylar plastic and balsa wood as a test platform for aerodynamics and flight dynamics. The blimp, 2.3 meters long and 420 gram mass, is propelled by its flapping wings. Due to buoyancy the wings have no lift requirement so that the distinction between lift and propulsion can be analyzed in a flight platform at low flight speeds. The blimp is tested using a Vicon motion tracking system and various initial conditions are tested including accelerating flight from standstill, decelerating from an initial speed higher than its steady state, and from its steady-state speed but disturbed in pitch angle. Test results are used to estimate parameters in a coupled quasi-steady aerodynamics/Newtonian flight dynamics model. This model is then analyzed using Floquet theory to determine local dynamic modes and stability. It is concluded that the dynamic model adequately describes the vehicle＇s nonlinear behavior near the steady-state velocity and that the vehicle＇s linearized modes are akin to those of a fixed-wing aircraft.

关键词： omithopter blimp flight dynamics stability analysis

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Circadian rhythms of feeding, oviposition, and emergence of the boll weevil （Coleoptera： Curculionidae）

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Insect Science 2006年第6期13卷 461-467页

作者： SHOIL M. GREENBERG j. SCOTT ARMSTRONG MAMOUDOUSETAMOU thomas W. SAPPINGTON RANDY j. COLEMAN TONG-XIAN LIU USDA-ARS-SARC-BIRU Texas A&M University Agricultural Experiment Station Weslaco Texas USDA-ARS-CICGRU Ames Iow USA

Circadian rhythm of feeding, oviposition, and emergence of boll weevil adults were determined at five different photophases （24, 14, 12, 10, and 0 hours） and a constant 27℃ temperature, 65% RH in the laboratory. Squares from Petri dishes, where they were exposed to boll weevil females, were removed and examined for feeding and oviposition punctures every 4 hours during daylight （0700-1900 h） and every 12 h at night （1900-0700 h） over eight consecutive days. Cohorts of randomly selected egg-punctured squares were sampled from ovipositing females at 0700, 1100, 1500, and 1900 during 24 hours and under different photophase treatments, and maintained in Petri dishes at 27 ＋ I℃, 65% RH. Dishes were observed twice daily （1900 and 0700 h） for adults emerging at day or night. Circadian rhythm of oviposition was not affected by the length of the photophase. The boll weevil has round-the-clock circadian rhythm of oviposition, with a daytime preference. We observed that 82.4%-86.0% of the boll weevil eggs were deposited between 0700 and 1900 h, and 14.0%-17.6% between 1900 and 0700 h during a 24-h period. Feeding of boll weevil females in photoperiods 24：0 h （complete light） and 0：24 h （complete darkness） did not significantly change between 0700-1900 h versus 1900-0700 h, while the d .ally cycle of light and darkness in other photoperiods significantly increased the feeding punctures from 0700-1900 compared with 1900-0700 h. The circadian rhythm of emergence depended significantly on the time of oviposition and the length of the photophase. Investigation of boll weevil circadian rhythm provides a better understanding of boll weevil ecology and reveals potential weak links for improving control technologies targeting their reproductive strategies.

关键词： Anthonomus grandis emergence circadian rhythm oviposition photophase

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Experimental　Investigation　of　Forced　Convective　Boiling　Flow　Instabilities　in　Horizontal　Helically　Coiled　Tubes

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journal of Thermal Science 1996年第3期5卷 210-216页

作者： L. j. Guo Z. P. Feng X. j. Chen N. H. thomas National Laboratory of Multiphase Flow in Power Engineering Xi’an Jiaotong University Xi’an China Fluid and Surface Transport Team School of Chemical Engineering The University of Birmingham Edgbaston Birmingham UK

An experimental investigation is described for the characteristics of convective boiling flow instabilities in horizontally helically coiled tubes using a steam-water two-phase closed circulation test loop at pressure from 0.5 MPa to 3.5 MPa. Three kinds of oscillation are reported: density waves; pressure drop excursions; thermal fluctuations. We describe their dependence on main system parameters such as system pressure, mass flowrate, inlet subcooling, compressible volume and heat flux. Utilizing the experimental data together with conservation constraints, a dimensionless correlation is proposed for the occurrence of density waves.

关键词： two-phase flow forced convective boiling flow instabilities horizontal helically coiled tubes experimental investigation

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