检索结果-南通市图书馆

New U-Pb-Hf zircon isotope data for the Paleoproterozoic Ubendian belt in the Chimala area,SW Tanzania

在线全文

学校读者我要写书评

暂无评论

Geoscience Frontiers 2019年第6期10卷 1993-2006页

作者： Robert j.thomas joachim jacobs Marlina A.Elburg Abdul Mruma Godson Kamihanda Anthony Kankila Alex Masanja Hamisi Saidi Council for Geoscience 3 Oos StreetBellvilleCape Town7535South Africa Department of Earth Science University of BergenPO Box 7803Norway Department of Geology University of JohannesburgPO Box 524Auckland Park2006South Africa Geological Survey of Tanzania DodomaTanzania

We present new U-Pb and Hf zircon isotope data on a suite of granitoids from a hitherto unstudied area of the Palaeoproterozoic Lupa terrane of the Ubendian belt in SW *** major part of the area comprises a sequence of upper amphibolite grade paragneisses and ***,the field relations show a complex history of granitoid emplacement from early pre-tectonic strongly foliated diorite-tonalite-granodiorite orthogneiss to late tectonic,weakly deformed ellipsoidal granitoid *** were followed by emplacement of undeformed K-feldspar rich porphyritic alkali granite.U-Pb zircon data on the granitoids show their emplacement ages span the period^1925 Ma to 1890 Ma and constrain the culmination of the Ubendian orogeny in the Lupa terrane to about 1900 *** undeformed K-feldspar rich Chimala granite,previously considered to be unconformably overlain by the Buanji Group volcano-sedimentary rocks(recently shown to be^1675 Ma,not Neoproterozoic as originally thought)was dated at^1407 Ma showing that it must intrude the sedimentary rocks,although the age relationships are not exposed in the mapping *** is the first record of early Irumide/Kibaran-aged post-tectonic granites in this part of East *** isotope data from the zircons show that the granitoids have a long crustal pre-history stretching back to as far as^3.9 Ga,and showing that the Lupa terrane may form part of the"metacratonic"margin of an originally much more extensive Tanzania Craton.

关键词： Ceochronology Tanzania Ubendian Palaeoproterozoic Mesoprorerozoic

Portal vein thrombosis and arterioportal shunts:Effects on tumor response after chemoembolization of hepatocellular carcinoma

在线全文

学校读者我要写书评

暂无评论

World journal of Gastroenterology 2011年第10期17卷 1267-1275页

作者： thomas j Vogl Nour-Eldin Nour-Eldin Sally Emad-Eldin Nagy NN Naguib joerg Trojan Hans Ackermann Omar Abdelaziz Institute for Diagnostic and Interventional Radiology Johan Wolfgang Goethe University Hospital Diagnostic and Interventional Radiology Department Cairo University Hospital

AIM: To evaluate the effect of portal vein thrombosis and arterioportal shunts on local tumor response in advanced cases of unresectable hepatocellular carcinoma treated by transarterial chemoembolization. METHODS: A retrospective study included 39 patients (mean age: 66.4 years, range: 45-79 years, SD: 7) with unresectable hepatocellular carcinoma (HCC) who were treated with repetitive transarterial chemoembolization (TACE) in the period between March 2006 and October 2009. The effect of portal vein thrombosis (PVT) (in 19 out of 39 patients), the presence of arterioportal shunt (APS) (in 7 out of 39), the underlying liver pathology,Child-Pugh score, initial tumor volume, number of tumors and tumor margin definition on imaging were correlated with the local tumor response after TACE. The initial and end therapy local tumor responses were evaluated according to the response evaluation criteria in solid tumors (RECIST) and magnetic resonance imaging volumetric measurements. RESULTS: The treatment protocols were well tolerated by all patients with no major complications. Local tumor response for all patients according to RECIST criteria were partial response in one patient (2.6%), stable disease in 34 patients (87.1%), and progressive disease in 4 patients (10.2%). The MR volumetric measurements showed that the PVT, APS, underlying liver pathology and tumor margin definition were statistically significant prognostic factors for the local tumor response (P = 0.018, P = 0.008, P = 0.034 and P = 0.001, respectively). The overall 6-, 12- and 18-mo survival rates from the initial TACE were 79.5%, 37.5% and 21%, respectively. CONCLUSION: TACE may be exploited safely for palliative tumor control in patients with advanced unresectable HCC; however, tumor response is significantly affected by the presence or absence of PVT and APS.

关键词： Hepatocellular carcinoma Transarterialchemoembolization Portal Shunt Thrombosis

On the Temperature Dependent Excitation and Reflection Spectra of Ln3Al5O12:Ce3+Ceramics (Ln = Y, Lu) for White LEDs

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Materials Sciences and Applications 2014年第14期5卷 1074-1078页

作者： thomas jansen thomas jüstel Department of Chemical Engineering Münster University of Applied Sciences Steinfurt Germany

Yttrium aluminum garnet (YAG) and Lutetium aluminum garnet (LuAG) doped with Ce3+ are widely applied phosphor powders or ceramics for the conversion of blue into green to yellow light in the rapidly expanding market of white light emitting high power LEDs. Surprisingly, the temperature dependent reflection and excitation spectra of these well-established materials have not been investigated until today. In this work, we report the temperature dependence of the reflection and excitation spectra of Ce3+ doped YAG and LuAG in the temperature range from 300 to 800 K.

关键词： Temperature-Dependent Reflection Excitation Spectra Garnet Phosphor Ceramics Thermal Population

Evaluating the Spatial Uncertainty of Future Land Abandonment in a Mountain Valley(Vicdessos, Pyrenees-France): Insights from Model Parameterization and Experiments

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

journal of Mountain Science 2015年第5期12卷 1095-1112页

作者： thomas Houet Laure Vacquié David Sheeren GEODE UMR 5602 CNRS –UT2j Université Toulouse Jean Jaurès Maison de la recherche 5 allées Antonio Machado31058 Toulouse Cedex Dynafor UMR 1201 INRA/INPT-ENSAT Ecole Nationale Supérieure Agronomique de Toulouse Avenue del’Agrobiopole B.P. 32607 - Auzeville-Tolosane 31326 - Castanet-Tolosan Cédex

European mountains are particularly sensitive to climatic disruptions and land use *** latter leads to high rates of natural reforestation over the last 50 years. Faced with the challenge of predicting possible impacts on ecosystem services,LUCC models offer new opportunities for land managers to adapt or mitigate their *** the spatial uncertainty of future LUCC is crucial for the definition of sustainable land use strategies. However, the sources of uncertainty may differ, including the input parameters, the model itself, and the wide range of possible futures. The aim of this paper is to propose a method to assess the probability of occurrence of future LUCC that combines the inherent uncertainty of model parameterization and the ensemble uncertainty of the future based scenarios. For this purpose, we used the Land Change Modeler tool to simulate future LUCC on a study site located in the Pyrenees Mountains(France) and two scenarios illustrating two land use strategies. The model was parameterized with the same driving factors used for its calibration. The definition of ‘static vs. dynamic' and ‘quantitative ***(discretized)' driving factors, and their combination resulted in four parameterizations. The combination of model outcomes produced maps of the spatial uncertainty of future LUCC. This work involves adapting the definition of spatial uncertainty in the literature to future-based LUCC studies. It goes beyond the uncertainty of simulation models by integrating the uncertainty of the future to provide maps to help decision makers and land managers.

关键词： Land use Land cover Scenario Model Mountainous reforestation Land abandonment Landmanagement

The First Pilot Epigenetic Type Improvement of Neuropsychiatric Symptoms in a Polymorphic Dopamine D2 (-DRD2/ANKK (Taq1A)), OPRM1 (A/G), DRD3 (C/T), and MAOA (4R) Compromised Preadolescence Male with Putative PANDAS/CANS: Positive Clinical Outcome with Precision-Guided DNA Testing and Pro-Dopamine Regulation (KB220) and Antibacterial Therapies

在线全文

学校读者我要写书评

暂无评论

Open journal of Immunology 2024年第3期14卷 60-86页

作者： Kenneth Blum Igor Elman David Han Colin Hanna David Baron Ashim Gupta Shan Kazmi jag Khalsa Debasis Bagchi thomas McLaughlin Rajendra D. Badgaiyan Edward j. Modestino Drew Edwards Catherine A. Dennen Eric R. Braverman Abdalla Bowirrat Keerthy Sunder Kevin Murphy Nicole jafari Foojan Zeine Paul R. Carney Mark S. Gold Kai-Uwe Lewandowski Alireza Sharafshah Aryeh R. Pollack Panayotis K. Thanos Division of Addiction Research & Education Center for Sports and Mental Health Western University of Health Sciences Pomona CA USA Department of Psychiatry Boonshoft School of Medicine Wright State University and Dayton VA Medical Centre Dayton OH USA Division of Nutrigenomics Victory Nutrition International Lederoch PA USA Institute of Psychology ELTE Etvs Lornd University Budapest Hungary Department of Psychiatry School of Medicine University of Vermont Burlington VT USA The Kenneth Blum Behavioral & Neurogenetic Institute LLC. Austin TX USA Department of Molecular Biology Adelson School of Medicine Ariel University Ariel Israel Division of Neuromodulation Research Karma Doctors & Karma TMS Palm Springs CA USA Division of Personalized Interventions Peak Logic Del Mar CA USA Division of Personalized Medicine Cross-Cultural Research & Educational Institute San Clemente CA USA Awareness Integration Institute San Clemente CA USA Division of Personalized Pain Therapy Center for Advanced Spine Care of Southern Arizona Tucson AZ USA Department of Psychiatry Harvard School of Medicine Cambridge MA USA Department of Management Science and Statistics University of Texas San Antonio TX USA Behavioral Neuropharmacology and Neuroimaging Laboratory Clinical Research Institute on Addictions Department of Pharmacology and Toxicology Jacobs School of Medicine and Biomedical Sciences University at Buffalo Buffalo NY USA Future Biologics Lawrenceville GA USA Department of Microbiology Immunology & Tropic Diseases School of Medicine Georgetown University Washington DC USA Department of Pharmaceutical Sciences College of Pharmacy Texas Southern University Houston TX USA Department of Psychiatry School of Medicine Case Western University Cleveland OH USA Brain and Behavior Laboratory Curry College Milton MA USA The Neurogenesis Project Jacksonville FL USA Department of Family Medicine Jefferson Health Northeast Philadelphia PA USA Departmen

Pediatric autoimmune neuropsychiatric disorders associated with or without streptococcal and other bacterial infections (PANDAS/CANS) are emerging as a featured pediatric disorder. Although there is some controversy regarding treatment approaches, especially related to the behavioral sequelae, we have hypothesized in other published work that it is characterized by the rapid onset of Reward Deficiency Syndrome (RDS) in children. We propose utilizing a multi-systems biological approach involving the coupling of genetic addiction risk testing and pro-dopamine regulation (KB220/POLYGEN®) to help induce “dopamine homeostasis” in patients with PANDAS, especially those with known DNA-induced hypodopaminergia. This case study examines a 12-year-old Caucasian male with no prior psychiatric issues who presented with a sudden onset of severe anxiety, depression, emotional liability, and suicidal ideation. The patient underwent genotyping and the genetic addiction risk score (GARS) testing, which revealed risk polymorphisms in the dopamine D2 (-DRD2/ANKK (Taq1A), OPRM1 (A/G), DRD3 (C/T), and MAOA (4R) genes. These polymorphisms have been linked to hypodopaminergia. The patient was subsequently placed on research ID-KB220ZPBMPOLY (POLYGEN®), and albeit the possibility of bias, based upon self and parental assessment, a marked rapid improvement in psychiatric symptoms was observed. In the second phase of treatment (102 days utilizing KB220), the patient received standard antibody testing, which was positive for Lyme. Antibacterial therapy started immediately, and KB220z was discontinued to provide a wash-out period. A monotonic trend analysis was performed on each outcome measure, and a consistently decreasing trend was observed utilizing antibacterial therapy. Our recommendation, albeit only one case, is to utilize and further research a combined therapeutic approach, involving precision-guided DNA testing and pro-dopamine regulation along with antibacterial therapy, as well as

关键词： PANDAS CANS Genetic Addiction Risk Testing (GARS) Pro-Dopamine Regulation Hypodopaminergia Polymorphisms Antibacterial Therapy Infections

Molecular mechanisms controlling seed set in cereal crop species under stress and non-stress conditions

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

journal of Integrative Agriculture 2018年第5期17卷 965-974页

作者： LI Hui-yong thomas Lübberstedt Cereal Crops Research Institute Henan Academy of Agricultural Sciences Department of Agronomy Iowa State University

Maximizing seed yield is the ultimate breeding goal in important cereal crop species. Seed set is a key developmental stage in the process of seed formation, which determines grain number, seed mass, and realized yield potential, and can be severely affected by abiotic and biotic stresses. However, seed set can also be substantially reduced by genetic factors even under optimal fertilization conditions. The underlying molecular genetic mechanisms are still obscure. In this review, we elucidate the process of seed set of cereal crop species in detail, including development of floral structures, formation of viable gametes, double fertilization, seed development, and abortion. We discuss how genetic and non-genetic factors affect seed set in different development stages. Finally, we will propose novel strategies to study genetic mechanisms controlling seed set and exploit genetic resources to improve seed set in cereal crop species.

关键词： maize seed set molecular mechanism

Saturation-excess overland flow in the European loess belt:An underestimated process?

在线全文

学校读者我要写书评

暂无评论

International Soil and Water Conservation Research 2023年第4期11卷 688-699页

作者： Valentin Landemaine Olivier Cerdan thomas Grangeon Rosalie Vandromme Benoit Laignel Olivier Evrard Sébastien Salvador-Blanes j.Patrick Laceby BRGM F-45060OrléansFrance University of Rouen M2CRouenFrance Laboratoire des Sciences du Climat et de l'Environnement(LSCE/IPSL) UnitéMixte de Recherche 8212(CEA/CNRS/UVSQ)UniversitéParis-SaclayGif-sur-YvetteFrance University of Tours UR 6293-GéoHydrosystèmes Continentaux(GEHCO)France Alberta Environment and Protected Areas CalgaryCanada

A major challenge in runoff and soil erosion modelling is the adequate representation of the most relevant processes in models while avoiding over *** the European loess belt,pro-gressive soil crusting during rainfall events,resulting in infiltration-excess runoff,is usually considered the dominant process generating runoff on catchments covered with silty ***-excess may also occur and affect their runoff and erosion ***,saturation-excess runoff occurrence and quantification have rarely been performed and is usually not taken into account when modelling runoff and erosion in these ***,a continuous simulation of the Austreberthe catchment(214 km^(2)),located in the European loess belt(Normandy,France),was conducted with the new Water and Sediment(WaterSed)model over 12 years,corresponding to more than 780 individual rainfall events,at a 25 m spatial *** inter-annual variability of runoff and erosion was closely linked to the number of intense events per year and their distribution through the *** model was properly calibrated over a representative set of 35 rainfall events,considering either infiltration-excess and/or saturation-excess *** was also able to reproduce the measured runoff volume for most of the monitoring ***,the three years with most rainfall were adequately modelled only including saturation-excess *** analysis performed at the seasonal scale revealed that saturation was modelled in the catchment during almost all of the modelling period,suggesting the importance of this often overlooked process in current modelling attempts.

关键词： European loess belt Soil erosion Saturation-excess runoff WaterSed model

Translational bioengineering strategies for peripheral nerve regeneration:opportunities,challenges,and novel concepts

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2023年第6期18卷 1229-1234页

作者： Karim A.Sarhane Chenhu Qiu thomas G.W.Harris Philip j.Hanwright Hai-Quan Mao Sami H.Tuffaha Department of Plastic and Reconstructive Surgery Peripheral Nerve Research LaboratoryJohns Hopkins University School of MedicineBaltimoreMDUSA Department of Materials Science and Engineering Johns Hopkins University Whiting School of EngineeringBaltimoreMDUSA Institute for NanoBioTechnology Johns Hopkins UniversityBaltimoreMDUSA Translational Tissue Engineering Center Johns Hopkins University School of MedicineBaltimoreMDUSA Department of Biomedical Engineering Johns Hopkins University School of MedicineBaltimoreMDUSA

Peripheral nerve injuries remain a challenging problem in need of better treatment *** best efforts at surgical reconstruction and postoperative rehabilitation,patients are often left with persistent,debilitating motor and sensory *** are currently no therapeutic strategies proven to enhance the regenerative process in humans.A clinical need exists for the development of technologies to promote nerve regeneration and improve functional *** advances in the fields of tissue engineering and nanotechnology have enabled biomaterial scaffolds to modulate the host response to tissue repair through tailored mechanical,chemical,and conductive *** bioengineered approaches have enabled targeted,sustained delivery of protein therapeutics with the capacity to unlock the clinical potential of a myriad of neurotrophic growth factors that have demonstrated promise in enhancing regenerative *** such,further exploration of combinatory strategies leveraging these technological advances may offer a pathway towards clinically translatable solutions to advance the care of patients with peripheral nerve *** review first presents the various emerging bioengineering strategies that can be applied for the management of nerve gap *** cover the rationale and limitations for their use as an alternative to autografts,focusing on the approaches to increase the number of regenerating axons crossing the repair site,and facilitating their growth towards the distal *** also discuss the emerging growth factor-based therapeutic strategies designed to improve functional outcomes in a multimodal fashion,by accelerating axonal growth,improving the distal regenerative environment,and preventing end-organs atrophy.

关键词： bioengineering biomaterials growth hormone insulin-like growth factor 1 nanotechnology neurobiology peripheral nerve regeneration Schwann cells translational research

Evaluating the probability of silent circulation of polio in small populations using the silent circulation statistic

在线全文

学校读者我要写书评

暂无评论

Infectious Disease Modelling 2019年第1期4卷 239-250页

作者： Celeste Vallejo Carl A.B.Pearson james Koopman thomas j.Hladish Mathematical Biosciences Institute The Ohio State UniversityJennings Hall 3rd Floor1735 Neil Ave.ColumbusOH 43210United States Department of Infectious Disease Epidemiology&Centre for Mathematical Modelling of Infectious Disease London School of Hygiene&Tropical MedicineUnited Kingdom South African Centre for Epidemiological Modeling and Analysis Stellenbosch UniversitySouth Africa Very Good Research&Development LLCUnited States Department of Epidemiology University of Michigan1415 Washington HeightsAnn ArborMI 48109United States Emerging Pathogens Institute University of FloridaP.O.Box 1000092055 Mowry RoadGainesvilleFL 32610United States Department of Biology University of Florida220 Bartram HallP.O.Box 118525GainesvilleFL 32611United States

As polio-endemic countries move towards elimination,infrequent first infections and incomplete surveillance make it difficult to determine when the virus has been eliminated from the *** and Dietz[American journal of Epidemiology,143,8(1996)]proposed a model to estimate the probability of silent polio circulation depending upon when the last paralytic case was *** the same kind of stochastic model they did,we additionally model waning polio immunity in the context of isolated,small,and unvaccinated *** compare using the Eichner and Dietz assumption of an initial case at the start of the simulation to a more accurate determination that observes the first *** former estimates a higher probability of silent circulation in small populations,but this effect diminishes with increasing model *** also show that stopping the simulation after a specific time estimates a lower probability of silent circulation than when all replicates are run to extinction,though this has limited impact on small *** extensions to the Eichner and Dietz work improve the basis for decisions concerning the probability of silent *** model realism will be needed for accurate silent circulation risk assessment.

关键词： Silent circulation Silent circulation statistic Polio