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Cementless Semi-Constrained Rotating Platform Total Knee Replacement: A Concise follow-Up of a Previous Report at a Minimum of Twenty Years

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Open Journal of Orthopedics 2023年第3期13卷 71-77页

作者： frederick f. Buechel Sr. frederick f. Buechel Jr. thomas E. Helbig Rutgers NJ Medical School Newark USA South Mountain Orthopaedic Associates South Orange USA Lenox Hill Hospital New York USA

Background: A previous report evaluated the initial 310 cementless, Buechel-Pappas (B-P), Semi-Constrained Rotating Platform total knee replacements in 257 patients followed for an average of 7.6 years, range 2 - 18 years. Diagnoses were osteoarthritis in 233 patients, post traumatic arthritis in 4 patients and rheumatoid arthritis in 22 patients. Knee Scores, using a strict knee scoring scale were 86.4% excellent, 12.3% good, 0.3% fair and 1.0% poor results. Survivorship, using an end point of revision for any mechanical reason (including component loosening, bearing wear and bearing dislocation) was 99.4%. Survivorship for a poor knee score (including persistent pain, loosening, instability and infection was 97.6%. The purpose of the present study is to report the updated results of this same patient cohort at a minimum follow-up of twenty years. Methods: The average age of patients at the time of surgery was 67 years, range 34 to 91 years. A total of 20 patients (22 knees) were still living, with a follow-up of 20 - 30 years (mean 23.47 years). The same strict knee scoring scale and survivorship analysis were used to evaluate patient outcomes at the 20 to 30 years interval. Results: Survivorship, in the current study, using the same end points as in the previous study, was 96.5% at the 20 and 30-year intervals. Late mechanical failure and osteolysis were not identified. Conclusion: This cementless, semi-constrained rotating platform total knee replacement has stood the test of time for more than 20 years and can be considered acceptable for long-term use, in properly selected patients.

关键词： Knee Replacement Cementless Semi-Constrained Rotating

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Gaining access to acetyl-CoA by peroxisomal surface display

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Synthetic and Systems Biotechnology 2023年第2期8卷 224-226页

作者： thomas Perrot Sebastien Besseau Nicolas Papon Vincent Courdavault Biomolecules et Biotechnologies Vegetales BBVEA2106Universite de ToursToursFrance Univ Angers Univ BrestIRFSFR ICATF-49000AngersFrance

Synthetic biology is constantly making progress for producing compounds on ***,Yocum and collaborators have developed an outstanding approach based on the anchoring of biosynthetic enzymes to the peroxisomal *** allow... 详细信息

关键词： Synthetic biology Enzymes colocalization Peroxisomal membrane Acetyl-CoA Polyketides

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Anti-inflammatory properties of the glial scar

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Neural Regeneration Research 2016年第11期11卷 1742-1743页

作者： Tarsis f.Gesteira Yvette M.Coulson-thomas Vivien J.Coulson-thomas Department of Ophthalmology University of CincinnatiCincinnati OH USA Department of Biochemistry Universidade Federal de Sao Paulo Sao Paulo SP Brazil College of Optometry University of Houston Houston TX USA

Glial cells comprise -90% of the human brain and are divided into two subtypes： microglia and astrocytes. Astrocytes play a vital role in maintaining central nervous system （CNS） homeostasis, regulating ion concentrations and providing metabolic support for neighboring neurons, stabilizing synapses, supporting the neurovascular system including maintenance of the blood-brain barrier （BBB） and also producing the extracellular matrix （ECM）.

关键词： TSG Anti-inflammatory properties of the glial scar GfAP STAT

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Identification and initial characterization of the 3＇ end of gene transcripts encoding putative members of the pheromone receptor subfamily in Lepidoptera

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Insect Science 2012年第1期19卷 64-74页

作者： Stephen f. Garczynski Kevin W. Wanner thomas R. Unruh USDA-ARS Yakima Agricultural Research Laboratory Wapato Washington Department of Plant Sciences and Plant Pathology Montana State University Bozeman Montana USA

Semiochemicals, including pheromones and kairomones, used in pest man- agement programs reduce the need for chemical insecticides, and understanding their interactions with their membrane receptors may help make them more effective in the field. Identification of odorant receptors in the Lepidoptera has mainly been achieved us- ing bioinformatics to search DNA sequences generated by genome or expressed sequence tag （EST） sequencing projects. This study reports a rapid method to identify members of the pheromone receptor subfamily in Lepidoptera. Degenerate oligonucleotide primers were designed against a conserved amino acid sequence in the carboxyl terminus of known lepidopteran pheromone receptors, and the primers were used in a 3＇ rapid amplifica- tion of complementary DNA （cDNA） ends procedure. Polymerase chain reaction products generated from seven different lepidopteran species were TA cloned and sequenced. The cDNA sequences of 25 transcripts were determined to encode potential members of the pheromone receptor subfamily. These cDNAs ranged from 238 to 642 bp and encoded 49-54 amino acids of the carboxyl terminus. Analysis of the 3＇ untranslated region reveals that most of the transcripts contain multiple polyadenylation signal sequences, and in the case ofManduca sexta, an alternate polyadenylation signal appears to be used in transcript processing. The 3＇ untranslated region was also useful in determining unique receptors en- coded by transcripts having highly similar nucleotide and amino acid sequences. Overall, this technique provides a complementary method of pheromone receptor identification in EST sequencing projects, or can be used as a stand-alone method in conjunction with 5＇ rapid amplification of cDNA ends procedures.

关键词： degenerate primer PCR odorant receptor pheromone receptor polyadeny- lation signals 3' untranslated region

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Neural grafting for Parkinson's disease:challenges and prospects

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Neural Regeneration Research 2017年第3期12卷 389-392页

作者： thomas B.Stoker Nicholas f.Blair Roger A.Barker John van Geest Center for Brain Repair Department of Clinical NeurosciencesUniversity of CambridgeCambridgeUK Wellcome Trust-Medical Research Council Stem Cell Institute University of CambridgeCambridgeUK

Parkinson＇s disease（PD） is a neurodegenerative condition which causes a characteristic movement disorder secondary to loss of dopaminergic neurons in the substanitia *** motor disorder responds well to dopamine-replacement therapies,though these result in significant adverse effects due to non-physiological release of dopamine in the striatum,and off-target ***-based regenerative treatments offer a potential means for targeted replacement of dopamine,in a physiological *** neurons for cell-based therapies can be obtained from several *** ventral mesencephalon tissue contains dopaminergic neuron progenitors,and has been transplanted into the striatum of PD patients with good results in a number of ***,the ethical implications and logistical challenges of using fetal tissue mean that fetal ventral mesencephalon is unlikely to be used in a widespread clinical *** pluripotent stem cells can be used to generate dopaminergic neurons for transplantation,providing a source of autologous tissue for *** approach means that challenges associated with allografts,such as the potential for immune rejection,can be ***,the associated cost and difficulty in producing a standardized product from different cell lines means that,at present,this approach is not commercially viable as a cell-based *** neurons derived from embryonic stem cells offer the most promising basis for a cell-based therapy for Parkinson＇s disease,with trials due to commence in the next few *** there are ethical considerations to take into account when using embryonic tissue,the possibility of producing a standardized,optimized cell product means that this approach can be both effective,and commercially viable.

关键词： Parkinson's disease neural grafting embryonic stem cells induced pluripotent stem cells induced neurons cell-based therapies

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Spatially engineered nonlinearity in resonant metasurfaces

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Photonics Research 2023年第2期11卷 252-259页

作者： ANNA fEDOTOVA MOHAMMADREZA YOUNESI MAXIMILIAN WEISSfLOG DENNIS ARSLAN thomas PERTSCH ISABELLE STAUDE fRANK SETZPfANDT Institute of Solid State Physics Friedrich Schiller University Jena07743 JenaGermany Institute of Applied Physics Abbe Center of PhotonicsFriedrich Schiller University Jena07745 JenaGermany Max Planck School of Photonics 07745 JenaGermany fraunhofer Institute for Applied Optics and Precision Engineering 07745 JenaGermany

Spatial engineering of the nonlinear susceptibility χ^((2)) in resonant metasurfaces offers a new degree of freedom in the design of the far-field response of second-harmonic generation(SHG). We demonstrate this by applying electric field poling to lithium niobate(LN) thin films, which inverts the spontaneous polarization and thus the sign of χ^((2)). Metasurfaces fabricated in periodically poled LN films reveal the distinct influence of theχ^((2))-patterning on the spatial distribution of the second harmonic. This work is a first step toward far-field engineering of SHG in metasurfaces with electric field poling.

关键词： resonant surfaces harmonic

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Pathology and genetic connectedness of the mangrove crab (Aratus pisonii) – a foundation for understanding mangrove disease ecology

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Animal Diseases 2022年第2期2卷 73-88页

作者： Jamie Bojko Amy L.Burgess thomas W.Allain Erica P.Ross Devon Pharo Jan f.Kreuze Donald C.Behringer National Horizons Centre Teesside UniversityDarlington DL11HGUK School of Health and Life Sciences Teesside UniversityMiddlesbrough TS13BXUK fisheries and Aquatic Sciences University of FloridaGainesvilleFL 32653USA Emerging Pathogens Institute University of FloridaGainesvilleFL 32611USA florida fish and Wildlife Research Institute MarathonFL 33050USA International Potato Centre(CIP) Apartado 1558LimaPeru

Mangrove forests are productive ecosystems,acting as a sink for CO_(2),a habitat for a diverse array of terrestrial and marine species,and as a natural barrier to coastline *** species that reside within mangrove ecosystems have important roles to play,including litter decomposition and the recycling of *** are important detritivores in such ecosystems and understanding their limitations(***)is an important endeavour when considering the larger ecological services *** and metagenomics were used to identify viral(Nudiviridae,Alphaflexiviridae),bacterial(Paracoccus sp.,'Candidatus Gracilibacteria sp.’,and Pseudoalteromonas sp.),protozoan,fungal,and metazoan diversity that compose the symbiome of the mangrove crab,Aratus *** symbiotic groups were observed at varying prevalence under histology:nudivirus(6.5%),putative gut epithelial virus(3.2%),ciliated protozoa(35.5%),gonad fungus(3.2%),gill ectoparasitic metazoan(6.5%).Metagenomic analysis of one specimen exhibiting a nudivirus infection provided the complete host mitochondrial genome(15,642 bp),nudivirus genome(108,981 bp),and the genome of a Cassava common mosaic virus isolate(6387 bp).Our phylogenetic analyses group the novel nudivirus with the Gammanudivirus and protein similarity searches indicate that Carcinus maenas nudivrius is the most similar to the new *** mitochondrial genome were used to mine short fragments used in population genetic studies to gauge an idea of diversity in this host species across the USA,Caribbean,and central and southern *** study report several new symbionts based on their pathology,taxonomy,and genomics(where available)and discuss what effect they may have on the crab *** role of mangrove crabs from a OneHealth perspective were explored,since their pathobiome includes cassava-infecting ***,given that this species is abundant in mangrove forests and now boasts a well-described pathogen prof

关键词： Alphaflexiviridae Nudiviridae Mitochondria Pathology Histology Metagenomics

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Power flow forecasts at transmission grid nodes using Graph Neural Networks

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Energy and AI 2023年第4期14卷 189-200页

作者： Dominik Beinert Clara Holzhuter Josephine M.thomas Stephan Vogt fraunhofer Institute for Energy Economics and Energy System Technology IEE Joseph-Beuys-Straße 8Kassel34117Germany Intelligent Embedded Systems Lab University of KasselWilhelmshöher Allee 73Kassel34121Germany

The increasing share of renewable energy in the electricity grid and progressing changes in power consumption have led to fluctuating,and weather-dependent power *** ensure grid stability,grid operators rely on power forecasts which are crucial for grid calculations and *** this paper,a Multi-Task Learning approach is combined with a Graph Neural Network(GNN)to predict vertical power flows at transformers connecting high and extra-high voltage *** proposed method accounts for local differences in power flow characteristics by using an Embedding Multi-Task Learning *** use of a Bayesian embedding to capture the latent node characteristics allows to share the weights across all transformers in the subsequent node-invariant GNN while still allowing the individual behavioral patterns of the transformers to be *** the same time,dependencies between transformers are considered by the GNN architecture which can learn relationships between different transformers and thus take into account that power flows in an electricity network are not independent from each *** effectiveness of the proposed method is demonstrated through evaluation on two real-world data sets provided by two of four German Transmission System Operators,comprising large portions of the operated German transmission *** results show that the proposed Multi-Task Graph Neural Network is a suitable representation learner for electricity networks with a clear advantage provided by the preceding embedding *** is able to capture interconnections between correlated transformers and indeed improves the performance in power flow prediction compared to standard Neural Networks.A sign test shows that the proposed model reduces the test RMSE on both data sets compared to the benchmark models significantly.

关键词： Power flow forecasting Graph Neural Network Graph Convolutional Network Embedding Multi-Task Learning

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fIB-4 score and hepatocellular carcinoma risk after hepatitis C virus cure:time to revise surveillance?

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Hepatobiliary Surgery and Nutrition 2020年第5期9卷 661-664页

作者： Antonio Saviano Simona Tripon thomas f.Baumert Institut de Recherche sur les Maladies Virales et Hépatiques(IVH) Inserm U1110StrasbourgFrance Institut Hospitalo-Universitaire Pôle Hépato-digestifHôpitaux Universitaires de StrasbourgStrasbourgFrance University of Strasbourg StrasbourgFrance Institut Universitaire de france(IUf) ParisFrance

Hepatitis C virus(HCV)is a main cause and important risk factor for hepatocellular carcinoma(HCC)in Western countries(1).Direct antiviral agents(DAAs)for HCV are highly effective and well-tolerated antiviral drugs which allow HCV cure even in patients with advanced liver ***,whilst HCV cure improves liver function and decreases overall HCC risk,a significant HCC risk persists in particular in patients with advanced fibrosis including cirrhosis who have the highest risk of developing HCC(2-4).

关键词： drugs liver carcinoma

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Structural,magnetic and antibacterial properties of manganese-substituted magnetite ferrofluids

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International Journal of Minerals,Metallurgy and Materials 2023年第7期30卷 1417-1426页

作者： Blessy Babukutty Deepalekshmi Ponnamma Swapna S.Nair Jiya Jose Saritha G.Bhat Sabu thomas Department of Physics Central University of KeralaKasargod 671314India Materials Science and Technology Program College of Arts and SciencesQatar UniversityP.O.Box 2713DohaQatar Department of Biotechnology Cochin University of Science and TechnologyKalamasseryKeralaIndia Department of Chemistry Mahatma Gandhi UniversityKottayam 686560KeralaIndia

Manganese-substituted magnetite ferrofluids(ffs)Mnx fe_(1-x)fe_(2)O_(4)(x=0–0.8)were prepared in this work through a chemical coprecipitation *** controlled growth of ff nanomaterials for antibacterial activities is challenging,and therefore,very few reports are available on the *** research focuses on stabilizing aqueous ffs with the tetramethylammonium hydroxide surfactant to achieve high *** characterization reveals nanoparticles of 5–11 nm formed by the chemical reaction and nanocrystalline nature,as evident from structural ***-substituted magnetic ffs are analyzed for their structural,functional,and antibacterial performance according to the Mn-substituent *** studies show a high blue shift for Mn^(2+)-substituted Mnx fe_(1-x)fe_(2)O_(4)with the theoretical correlation of optical band gaps with the Mn *** superparamagnetic nature of substituted ffs causes zero coercivity and remanence,which consequently influence the particle size,cation distribution,and spin *** structural and functional performance of the ffs is correlated with the antibacterial activity,finally demonstrating the highest inhibition zone formation for Mnx fe_(1-x)fe_(2)O_(4)ffs.

关键词： manganese ferrofluids homogeneity antibacterial stability

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