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10 Years Industrial Experience with Low-Emission Additives for Molding Sand

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Potentially life-threatening intravenous acetaminophen overdose in a 3-month-old (40 weeks’ post-menstrual age), 2.3 kg baby girl

2019中国铸造活动周

作者： thomas engelhardt Zefen He Clariant Germany Clariant China

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Open Journal of Pediatrics 2013年第3期3卷 186-187页

作者： Shane Campbell thomas engelhardt James McLay Brian Anderson Department of Anaesthesia Royal Aberdeen Children’s Hospital Aberdeen UK Intensive Care Medicine Auckland Children’s Hospital Auckland New Zealand

A case is presented of a serious, potentially life-threatening intravenous acetaminophen overdose in a 3-month-old (40 weeks’ post menstrual age),2.3 kgbaby girl. The neonate was scheduled for urgent laser therapy for retinopathy of prematurity. Instead of an intended intravenous Hartmann’s solution bolus of 10 ml·kgˉ1, the neonate received a 17 ml bolus of correctly labelled intravenous 1% acetaminophen. The National Poisons Bureau was immediately contacted for advice and in the absence of data suggested a treatment with N-acetylcysteine for a 24-hour period. Baseline blood samples for clotting, liver function, urea and electrolytes, full blood count and plasma acetaminophen concentration were taken 30 min, 8.25 h, 12.5 h, 18.5 h and 120 h after the overdose. Acetaminophen concentration was 78 mg·Lˉ1 at 30 min, but it was undetectable at any other time. Using a recent and complete PK-PD dataset we are able to show that the measured plasma acetaminophen concentration fits well on PK estimates for acetaminophen in this neonate. The non-detectable (low) plasma acetaminophen concentration at >8 h is also consistent with this model, especially if clearance is slightly increased in the premature nursery graduate. Medical errors are rarely the fault of an individual and they are often due to a combination of factors. Contributing factors, in this case, are described under the following headings: Catalyst event, system fault, loss of situational awareness, and human error.

关键词： Neonate Acetaminophen Overdose No Sequelae PK Models Drug Error

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适用于湿砂造型的低排放添加剂

铸造工程 2017年第5期41卷 29-32页

作者： thomas engelhardt 科莱恩化工(中国)有限公司上海200335

探讨了当前采用膨润土添加剂进行湿砂造型的技术。该添加剂对环境无害，值得推广应用。概述了新研制的添加剂的工作原理和在实际铸造生产中检测芳烃排放物的方法。新的低排放膨润土添加剂用于铸件的湿砂造型可使铸造厂的湿砂系统的BTEx... 详细信息

探讨了当前采用膨润土添加剂进行湿砂造型的技术。该添加剂对环境无害，值得推广应用。概述了新研制的添加剂的工作原理和在实际铸造生产中检测芳烃排放物的方法。新的低排放膨润土添加剂用于铸件的湿砂造型可使铸造厂的湿砂系统的BTEx排放量降低80％，并可以提高生产效率，提高铸件的表面光洁度。

关键词：湿砂造型添加剂排放

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适用于湿型砂造型的低排放添加剂

金属加工（热加工） 2017年第13期 60-62页

作者： thomas engelhardt 科莱恩欧洲中东和非洲地区(EMEA)应用开发部

探讨了当前膨润土湿型砂减排的主要技术,以期对这项技术的潜力进行评估,并为铸造厂和相关产业所需的可持续性改进做出贡献。概述了新技术的原理,并解释了公司创新研发的检测方法,用于测量和比较在实际铸造工艺条件下此新技术与加光亮碳... 详细信息

探讨了当前膨润土湿型砂减排的主要技术,以期对这项技术的潜力进行评估,并为铸造厂和相关产业所需的可持续性改进做出贡献。概述了新技术的原理,并解释了公司创新研发的检测方法,用于测量和比较在实际铸造工艺条件下此新技术与加光亮碳形成剂的湿型砂的芳烃排放物的比较。展示了低排放添加剂新技术在欧洲铸造厂实际应用中取得的成果。

关键词：湿型砂排放 BTEX 替代方案

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型砂添加剂系统低排放技术的减排实践经验

型砂添加剂系统低排放技术的减排实践经验

2015中国铸造活动周

作者： thomas engelhardt 科莱恩产品(德国)有限公司

2010年,科莱恩推出了一项创新技术,能够显著减少膨润土型砂的排放量。综合开发结果表明:将特殊的石墨与适当的分散剂结合,可以全部或部分取代传统的光亮碳载体煤。这一概念已被开发成一个产品系列,作为低排放技术用于铸造实践。为了将... 详细信息

2010年,科莱恩推出了一项创新技术,能够显著减少膨润土型砂的排放量。综合开发结果表明:将特殊的石墨与适当的分散剂结合,可以全部或部分取代传统的光亮碳载体煤。这一概念已被开发成一个产品系列,作为低排放技术用于铸造实践。为了将这项低排放技术成功推向市场,首先要开发出一款合适的测量装置,在实际环境中测出膨润土型砂系统的排放量。我们利用这一测量装置对欧洲60多家铸造厂的膨润土型砂的气态芳香烃排放量进行了测量。测试结果表明:各铸造厂之间的芳烃排放量存在巨大的差异,在减少关键气体排放方面,仍有进一步提高的空间。总体而言,低排放技术在欧洲15家铸造厂的生产过程中得到了成功应用。低排放技术的推广是缓慢渐进式的。在单个铸造厂,这种渐进式的转换过程需要花费两年的时间,期间需要同时在实验室进行全面的排放量检测和分析。大量实践经验表明:在大多数情况下,膨润土型砂的挥发性芳烃化合物的排放量能够减少80%,绝大多数铸造厂可以实现50%的减排。除了减排,很多时候石墨还能对型砂的性能带来积极的影响。比如:石墨可用作内部润滑剂,使型砂的紧实更加充分和均匀,从而大大减少因型砂紧实不充分而导致的各类铸造缺陷。

关键词：型砂低排放减排实践经验

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儿童气道管理：超声可否实时评价气管插管？

麻醉与镇痛 2011年第4期7卷 79-83页

作者： Bruno Marciniak, MD Pierre Fayoux, MD Anne Hebrard MD Renee Krivosic-Horber, MD thomas engelhardt, MD, PhD Bruno Bissonnette, BSc, MD, FRCPC 何睿林(译) 蒋宗滨(校) Pole d'Anesthesie Reanimation Hopital Jeanne de Flandre CHRU Rue Eugene Avine 59037 Lille Cedex France UPRES JE2490 Predinical research group in perinatal medicine Lille 2 University Lille France U. F. d' ORL pediatrique Pole d' ORL Hopital Claude Huriez. CHRU Lille France Royal Aberdeen Children's Hospital Foresterhill Aberdeen UK Department of Anesthesia Hospital Sick Children Toronto Canada 不详

背景儿童气管插管需要相当的专业知识，对许多麻醉医师而言也是一种挑战。确认气管导管位置的方法有直接目测法或间接测法，例如听诊和二氧化碳波形图。这些方法具有不同的敏感性和特异性，尤其在婴幼儿。超声检查是无创的方法，更容易... 详细信息

背景儿童气管插管需要相当的专业知识，对许多麻醉医师而言也是一种挑战。确认气管导管位置的方法有直接目测法或间接测法，例如听诊和二氧化碳波形图。这些方法具有不同的敏感性和特异性，尤其在婴幼儿。超声检查是无创的方法，更容易被麻醉医师所采用。本研究中，我们探讨了正常小儿气道气管插管期间的特征性实时超声检查所见及这种方法在临床应用的可行性。方法需行气管插管并具有正常气道的30例健康儿童被纳入研究。在使用深度吸入麻醉行气管插管时，应用Sonosite Titan（Sonosite。Bothell，WA）超声仪扫描小儿气道，记录特征性图像。通过听诊和良好的呼气末二氧化碳波形图来进一步确认气管导管放置位置的正确性。结果研究病例的平均年龄（±标准差）为48±37个月，体重19．7±8．6kg，性别比（男／女）为1：2。验证气管插管成功依据下列标准：1）确认气管和气管环；2）确认声带；3）气管导管经过时声门变宽；4）气管导管位于隆突上方，给予肺手动通气后可确认胸腔脏层．壁层胸膜界面的运动（如滑动征）。一例食管插管因见到导管位于左侧气管旁间隙而被识别。结论本研究描述了正常小儿气管插管期间超声气道的特征，提示超声检查可用于儿童气道管理。

关键词：实时超声检查气管插管气道管理健康儿童呼气末二氧化碳波形图实时评价气管导管位置麻醉医师

Twenty-first century climate change and submerged aquatic vegetation in a temperate estuary:the case of Chesapeake Bay

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Ecosystem Health and Sustainability 2017年第7期3卷 14-34页

作者： thomas M.Arnold Richard C.Zimmerman Katharina A.M.engelhardt J.Court Stevenson Departments of Biology and Environmental Studies Dickinson CollegeCarlislePAUSA Department of Ocean Earth and Atmospheric SciencesOld Dominion UniversityNorfolkVAUSA Appalachian Laboratory University of Maryland Center for Environmental ScienceFrostburgMDUSA Horn Point Laboratory University of Maryland Center for Environmental ScienceCambridgeMDUSA

Introduction:The Chesapeake Bay was once renowned for expansive meadows of submerged aquatic vegetation(SAV).However,only 10%of the original meadows *** restoration effortswill be complicated by accelerating climate change,including physiological stressors such as a predicted mean temperature increase of 2-6℃and a 50-160%increase in CO_(2)***:As the Chesapeake Bay begins to exhibit characteristics of a subtropical estuary,summer heat waves will become more frequent and *** alone would eventually eliminate eelgrass(Zostera marina)from the *** will favor native heat-tolerant species such as widgeon grass(Ruppia maritima)while facilitating colonization by non-native seagrasses(e.g.,Halodule spp.).Intensifying human activity will also fuel coastal zone acidification and the resulting high CO_(2)/low pH conditions may benefit SAV via a“CO_(2)fertilization effect.”Discussion:Acidification is known to offset the effects of thermal stress and may have similar effects in estuaries,assuming water clarity is sufficient to support CO_(2)-stimulated photosynthesis and plants are not overgrown by ***,coastal zone acidification is variable,driven mostly by local biological processes that may or may not always counterbalance the effects of regional *** precarious equipoise between two forces-thermal stress and acidification-will be critically important because it may ultimately determine the fate of cool-water plants such as Zostera marina in the Chesapeake ***:The combined impacts of warming,coastal zone acidification,water clarity,and overgrowth of competing algae will determine the fate of SAV communities in rapidly changing temperate estuaries.

关键词： Submerged aquatic vegetation climate temperature coastal acidification Chesapeake Bay

Role of the intracellular receptor domain of gp130 (exon 17) in human inflammatory bowel disease

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World Journal of Gastroenterology 2005年第8期11卷 1196-1199页

作者： Christoph J.Auernhammer Kathrin Zitzmann Fabian Schnitzler Julia Seiderer Peter Lohse George Vlotides Dieter engelhardt Michael Sackmann Burkhard G(o|¨)ke thomas Ochsenkühn Department of Internal Medicine Ⅱ-Grosshadern Department of Clinical Chemistry-Grosshadern

AIM: To study the role of the intracellular receptor domain of gp130 in human inflammatory bowel disease (IBD).METHODS: We amplified and sequenced the complete exon 17 of the human gp130 gene in 146 patients with IBD. According to clinical and histopathological signs,the 146 patients with IBD were classified as having Crohn's disease (n = 73) or ulcerative colitis (n = 63),or as indeterminate status (n = 10).RESULTS: No mutations in exon 17 of the gp130 gene could be detected in any of the 146 patients with IBD ***: There is no evidence that mutations in exon 17 of the gp130 gene are involved in the pathogenesis of human IBD.

关键词： Exon 17 Inflammatory bowel disease gp130 gene