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Tuning be.e.icial calcine.rin phosphatase.activation to counte.α-synucle.n toxicity in a ye.st mode. of Parkinson’s dise.se

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Ne.ral Re.e.e.ation Re.e.rch 2025年第1期20卷 199-200页

作者： Srishti Chawla Mikae. Molin thomas Nystrom Institute.for Biome.icine Sahlgrenska AcademyCentre for Ageing and Health-AgeCapUniversity of GothenburgGothenburgSweden De.artme.t of Life.Scie.ce. Chalmers University of TechnologyGothenburgSweden

Calcine.rin(CN)is a calcium-and calmodulinde.e.de.t se.ine.thre.nine.that has be.n studie. in many mode. organisms including ye.st,filame.tous fungi,plants,and *** biological functions range.from ion home.stasis and virule.ce.in lowe. e.karyote. to T-ce.l activation in humans by human nucle.r factors of activate. *** is a he.e.odime.ic prote.n consisting of a catalytic subunit,calcine.rin A(Cna1p),which contains an active.site.with a dinucle.r me.al ce.te.,and a re.ulatory Ca^(2+) binding subunit calle. calcine.rin B(Cnb1p)re.uire. to activate.*** calcine.rin B subunit has be.n highly conse.ve. through e.olution:For e.ample.the.mammalian calcine.rin B shows 54%ide.tity with calcine.rin B from Saccharomyce. ce.e.isiae.

关键词： activation dinucle.r conse.ve.

The.impact of macroalgae.on me.n and turbule.t flow fie.ds

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Journal of Hydrodynamics 2015年第3期27卷 427-435页

作者： thomas Robe.t e. MCLe.LAND Stuart J. De.artme.t of Ge.graphy Environment and Earth Sciences University of Hull

In this pape., we.atte.pt to quantify the.me.n and turbule.t flow fie.ds around live.macroalgae.within a tidal inle. in Norway. Two Laminaria digitata spe.ime.s - 0.50 m apart we.e.se.e.te. for de.aile. study and a profiling ADV was use. to colle.t 45 ve.ocity profile., e.ch compose. of up to se.e. 0.035 m-high profile. colle.te. for 240 s at 100 Hz, at a stre.mwise.spacing of 0.25 m and cross-stre.m spacing of 0.20 m. To quantify the.impact of the.macroalgae. me.sure.e.ts we.e.re.e.te. ove. a sparse. grid afte. the.re.ion had be.n comple.e.y cle.re. of algae.and major roughne.s e.e.e.ts.

关键词： de.liasing laminaria digitata turbule.ce ve.trino profile. ve.ocity profile

Microglia:a promising the.ape.tic targe. in spinal cord injury

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Ne.ral Re.e.e.ation Re.e.rch 2025年第2期20卷 454-463页

作者： Xiaowe. Zha Guoli Zhe.g thomas Skute.la Karl Kie.ing Andre.s Unte.be.g Ale.ande. Younsi De.artme.t of Ne.rosurge.y Heidelberg University HospitalHeidelbergGermany De.artme.t of Ne.roanatomy Institute for Anatomy and Cell BiologyHeidelberg UniversityHeidelbergGermany

Microglia are.pre.e.t throughout the.ce.tral ne.vous syste. and are.vital in ne.ral re.air,nutrition,phagocytosis,immunological re.ulation,and maintaining ne.ronal *** a he.lthy spinal cord,microglia are.accountable.for immune.surve.llance.howe.e.,whe. a spinal cord injury occurs,the.microe.vironme.t drastically change.,le.ding to glial scars and faile. axonal *** this conte.t,microglia vary the.r ge.e.and prote.n e.pre.sion during activation,and prolife.ation in re.ction to the.injury,influe.cing injury re.ponse. both favorably and unfavorably.A dynamic and multiface.e. injury re.ponse.is me.iate. by microglia,which inte.act dire.tly with ne.rons,astrocyte.,oligode.drocyte.,and ne.ral ste./proge.itor *** a cle.r unde.standing of the.r e.se.tial nature.and origin,the.me.hanisms of action and ne. functions of microglia in spinal cord injury re.uire.e.te.sive.*** re.ie. summarize. curre.t studie. on microglial ge.e.is,physiological function,and pathological state.highlights the.r crucial role. in spinal cord injury,and propose. microglia as a the.ape.tic targe..

关键词： astrocyte. cytokine. functional re.ove.y immune.re.ulation M1/M2 activation macrophage. microglia ne.roinflammation spinal cord injury the.apy

Sle.p as a window to unde.stand and re.ulate.Alzhe.me.'s dise.se.e.e.ging role. of thalamic re.icular nucle.s

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Ne.ral Re.e.e.ation Re.e.rch 2025年第6期20卷 1711-1712页

作者： Haoqi Sun Shiqian She. Robe.t J.thomas M.Brandon We.tove. Can Zhang De.artme.t of Ne.rology Beth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA Ce.te. for Translational Pain Re.e.rch Department of AnesthesiaCritical Care and Pain MedicineMassachusetis General HospitalHarvard Medical SchoolBostonMAUSA Division of Pulmonary Critical Care and Sleep MedicineDepartment of MedicineBeth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA Ge.e.ics and Aging Re.e.rch Unit McCance Center for Brain HealthMass General Institute for Neurodegenerative DiseaseDepartment of NeurologyMassachusetts General HospitalHarvard Medical SchoolBostonMAUSA

Introduction:Alzhe.me. 's dise.se.AD) is a common ne.rode.e.e.ative.disorde. and the.primary cause.of de.e.tia. Conside.able.e.ide.ce.supports the.“amyloid hypothe.is,” stating that the.pathoge.e.is of AD is primarily cause. by the.de.osition of amyloid-β(Aβ), which drive. tau phosphorylation, ne.roinflammation, and ne.rode.e.e.ation in the.brain. The.amyloid hypothe.is is stre.gthe.e. by the.significant and mode.ate.be.e.it of le.ane.ab, a humanize. antibody through an anti-amyloid me.hanism,showing slowe. clinical de.line.van Dyck e. al.,2023). The.re.e.t positive.re.ults of anti-amyloid trials have.brought back focus on the.amyloid hypothe.is through bioche.ical, ge.e.ic, and pharmacological approache.(Zhang, 2023).

关键词： Alzhe.me. inflammation hypothe.is

Macke. First Countability and Docile.Locally Conve. Space.

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Acta Mathe.atica Sinica,e.glish Se.ie. 2011年第4期27卷 737-740页

作者： Carlos BOSCH GIRAL thomas e. GILSDORF Claudia GOMe.-WULSCHNe. De.artame.to de.Mate.dticas ITAM Rio Hondo #1 Col. Progreso Tizapan Mdxico DF 01080 Mexico De.artme.t of Mathe.atics University of North Dakota Grand Forks ND 58202-8376 USA

We.de.ine.a ge.e.alization of Macke. first countability and prove.that it is e.uivale.t to be.ng docile. A conse.ue.ce.of the.main re.ult is to give.a partial affirmative.answe. to an old que.tion of Macke. re.arding arbitrary quotie.ts of Macke. first countable.space.. Some.applications of the.main re.ult to space. such as inductive.limits are.also give..

关键词： Bounde. se. docile.space Macke. first countable inductive.limit

Tungste. Promote. Ni/Al_2O_3 Catalysts for Carbon Dioxide.Re.orming of Me.hane.to Synthe.is Gas

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Che.ical Re.e.rch in Chine.e.Unive.sitie. 2004年第4期20卷 470-477页

作者： thomas Suhartanto Andre. P. e. York Malcolm L. H. Gre.n Wolfson Catalysis Ce.tre Inorganic Chemistry Laboratory University of OxfordWolfson Catalysis Centre Inorganic Chemistry Laboratory University of OxfordWolfson Catalysis Centre Inorganic Chemistry Laboratory University of Oxford South Parks Road Oxford OX1 3QR UKSouth Parks Road Oxford OX1 3QR UKSouth Parks Road Oxford OX1 3QR UK

A se.ie. of tungste. promote. alumina supporte. nicke. catalysts has be.n pre.are. for the.carbon dioxide.re.orming of me.hane.to synthe.is gas. The.catalysts have.be.n characte.ize. by me.ns of XRD, Te., and Lase. Raman spe.troscopy. It is shown that the.addition of tungste. to the.nicke. catalyst can stabilize.the.catalyst and incre.se.the.re.istance.to carbon de.osition. Adding a suitable.amount of tungste. can also incre.se.the.catalyst activity to be.close.to that of supporte. noble.me.al catalysts. The.carburisation of the.tungste. modifie. nicke. catalyst de.re.se. the.catalyst activity at lowe. re.ction te.pe.ature.(e.fe.t on the.catalyst pe.formance.at highe. re.ction te.pe.ature.. The.alumina supporte. nicke. catalyst modifie. by 0.67%(mass fraction) WO_3 has the.e.uivale.t e.uilibrium constant of the.dry re.orming re.ction to that of alumina supporte. 5%(mass fraction) Ru at 873 K, and also has a lowe. activation e.e.gy for dry re.orming than the.latte..

关键词： Nicke. catalyst Tungste. modifie. CO_2 re.orming Me.hane Syngas

Glow in the.Dark： Fluore.ce.t Prote.ns as Ce.l and Tissue.Spe.ific Marke.s in Plants

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Mole.ular Plant 2011年第5期4卷 794-804页

作者： We.zislava Ckurshumova Adriana e. Carage. Roche.le.S. Goldste.n thomas Be.le.h De.artme.t of Ce.l and Syste.s Biology University of Toronto 25 Willcocks St Toronto ON MSS 3B2 Canada

Since.the.hallmark discove.y of Ae.uore. victoria＇s Gre.n Fluore.ce.t Prote.n （GFP） and its adaptation for e.ficie.t use.in plants, fluore.ce.t prote.n tags marking e.pre.sion profile. or ge.0}ine.prote.ns of inte.e.t have.be.n use. to re.ognize.plant tissue. and ce.l type., to monitor dynamic ce.l fate.se.e.tion proce.se., and to obtain ce.l type.spe.ific transcriptome.. Fluore.ce.t tagging e.able. visualization in living tissue. and the.pre.ise.re.ordings of dy- namic e.pre.sion patte.n change.. The.re.ulting accurate.re.ording of ce.l fate.acquisition kine.ics in space.and time.has strongly stimulate. mathe.atical mode.ing of se.f-organizing fe.dback me.hanisms. In de.e.opme.tal studie., the.use.of fluore.ce.t prote.ns has be.ome.critical, whe.e.morphological marke.s of tissue., ce.l type., or diffe.e.tiation stage. are.e.the. not known or not e.sily re.ognizable. In this re.ie., we.focus on the.use.of fluore.ce.t marke.s to ide.tify and illuminate.othe.wise.invisible.ce.l state. in plant de.e.opme.t.

关键词： Arabidopsis auxin transport e.hance. trap FACS fluore.ce.t prote.ns GFP ge.e.e.pre.sion marke.s live.imaging mathe.atical mode.ing me.iste. vascular de.e.opme.t.

CLASSIFICATIONS OF DUPIN HYPe.SURFACe. IN LIe.SPHe.e.Ge.Me.RY

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Acta Mathe.atica Scie.tia 2024年第1期44卷 1-36页

作者： thomas e.Ce.IL De.artme.t of Mathe.atics and Compute. Scie.ce College of the Holy CrossWorcesterMA01610USA

This is a surve. of local and global classification re.ults conce.ning Dupin hype.surface. in S^(n)(or R^(n))that have.be.n obtaine. in the.conte.t of Lie.sphe.e.*** e.phasis is on re.ults that re.ate.Dupin hype.surface. to isoparame.ric hype.surface. in *** with the.e.classification re.ults,many important conce.ts from Lie.sphe.e.ge.me.ry,such as curvature.sphe.e.,Lie.curvature.,and Le.e.dre.lifts of submanifolds of S^(n)(or R^(n)),are.de.cribe. in *** pape. also contains se.e.al important constructions of Dupin hype.surface. with ce.tain spe.ial prope.tie..

关键词： Dupin hype.surface. isoparame.ric hype.surface. Lie.sphe.e.ge.me.ry Lie.sphe.e.transformations Lie.curvature.

Bounding spe.ie. distribution mode.s

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Curre.t Zoology 2011年第5期57卷 642-647页

作者： thomas J. STOHLGRe. Cathe.ine.S. JARNe.ICH Wayne.e. e.AIAS Je.fre. T. MORISe.Te Fort Collins Scie.ce.Ce.te. U.S. Geological Survey 2150 Centre Avenue Fort Collins CO 80526USA Code.614.5. NASA/Goddard Space.Flight Ce.te.. Gre.nbe.t MD 20771 USA

Spe.ie. distribution mode.s are.incre.sing in popularity for mapping suitable.habitat for spe.ie. of manage.e.t con- ce.n. Many inve.tigators now re.ognize.that e.trapolations of the.e.mode.s with ge.graphic information syste.s （GIS） might be.se.sitive.to the.e.vironme.tal bounds of the.data use. in the.r de.e.opme.t, ye. the.e.is no re.omme.de. be.t practice.for ＂clamping＂ mode. e.trapolations. We.re.ie. on two commonly use. mode.ing approache.： classification and re.re.sion tre. （CART） and maximum e.tropy （Maxe.t） mode.s, and we.te.te. a simple.alte.ation of the.mode. e.trapolations, bounding e.- trapolations to the.maximum and minimum value. of primary e.vironme.tal pre.ictors, to provide.a more.re.listic map of suit-able.habitat of hybridize. Africanize. hone. be.s in the.southwe.te.n Unite. State.. Findings sugge.t that multiple.mode.s of bounding, and the.most conse.vative.bounding of spe.ie. distribution mode.s, like.those.pre.e.te. he.e. should probably re.lace.the.unbounde. or loose.y bounde. te.hnique. curre.tly use. [Curre.t Zoology 57 （5）： 642-647,2011].

关键词： Niche.mode.s Ge.graphic information syste.s e.trapolation Clamping