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Family Medicine and Community Health 2023年第4期11卷 4-12页

作者： Juliane Regina Framme Su-Jong kim-Dorner Bettina Heidtmann thomas Michael Kapellen Karin Lange Olga Kordonouri Heike Saßmann Medical Psychology Hannover Medical SchoolHannoverGermany Paediatric Endocrinology and Diabetology Catholic Childrens Hospital WilhelmstiftHamburgGermany Hospital for Children and Adolescents University of Leipzig Medical CenterLeipzigGermany Department of Paediatrics MEDIAN Children's Hospital"Am Nicolausholz"Bad KösenGermany Diabetes Center for Children and Adolescents Auf der Bult Children's HospitalHannoverGermany

Objective The COVID-19 pandemic had an impact on everyday life and in general,reduced the health-related quality of life(HRQoL)of *** this study,we assess the HRQoL of adolescents with type 1 diabetes(T1D)in Germany since the second wave of the COVID-19 pandemic by using self-report and parent-proxy reports,to identify risk factors,to compare to peers and to examine the agreement of HRQoL between parents and their *** A total of 445 adolescents(12–18 years)and 413 parents participated in an anonymous cross-sectional survey conducted at three German diabetes centres from January 2021 to June *** criteria were diabetes duration≥1year and *** HRQoL was assessed by using self-report and parent-proxy report versions of the KIDSCREEN-10 *** The majority of adolescents reported average(75.5%)*** 11.3%of teens reported high and 13.2%low ***’s female gender,older age,higher diabetes burden and parental depression symptoms contributed to lower self-reported HRQoL among *** parent-proxy reports,increasing diabetes burdens,parental depression symptoms,non-migrant status,high education and ketoacidosis contributed to lower scores on teen *** mean scores of the KIDSCREEN-10 index for adolescents did not differ from the German *** comparison to healthy peers during the first wave of the pandemic,adolescents in the current study reported higher *** overall teen-parent agreement was fair although parents reported significantly lower teen HRQoL than adolescents *** HRQoL of most adolescents with T1D during the COVID-19 pandemic was average with parents reporting significantly lower ***-reported and parent-proxy-reported HRQoL and the level of agreement due to different perspectives can provide important information for clinical care and intervention planning.

关键词： adolescent wave life

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Oral transforming growth factor-beta receptor 1 inhibitor vactosertib promotes osteosarcoma regression by targeting tumor proliferation and enhancing anti-tumor immunity

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Cancer Communications 2024年第8期44卷 884-888页

作者： Sung Hee Choi Jay thomas Myers Suzanne Louise Tomchuck Melissa Bonner Saada Eid Daniel Tyler Kingsley Kristen Ashley Van Heyst Seong-Jin kim Byung-Gyu kim Alex Yee-Chen Huang Department of Pediatrics CaseWestern Reserve University School of MedicineClevelandOhioUSA Case Comprehensive Cancer Center CaseWestern Reserve University School of MedicineClevelandOhioUSA Department of Pathology CaseWestern Reserve University School of MedicineClevelandOhioUSA MedPacto Inc. SeoulRepublic of Korea Center for Pediatric Immunotherapy Angie Fowler AYA Cancer InstituteUH Rainbow Babies and Children’s HospitalClevelandOhioUSA

Osteosarcoma is an aggressive malignant bone sarcoma common among children,adolescents,and young *** 20%of patients present with pulmonary metastasis,and an additional 40%develop pulmonary osteosarcoma *** survival ou... 详细信息

关键词： osteosarcoma immunity patients

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Impact of Korean Ginseng （Panax Ginseng） on Power Generation of Microbial Fuel Cells

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Journal of Chemistry and Chemical Engineering 2015年第7期9卷 448-453页

作者： Wonjae kim Peter Lee thomas W. kim George kim Jonathan Sukhee Chung Jihwan Alex. Joo Sung-Jae Chung Fuzbien Technology Institute MD 20850 United States Collegiate School NY 10024 United States_ Department of Chemistry University of lllinois-Urbana Champaign IL 61801 United States Centreville High School VA 20124 United States Seoul International School Seoul 13113 South Korea School of Arts and Sciences Marymount University Arlington 22207 United States STEM Research Institute VA 22031 United States

This study reports an increase in power generation of a MFC （microbial fuel cell） by the addition of Korean ginseng （Panax ginseng）. It was noted that the use of ginseng enhances the microbial anaerobic degradation of cellobiose, a disaccharide that was used as a substrate in the anode chamber of the MFC. The power output of the MFC where ginseng was added showed noticeable enhancement compared to the control MFC. The increase slowly ramped at the initial days and became appreciably higher after the 11th day of incubation in an experiment set up for 16 days duration. It is attributed that the ginseng increases the CO2 production by accelerating the fermentation process. Decrease in CH4/CO2 ratio was observed also due to decrease in methane production per digested cellobiose, the proton donor in the current study. Four ring steroid-like structural moiety Ginsenoside of Panax ginseng seemed to play a beneficial role in the electron transfer from ceilobiose to the anode, perhaps by rendering easier electron transfer due to favorable energy level alignments.

关键词： MFC Korean ginseng Panax anaerobic degradation.

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Newly established autonomous adaptive low-power instrument platform(AAL-PIP) chain on East Antarctic Plateau and operation

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Advances in Polar Science 2019年第4期30卷 362-374页

作者： Zhonghua XU Michael DHARTINGER Robert CLAUER Daniel WEIMER Kshitija DESHPANDE Hyomin kim Stephen MUSKO Anna WILLER thomas EDWARDS Shane COYLE Yuxiang PENG Dong LIN John BOWMAN Bradley Department of Electrical and Computer Engineering Virginia TechBlacksburgVA 24061USA Center for Space Plasma Physics Space Science InstituteBoulderCO 80301USA Department of Physical Sciences Embry-Riddle Aeronautical UniversityDaytona BeachFL 32114USA Center for Solar-Terrestrial Research New Jersey Institute of TechnologyNewarkNJ 07102USA Space Physics Research Laboratory College of EngineeringUniversity of MichiganAnn ArborMI48109USA DTU Space National Space InstituteTechnical University of DenmarkKongens LyngbyDenmark

An autonomous adaptive low-power instrument platform(AAL-PIP)chain of six stations has been newly established on East Antarctic Plateau along the 40°geomagnetic meridian,to investigate interhemispheric geomagnetically conjugate current systems,waves,and other space weather phenomena in Polar *** six stations,PG0 to PG5,which host low-power magnetometers(Fluxgate and Searchcoil),dual frequency GPS receivers,HF radio experiment,and run autonomously with solar power and two-way satellite communication,are designated at the geomagnetically conjugate(based on the International Geomagnetic Reference Field)locations of the West Greenland geomagnetic chain covering magnetic latitudes from 70°to 80°.We present the development,deployment,and operation of this chain,as well as the data collected by the chain and some preliminary scientific results showing evidence of interhemispheric asymmetries,which are important to better understand Solar Wind–Magnetosphere–Ionosphere(SWMI)coupling in Polar *** investigations focus on magnetic impulse(MI)events,traveling convection vortices(TCVs),and ultra-low frequency(ULF)waves in the coupled southern and northern hemispheres.

关键词： magnetometers magnetic perturbation magnetic conjugate

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Approaching Laozr. Comparing a Syncretic Reading to a Synthetic One

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Frontiers of Philosophy in China 2017年第1期12卷 10-25页

作者： thomas Michael CHEN Yazhou School of Philosophy Beijing Normal University Beijing 100875 China

Is Laozi a syncretic text whose primary body of ideas were cobbled together from multiple and various sources, none of which can reasonably be identified as Daoist, or is it a synthetic text whose ideas emerged from a single source that for all intents embodies the core elements of a tradition that meets the standards of inclusion for a tradition of early Daoism？ The present work examines the key points of Hongkyung kim＇s sophisticated account of Laozi＇s origins as a syncretic text. It then goes on to present the key points of what would have to be involved in its original circulations as a synthetic text. It concludes by suggesting a middle ground that is able to explain why an originally synthetic Laozi is all too easily read by modem scholars as a syncretic text.

关键词： Laozi Dao De Jing early Daoism Lishi Chunqiu yangsheng Hongkyung kim

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Bioreactor design and validation for manufacturing strategies in tissue engineering

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Bio-Design and Manufacturing 2022年第1期5卷 43-63页

作者： Diana Lim Eric S.Renteria Drake S.Sime Young Min Ju Ji Hyun kim Tracy Criswell thomas D.Shupe Anthony Atala Frank C.Marini Metin N.Gurcan Shay Soker Joshua Hunsberger James J.Yoo Wake Forest Institute for Regenerative Medicine Wake Forest School of MedicineWinston-SalemNC 27157USA Center for Biomedical Informatics Wake Forest School of MedicineWinston-SalemNC 27157USA RegenMed Development Organization(ReMDO) Winston SalemNC 27106USA

The fields of regenerative medicine and tissue engineering offer new therapeutic options to restore,maintain or improve tissue function following disease or *** maximize the biological function of a tissue-engineered clinical product,specific conditions must be maintained within a bioreactor to allow the maturation of the product in preparation for ***,the bioreactor should be designed to mimic the mechanical,electrochemical and biochemical environment that the product will be exposed to in ***-time monitoring of the functional capacity of tissue-engineered products during manufacturing is a critical component of the quality management *** present review provides a brief overview of bioreactor engineering *** addition,strategies for bioreactor automation,in-line product monitoring and quality assurance are discussed.

关键词： Bioreactor Monitoring sensors and automation Manufacturing Tissue engineering Regenerative medicine

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Sexually Transmitted Diseases at Monkey Bay Community Hospital in Mangochi, Malawi;an Analysis of Characteristics of Common Sexually Transmitted Diseases

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Advances in Infectious Diseases 2020年第4期10卷 243-252页

作者： David S. Chung Min Jung Koh Sung Hwan Chough Seog In Moon Gene K. Lee Ivy kim Yujin kim Jae Hee kim Lorie kim Hyunjin kim Eunice Kang Fatsani Manase thomas Nyirenda School of Medicine University of Virginia Charlottesville VA USA Youth with Talents Fairfax VA USA School of Medicine Georgetwon University Washington DC USA College of Dentistry NYU New York NY USA Clinical Research Education and Management Service Lilongwe Malawi

We present the characteristics of the commonly diagnosed sexually transmitted infections (STI) at a clinic of Monkey Bay community hospital by a retrospective study. We conducted an audit of patients’ hospital records from a STIs clinic at Monkey Bay community hospital in Mangochi District (Malawi) covering a period from January 2019 to June 2019 (18 months). Data was tabulated in excel and analyses were made based on sex, age, male circumcision status, pregnancy and the pattern of STIs diagnosed within the chosen study period. A total number of 659 clients presented at STI clinic of Monkey Bay community hospital between January 2018 and June 2019. Out these clients, 409 (62%) were females and 250 (38%) were males. Most of the patients were in the age range of 25 years or above (447, 68%). Majority of the patients were HIV negative (523, 79%). Out of the 250 males, 113 (45%) were circumcised. Among female patients 56 of the 409 (14%) were pregnant. The most common presentations for all cases put together were lower abdominal pain (253, 38%), then urethral discharge (189, 29%), abnormal vaginal discharge (141, 21%), genital ulcer disease (64, 10%), in that order. Syphilis, genital warts, inguinal bubo and scrotal swelling were less common. The most common presentation in males was urethral discharge (178, 71%), while in females it was lower abdominal pain (214, 52%). Our audit showed that in Mangochi (Malawi) sexually transmitted diseases of various types are more common among young adults, females and uncircumcised men. There was no much difference in the percentage of STI’s between HIV positive and HIV negative people. These results point to an alarmingly high level of risky sexual behaviors among sexually active age groups in this part of Malawi, a country which still has one of the highest HIV prevalence in sub-Saharan Africa. This calls for continued and better research and control for transmission of STIs in the district.

关键词： Sexually Transmitted Infections (STIs) Mangochi Malawi

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Intraoperative endoscopic retrograde cholangiopancreatography for traumatic pancreatic ductal injuries:Two case reports

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World Journal of Gastrointestinal Endoscopy 2022年第5期14卷 342-350页

作者： Andrew Canakis Varun Kesar Caleb Hudspath Raymond E kim thomas M Scalea Peter Darwin Division of Gastroenterology and Hepatology University of Maryland School of MedicineBaltimoreMD 21201United States Department of Surgery R.Adams Cowley Shock Trauma CenterUniversity of Maryland School of MedicineBaltimoreMD 21201United States

BACKGROUND In order to successfully manage traumatic pancreatic duct(PD)leaks,early diagnosis and operative management is paramount in reducing morbidity and *** the acute setting,endoscopic retrograde cholangiopancreatography(ERCP)can be a useful,adjunctive modality during exploratory *** with sphincterotomy and stent placement improves preferential drainage in the setting of injury,allowing the pancreatic leak to properly ***,data in this acute setting is *** SUMMARY In this case series,a 27-year-old male and 16-year-old female presented with PD leaks secondary to a gunshot wound and blunt abdominal trauma,*** underwent intraoperative ERCP within an average of 5.9 h from time of presentation.A sphincterotomy and plastic pancreatic stent placement was performed with a 100%technical and clinical *** were no associated immediate or long-term *** discharge,both patients underwent repeat ERCP for stent removal with resolution of ductal *** These experiences further demonstrated that widespread adaption and optimal timing of ERCP may improve outcomes in trauma centers.

关键词： Pancreatic ductal injury Pancreatic leaks Endoscopic retrograde cholangiopancreatography Trauma Endoscopic stenting Case report

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DSSylation, a novel protein modification targets proteins induced by oxidative stress, and facilitates their degradation in cells

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Protein & Cell 2014年第2期5卷 124-140页

作者： Yinghao Zhang Fang-Mei Chang Jianjun Huang Jacob J. Junco Shivani K. Maffi Hannah I. Pridgen Gabriel Catano Hong Dang Xiang Ding Fuquan Yang Dae Joon kim thomas J. Slaga Rongqiao He Sung-Jen Wei Medical Research Division Regional Academic Health Center Edinburg TX 78541 USA State Key Laboratory of Brain and Cognitive Science Institute of Biophysics Chinese Academy of Sciences Beijing 100101 China Department of Clinical Biochemistry Xiangya Medical College Central South University Changsha 410013 China Department of Pharmacology The University of Texas Health Science Center at San Antonio San Antonio TX 78229 USA Department of Molecular Me'dicine The University of Texas Health Science Center at San Antonio San Antonio TX 78229 5 USA Department of Medicine The University of Texas Health Science Center at San Antonio San Antonio TX 78229 USA The Cancer Therapy and Research Center The University of Texas Health Science Center at San Antonio San Antonio TX 78229 USA Cystic Fibrosis and Pulmonary Diseases Research and Treatment Center School of Medicine University of North Carolina at Chapel Hill Chapel Hill NC 27599 USA Laboratory'of Proteomics Institute 'of Biophysics Chinese Academy of Sciences Beijing 100101 China

Timely removal of oxidatively damaged proteins is crit- ical for cells exposed to oxidative stresses; however, cellular mechanism for clearing oxidized proteins is not clear. Our study reveals a novel type of protein modifi- cation that may play a role in targeting oxidized proteins and remove them. In this process, DSS1 （deleted in split hand/split foot 1）, an evolutionally conserved small protein, is conjugated to proteins induced by oxidative stresses in vitro and in vivo, implying oxidized proteins are DSS1 clients. A subsequent ubiquitination targeting DSSl-protein adducts has been observed, suggesting the client proteins are degraded through the ubiquitin- proteasome pathway. The DSS1 attachment to its clients is evidenced to be an enzymatic process modulated by an unidentified ATPase. We name this novel protein modification as DSSylation, in which DSS1 plays as amodifier, whose attachment may render target proteins a signature leading to their subsequent ubiquitination, thereby recruits proteasome to degrade them.

关键词： DSS1 shfml free radicals oxidativestress proteasome protein modification DSSylation

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An Assessment of the Social, Cultural, and Economical Barriers to Option B+Retention and Their Solutions in Malawi: A Review

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World Journal of AIDS 2021年第1期11卷 15-24页

作者： Jamie Yoon David S. Chung Michelle kim Kunmin kim Sang Heon Lee Tae Youn kim Hark Joon Lee Seog In Moon Jooheon Park Paul S. Chung thomas Nyirenda School of Medical Boston University Boston USA Edward Via College of Osteopathic Medicine Blacksburg USA School of Medicine University of Virginia Charlottesville USA Youth with Talents Fairfax USA Department of Art & Science Biology Johns Hopkins University Baltimore USA Clinical Research Education and Management Service Lilongwe Malawi

Malawi has one of the highest rates of HIV prevalence in the world, and accounts for 4% of the total number of people living in sub-Saharan Africa with HIV. Approximately one million people in Malawi were living with HIV in 2016, with 24,000 HIV-related deaths. The Option B+ program, first implemented in Malawi, aimed to initiate ART for all pregnant women, regardless of their CD4 cell count or disease stage. This study serves to analyze and assess the effectiveness of Option B+ retention, in relation to the facilitation of how various social and cultural barriers were handled. A literature review of 29 publications was conducted. Careful evaluation of various studies indicates that although there is a myriad of reasons explaining low levels of retention, the women who were at the highest risk for low retention were young pregnant women who were treated on the same day of HIV-diagnosis. Solutions focused around women and their partners or communities showed promising evidence of success in increasing adherence, as these strategies likely provided women reliable social and emotional support to address major barriers to retention such as a lack of support from male partners, ineffective education from healthcare workers, or stigma towards their HIV disclosure statue.

关键词： HIV Option B+ Malawi Retention CHTC PMTCT

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