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The miracle transplantation of a black leg by the surgeon saints Cosmas and Damian

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Hepatobiliary surgery and Nutrition 2024年第1期13卷 1-2页

作者： thom.s m.van gulik Department of surgery Amsterdam University Medical CenterUniversity of AmsterdamAmsterdamThe Netherlands

The miracle of the saints Cosmas and Damian refers to transplantation of a black leg onto a white man that took place in medieval Rome(Figure 1)(1).A sexton of a church in Rome was seriously affected by cancer in his right *** into a delirious fever,he dreamed that the holy surgeons,saint Cosmas and saint Damian,visited him and skilled as they were,decided to remove the affected leg and replace it with a healthy *** went to the grave of a recently deceased Ethiopian man and retrieved the right leg of this black man and took it to the *** sick leg of the sexton was amputated and they transplanted onto him the leg of the black *** their miracle operation,Cosmas and Damian have been elevated to patron saints of the surgical profession and many surgical societies have adopted their names in honor of them.

关键词： black Figure replace

The lymphatic vessels of the liver observed by Frederik Ruysch

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Hepatobiliary surgery and Nutrition 2024年第5期13卷 757-758页

作者： thom.s m.van gulik Department of surgery Amsterdam University Medical CenterUniversity of AmsterdamAmsterdamThe Netherlands

The Dutch physician and anatomist Frederik Ruysch[1638-1731]was back in the 17th century,one of the first to discover the lymphatic vessels and associated lymph *** exposed the inguinal lymph nodes during dissection of a human cadaver;however,most of his observations were based on anatomical dissections of living animals(1).He had a wide reputation for his exceptional anatomical dissection *** performed an anatomical dissection of a horse three hours after the animal had eaten,and noted‘white vessels’with a milky content in the mesentery of the *** prepared these lymphatic vessels and after tying off on two sides,he filled a vessel with air using a fine *** observed‘crescent-shaped’valves in the lymphatic vessels and concluded that the flow of lymph was directed into one direction(2).

关键词： Dutch white exceptional

Liver anatomy by Francis Glisson

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Hepatobiliary surgery and Nutrition 2022年第4期11卷 502-503页

作者： thom.s m.van gulik Department of surgery Amsterdam University Medical CentersUniversity of AmsterdamAmsterdamThe Netherlands

Francis Glisson(1598-1677)was born in Bristol and studied to become a doctor at Caius College,Cambridge,where he eventually was appointed as professor of *** wrote the first monograph on the anatomy of the liver in hi... 详细信息

关键词： anatomy College eventually

*** of Assisi receives the stigma on his liver

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Hepatobiliary surgery and Nutrition 2023年第3期12卷 300-301页

作者： thom.s m.van gulik Department of surgery Amsterdam University Medical CentersUniversity of AmsterdamAmsterdamThe Netherlands

A remarkable painting of *** of Assisi is on display in the Indianapolis museum of Art at Newfields,UsA,painted by the Italian master Pietro da Rimini around 1330(Figure 1)(1).The painting is entitled‘saint Francis receives the stigmata’,and depicts the saint experiencing a vision as he *** sees Christ,bearing the wounds from his crucifixion,flying with an angel-like creature called a *** wounds of Christ represent the four places where nails were driven through his hands and feet during his crucifixion,each denoting a stigma.A fifth stigma appears as a wound on the right side of his chest,where he was stabbed with a lance between the ribs by the Roman soldier who wanted to ascertain his death.

关键词： Italian Figure painting

Babylonian clay tablet of the liver

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Hepatobiliary surgery and Nutrition 2023年第1期12卷 1-2页

作者： thom.s m.van gulik Department of surgery Amsterdam University Medical CentersUniversity of AmsterdamAmsterdamThe Netherlands

The Babylonians were an ancient people living from approximately 2000 BC to 1600 BC in southern mesopotamia,a fertile region situated between the Tigris and Euphrates river,an area for the greater part corresponding with modern *** reached a high level of civilization with their own Akkadian language,writings and *** the realm of their religion,they worshipped a host of gods and goddesses,each with different names and distinct functions.

关键词： situated approximate realm

Couinaud’s corrosion casts of the liver

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Hepatobiliary surgery and Nutrition 2022年第2期11卷 174-175页

作者： thom.s m.van gulik Department of surgery Amsterdam University Medical CentersUniversity of AmsterdamAmsterdamThe Netherlands

Claude Couinaud[1922-2008],a French surgeon-anatomist,became famous for his classification of the segmental division of the *** defined each segment by its distinct portal venous anatomy and its intersegmental,watershed *** segment would function as an independent functional unit with its own biliary ductal system draining into the central bile *** from all segments is collected into the three main hepatic veins that drain into the caval vein.

关键词： drain watershed Blood

Tumor progression in two-stage liver resections—is the shorter inter-stage period in associated liver partition and portal vein ligation for staged hepatectomy (ALPPs) of benefit to the patient?

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Hepatobiliary surgery and Nutrition 2019年第3期8卷 316-317页

作者： Ernesto sparrelid thom.s m.van gulik Division of surgery Department of Clinical ScienceIntervention and TechnologyKarolinska InstitutetKarolinska University HospitalStockholmSweden Department of surgery Amsterdam UMCUniversity of AmsterdamAmsterdamThe Netherlands

A two-stage liver resection is a surgical option in patients with bilobar liver tumors in whom a single procedure is not feasible because of insufficient functional volume of the future liver *** use of unilateral portal vein occlusion,such as portal vein embolization,induce hypertrophy of the future liver remnant in order to enable subsequent *** enhancement of tumor growth along with the hypertrophy response has raised concerns regarding oncological outcomes of the procedure.

关键词： occlusion portal partition

Pathway engineering strategies for improved product yield in yeast-based industrial ethanol production

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synthetic and systems Biotechnology 2022年第1期7卷 554-566页

作者： Aafke C.A.van Aalsta sophie C.de Valk Walter m.van gulik mickel L.A.Jansen Jack T.Pronka Robert mans Department of Biotechnology Delft University of TechnologyVan der Maasweg 92629HZ Delftthe Netherlands Dsm Biotechnology Centre Alexander Fleminglaan 12613AX Delftthe Netherlands

Product yield on carbohydrate feedstocks is a key performance indicator for industrial ethanol production with the yeast saccharomyces *** paper reviews pathway engineering strategies for improving ethanol yield on glucose and/or sucrose in anaerobic cultures of this yeast by altering the ratio of ethanol production,yeast growth and glycerol *** attention is paid to strategies aimed at altering energy coupling of alcoholic fermentation and to strategies for altering redox-cofactor coupling in carbon and nitrogen meta-bolism that aim to reduce or eliminate the role of glycerol formation in anaerobic redox *** addition to providing an overview of scientific advances we discuss context dependency,theoretical impact and potential for industrial application of different proposed and developed strategies.

关键词： saccharomyces cerevisiae synthetic biology metabolic engineering Biofuels Redox metabolism Energy metabolism

short-and long-term outcomes after hemihepatectomy for perihilar cholangiocarcinoma:does left or right side matter?

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Hepatobiliary surgery and Nutrition 2021年第2期10卷 154-162,I0001,I0002页

作者： Lotte C.Franken Pim B.Olthof Joris I.Erdmann Otto m.van Delden Joanne Verheij marc G.Besselink Olivier R.Busch thom.s m.van gulik Department of surgery Cancer Center AmsterdamAmsterdam UMCUniversity of AmsterdamThe Netherlands Department of surgery Erasmus Medical CenterErasmus UniversityRotterdamThe Netherlands Department of Radiology and Nuclear medicine Amsterdam UMCUniversity of AmsterdamAmsterdamThe Netherlands Department of Pathology Cancer Center AmsterdamAmsterdam UMCUniversity of AmsterdamAmsterdamThe Netherlands

Background:The only potentially curative option for patients with perihilar cholangiocarcinoma(PHC)is resection,typically an extrahepatic bile duct resection in combination with(extended)liver *** such as bile leakage and liver failure have been suggested to be more common after right-sided resections compared to left-sided resections,whilst superior oncological outcomes have been reported after right-sided ***,data on outcomes after right-sided or left-sided liver resections in PHC are ***,we aimed to investigate short-and long-term outcomes after left and right hemihepatectomy in patients with ***:In this retrospective study,patients undergoing major liver resection for suspected PHC in a tertiary center between 2000-2018 were *** who had undergone left-sided resections were compared to patients with right-sided resections in terms of complications(90-day mortality,overall and severe morbidity and specific complications).For long-term outcomes,only patients with pathologically proven PHC were included in the survival ***:A total of 178 patients undergoing hemihepatectomy for suspected PHC were analysed,including 76 left-sided and 102 right-sided *** 90-day mortality was 14%(24 out of 178),with no significant difference after left-sided resection(11%;8 out of 76)versus right-sided resection(16%;16 out of 102)(P=0.319).severe morbidity(Clavein Dindo≥3)was also comparable in both groups:54%versus 61%(P=0.361).No differences in specific complications including bile leakage were observed,although liver failure appeared to occur more frequently after right hemihepatectomy(22%versus 11%,P=0.052).Five-year overall survival for pathologically proven PHC,excluding in-hospital mortality,did not differ;43.7%after left-sided resection *** 38.2%after right-sided resection(P=0.553).Conclusions:Both short-and long-term outcomes between patients undergoing left and right hemihepate

关键词： Perihilar cholangiocarcinoma(PHC) hepatectomy outcomes mortality survival