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Minor fibrillar collagens,variable regions alternative splicing,intrinsic disorder,and tyrosine sulfation

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Protein & Cell 2012年第6期3卷 419-433页

作者： Ming Fang Reed Jacob Owen McDougal Julia thom Oxford Department of Biological sciences Boise State UniversityBoiseID 83725USA Department of Chemistry and Biochemistry Boise State UniversityBoiseID 83725USA Biomolecular Research Center Boise State UniversityBoiseID 83725USA

Minor fibrillar collagen types V and XI,are those less abundant than the fibrillar collagen types I,II and *** alpha chains share a high degree of similarity with respect to protein sequence in all domains except the variable *** variation and,in some cases,extensive alternative splicing contribute to the unique sequence characteristics of the variable *** unique expression patterns in tissues exist,the functions and biological relevance of the variable regions have not been *** this review,we summarize the existing knowledge about expression patterns and biological functions of the collagen types V and XI alpha *** of biochemical similarities among the peptides encoded by each exon of the variable region suggests the potential for a shared *** alternative splicing,conservation of biochemical characteristics in light of low sequence conservation,and evidence for intrinsic disorder,suggest modulation of binding events between the surface of collagen fibrils and surrounding extracellular molecules as a shared function.

关键词： minor fibrillar collagens variable regions alternative splicing fibrillogenesis heparan sulfate binding sites intrinsic disorder tyrosine sulfation

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seasonal biostabilization and erosion behavior of fluvial biofilms under different hydrodynamic and light conditions

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International Journal of sediment Research 2015年第4期30卷 273-284页

作者： Moritz thom Holger schmidt sabine U.Gerbersdorf silke Wieprecht Institute for Modelling Hydraulic and environmental systems Department of Hydraulic Engineering and Water Resources ManagementUniversity of Stuttgart

Biofilm growth may considerably influence the erodibility of river bed sediments and is,thus,an important morphological *** extent to which the sediment is stabilized depends on many environmental conditions and even though it is well accepted that these conditions are responsible for the variance of results obtained from field studies,little is known about their impact on *** this article,the results from five long-term(4-8 weeks) experiments are presented,investigating the impact of hydrodynamics and light intensity on biostabilization in different *** are cultivated in a sophisticated setup of six identical straight flumes by circulating natural river water over glass beads with diameters between 0.1 and 0.2 *** the course of the experiments biofilm samples are eroded regularly to determine the critical shear stress and to learn more about the erosional behavior of biostabilized *** results indicate a large variance of biostabilization between seasons with the highest values in spring and the lowest in late ***,this is explained by the differences in biofilm growth and composition resulting in mechanically diverse responses to the increased bed shear *** bed shear stress during cultivation delayed biofilm growth possibly due to reduced net attachment and growth of formerly advected microbes on the sediment ***,no substantial biostabilization effect is detected in experiments where biofilms are cultivated in *** focus in this article is the analysis of the mechanical behavior observed during erosion of the biofilms,that is shown to be an important aspect for the understanding of freshwater biostabilization caused by young growing biofilms.

关键词： Biofilm Critical bed shear stress erosion mechanisms environmental conditions seasonal variations

Physiology and health assessment,risk balance,and model for endstage liver disease scores:Postoperative outcome of liver transplantation

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World Journal of Transplantation 2025年第1期15卷 86-94页

作者： Raquel Hohenreuther Andresa thom.silveira edison Moraes Rodrigues Filho Anderson Garcez Bruna Goularth lacerda sabrina Alves Fernandes Claudio Augusto Marroni Postgraduate Program in Hepatology Universidade Federal de Ciências da Saúde de Porto AlegrePorto Alegre 90050-170Brazil Department of Intensive Medicine Hospital de Clínicas de Porto AlegrePorto Alegre 90035-903Brazil Department of Public Health University of Vale do Rio dos SinosSao Leopoldo 93022-750Brazil

BACKGROUND liver transplantation aims to increase the survival of patients with end-stage liver diseases and improve their quality of *** number of organs available for transplantation is lower than the *** provide fair organ distribution,predictive mortality scores have been *** To compare the Acute Physiology and Chronic Health evaluation IV(APACHe IV),balance of risk(BAR),and model for end-stage liver disease(MelD)scores as predictors of *** Retrospective cohort study,which included 283 adult patients in the postoperative period of deceased donor liver transplantation from 2014 to *** The transplant recipients were mainly male,with a mean age of 58.1 *** were mostly male,with a mean age of 41.6 *** median cold ischemia time was 3.1 hours,and the median intensive care unit stay was 5 *** APACHe IV,a mean of 59.6 was found,BAR 10.7,and MelD *** 28-day mortality rate was 9.5%,and at 90 days,it was 3.5%.The 28-day mortality prediction for APACHe IV was very good[area under the curve(AUC):0.85,PelD(AUC:0.66,Ps,the data for APACHe IV were very good(AUC:0.80,Perate for BAR and MelD,respectively,(AUC:0.66,Pll showed good discrimination between deaths and *** for the best value for liver transplantation,it was significant only for APACHe IV(PlUsION The APACHe IV assessment score was more accurate than BAR and MelD in predicting mortality in deceased donor liver transplant recipients.

关键词： liver transplantation Acute physiology and chronic health evaluation IV Balance of risk Model for end-stage liver disease Mortality Intensive care unit

Finite element analysis of overlay incorporating stress absorbing membrane interlayers against reflective cracking

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Journal of Modern Transportation 2014年第2期22卷 104-111页

作者： O.M.Ogundipe N.H.thom A.C.Collop Civil engineering Department Ekiti State University NTeC University of Nottingham Faculty of Technology De-Montfort University

A wheel tracking test was modelled to gain better understanding of the deflection and stress-strain distribution in an overlaid cracked pavements with and without membrane interlayer （sAMI）. For this purpose, commercial finite element software Abaqus 6.7-1 was used. Two different models were considered, one incorporating stress absorbing membrane interlayers （sAMIs） and the other without sAMI. In the study, full bond condition was assumed for the boundaries between the layers, and a linear elastic model was used for the analysis. The results show that introduction of sAMI caused greater deflection of the pavement. It is found that although with sAMIs, low stiffness is required, a very low stiffness may yield undesirable results. The results show that the introduction of sAMIs results in high strain concentration around the crack region, whilst the strain in the overlay is smaller than the values predicted in the models without sAMIs.

关键词： Overlay Interlayers Crack - strain stress

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The Central Axis of Beijing and Chinese Wisdom

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China Today 2023年第1期72卷 42-45页

作者： lARs UlRIK thom Beijing Postcards

A foreigner’s probe into the cultural connotations and origins of the Central Axis of *** pioneering journalist eliza scidmore,National Geographic’s first official female writer,photographer,and board member,visited... 详细信息

关键词： Axis Central journal

14 Guides to Becoming a successful leader

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技术经济与管理研究 2000年第3期 9-10页

作者： Bruce e.thom,Q.C. 加拿大埃德蒙顿市市长

1995年，笔者曾在这份杂志上发表过一篇文章，内容是关于城市管理者如何越过政府重组这一“丛林”的20条指针。本文将要阐述的是第二道“丛林”——成为一个成功领导者的艰难历程。在跨越这一历程的过程中，以下14条指针也许会对你有所... 详细信息

1995年，笔者曾在这份杂志上发表过一篇文章，内容是关于城市管理者如何越过政府重组这一“丛林”的20条指针。本文将要阐述的是第二道“丛林”——成为一个成功领导者的艰难历程。在跨越这一历程的过程中，以下14条指针也许会对你有所帮助。需要说明的是，没有人能够告诉你走向成功的全部真谛。但是你可以从成功的领导者那里取得通常的经验，也可以了解到一些影响取得成功的禁忌……

关键词：领导者指针政府重组历程丛林管理者经验禁忌城市

le reflet de la sagesse chinoise

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今日中国（法文版） 2022年第8期60卷 34-36页

作者： lARs UlRIK thom Beijing Postcards

eliza scidmore,une journaliste du National Geographie,avait visité Beijing en *** n'avait pas tari d’éloges sur 20 pages pour présenter Beijing sous tous les *** que j'ai trouvé curieux,c'est que nulle part ell... 详细信息

关键词： let journal pour

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成为一个成功领导者的14条指针

技术经济与管理研究 2000年第3期 11-12页

作者： Bruce e.thom Q.C. 李岩

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Acute bacterial infection negatively impacts cancer specific survival of colorectal cancer patients

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World Journal of Gastroenterology 2014年第38期20卷 13930-13935页

作者： Regina Attiê ludmilla thomé Domingos Chinen eliane Muta Yoshioka Michele Cristina F silva Vladmir Cláudio Cordeiro de lima Pharmacy Department A.C.Camargo Cancer Center Medical Oncology Department International Research Center Research Department A.C.Camargo Cancer Center

AIM:To assess the impact of bacterial infections on cancer-specific survival in patients with colorectal cancer. MeTHODs:This was a retrospective cohort study of colorectal cancer patients treated at the A.C. Camargo Cancer Center between January 2006 and April 2010. The presence of bacterial infection during cancer treatment,or up to one year after,was confirmed by laboratory tests or by the physician. Infections of the urinary,respiratory or digestive tracts,bloodstream,skin or surgical site were defined by testing within a single laboratory. Criteria for exclusion from the study were:chronically immunosuppressed patients;transplant patients(due to chronic immunosuppression);human immunodeficiency virus carriers;chronic use of corticosteroids or other immunosuppressive drugs;patients with autoimmune disease or primary immunodeficiency;known viral or parasitic infections. Patients with infections that did not require hospitalization were not included in the study because of the difficulty of collecting and tracking data related to infectious processes. In addition,patients hospitalized for pulmonary thromboembolism,stroke,acute myocardial infarction,uncontrolled diabetes,malignant hypercalcemia or other serious non-infectious complications not directly related to infection were also excluded. survival curves were plotted using the Kaplan-Meier method,and logrank tests(univariate analysis) and a Cox test assuming a proportional hazards model(multivariate analysis) were performed to examine associations between clinical history and characteristics of infection with cancer-specific survival. ResUlTs:One-hundred and six patients with colorectal cancer were divided into two groups based on the presence or absence of bacterial infection. Patient ages ranged from 23 to 91 years,with a median of 55 years. The majority of patients were male(57/106,53.77%) with stage Ⅲ colorectal cancer(45/106,44.11%). A total of 86 bacteriologic events were recorded. Results indicate that t

关键词： Colorectal cancer Bacterial infections survival