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世界核心医学期刊文摘（妇产科学分册） 2006年第1期2卷 21-22页

作者： Spong C.Y. Meis P.J. thom e.a. 高雪莲 National Institute of Child Health and Human Development Bethesda MD United StatesDr.

Preterm birth occurs in 1 of 8 pregnancies and may result in significant morbidity and mortality. 17- alpha hydroxyprogesterone caproate (17- OHP caproate) has been found to be efficacious in reducing the risk of subsequent preterm delivery in women who have had a previous spontaneous preterm birth (sPTB). This analysis was undertaken to e.a.uate if 17- OHP caproate the.a.y works preferentially depending on the gestational age.a. previous spontaneous delivery. We hypothesized that treatment with 17- OHP caproate is more effective in prolonging pregnancy depending on the gestational age of the earliest previous preterm birth (20- 27.9, 28- 33.9 vs 34- 36.9 weeks). Study design: This was a secondary analysis of 459 women with a previous sPTB enrolled in a randomized controlled trial e.a.uating 17- OHP caproate versus placebo. effectiveness of 17- OHP caproate for pregnancy prolongation was e.a.uated based on gestational age.a. earliest previous delivery according to clinically rele.a.t groupings (20- 27.9, 28- 33.9, and 34- 36.9 weeks). Statistical analysis included the chi-square, Fisher e.a.t, and Kruskal-Wallis tests, logistic regression, and survival analysis using proportional hazards. Results: Gestational age.a. earliest previous delivery was similar between women treated with 17- OHP caproate or placebo (P = .1). Women with earliest delivery at 20 to 27.9 weeks and at 28 to 33.9 weeks delivered at significantly more.a.vanced gestational age if treated with 17- OHP caproate than with placebo (median 37.3 vs 35.4 weeks, P = .046 and 38.0 vs 36.7 weeks, P = .004, respectively) and were less likely to deliver eeks (42% vs 63% , P = .026 and 34% vs 56% , P = .005, respectively). Those with earliest delivery at 34 to 36.9 weeks were not significantly different between 17- OHP caproate or control. Conclusion: 17- OHP caproate the.a.y given to prevent recurrent PTB is associated with a prolongation of pregnancy ove.a.l, and especially for women with a previous sp

关键词：分娩孕周自然早产 Kruskal-Wallis检验复发性羟孕酮 logistic回归安慰剂治疗预防随机对照试验 Fisher

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中孕期泌尿生殖系统沙眼衣原体感染:与细菌性阴道病和滴虫性阴道炎妇女其后发生早产的相关性

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世界核心医学期刊文摘（妇产科学分册） 2006年第8期2卷 22-22页

作者： Andrews W.W. Kle.a.off M.A. thom e.a. 吕涛 De.a.tment of Obstetrics and Gynecology University of Alabama at Birmingham Birmingham AL United States Dr.

Objective: The objective of the study was to estimate whether midpregnancy genitourinary tract infection with Chlamydia trachomatis is associated with an increased risk of subsequent preterm delivery. Study design: Infection with C. trachomatis was determined using a ligase chain reaction assay (performed in batch after delivery) of voided urine samples collected at the randomization visit (160/7 to 236/7 weeks’ gestation) and the follow-up visit (240/7 to 296/7 weeks) among 2470 gravide women with bacterial vaginosis or Trichomonas vaginalis infection enrolled in 2 multicenter randomized antibiotic treatment trials (metronidazole versus. placebo). Results: The ove.a.l pre.a.ence of genitourinary tract C. trachomatis infection at both visits was 10% . Preterm delivery less than 37 weeks’ or less than 35 weeks’ gestational age was not associated with the presence or absence of C. trachomatis infection at either the randomization (less than 37 weeks: 14% versus 13% , P=.58; less than 35 weeks: 6.4% versus 5.5% , P=.55) or the follow-up visit (less than 37 weeks: 13% versus 11% , P=.33; less than 35 weeks: 4.4% versus 3.7, P=.62). Treatment with an antibiotic effective.a.ainst chlamydia infection was not associated with a statistically significant difference in preterm delivery. Conclusion: In this secondary analysis, midtrimester chlamydia infection was not associated with an increased risk of preterm birth. Treatment of chlamydia was not associated with a decreased frequency of preterm birth.

关键词：细菌性阴道病沙眼衣原体感染滴虫性阴道炎泌尿生殖系统中孕期早产率连接酶链反应临床试验总

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14 Guides to Becoming a Successful Leader

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技术经济与管理研究 2000年第3期 9-10页

作者： Bruce e.thom,Q.C. 加拿大埃德蒙顿市市长

1995年，笔者曾在这份杂志上发表过一篇文章，内容是关于城市管理者如何越过政府重组这一“丛林”的20条指针。本文将要阐述的是第二道“丛林”——成为一个成功领导者的艰难历程。在跨越这一历程的过程中，以下14条指针也许会对你有所... 详细信息

1995年，笔者曾在这份杂志上发表过一篇文章，内容是关于城市管理者如何越过政府重组这一“丛林”的20条指针。本文将要阐述的是第二道“丛林”——成为一个成功领导者的艰难历程。在跨越这一历程的过程中，以下14条指针也许会对你有所帮助。需要说明的是，没有人能够告诉你走向成功的全部真谛。但是你可以从成功的领导者那里取得通常的经验，也可以了解到一些影响取得成功的禁忌……

关键词：领导者指针政府重组历程丛林管理者经验禁忌城市

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成为一个成功领导者的14条指针

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技术经济与管理研究 2000年第3期 11-12页

作者： Bruce e.thom Q.C. 李岩加拿大埃德蒙顿市市长

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Tierexperimentelle Untersuchung zur effektivit tder transarteriellen Chemoembolisation unter einsatz von Poly-Laktide-co-Glykolide-Mikrosph ren

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Journal of Huazhong University of Science.a.d Technology(Medical Sciences) 2002年第4期22卷 346-349页

作者：钱骏 Rntge.a.teilung

e.a.uierung der effektivit t von Poly- L aktide- co- Glykolide (PL CG ) - Mikrosph ren als em bolisationsm aterial in der transarteriellen Chem oem bolisation(TACe) im tierexperimentellen *** m nnlichen ACI- Ratten(n=11) erfolgte die Im plantation eines soliden Morris He.a.omas(1m m3) subkapsul r in den linken L eberlappen. 13Tage nach Implan- tation wurden die Tumorvolumina kernspintom ographisch bestim *** Tiere wurden in The.a. piegruppe (n =4 ) und Kontrollgruppe (n=7) geteilt. Nach L aparotomie und retrograder Ka- theterisierung der Arteria gastroduode.a.is wurden 4 0 mg PL CG- Mikrosph ren und 0 ,0 5 m g Mit- omycin in The.a.iegruppe,1,5 ml 0 ,9% Kochsalzl sung in Kontrollgruppe zum Vergleich *** effektivit tsbeurteilung der beiden Methoden erfolgte14 Tage nach Katheter- isierung eine erneute kernspintomographische Volumenbestimm ung der Tum *** deutliche Tumorvolumenzunahme von2 7,12 fache in Kontrollgruppe wurde im Beobachtungszeitraum gese- *** Vergleich zur Kontrollgruppe zeigte die The.a.iegruppe eine sehr geringere Tumorvolu- menzunahme von 2 ,87fache im Beobachtungszeitraum . Die Tum orvolumenzunahm e zwischen der beiden Gruppen zeigten beim T- Test einen signifikanten U nterschied (Pes L ebertum ors wurde unter einsatz von PL CG- Mikrosph ren in der TACe im tierexperi- mentellen Modell deutlich gehemmt.

关键词： L eber Tumor TACe PL CG Mikrosph ren

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Impacts of land use.a.d land cover changes on hydrological processes and sediment yield determined using the SWAT model

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International Journal of Sediment Research 2022年第1期37卷 54-69页

作者： edivaldo Afonso de Oliveira Serr?o Madson Tavares Silva thomás Rocha Ferreira Lore.a.Concei??o Paiva de.a.aide Cleber Assis dos Santos Aline Maria Meiguins de Lima Vicente de Paulo Rodrigues da Silva Francisco de.a.sis Salviano de Sousa Denis José Cardoso Gomes Academic Unit of Atmospheric Sciences Federal University of Campina Grande De.a.tment of Physics Center for Natural and Exact Sciences Federal University of Santa Maria Institute of Technology Civil Engineering Graduate Program Federal University of Pará earth System Science Center National Institute of Space Research Institute of Geosciences Federal University of Pará

Land use.a.d land cover (LULC) changes strongly affect local hydrology and sediment *** current study focused on a basin in the Brazilian Amazon and had the following three objectives:(1) to perform an effective diagnosis of flow and sediment yield,(2) to e.a.uate the impacts of LULC changes over the last 40 years on the hydro-sedimentological variables,and (3) to investigate the impacts of the possible trends or breaking points in the flow,surface runoff,and sediment yield *** Soil and Water Assessment Tool (SWAT) model validation showed that the simulated results were consistent with the data measured in the dynamic reproduction of flow ***,changes in LULC altered surface runoff,sediment yield,and flow according to the Mann-Kendall and Pettitt non-parametric *** was also observed that the sub-basins in which pasture.a.d is predominant are more susceptible to increased surface runoff and sediment *** to trend and homogeneity tests,these sub-basins had break points in the time series of these *** the other hand,in the sub-basins whose land cover is predominantly forest,the time series is homogeneous and *** current study highlighted the impacts that 40 years of LULC changes in an Amazonian basin had on hydro-sedimentological variables,which,in turn,can play an important role in changing the hydrological cycle,consequently these changes can also impact diverse human activities in the region,such as agribusiness,livestock,energy production,food security,and public water ***,it is concluded that the SWAT model is a good estimator of hydro-sedimentological processes in Amazonian basins and can be used by decision makers in the management of water and environmental resources.

关键词： Hydrological modeling Sediment yield Amazon basin SWAT model

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跟大师学汽车造型 1-1

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2017年

作者：（美）汤姆·泰勒（thom Taylor）柯善军译

本书从汽车设计的历史讲起，介绍了绘画的基础知识和必会技能，涵盖了透视、比例、椭圆与轴线、投影、色彩等特别适用的技法，旨在让有志于从事汽车设计的读者迅速掌握汽车造型图的画法。

ISBN: (数字)9787111567721

ISBN: (纸本)9787111567721

关键词：汽车造型设计

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ID7 Isolated from Bauhinia varie.a.a Stem Inhibits Tumor Progression and Me.a.tatic Mechanisms of Triple Ne.a.ive Breast Cancer in Vivo

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Journal of Pharmacy and Pharmacology 2019年第7期7卷 368-384页

作者： Kamilla Monteiro dos Santos Izabe.a.Natalia Faria Gomes Re.a.o JoséSilva Oliveira Fernanda e.Pinto Bruno Oliveira Fabrício P.Batista Rafael Ce.a. Russo Chagas Hélio B.Santos Ralph G.thomé Wanderson Romao Rui Manuel Reis Maria Luiza Vile.a.Oliva Rosy Iara Maciel de.a.ambuja Ribeiro Laboratory of experimental Pathology Federal University of Sao Joao del-Rei(UFSJ)DivinópolisMGBrazil Josédo Rosário Vellano University UnifenasDivinópolisMGBrazil Molecular Oncology Research Center(CPOM) Barretos Cancer HospitalBarretosSPBrazil Petroleomic and Forensic Chemistry Laboratory Department of ChemistryFederal Institute of Espírito Santo(IFES)VitóriaESBrazil Chemistry De.a.tment Federal University of Sao PauloBrazil Tissue Processing Laboratory Federal University of Sao Joao del-Rei(UFSJ)DivinópolisMGBrazil Life.a.d Health Sciences Research Institute(ICVS) Medical SchoolUniversity of MinhoBragaPortugal 3ICVS/3B’s-PT Government Associate Laboratory GuimaraesBragaPortugal

Background:The breast cancer has been the most common form of cancer among *** triple ne.a.ive subtype represents 20%of all breast cancer cases in the world and is standing out by affecting young women and being *** main cause of death of patients with cancer is due to me.a.tasis,which can reach the liver and ***:The.a.tivities of ID7 fraction of the stems of Bauhinia varie.a.a *** breast cancer,lung me.a.tasis and liver inflammatory process were ***:ID7 was characterized by *** viability of murine mammary cells(4T1)treated with ID7 was assessed by MTT,trypan blue.a.d fluorescence.a.say and viability of BT-20,MDA-MB-231 and MCF-7 human breast cancer tumor lines by *** cell migration,invasion using matrigel and adhesion were *** expression of cell death proteins was quanitified by western blot and the ge.a.inases by *** ID7 activity of the tumor(4T1)and me.a.tatic progession in vivo was ***:ID7 reduced the 4T1 and MDA-MB-231viability and increased the late.a.optosis,inhibited the 4T1 migration and invasion,increased the 4T1 adhesion and decreased the secreted active ***7 also increased the expression of PARP,caspase-7 and caspase-8,RIP and *** vivo,the ID7 decreased the volume.a.d weight of the tumors and decreased lung me.a.tasis and inflammation in the *** characterization showed mainly the presence of oleic acid,myricetin,quercetin and kaempferol in ***:Thus,it was found that ID7 fraction exhibits selective.a.titumor and on the mechanisms of breast cancer me.a.tasis activity,preventing lung me.a.tasis and inflammation in the *** is suggested that fatty acids and flavonoids are corre.a.ed with such activities.

关键词： 4T1 cells MDA-MB-231 medicinal plants kaempferol ge.a.inases apoptosis cell viabilty in vivo

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An Optimal Control Approach to HIV Immunology

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Applied Mathe.a.ics 2015年第6期6卷 1115-1130页

作者： edilson F. Arruda Claudia M. Dias Camila V. de Magalh&atilde es Dayse H. Pastore Roberto C. A. thomé Hyun Mo Yang Instituto Alberto Luiz Coimbra de P&oacute s Gradua&ccedil &atilde o e Pesquisa de engenharia Universidade Federal do Rio de Janeiro Rio de Janeiro Brazil Instituto Multidisciplinar Universidade Federal Rural do Rio de Janeiro Nova Igua&ccedil u Brazil De.a.tamento de Matem&aacute tica Centro Federal de Educa&ccedil &atilde o Tecnol&oacute gica Celso Suckow da Fonseca Rio de Janeiro Brazil De.a.tamento de Matem&aacute tica Aplicada Universidade Estadual de Campinas Campinas Brazil

This paper introduces a mathe.a.ical model which describes the dynamics of the spread of HIV in the human body. This model is comprised of a system of ordinary differential equations that involve susceptible cells, infected cells, HIV, immune cells and immune.a.tive cells. The distinguishing feature in the proposed model with respect to other models in the lite.a.ure is that it takes into account cells that represent two distinct mechanisms of the immune system in the defense.a.ainst HIV: the non-HIV-activated cells and the HIV-activated cells. With a view at minimizing the side effects of a treatment that employs a drug combination designed to attack the HIV at various stages of its life cycle, we introduce control variables that represent the infected patient’s medication. The optimal control rule that prescribes the medication for a given time period is obtained by means of Pontryagin’s Maximum Principle.

关键词： HIV Mathe.a.ical Modelling Optimal Control Pontryagin’s Maximum Principle

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视网膜病变、视网膜微血管异常与脑卒中、脑血管病的关系

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中华高血压杂志 2016年第11期24卷 1069-1069页

作者：刘莉叶鹏 Hughes AD Falaschetti e Witt N Wijetunge S thom SA Tillin T Aldington SJ Chaturvedi N

视网膜循环异常可能与脑血管病有关。该研究基于英国的三民族人口的基础队列调查了视网膜微血管异常与脑卒中和亚临床脑梗死及脑白质病变之间的相关性。方法：纳入1185名受试者[年龄（68.8±6.1）岁,77%为男性]进行视网膜成像和脑磁共... 详细信息

视网膜循环异常可能与脑血管病有关。该研究基于英国的三民族人口的基础队列调查了视网膜微血管异常与脑卒中和亚临床脑梗死及脑白质病变之间的相关性。方法：纳入1185名受试者[年龄（68.8±6.1）岁,77%为男性]进行视网膜成像和脑磁共振成像。利用磁共振成像识别脑梗死和脑白质高信号,对视网膜病变进行分级,并测量视网膜血管参数。

关键词：视网膜微血管视网膜病变脑血管病视网膜血管脑白质病变视网膜循环动脉直径亚临床视网膜成像磁共振成像

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