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细胞色素c在咔唑修饰的金电极上的直接电化学

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应用化学 1993年第4期10卷 82-83页

作者：周成立曲晓刚陆天虹董绍俊 therese m.cotton 中国科学院长春应用化学研究所电分析化学开放实验室 Department of Chemistry Iowa State UniversityAmesIowa 50011 U.S.A.

在生物体内,细胞色素c是一种电子载体,它能进行可逆的氧化还原反应,但在金属电极上的电化学反应却不可逆。1977年,Hill研究组发现,在4,4′-联吡啶存在时,细胞色素c在金电极上能进行准可逆的电化学反应。4,4′-联吡啶在细胞色素c电化学... 详细信息

在生物体内,细胞色素c是一种电子载体,它能进行可逆的氧化还原反应,但在金属电极上的电化学反应却不可逆。1977年,Hill研究组发现,在4,4′-联吡啶存在时,细胞色素c在金电极上能进行准可逆的电化学反应。4,4′-联吡啶在细胞色素c电化学反应的过程中不起氧化还原反应而被称为促进剂。Hill等对50多种有机化合物的促进作用进行评价后提出,能加速细胞色素c电化学反应速率的促进剂分子至少应具有两个功能团。

关键词：细胞色素咔唑修饰金电极

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细胞色素C电化学反应的静电作用模型

分析测试通报 1992年第5期11卷 24-27页

作者：陆天虹周成立叶淑玉于秀娟董绍俊 therese m.cotton 中国科学院长春应用化学研究所 Department of Chemistry Iowa State UniversityAmesIowa 50011U.S.A.

首次发现,简单的阴离子Ⅰ^-是细胞色素c电化学反应的良好促进剂。在碘离子修饰的金电极上能观察到细胞色素c的准可逆电化学反应。根据细胞色素c的结构特点和碘离子的吸附特性,提出了一个以静电作用为基础的细胞色素c的电化学反应的模型。

关键词：碘离子细胞色素C 静电作用

Abundance of volatile organic compounds in white ash phloem and emerald ash borer larval frass does not attract Tetrastichus planipennisi in a Y-tube olfactometer

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Insect Science 2016年第5期23卷 712-719页

作者： Yigen Chen michael D. Ulyshen therese m. Poland Department of Entomology Michigan State University 288 Farm Lane Natural Science Building Room 243 East Lansing MI 48824 Department of Entomology and Nematology University of California One Shields Avenue Davis CA 95616 USDA Forest Service 320 Green Street Athens GA 30602 USDA Forest Service 3101 Technology Blvd. Suite F Lansing M148910 USA

many natural enemies employ plant- and/or herbivore-derived signals for host/prey location. The larval parasitoid Tetrastichus planipennisi Yang （Hymenoptera： Eulophidae） is 1 of 3 biocontrol agents currently being released in an effort to control the emerald ash borer （EAB）, Agrilus planipennis Fairmaire （Coloeptera： Burprestidae） in North America. To enhance its efficiency, allelochemicals that attract it need to be assessed. In this study, ash phloem volatile organic compounds （VOCs） of black, green, and white ash, and EAB larval frass were compared. Foraging behavior of T. planipennisi females in response to VOCs of white ash or frass from EAB larvae feeding on white ash phloem was tested using a Y-tube olfactometer. Results indicated that the 3 ash species had similar VOC profiles. EAB larval frass generally contained greater levels of VOCs than phloem. Factor analysis indicated that the 11 VOCs could be broadly divided into 2 groups, with c^-bisabolol, fl-caryophyllene, （E）-2-hexenal, （Z）-3-hexenal, limonene, methyl benzoate, methyl indole-3-acetic acid, methyl jasmonate, methyl salicylate as the first group and the rest （i.e., methyl linoleate and methyl linolenate） as a second. Abundance of VOCs in white ash phloem tissue and frass, nevertheless, did not attract T. planipennisi females. The concealed feeding of EAB larvae might explain the selection for detectable and reliable virbrational signals, instead of undetectable and relatively unreliable VOC cues from phloem and frass, in short-range foraging by T. planipennisi. Alternatively, it is possible that T. planipennisi is not amenable to the Y-tube olfactometer assay employed.

关键词： Agrilus planipennis biological control Fraxinus invasive species semiochemical

Degradation of superhydrophobic aluminium overhead line conductor surfaces

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High Voltage 2024年第4期9卷 763-772页

作者： Xu Zhang Chorphaka Plaengpraphan Chengxing Lian Wenyuan Li Qinghua Han Simon m.Rowland Ian cotton Qi Li School of Engineering University of WarwickCoventryUK State Key Laboratory of Electrical Insulation and Power Equipment Xi'an Jiaotong UniversityXi'anChina School of Engineering University of ManchesterManchesterUK School of Engineering Imperial College LondonLondonUK Electrical Engineering School Chongqing UniversityChongqingChina

It has been shown that noise emissions from HV overhead line conductors can be reduced under rain conditions by making their surfaces *** working environment makes ensuring the longevity of any treatment a major *** degradation of various superhydrophobic surfaces generated by applying a superhydrophobic coating and patterning microscale channels is assessed under an AC electric field(18 kV/cm)with continuous water *** examining the droplet distribution on the surfaces during the degradation and the surface roughness before and after degra-dation,the authors demonstrate that no water droplets were found on the microscale patterned surface,but droplets were formed on the coated surface after *** surface roughness reduction of the coated surface and microscale patterned surface was 29.8% and 11.3%,respectively,indicating that the microscale patterned surface has better durability than the superhydrophobic coating under the AC electric stress.

关键词： coating roughness surface

Experimental verification of the potential of superhydrophobic surfaces in reducing audible noise on HVAC overhead line conductors

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High Voltage 2022年第4期7卷 692-704页

作者： Xu Zhang Ian cotton Qi Li Simon mRowland Christopher Emersic Chengxing Lian Wenyuan Li Department of Electrical and Electronic Engineering The University of ManchesterManchesterUK School of Electrical Engineering Chongqing UniversityChongqingChina

Overhead line conductors can generate audible noise across a wide frequency spectrum as a result of elevated electric fields at the conductor *** fields are enhanced by the presence of surface defects,insects,water drops and *** this paper,the impact of a superhydrophobic coating on the audible noise produced by an overhead line conductor is *** levels from a conductor coated with a superhydrophobic coating were compared to those from a bare conductor in a semi-anechoic *** conductors were energised at voltages to provide surface electric fields ranging from 6 kV/cm to 21 kV/cm(rms).With a continuous water spray system depositing droplets on the conductor surface,the frequency domain sound pressure level,overall sound pressure levels and corona discharge magnitude were *** is demonstrated that the use of a superhydrophobic coating reduced audible noise levels and corona discharge magnitude,especially at electric fields above 14 kV/*** image analysis suggests that the water drop size distribution and the position of surface droplets on the conductor circumference play an important role in the magnitude of audible noise.

关键词： coating surface potential

Physical activity, obesity and gastroesophageal reflux disease in the general population

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World Journal of Gastroenterology 2012年第28期18卷 3710-3714页

作者： therese Djrv Anna Wikman Helena Nordenstedt Asif Johar Jesper Lagergren Pernilla Lagergren Unit of Upper Gastrointestinal Research Department of Molecular Medicine and Surgery Karolinska Institutet SE-17176 Stockholm Sweden Jesper Lagergren Division of Cancer Studies King's College London London WC2R 2LS United Kingdom

AIm: To clarify the association between physical activity and gastroesophageal reflux disease (GERD) in nonobese and obese people. mETHODS: A Swedish population-based cross-sectional survey was conducted. Participants aged 40-79 years were randomly selected from the Swedish Registry of the Total Population. Data on physical activity, GERD, body mass index (BmI) and the covariates age, gender, comorbidity, education, sleeping problems, and tobacco smoking were obtained using validated questionnaires. GERD was self-reported and defined as heartburn or regurgitation at least once weekly, and having at least moderate problems from such symptoms. Frequency of physical activity was categorized into three groups: (1) "high" (several times/week); (2) "intermediate" (approximately once weekly); and (3) "low" (1-3 times/mo or less). Analyses were stratified for participants with "normal weight" (BmI m 2 ), "overweight" (BmI 25 to ≤ 30 kg/m 2 ) and "obese" (BmI > 30 kg/m 2 ). multivariate logistic regression was used to calculate odds ratios (ORs) with 95% confidence intervals (CIs), adjusted for potential confounding by covariates. RESULTS: Of 6969 eligible and randomly selected individuals, 4910 (70.5%) participated. High frequency of physical activity was reported by 2463 (50%) participants, GERD was identified in 472 (10%) participants, and obesity was found in 680 (14%). There were 226 (5%) individuals with missing information about BmI. Normal weight, overweight and obese participants were similar regarding distribution of gender and tobacco smoking status, while obese participants were on average slightly older, had fewer years of education, more comorbidity, slightly more sleeping problems, lower frequency of physical activity, and higher occurrence of GERD. Among the 2146 normal-weight participants, crude point estimates indicated a decreased risk of GERD among individuals with high frequency of physical activity (OR: 0.59, 95% CI: 0.39-0.89), compared to low

关键词： Physical exercise Gastroesophageal reflux disease Population-based study Risk factor Body mass index Obesity

细胞色素c突变体F82H的表面增强拉曼和电化学研究

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电化学 2001年第1期7卷 37-40页

作者：郑军伟顾仁敖陆天虹 George Chumanov therese cotton 苏州大学化学系中国科学院长春应用化学研究所 Dept.of Chem. Iowa State Univ.AmesIA50011USA

应用表面增强拉曼光谱和循环伏安法研究了细胞色素c及其突变体F82H的氧化还原性质 .结果表明苯丙氨酸对组氨酸的取代使得蛋白质结构更为稳定 .相对于原体蛋白质 ,突变体的氧化还原电位向负电位方向移动 ,这被归因于由氧化还原过程中伴... 详细信息

应用表面增强拉曼光谱和循环伏安法研究了细胞色素c及其突变体F82H的氧化还原性质 .结果表明苯丙氨酸对组氨酸的取代使得蛋白质结构更为稳定 .相对于原体蛋白质 ,突变体的氧化还原电位向负电位方向移动 ,这被归因于由氧化还原过程中伴随有配体转换反应影响所致 .

关键词：细胞色素c 突变体表面增强拉曼

Cryopreservation for delayed circulating tumor cell isolation is a valid strategy for prognostic association of circulating tumor cells in gastroesophageal cancer

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World Journal of Gastroenterology 2018年第7期24卷 810-818页

作者： Daniel Brungs David Lynch Alison WS Luk Elahe minaei marie Ranson morteza Aghmesheh Kara L Vine martin Carolan mouhannad Jaber Paul de Souza therese m Becker Illawarra Health and medical Research Institute University of WollongongWollongong 2500Australia School of Biological Sciences University of WollongongWollongong 2500Australia Illawarra Cancer Centre Wollongong HospitalWollongong 2500Australia CONCERT-Translational Cancer Research Centre New South Wales 2000Australia Centre for Circulating Tumor Cell Diagnostics and Research Ingham Institute for Applied Medical ResearchLiverpool HospitalSydney 2170Australia School of medicine University of Western SydneySydney 2170Australia South Western medical School University of New South WalesSydney 2170Australia

AIm To demonstrate the feasibility of cryopreservation of peripheral blood mononuclear cells(PBmCs) for prognostic circulating tumor cell(CTC) detection in gastroesophageal *** Using 7.5 m L blood samples collected in EDTA tubes from patients with gastroesopheagal adenocarcinoma, CTCs were isolated by epithelial cell adhesion molecule based immunomagnetic capture using the Iso Flux platform. Paired specimens taken during the same blood draw(n = 15) were used to compare number of CTCs isolated from fresh and cryopreserved PBmCs. Blood samples were processed within 24 h to recover the PBmC fraction, with PBmCs used for fresh analysis immediately processed for CTC isolation. Cryopreservation of PBmCs lasted from 2 wk to 25.2 mo(median 14.6 mo). CTCs isolated from pre-treatment cryopreserved PBmCs(n = 43) were examined for associations with clinicopathological variables and survival *** While there was a significant trend to a decrease in CTC numbers associated with cryopreserved specimens(mean number of CTCs 34.4 vs 51.5, P = 0.04), this was predominately in samples with a total CTC count of > 50, with low CTC count samples less affected(P = 0.06). There was no significant association between the duration of cryopreservation and number of CTCs. In cryopreserved PBmCs from patient samples prior to treatment, a high CTC count(> 17) was associated with poorer overall survival(OS)(n = 43, HR = 4.4, 95%CI: 1.7-11.7, P = 0.0013). In multivariate analysis, after controlling for sex, age, stage, ECOG performance status, and primary tumor location, a high CTC count remained significantly associated with a poorer OS(HR = 3.7, 95%CI: 1.2-12.4, P = 0.03). CONCLUSION PBmC cryopreservation for delayed CTC isolation is a valid strategy to assist with sample collection, transporting and processing.

关键词： Cryopreservation Circulating tumor cells Liquid biopsy Gastroesophageal cancer Gastric cancer

Autophagy is increased in cryptorchid testis resulting in abnormal spermatozoa

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Asian Journal of Andrology 2019年第6期21卷 570-576页

作者： marina G Yefimova Antoine Buschiazzo Agnes Burel marie-therese Lavault Celine Pimentel Guilhem Jouve Sylvie Jaillard Bernard Jegou Nicolas Bourmeyster Celia Ravel Univ Rennes CHU RennesLaboratoire de Biologie de la Reproduction-CECOSInsermEH ESPIrset(Institut de recherche en santeenvironnement et travail)-UMR_S 1085Rennes F-35000France Sechenov Institute of Evolutionary Physiology and Biochemistry Russian Academy of Sciences194223 St-PetersburgRussia Univ Rennes Biosit Platform-MRICRennes 35000France Univ Rennes CHU RennesDepartment of Gynecology Obstetric and Human ReproductionRennes 35000France Univ Rennes CHU RennesDepartment of CytogeneticIrset(Institute for Environmental and Occupational Health)-UMR_S 1085Rennes 35000France Univ Rennes InsermEH ESPIrset(Institute for Environmental and Occupational Health)-UMR_S 1085Rennes F-35000France University of Poitiers-CHU Poitiers STIM ERL 7003 CNRSPoitiers 86021France

Autophagy is invoIved in spermatogenesis by regulating germ cell *** catabolic process increases with hyperthermic conditions to prevent the accumulation of damaged *** is associated with impairment of germ cell maturation revealed by the presence of immature forms of sperm cells in *** aim of the present study was to evaluate the status of autophagy in sperm cells from cryptorchid *** samples of cryptorchid patients and normozoospermic controls were analyzed by immuno cytochemistry and electron *** protei ns,autophagy-related protein 9(ATG9)and microtubule-associated protein,lA/lB-light chain 3(LC3)were localized by immunocytochemistry on the acrosome and on the equatorial segment of sperm ***3 was also detected in the midpiece of cryptorchid sperm *** substrate p62 protein was present in the acrosome and in the postequatorial segment of sperm in control samples,but not in the cryptorchid *** electron microscopy revealed double-membrane-limited autophagosomes in postequatorial part of spermatozoa head and midpiece in cryptorchid *** degraded mitochondria were frequently discerned in autophagic *** conclusion,autophagy is increased in sperm cells from patients with cryptorchid history comparatively to *** work provides insights into the role of autophagy in the maturation and survival of human male gametes in pathological ***,regulating autophagy could represent a potential way to improve sperm quality in cryptorchid men.

关键词： autophagy cryptorchidism mitophagy spermatozoa