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Bone mineral density in lifelong trained male football players compared with young and elderly untrained men

Journal of Sport and Health Science 2018年第2期7卷 159-168页

作者： Marie Hagman Eva Wulff Helge therese hornstrup Bjorn Fristrup Jens Jung Nielsen Niklas Rye Jorgensen Jesper Lovind Andersen Jorn Wulff Helge Peter Krustrup Department of Sports Science and Clinical Biomechanics SDU Sport and Health Sciences Cluster (SHSC) University of Southern Denmark Odense 3450 Denmark Department of Nutrition Exercise and Sports University of Copenhagen Copenhagen N 2200 Denmark Institute of Sports Medicine Copenhagen Bispebjerg Hospital Copenhagen NV 2400 Denmark Department of Clinical Biochemistry Rigshospitalet Research Center for Ageing and Osteoporosis Glostrup 2600 Denmark Center of Healthy Aging Department of Biomedical Sciences University of Copenhagen Copenhagen N 2200 Denmark Sport and Health Sciences University of Exeter Exeter EX1 2LU UK

Purpose: The purpose of the present controlled cross-sectional study was to investigate proximal femur and whole-body bone mineral density(BMD), as well as bone turnover profile, in lifelong trained elderly male football players and young elite football players compared with untrained age-matched ***: One hundred and forty healthy, non-smoking men participated in the study, including lifelong trained football players(FTE, n = 35)aged 65—80 years, elite football players(FTY, n = 35) aged 18—30 years, as well as untrained age-matched elderly(UE, n = 35) and young(UY,n = 35) men. All participants underwent a regional dual-energy X-ray Absorptiometry(DXA) scan of the proximal femur and a whole-body DXA scan to determine BMD. From a resting blood sample, the bone turnover markers(BTMs) osteocalcin, carboxy-terminal type-1 collagen crosslinks(CTX-1), procollagen type-1 amino-terminal propeptide(P1NP), and sclerostin were ***: FTE had 7.3%—12.9% higher(p < 0.05) BMD of the femoral neck, wards, shaft, and total proximal femur in both legs compared to UE,and 9.3%—9.7% higher(p < 0.05) BMD in femoral trochanter in both legs compared to UY. FTY had 24.3%—37.4% higher(p < 0.001) BMD in all femoral regions and total proximal femur in both legs compared to UY. The whole-body DXA scan confirmed these results, with FTE showing similar whole-body BMD and 7.9% higher(p < 0.05) leg BMD compared to UY, and with FTY having 9.6% higher(p < 0.001) wholebody BMD and 18.2% higher(p < 0.001) leg BMD compared to UY. The plasma concentration of osteocalcin, CTX-1, and P1NP were 29%,53%, and 52% higher(p < 0.01), respectively, in FTY compared to ***: BMD of the proximal femur and whole-body BMD are markedly higher in lifelong trained male football players aged 65—80 years and young elite football players aged 18—30 years compared to age-matched untrained men. Elderly football players even show higher BMD in femoral trochanter and leg BMD than untrained young despi

关键词： Bone mass Bone turnover markers Dual-energy X-ray absorptiometry Proximal femur bone mineral density Soccer Whole-body bone mineral density

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Fitness and health benefits of team handball training for young untrained women--A cross-disciplinary RCT on physiological adaptations and motivational aspects

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Journal of Sport and Health Science 2018年第2期7卷 139-148页

作者： therese hornstrup Johan M.Wikman Bjorn Fristrup Susana Povoas Eva W.Helge Signe H.Nielsen Jorn W.Helge Jesper L.Andersen Lars Nybo Peter Krustrup Department of Nutrition Exercise and Sports University of Copenhagen Copenhagen N 2200 Denmark Research Center in Sports Sciences Health Sciences and Human Development CIDESD University Institute of Maia ISMAI Maia 4475-690 Portugal Center of Healthy Aging Department of Biomedical Sciences University of Copenhagen Copenhagen N 2200 Denmark Institute of Sports Medicine Copenhagen Bispebjerg Hospital Copenhagen NV 2400 Denmark Department of Sports Science and Clinical Biomechanics SDU Sport and Health Sciences Cluster (SHSC) University of Southern Denmark Odense 3450 Denmark Sport and Health Sciences University of Exeter Exeter EX1 2LU UK

Purpose: The present study evaluated the effects of regular participation in small-sided team handball training on body composition, osteogenic response, physical performance, and cardiovascular risk factors, as well as well-being and motivation, in young untrained ***: Twenty-eight untrained 20- to 30-year-old women were randomized to a handball training group(HG; n = 14, height 170 ± 5 cm, weight 73 ± 11 kg, VO_(2peak) 37.7 ± 4.1 mL/min/kg) that trained 1.7 ± 0.3 times per week over 12 weeks(70 min 4 v 4 handball sessions) or an inactive control group(CG; n = 14, 169 ± 5 cm, 71 ± 12 kg, 38.1 ± 3.7 mL/min/kg). Physiological and psychological and motivational training adaptations were assessed pre-and post-intervention by dual-energy X-ray Absorptiometry(DXA) scans, blood sampling, physical tests, and ***: The average heart rate(HR) over all training sessions was equal to 85% ± 6% HR_(max). Between-group intervention effects were observed in favor of HG for muscle mass(2.1%, p = 0.024), proximal femur bone mineral density(0.8%, p = 0.041), Yo-Yo IE1 intermittent endurance test level 1(IE1) performance(35%, p < 0.001), and incremental treadmill test performance(11.5%, p = 0.003), but not total fat mass(p = 0.176),mean arterial blood pressure(p = 0.328), resting HR(p = 0.219), or blood lipids(p = 0.298—0.854). In CG, no changes were observed in any of the measured physiological variables after the training period. Compared to CG, HG had an increase in intrinsic motivation(p < 0.001) and in the well-being subscale "energy"(p = 0.010).Conclusion: Participation in regular recreational team handball training organized as small-sided games has marked beneficial effects on physical performance, musculoskeletal fitness, well-being, and motivation in untrained young women.

关键词： Bone mineral density (BMD) Intensity Intermittent Motivation Muscle mass Physical performance Recreational handball Well-being

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Cardiac Structure and Function in Men with Prostate Cancer Receiving Androgen-Deprivation Therapy and the Effects of Recreational Small-Sided Football Training:A Randomized Controlled Trial

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World Journal of Cardiovascular Diseases 2017年第9期7卷 308-322页

作者： Jakob Friis Schmidt Lars Juel Andersen Jacob Uth therese hornstrup Jesper Christensen Julie Midtgaard Klaus Brasso Peter Krustrup Mikael Rorth Peter Riis Hansen Department of Cardiology Copenhagen University HospitalGentofteDenmark Department of Nutrition Exercise and SportsCentre for Team Sport and HealthUniversity of CopenhagenCopenhagenDenmark Department of Cardiology Roskilde HospitalRoskildeDenmark The University Hospitals Centre for Health Care Research(UCSF) Copenhagen University HospitalRigshospitaletDenmark Department of Public Health University of CopenhagenCopenhagenDenmark Copenhagen Prostate Cancer Center Department of UrologyCopenhagen University HospitalRigshospitaletDenmark Sport and Health Sciences University of ExeterExeterGreat Britain Department of Sports Science and Clinical Biomechanics SDU Sport and Health Sciences Cluster(SHSC)University of Southern DenmarkOdenseDenmark Department of Oncology Copenhagen University HospitalRigshospitaletDenmark

Purpose: Androgen deprivation therapy (ADT) is a cornerstone in prostate cancer (PCa) management that prolongs PCa-free and overall survival, but effects of ADT on human cardiac function have not been investigated. We used echocardiography to examine cardiac structure and function in patients with prostate cancer receiving ADT and to determine whether an exercise intervention can elicit cardiac adaptations in these subjects. Methods: Forty-three patients with prostate cancer receiving ADT were randomized to 12 weeks football training (ST group;n = 20) or usual care (control [CO] group;n = 23). Cardiac function was assessed at baseline and after 12 weeks by comprehensive echocardiography. Peak oxygen consumption, blood pressure and peripheral microvascular function was also measured. Results: At baseline, no considerable echocardiographic abnormalities were observed. In the ST group, increases in left ventricular diastolic function variables including E/A ratio (P = 0.03), E’ (P = 0.016), E’TDIcolor (P = 0.040) and in left atrial diameter (P = 0.001) were observed after 12 weeks. In addition, diastolic blood pressure (P = 0.027) and resting heart rate (P 0.001) were reduced after ST. In the CO group, no significant changes were observed in the examined variables after 12 weeks. Despite within group changes in the ST group, no significant differences were observed after 12 weeks between groups in echocardiographic variables, peak oxygen consumption, blood pressure and peripheral microvascular function. Conclusion: In men with prostate cancer receiving ADT, echocardiography showed no abnormalities in cardiac structure and function. Twelve weeks of ST failed to elicit significant cardiovascular adaptations and ADT may blunt cardiovascular adaptations to short-term exercise training.

关键词： Prostate Cancer Exercise Rehabilitation Cardiovascular

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From Solar System to Exoplanets:What can we learn from Planetary Spectroscopy?

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Research in Astronomy and Astrophysics 2022年第12期22卷 1-14页

作者： therese Encrenaz LESIA Paris Observatory-PSL UniversitéCNRSSorbonne UniversitéUniversitéde ParisParisFrance

The purpose of this paper is to address the question:Using our knowledge of infrared planetary spectroscopy,what can we learn about the atmospheres of exoplanets?In a first part,a simplified classification of exoplanets,assuming thermochemical equilibrium,is presented,based on their masses and their equilibrium temperatures,in order to propose some possible estimations about their atmospheric *** the second part,infrared spectra of planets are discussed,in order to see what lessons can be drawn for exoplanetary *** the last part,we consider the solar system as it would appear from a star located in the ecliptic *** first appears that the solar system(except in a few specific cases)would not be seen as a multiple system,because,contrary to many exoplanetary systems,the planets are too far from the Sun and the inclinations of their orbits with respect to the ecliptic plane are too *** transit synthetic spectra of solar system planets are used to discuss the relative merits of transmission and direct emission spectroscopy for probing exoplanetary atmospheres.

关键词： planets and satellites:atmospheres planets and satellites:composition (stars:)planetary systems

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Usability perceptions and beliefs about smart thermostats by chi-square test, signal detection theory, and fuzzy detection theory in regions of Mexico

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Frontiers in Energy 2019年第3期13卷 522-538页

作者： Pedro PONCE therese PEFFER Arturo MOLINA Tecnologico de Monterrey calle del puente 222 MexicoMexico CityNon-US/Non-Canadian 64849Mexico California Institute for Energy and Environment University of California BerkeleyBerkeleyCA 94720USA

It is well known that smart thermostats (STs) have become key devices in the implementation of smart homes;thus, they are considered as primary elements for the control of electrical energy consumption in households. Moreover, energy consumption is drastically affected when the end users select unsuitable STs or when they do not use the STs correctly. Furthermore, in future, Mexico will face serious electrical energy challenges that can be considerably resolved if the end users operate the STs in a correct manner. Hence, it is important to carry out an in-depth study and analysis on thermostats, by focusing on social aspects that influence the technological use and performance of the thermostats. This paper proposes the use of a signal detection theory (SDT), fuzzy detection theory (FDT), and chi-square (CS) test in order to understand the perceptions and beliefs of end users about the use of STs in Mexico. This paper extensively shows the perceptions and beliefs about the selected thermostats in Mexico. Besides, it presents an in-depth discussion on the cognitive perceptions and beliefs of end users. Moreover, it shows why the expectations of the end users about STs are not met. It also promotes the technological and social development of STs such that they are relatively more accepted in complex electrical grids such as smart grids.

关键词： thermostats perceptions beliefs signal detection theory (SDT) fuzzy signal detection theory (FSDT) chi-square (CS) test

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Modeling analytics in COVID-19: prediction, prevention, control, and evaluation

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Journal of Management Analytics 2021年第3期8卷 424-442页

作者： Yang Lu therese L.Williams Department of Information Systems and Operations Management University of Central OklahomaEdmondOKUSA

The outbreak of COVID-19 has attracted attention from all around the *** and institutions have adopted ways to fight COVID-19, but itsprevalence is still strong. The SIR model has important reference value for thenovel coronavirus epidemic, offering both preventive measures and the ability topredict future trends. Based on an analysis of the classical epidemiological SIRmodel along with key parameters, this paper aims to analyze the patterns ofCOVID-19, to discuss potential anti-COVID-19 measures, and to explain whywe need to conduct appropriate measures against COVID-19. The use of theSIR model can play an important role in public health emergencies. Among theparameters of the SIR model, the contact ratio and the reproduction ratio arethe factors that have the potential to mitigate the consequences of ***-COVID-19 measures include wearing a mask, washing one’s hands,keeping social distance, and staying at home if possible.

关键词： COVID-19 epidemiological compartment model SIR model the contact ratio the reproduction ratio social distancing

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Review on Dynamic Bandwidth Allocation of GPON and EPON

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Journal of Electronic Science and Technology 2020年第4期18卷 297-307页

作者： Theresal Thangappan Brintha therese Adi Suvarnamma Gadda Sai Swapna School of Electronics and Communication Engineering Vellore Institute of Technology(Chennai Campus)Chennai 632014 School of Electronics and Communication Engineering Vels UniversityChennai 600117 School of Electronics and Communication Engineering Government Polytechnic CollegeAdhoni 518301

The passive optical network(PON)technology has been drastically improved in recent *** spite of using the optical technology,the utilization of the entire bandwidth is a very challenging *** main categories of PON are the Ethernet passive optical network(EPON)and gigabit passive optical network(GPON).These two networks use the dynamic bandwidth allocation(DBA)algorithm to attain the maximum usage of bandwidth,which is provided in the network dynamically according to the need of the customers with the support of the service level agreement(SLA).This paper will provide a clear review about the DBA algorithm of both technologies as well as the comparison。

关键词： Dynamic bandwidth allocation(DBA) Ethernet passive optical network(EPON) gigabit passive optical network(GPON)

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Blast disruption using 3D grids/perforated plates for vehicle protection

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Defence Technology（防务技术） 2023年第7期25卷 60-68页

作者： therese Schunck Dominique Eckenfels Laurent Sinniger French-German Research Institute of Saint-Louis ISL5 Rue Du General Cassagnou68300Saint-LouisFrance

In this work, blast disruption and mitigation using 3D grids/perforated plates were tested for underbelly and side protection of vehicles. Two vehicle simulants were used: a small-scale one for side vehicle protection assessment and a true-to-scale simulant for underbelly protection testing. The deformation of target plates was assessed. These were either unprotected or protected by three different types of disruptors. The first disruptor was made of a sandwich structure of two perforated plates filled with a thin aluminum structure allowing the air to pass through. The two other disruptors were made of pieces of cast metallic foam. Two different kinds of foams were used: one with large cells and the second one with small cells. Beforehand, the mitigation efficiency of the disruptors was evaluated using an explosivedriven shock tube(EDST). The experiments showed that blast disruption/mitigation by 3D grid/perforated plate structures was not suitable for vehicle side protection. However, 3D grids/perforated structures proved to be relatively effective for underbelly protection compared to an equivalent mass of steel.

关键词： Blast Mitigation Perforated plates 3D grids Vehicle protection

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Development of PROTACS degrading KRAS and SOS1

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Oncology Research 2024年第8期32卷 1257-1264页

作者： GERHARD HAMILTON MARIE-therese EGGERSTORFER SANDRA STICKLER Institute of Pharmacology Medical University of ViennaVienna1090Austria

The Kirsten rat sarcoma virus—son of sevenless 1(KRAS-SOS1)axis drives tumor growth preferentially in pancreatic,colon,and lung ***,KRAS G12C mutated tumors can be successfully treated with inhibitors that covalently block the cysteine of the switch II binding pocket of ***,the range of other KRAS mutations is not amenable to treatment and the G12C-directed agents Sotorasib and Adragrasib show a response rate of only approximately 40%,lasting for a mean period of 8 *** approach to increase the efficacy of inhibitors is their inclusion into proteolysis-targeting chimeras(PROTACs),which degrade the proteins of interest and exhibit much higher antitumor activity through multiple cycles of ***,PROTACs have been developed based on KRAS-or SOS1-directed inhibitors coupled to either von Hippel-Lindau(VHL)or Cereblon(CRBN)ligands that invoke the proteasomal *** of these PROTACs show increased activity in vitro and in vivo compared to their cognate inhibitors but their toxicity in normal tissues is not *** CRBN PROTACs containing thalidomide derivatives cannot be tested in experimental *** to such PROTACS arises through downregulation or inactivation of CRBN or factors of the functional VHL E3 ubiquitin *** highly active KRAS and SOS1 PROTACs have been formulated their clinical application remains difficult.

关键词： Proteolysis-targeting chimeras(PROTACs) Kirsten rat sarcoma virus(KRAS) Son of sevenless 1(SOS1) Von Hippel-Lindau Cereblon

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Abundance of volatile organic compounds in white ash phloem and emerald ash borer larval frass does not attract Tetrastichus planipennisi in a Y-tube olfactometer

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Insect Science 2016年第5期23卷 712-719页

作者： Yigen Chen Michael D. Ulyshen therese M. Poland Department of Entomology Michigan State University 288 Farm Lane Natural Science Building Room 243 East Lansing MI 48824 Department of Entomology and Nematology University of California One Shields Avenue Davis CA 95616 USDA Forest Service 320 Green Street Athens GA 30602 USDA Forest Service 3101 Technology Blvd. Suite F Lansing M148910 USA

Many natural enemies employ plant- and/or herbivore-derived signals for host/prey location. The larval parasitoid Tetrastichus planipennisi Yang （Hymenoptera： Eulophidae） is 1 of 3 biocontrol agents currently being released in an effort to control the emerald ash borer （EAB）, Agrilus planipennis Fairmaire （Coloeptera： Burprestidae） in North America. To enhance its efficiency, allelochemicals that attract it need to be assessed. In this study, ash phloem volatile organic compounds （VOCs） of black, green, and white ash, and EAB larval frass were compared. Foraging behavior of T. planipennisi females in response to VOCs of white ash or frass from EAB larvae feeding on white ash phloem was tested using a Y-tube olfactometer. Results indicated that the 3 ash species had similar VOC profiles. EAB larval frass generally contained greater levels of VOCs than phloem. Factor analysis indicated that the 11 VOCs could be broadly divided into 2 groups, with c^-bisabolol, fl-caryophyllene, （E）-2-hexenal, （Z）-3-hexenal, limonene, methyl benzoate, methyl indole-3-acetic acid, methyl jasmonate, methyl salicylate as the first group and the rest （i.e., methyl linoleate and methyl linolenate） as a second. Abundance of VOCs in white ash phloem tissue and frass, nevertheless, did not attract T. planipennisi females. The concealed feeding of EAB larvae might explain the selection for detectable and reliable virbrational signals, instead of undetectable and relatively unreliable VOC cues from phloem and frass, in short-range foraging by T. planipennisi. Alternatively, it is possible that T. planipennisi is not amenable to the Y-tube olfactometer assay employed.

关键词： Agrilus planipennis biological control Fraxinus invasive species semiochemical

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