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沙鼠精囊中的雄激素依赖性分泌蛋白POSVP21证实为转胶蛋白

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Asian Journal of Andrology 2010年第3期12卷 422-430,I0012页

作者： Naima Kaci-Ouchfoun Anne Incamps Fatima Hadj-Bekkouche Mohamed CherifAbbadi Laurent Bellanger therese Gernigon-Spychalowicz Laboratory of Arid Areas Biological Sciences Institute USTHB BP 132 El Alia 16100 Algiers Algeria Department of biochemistry and nuclear toxicology （SBTN） CEA Marcoule BP 17171. F-30207 Bagnols-sur-Ceze France Laboratory of Biology and Organisms Physiology USTHB BP 132 El Alia 16100Algiers Algeria Department of Immunology Algerian Pasteur Institute 16000 Algiers Algeria

The seminal vesicles of adult sand rat contain a major secretory protein band （MW 21 kDa） designated as Psammomys obesus seminal vesicles protein of 21 kDa （POSVP21）. This protein is abundant in secretions, regulated by androgens and also present in the vaginal plug. POSVP21 accounts for over 22.3% of soluble proteins from homogenate during the breeding season, 13.3% during the middle season and 5.3% during the hormonal regression season. It is absent during the non-breeding season. POSVP21 is localized in the cytoplasm of epithelial cells and in secretory products in the lumen. It presents an immunological homology with two epididymal proteins with the same molecular weight and a high degree of homology with transgelin from rat （Rattus norvegicus）.

关键词： androgen-dependent Psammomys obesus seminal vesicles transgelin

Numerical Groundwater Flow Modeling of the Coastal Plain Sand Aquifer, Akwa Ibom State, SE Nigeria

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Journal of Water Resource and Protection 2014年第4期6卷 193-201页

作者： Aniekan Edet Ramadan Abdelaziz Broder Merkel Chiedu Okereke therese Nganje 1Department of Geology University of Calabar Calabar Nigeria 2Departement for Geology TU Bergakademie Freiberg Freiberg Germany Departement for Geology TU Bergakademie Freiberg Freiberg Germany Department of Geology University of Calabar Calabar Nigeria

Akwa Ibom State is located in the Niger delta region of Nigeria. The coastal plain sand aquifer, which underlies the area, is the major source of potable water for domestic, agricultural, and industrial use. The increase in demand for water has led to an increased exploitation of the aquifer in the last few years. Hence it is essential to quantify the amount of exploitable water in the aquifer. To achieve this goal, a regional numerical groundwater flow model using MODFLOW was calibrated under steady-state conditions to determine the aquifer’s hydraulic conductivity (K) and the recharge characteristics of the area. The hydraulic conductivity and recharge values from the pilot points calibration ranged from 1 to 75 m/d and 5.89 × 10-6 m3/d to1.23 × 10-4 m3/d. The calculations of the model showed that the average recharge rate amounts 0.40l/s/km2 or 12.60 mm/year. The estimated recharge suggests a high groundwater potential for the area. This is the first time that such a study has been carried out in the area, and it will serve as an important basis for future groundwater management and simulation of transient groundwater flow modeling in Akwa Ibom State.

关键词： Akwa Ibom Coastal Aquifer Modeling MODFLOW

Fitness and health benefits of team handball training for young untrained women--A cross-disciplinary RCT on physiological adaptations and motivational aspects

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Journal of Sport and Health Science 2018年第2期7卷 139-148页

作者： therese Hornstrup Johan M.Wikman Bjorn Fristrup Susana Povoas Eva W.Helge Signe H.Nielsen Jorn W.Helge Jesper L.Andersen Lars Nybo Peter Krustrup Department of Nutrition Exercise and Sports University of Copenhagen Copenhagen N 2200 Denmark Research Center in Sports Sciences Health Sciences and Human Development CIDESD University Institute of Maia ISMAI Maia 4475-690 Portugal Center of Healthy Aging Department of Biomedical Sciences University of Copenhagen Copenhagen N 2200 Denmark Institute of Sports Medicine Copenhagen Bispebjerg Hospital Copenhagen NV 2400 Denmark Department of Sports Science and Clinical Biomechanics SDU Sport and Health Sciences Cluster (SHSC) University of Southern Denmark Odense 3450 Denmark Sport and Health Sciences University of Exeter Exeter EX1 2LU UK

Purpose: The present study evaluated the effects of regular participation in small-sided team handball training on body composition, osteogenic response, physical performance, and cardiovascular risk factors, as well as well-being and motivation, in young untrained ***: Twenty-eight untrained 20- to 30-year-old women were randomized to a handball training group(HG; n = 14, height 170 ± 5 cm, weight 73 ± 11 kg, VO_(2peak) 37.7 ± 4.1 mL/min/kg) that trained 1.7 ± 0.3 times per week over 12 weeks(70 min 4 v 4 handball sessions) or an inactive control group(CG; n = 14, 169 ± 5 cm, 71 ± 12 kg, 38.1 ± 3.7 mL/min/kg). Physiological and psychological and motivational training adaptations were assessed pre-and post-intervention by dual-energy X-ray Absorptiometry(DXA) scans, blood sampling, physical tests, and ***: The average heart rate(HR) over all training sessions was equal to 85% ± 6% HR_(max). Between-group intervention effects were observed in favor of HG for muscle mass(2.1%, p = 0.024), proximal femur bone mineral density(0.8%, p = 0.041), Yo-Yo IE1 intermittent endurance test level 1(IE1) performance(35%, p < 0.001), and incremental treadmill test performance(11.5%, p = 0.003), but not total fat mass(p = 0.176),mean arterial blood pressure(p = 0.328), resting HR(p = 0.219), or blood lipids(p = 0.298—0.854). In CG, no changes were observed in any of the measured physiological variables after the training period. Compared to CG, HG had an increase in intrinsic motivation(p < 0.001) and in the well-being subscale "energy"(p = 0.010).Conclusion: Participation in regular recreational team handball training organized as small-sided games has marked beneficial effects on physical performance, musculoskeletal fitness, well-being, and motivation in untrained young women.

关键词：物理测试类脂化合物测试水平物理性能肉质量训练健康心血管

Beliefs and Experiences of Fear of Hypoglycemia and Use of Uncooked Cornstarch before Bedtime in Persons with Type 1-Diabetes

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Open Journal of Nursing 2018年第11期8卷 795-810页

作者： therese Anderbro Erik Moberg Ulf Adamson Per-Eric Lins Unn-Britt Johansson Stockholm University Department of Psychology Stockholm Sweden Karolinska Institutet Department of Clinical Sciences Danderyd Hospital Stockholm Sweden Karolinska Institutet Department of Medicine Karolinska University Hospital Huddinge Stockholm Sweden Sophiahemmet University Stockholm Sweden Karolinska Institutet Department of Clinical Sciences and Education S&#246 dersjukhuset Stockholm Sweden

Introduction: Among persons living with type 1-diabetes hypoglycemia and fear of hypoglycemia remain limiting barriers for achieving optimal glucose control and a good quality of life. Fear of hypoglycemia has been found stable over time if not treated. Uncooked cornstarch has been found to reduce the risk of hypoglycemia but has not been studied in relation to fear of hypoglycemia. The aims of this study were to through clinical data, self-reported measures and clinical interviews explore subjects’ experience of using uncooked cornstarch before bedtime and their beliefs and experiences of fear of hypoglycemia. Methods: Mixed methods with both quantitative and qualitative data were used. Self-reported measures of hypoglycemia and fear of hypoglycemia were compared to subjects’ responses during a clinical interview. The interviews were analyzed with a functional behavior analytical approach. Results: A total of five subjects took part in the study. One subject perceived the uncooked cornstarch helpful in reducing hypoglycemia. Several subjects could recall frightening hypoglycemic episodes triggering their fear. Three out of the five subjects reported avoidance behaviors such as excessive self-monitoring of blood glucose or overeating related to fear of hypoglycemia. Conclusions: The uncooked cornstarch was found appetizing but was not perceived as having an effect on BG or hypoglycemia frequency. The clinical interviews confirmed previous research regarding experience of hypoglycemia and fear of hypoglycemia.

关键词： Adults Fear of Hypoglycemia Experiences Type 1 Diabetes Uncooked Cornstarch

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儿童龋病学中英文对照 1

Purification and Characterisation of Xanthine Oxidoreductases from Local Bovids in Malta

丛书名：口腔临床要点快速掌握系列

2006年

作者： Chris Deery Marie therese Hosey Paula Waterhouse 秦满译

本书介绍了许多最新的儿童龋病治疗原则、修复方法及技术设备。具体包括：龋齿的诊断、治疗设计合止痛、预防龋齿的系列方法及其应用、操作简单的预成冠、乳牙牙髓治疗等。

ISBN: (纸本)7509101336

关键词：医药、卫生口腔科学儿童口腔疾病

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Advances in Enzyme Research 2014年第1期2卷 54-63页

作者： Marita Vella therese Hunter Claude Farrugia Arwen R. Pearson Gary Hunter Astbury Centre for Structural Molecular Biology University of Leeds Leeds UK Department of Chemistry University of Malta Msida Malta Department of Physiology and Biochemistry University of Malta Msida Malta

Xanthine oxidoreductase (XOR) is a molybdoflavoprotein mainly involved in purine catabolism. It exists in two forms, the oxidase (XO) and dehydrogenase (XDH) which are inter-convertible within mammalian cells. Although various researchers have reported the extraction of mammalian XOR, no extractions have yet been carried out in Malta and subsequently no characterizations are available. In this study, XOR was successfully purified from bovine, caprine and ovine milk through a multistep purification process involving both chemical and chromatographic techniques. The molecular weights of the native enzyme were found to be 295 kDa, 281 kDa and 275 kDa, representing the bovine, caprine and ovine XOR respectively. Western blot showed XOR to be represented on SDS-PAGE by a minimum of three major bands having molecular weights of 151 kDa, 131 kDa and 85 kDa. While all samples showed activity on native PAGE, spectrophotometric assays revealed the bovine XOR to be the most active. Surprisingly, the addition of NAD+ to the assay mixture inhibited enzyme activity of the bovine and caprine XOR whereas the ovine XOR doubled its activity in response to NAD+. The latter also showed a lower binding affinity to heparin. Following incubation with trypsin, XOR was irreversibly converted to its oxidase form in all samples as reflected by the observed increase in XO activity.

关键词： Xanthine Xanthine Dehydrogenase Xanthine Oxidase Milk Bovid Malta

Variability in Spatial Distribution of Precipitation Overall Rugged Topography of Lebanon, Using TRMM Images

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Atmospheric and Climate Sciences 2019年第3期9卷 369-380页

作者： Ihab Jomaa Marie therese Abi Saab Sleiman Skaf Nisrine El Haj Randa Massaad Lebanese Agricultural Research Institute Tal Amara Lebanon Lebanese Agricultural Research Institute Fanar Lebanon

Rain gages data represents limited spatial coverage, especially in rugged terrains like Lebanon. Other precipitation data sources are the developing satellite and radar technologies. In this study, Tropical Rain Measurement Mission (TRMM) monthly rainfall data of 18 years (1998-2014 and 2017) was used to understand monthly and yearly precipitation spatial distribution overall Lebanon. Topographic effect of rainfall spatial distribution was investigated in comparison to Plassard’s map of 1971. The annual precipitation over the country ranged between 850 mm and 200 mm that differs than the existing historical map. The maximum rainfall rate decreased by about 700 mm between the derived TRMM rainfall map and Plassard’s one. Spatial distribution of maximum precipitation rates does not coincide between maps. TRMM map of elevated terrains did not show similar trends of rainfall distribution as Plassard’s. Pixels (Lebanon was divided into 27 pixels) of lower rainfall rates was found toward the eastern side of Lebanon, in contrast to Plassard’s results. Anti-Lebanon did not show an increase in precipitation in accordance to altitude. Spatial variability of precipitation was about 50 mm between pixels which reveals the importance of considering topography while implemented rain gages as observation points. TRMM and satellite rainfall data aid in investigating complete spatial distribution of rainfall over continuous periods. Accumulating knowledge of spatial rainfall distribution on timely basis will lead to better future modelling on floods and drought conditions in Lebanon.

关键词： TRMM Data Rainfall Plassard’s Map Lebanon Topography

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变革的“清单”

董事会 2014年第6期 90-92页

作者： therese Kinal

长达一个世纪里,管理者一直在试图更好地控制人、流程和信息,而今转折点到来,公司需要认清过去起作用的思想和手段已经不再足以应付现在的新情况。如果公司想要的是顺从,那么传统的管理就很好;而如果想要创新和成长。

关键词：清单变革管理者控制人公司流程

Behavioral Evidence for Cognitive Dysfunctions in the(BALB/cByJ-Kv1.1mceph/mceph)Mouse Model for Epilepsy

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Journal of Behavioral and Brain Science 2011年第4期1卷 210-228页

作者： Sarah Holst Elin Aberg therese M.Eriksson Catharina Lavebratt Sven Ove Ogren Department of Neuroscience Karolinska InstituteStockholmSweden Department of Molecular Medicine and Surgery Karolinska University HospitalStockholmSweden Center of Molecular Medicine Department of Physiology and PharmacologyKarolinska InstituteStockholmSweden Department of Clinical Neuroscience Karolinska InstituteStockholmSweden

The epileptic mouse model BALB/cByJ-Kv1.1mceph/mceph (mceph/mceph) is homozygous for a spontaneous mutation truncating the Shaker-like voltage gated potassium channel, Kv1.1 (Kcna1). The mceph/mceph mice are asymptomatic at birth, but develop from 3 weeks of age epileptic seizures, overgrowth and neuronal hyperplasia of the hippocampus. Hippocampal cognitive function of the mice was examined by investigating emotional memory using the aversive Passive Avoidance (PA) task combined with studies of explorative behavior using the non-aversive Novel Cage test (NCT). The behavioural results were examined by multivariate analysis. Compared to wild type and heterozygous mice, the mceph/mceph mice displayed lower exploratory and safety assessment behavior in the NCT and impairment in PA retention 24 hours after training, indicating an impairment in cognitive functions. In conclusion, the epileptic mouse model BALB/cByJ-Kv1.1mceph/mceph, with chronic epilepsy related to potassium-channelopathy, display a behavioural phenotype characterized by impairments in emotional memory and defensive motivational responses probably related to hippocampal dysfunctions.

关键词： Epilepsy Potassium Ion-Channelopathy Hippocampus Passive Avoidance Novel Cage Test Principal Component Analysis