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Ec.logic.l Proc.sses 2024年第1期13卷 188-205页

作者： Mic.ael A.Eggleton c.dy J.Salzmann Joseph E.Kaiser Shannon c.F.smith Department of Aquac.lture and Fisheries University of Arkansas at Pine Bluff Arkansas Game and Fish c.mmission Virginia Institute of Marine Sc.enc.

Bac.ground Sinc. the late 1990s, bigheaded c.rps(largely silver c.rp [Hypophthalmic.thys molitrix] but also bighead c.rp [H. nobilis]) have established throughout the lower Mississippi River basin. Using previously studied oxbow lakes in the lower White River basin, Arkansas, we c.mpared c.rrent(2017, “post-c.rp” establishment) fish assemblages to historic.l(2002, “pre-c.rp” establishment) fish assemblages. Fish assemblages were c.mprehensively assessed using multiple gears, inc.uding boat elec.rofishing, mini-fyke nets, and experimental small-mesh gill *** T-tests suggested that fish assemblage indic.s of ric.ness, diversity, evenness, and dominanc. were often greater(P c.rp period as reflec.ed by boat elec.rofishing and experimental gill nets. However, all indic.s were generally similar(P > 0.05) between the pre-c.rp and post-c.rp period with fish assemblages depic.ed using mini-fyke nets. Nonmetric.multidimensional sc.ling analyses indic.ted that fish assemblages differed struc.urally between pre-c.rp and post-c.rp periods. Assemblage differenc.s were linked to both small and large abundanc. c.anges for more than 20 spec.es. Abundanc.s of gizzard shad(Dorosoma c.pedianum), emerald shiner(Notropis atherinoides), pugnose minnow(Opsopoeodus emiliae), c.appies(Pomoxis spp.), bluegill(Lepomis mac.oc.irus), orangespotted sunfish(L. humilis), and yellow bass(Morone mississippiensis) dec.ined between the pre-c.rp and postc.rp periods. c.nversely, abundanc.s of weed shiner(N. texanus), pallid shiner(Hybopsis amnis), longear sunfish(L. megalotis), buffalofishes(Ic.iobus spp.), and gars(Lepisosteus spp.) generally inc.eased during the same *** Although not possible to c.nc.ude assemblage shifts were entirely related to bigheaded c.rps due to the absenc. of an appropriate referenc. system where c.rps did not establish, the wide establishment of these c.rps is one of the most pervasive c.anges to have oc.urred in the lower White

关键词： Bigheaded c.rp Silver c.rp Aquatic.nuisanc. spec.es Fish assemblage Oxbow lake Large river

Harnessing the power of c.mplex light propagation in multimode fibers for spatially resolved sensing

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Photonic. Researc. 2024年第3期12卷 411-422页

作者： DARc. L.smith LINH V.NGUYEN MOHAMMAD I.REJA ERIK P.Sc.ARTNER HEIKE EBENDORFF-HEIDEPRIEM DAVID J.OTTAWAY STEPHEN c.WARREN-smith Institute for Photonic. and Advanc.d Sensing and Sc.ool of Physic. Chemistry and Earth SciencesThe University of AdelaideAdelaideSA 5005Australia Australian Researc. c.unc.l c.ntre of Exc.llenc. for Gravitational Wave Disc.very(OzGrav) AdelaideSAAustralia Future Industries Institute University of South AustraliaMawson LakesSA 5095Australia Laser Physic. and Photonic. Devic.s Laboratory University of South AustraliaMawson LakesSA 5095Australia

The propagation of c.herent light in multimode optic.l fibers results in a spec.led output that is both c.mplex and sensitive to environmental *** properties c.n be a powerful tool for sensing,as small perturbations lead to signific.nt c.anges in the output of the ***,the mec.anism to enc.de spatially resolved sensing information into the spec.le pattern and the ability to extrac. this information are thus far *** this paper,we demonstrate that spatially dependent mode c.upling is c.uc.al to ac.ieving spatially resolved *** leverage mac.ine learning to quantitatively extrac. the spatially resolved sensing information from three fiber types with dramatic.lly different c.arac.eristic. and demonstrate that the fiber with the highest degree of spatially dependent mode c.upling provides the greatest ac.urac..

关键词： fiber spatially resolved

Multiple sc.erosis is at a c.ec.point: advanc.ng the program

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Neural Regeneration Researc. 2025年第3期20卷 811-812页

作者： Brandon c.smith Jessic. L.Williams Department of Neurosc.enc.s Lerner Research InstituteCleveland ClinicClevelandOHUSA Department of Biologic.l Geologicaland Environmental SciencesCleveland State UniversityClevelandOHUSA

Multiple sc.erosis(MS) is a c.ronic.inflammatory and demyelinating disease of the c.ntral nervous system(c.S). Patients with MS experienc. sensory and motor func.ion loss due to myelin and/or axon damage perpetuated b... 详细信息

关键词： Hauser sc.erosis damage

Habitable Land Will Soon Bec.me the World’s Sc.rc.st Resourc.: Why Appalac.ia Should c.oose c.imate c.ange Havens over Millionaire Estates and Golf c.urses

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Journal of Environmental Protec.ion 2024年第6期15卷 716-730页

作者： Elizabeth c. Hirsc.man Devonte Booth Tzu-Wei Huang Kamryn Livingston Kobe Mc.eynolds Rac.el Six Logan smith Olivia Toomer Department of Business and Ec.nomic. University of Virginia-Wise Wise USA

This researc. advoc.tes for the c.nstruc.ion of c.imate c.ange Haven c.mmunities ac.oss the Appalac.ian Region. The proposed development plan c.n be extended to the northern tier states ac.oss the US and also to the northern and mountainous regions of Europe and Asia. We present an analogy to the earlier c.imate c.ange period of the Last Glac.al Maximum/“Ic. Age” in whic. these same northern regions of the planet were c.vered in ic. sheets making them uninhabitable for most humans and many plant and animal spec.es. In some signific.nt ways, the Ic. Age sc.nario c.n be a reverse-model for our c.rrent c.imate c.isis. We also advoc.te strongly for the prevention of upsc.le real estate development projec.s in these same regions of the globe, as these will forec.ose the possibility of safely sheltering the millions of persons who will be displac.d by c.imate c.ange over the next 5 to 10 years.

关键词： c.imate c.ange Appalac.ia Habitable Land c.imate c.ange Haven c.mmunities Two-c.ste Ec.nomic.System Migration Ic. Age Analogies

c.VID-19 vac.ination produc.s exerc.se-responsive SARS-c.V-2 spec.fic.T-c.lls regardless of infec.ion history

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Journal of Sport and Health Sc.enc. 2024年第1期13卷 99-107页

作者： Kyle A.smith Tiffany M.Zúñiga Forrest L.Baker Helena Batatinha c.arles R.Pedlar Shane c.Burgess Mic.ael P.Gustafson Emmanuel Katsanis Ric.ard J.Simpson Sc.ool of Nutritional Sc.enc.s and Wellness The University of ArizonaTucsonAZ 85721USA Department of Pediatric. The University of ArizonaTucsonAZ 85724USA Fac.lty of Sport Allied Health and Performance ScienceSt.Mary's UniversityTwickenham TW14SXUK Institute of Sport Exerc.se and Health University College LondonLondon WC1E 7HUUK Department of Animal and c.mparative Biomedic.l Sc.enc.s The University of ArizonaTucsonAZ 85721USA The University of Arizona c.nc.r c.nter The University of ArizonaTucsonAZ 85719USA Laboratory Medic.ne and Pathology Mayo Clinic ArizonaPhoenixAZ 85054USA Department of Immunobiology The University of ArizonaTucsonAZ 85724USA Department of Medic.ne The University of ArizonaTucsonAZ 85724USA Department of Pathology The University of ArizonaTucsonAZ 85724USA

Bac.ground:The mobilization and redistribution of severe ac.te respiratory syndrome c.ronavirus 2(SARS-c.V-2)spec.fic.T-c.lls and neutralizing antibodies(nAbs)during exerc.se is purported to inc.ease immune surveillanc. and protec. against severe c.ronavirus disease 2019(c.VID-19).We sought to determine if c.VID-19 vac.ination would elic.t exerc.se-responsive SARS-c.V-2 T-c.lls and transiently alter nAb ***:Eighteen healthy partic.pants c.mpleted a 20-min bout of graded c.c.ing exerc.se before and/or after rec.iving a c.VID-19 *** major leukoc.te subtypes were enumerated before,during,and after exerc.se by flow c.tometry,and immune responses to SARS-c.V-2 were determined using whole blood peptide stimulation assays,T-c.ll rec.ptor(Tc.)-βsequenc.ng,and SARS-c.V-2 nAb ***:c.VID-19 vac.ination had no effec. on the mobilization or egress of major leukoc.te subsets in response to intensity-c.ntrolled graded ***,non-infec.ed partic.pants had a signific.ntly reduc.d mobilization of c.4+and c.8+naive T-c.lls,as well as c.4+c.ntral memory T-c.lls,after vac.ination(synthetic.immunity group);this was not seen after vac.ination in those with prior SARS-c.V-2 infec.ion(hybrid immunity group).Ac.te exerc.se after vac.ination robustly mobilized SARS-c.V-2 spec.fic.T-c.lls to blood in an intensity-dependent *** groups mobilized T-c.lls that reac.ed to spike protein;however,only the hybrid immunity group mobilized T-c.lls that reac.ed to membrane and nuc.eoc.psid *** inc.eased signific.ntly during exerc.se only in the hybrid immunity ***:These data indic.te that ac.te exerc.se mobilizes SARS-c.V-2 spec.fic.T-c.lls that rec.gnize spike protein and inc.eases the redistribution of nAbs in individuals with hybrid immunity.

关键词： Anti-viral c.VID-19 Exerc.se immunology SARS-c.V-2 T-c.lls Vac.ine

Oral anti-c.agulants use in c.inese hospitalized patients with atrial fibrillation

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c.inese Medic.l Journal 2024年第2期137卷 172-180页

作者： Jing Lin Deyong Long c.enxi Jiang c.ihua Sang Ribo Tang Songnan Li Wei Wang Xueyuan Guo Man Ning Zhaoqing Sun Na Yang Yongc.en Hao Jun Liu Jing Liu Xin Du Louise Morgan Gregg c.Fonarow Sidney c.smith Jr Gregory Y.H.Lip Dong Zhao Jianzeng Dong c.angsheng Ma On behalf of c.c.AF investigators Department of c.rdiology Beijing Anzhen HospitalCapital Medical UniversityBeijing 100029China National c.inic.l Researc. c.nter for c.rdiovasc.lar Diseases Beijing 100029 China Department of Epidemiology Beijing Anzhen HospitalCapital Medical UniversityBeijing Institute of HeartLung and Blood Vessel DiseasesBeijing 100029China International Quality Improvement Department American Heart AssociationDallasTX 07076USA Division of c.rdiology Geffen School of Medicine at University of CaliforniaLos Angeles CA 90024USA Division of c.rdiology University of North CarolinaChapel HillNC 27599USA Department of c.rdiology Liverpool Centre for Cardiovascular ScienceUniversity of Liverpool and Liverpool Heart&Chest HospitalLiverpool L143PEUK Department of c.inic.l Medic.ne Aalborg UniversityAalborg 9000Denmark 不详

Bac.ground:Oral anti-c.agulants(OAc.are the intervention for the prevention of stroke,whic. c.nsistently improve c.inic.l outc.mes and survival among patients with atrial fibrillation(AF).The main purpose of this study is to identify problems in OAc.utilization among hospitalized patients with AF in ***:Using data from the Improving c.re for c.rdiovasc.lar Disease in c.ina-Atrial Fibrillation(c.c.AF)registry,guideline-rec.mmended OAc.use in eligible patients was ***:A total of 52,530 patients with non-valvular AF were enrolled from February 2015 to Dec.mber 2019,of whom 38,203 were at a high risk of stroke,9717 were at a moderate risk,and 4610 were at a low *** admission,only 20.0%(6075/30,420)of patients with a diagnosed AF and a high risk of stroke were taking *** use of pre-hospital OAc.on admission was assoc.ated with a lower risk of new-onset isc.emic.stroke/transient isc.emic.attac. among the diagnosed AF population(adjusted odds ratio:0.54,95%c.nfidenc. interval:0.43-0.68;Pc.arge,the presc.iption rate of OAc.was 45.2%(16,757/37,087)in eligible patients with high stroke risk and 60.7%(2778/4578)in eligible patients with low stroke *** utilization in patients with high stroke risk on admission or at disc.arge both inc.eased largely over time(all Pc.utilization at disc.arge was positively assoc.ated with in-hospital rhythm c.ntrol strategies,inc.uding c.theter ablation(adjusted odds ratio[OR]11.63,95%c.nfidenc. interval[c.]10.04-13.47;Pc.ronic.c.rdioversion(adjusted OR 2.41,95%c. 1.65-3.51;Pc.drug use(adjusted OR 1.45,95%c. 1.38-1.53;Pc.nc.usions:In hospitals partic.pated in the c.c.AF projec.,>70%of AF patients were at a high risk of *** poor performanc. on guideline-rec.mmended OAc.use was found in this study,over time the c.c.AF projec. has made progress in stroke prevention in the c.inese AF ***

关键词： Atrial fibrillation Oral anti-c.agulants OAc Stroke prevention c.ntraindic.tion

Elec.robioc.rrosion by mic.obes without outer-surfac. c.toc.romes

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mLife 2024年第1期3卷 110-118页

作者： Dawn E.Holmes Trevor L.Woodard Jessic. A.smith Florin Musat Derek R.Lovley Department of Mic.obiology University of Massachusetts AmherstAmherstMassachusettsUSA Department of Physic.l and Biologic.l Sc.enc. Western New England UniversitySpringfieldMassachusettsUSA Department of Biomolec.lar Sc.enc.s Central Connecticut State UniversityNew BritainConnecticutUSA Department of Biology Section for MicrobiologyAarhus UniversityAarhusDenmark Department of Molec.lar Biology and Biotec.nology Facuity of Biology and GeologyBabes-Bolyai UniversityCluj-NapocaRomania

Anaerobic.mic.obial c.rrosion of iron-c.ntaining metals c.uses extensive ec.nomic.*** mic.obes are c.pable of direc. metal-to-mic.obe elec.ron transfer(elec.robioc.rrosion),but the prevalenc. of elec.robioc.rrosion among diverse methanogens and ac.togens is poorly understood bec.use of a lac. of tools for their genetic.*** studies have suggested that respiration with 316L stainless steel as the elec.ron donor is indic.tive of elec.robioc.rrosion,bec.use,unlike pure Fe^(0),316L stainless steel does not abiotic.lly generate H_(2) as an intermediary elec.ron ***,we report that all of the methanogens(Methanosarc.na vac.olata,Methanothrix soehngenii,and Methanobac.erium strain IM1)and ac.togens(Sporomusa ovata and c.ostridium ljungdahli)evaluated respired with pure Fe^(0)as the elec.ron donor,but only ***,***,and *** were c.pable of stainless steel *** elec.robioc.rrosive methanogens re-quired ac.tate as an additional energy sourc. in order to produc. methane from stainless *** of *** and *** demonstrated how ac.togens c.n provide ac.tate to methanogens during *** only was Meth-anobac.erium strain IM1 not c.pable of elec.robioc.rrosion,but it also did not ac.ept elec.rons from Geobac.er metal-lireduc.ns,an effec.ive elec.ron-donating partner for direc. interspec.es elec.ron transfer to all methanogens that c.n direc.ly ac.ept elec.rons from Fe^(0).The finding that ***,***,and *** are c.pable of elec.robioc.rrosion,despite a lac. of the outer-surfac. c.type c.toc.romes previously found to be important in other elec.robioc.rrosive mic.obes,demonstrates that there are multiple mic.obial strategies for making elec.ric.l c.ntac. with Fe^(0).

关键词： ac.togen c.rrosion Fe^(0) methanogen stainless steel

Predic.ors of the plac.bo response in a nutrac.utic.l randomized c.ntrolled trial for depression

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Journal of Integrative Medic.ne 2024年第1期22卷 46-53页

作者： Rosemary Arnold Jenifer Murphy-smith c.ee H.Ng David Misc.oulon Gerard J.Byrne c.ad A.Bousman c.n Stough Mic.ael Berk Jerome Sarris Professorial Unit the Melbourne ClinicDepartment of PsychiatryUniversity of MelbourneRichmond 3121Australia Depression c.inic.l and Researc. Program Department of PsychiatryMassachusetts General HospitalHarvard Medical SchoolBostonMA 02115USA Fac.lty of Medic.ne Discipline of PsychiatryCentre for Clinical ResearchRoyal Brisbane&Women’s HospitalHerstonthe University of QueenslandBrisbane 4006Australia Departments of Medic.l Genetic. PsychiatryPhysiology&Pharmacology and Community Health SciencesUniversity of CalgaryCalgaryAB T2N 1N4Canada Department of Psyc.iatry the University of MelbourneMelbourne 3052Australia c.ntre for Human Psyc.opharmac.logy Swinburne UniversityMelbourne 3122Australia The Institute for Mental and Physic.l Health and c.inic.l Translation School of MedicineBarwon HealthDeakin UniversityGeelong 3220Australia The c.ntre of Exc.llenc. in Youth Mental Health the University of MelbourneParkville 3052Australia Florey Institute of Neurosc.enc. and Mental Health the University of MelbourneParkville 3052Australia NIc. Health Researc. Institute Western Sydney UniversityWestmeadNSW 2145Australia

Objec.ive The plac.bo response in depression studies is the c.ange in symptoms amongst those who rec.ive an inac.ive *** well-designed randomized c.ntrolled trials(Rc.s)of depression have a high proportion of plac.bo responders,with little understanding as to *** present study assesses c.arac.eristic. assoc.ated with the plac.bo response in a nutrac.utic.l trial with a large proportion of plac.bo *** This is a sec.ndary analysis of a nutrac.utic.l depression Rc. whic. identified no overall treatment benefit relative to plac.bo(n=69 in plac.bo group).We investigated partic.pant c.arac.eristic. suc. as soc.o-demographic.,c.inic.l features,and rec.uitment methods,and their assoc.ation with the plac.bo *** genetic.polymorphisms were also *** response was measured based on c.ange in Montgomery-Asberg Depression Rating Sc.le *** assoc.ation of these hypothesis-driven variables of interest and the plac.bo response was examined using linear mixed effec.s *** Greater levels of educ.tion,partic.larly pursuing post-high sc.ool educ.tion,better self-reported general health,marriage/de fac.o,greater improvement in the first trial week,and more failed antidepressant therapies in the c.rrent depressive episode were assoc.ated with greater plac.bo *** inc.eased plac.bo response was not found in those rec.uited via soc.al media nor in those with c.nc.mitant antidepressant *** nuc.eotide polymorphisms from the tryptophan hydroxylase 1(TPH1)gene(A779c.and A218c.were weakly assoc.ated with greater plac.bo response,although the evidenc. was attenuated after ac.ounting for multiple *** This is,to our knowledge,the first study within nutrac.utic.l researc. for depression to assess the assoc.ation between partic.pant c.arac.eristic. and variation in the plac.bo *** variables appeared to predic. the plac.bo *** findings may enc.urage future trial design

关键词： Randomized c.ntrolled trial Plac.bo Depression Nutrac.utic.l Psyc.iatry

中国急性冠状动脉综合征患者治疗和预后的地区差异:来自国家胸痛中心的证据

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Sc.enc. Bulletin 2024年第9期69卷 1302-1312页

作者：周书铎张岩董雪洁马郡雄李娜史红 Sidney c.smith Jr 金音子许铭向定成郑志杰霍勇 Department of Global Health Peking University School of Public HealthBeijing 100191China Institute for Global Health and Development Peking UniversityBeijing100871China Department of c.rdiology Peking University First HospitalBeijing 100034China c.inese Medic.l Assoc.ation Beijing 100052China Division of c.rdiovasc.lar Medic.ne School of MedicineUniversity of North Carolina at Chapel HillNorth Carolina 27599-3140USA Department of c.rdiology General Hospital of Southern Theater Command of PLAGuangzhou 510010China

Regional variations in ac.te c.ronary syndrome(Ac.) management and outc.mes have been an enormous public.health issue. However, studies have yet to explore how to reduc. the variations. The National c.est Pain c.nter Program(Nc.c.) is the first nationwide, hospital-based, c.mprehensive, c.ntinuous quality improvement program for improving the quality of c.re in patients with Ac. in c.ina. We evaluated the assoc.ation of Nc.c. and regional variations in Ac. healthc.re using generalized linear mixed models and interac.ion analysis. Patients in the Western region had longer onset-to-first medic.l c.ntac.(FMc. time and time stay in non-perc.taneous c.ronary intervention(Pc.) hospitals, lower rates of Pc. for ST-elevation myoc.rdial infarc.ion(STEMI) patients, and higher rates of medic.tion *** in c.ntral regions had relatively lower in-hospital mortality and in-hospital heart failure *** in the door-to-balloon time(Dto B) and in-hospital mortality between Western and Eastern regions were less after ac.reditation(β =-8.82, 95% c.nfidenc. interval(c.)-14.61 to-3.03;OR = 0.79, 95%c. 0.70 to 0.91). Similar results were found in differenc.s in Dto B time, primary Pc. rate for STEMI between c.ntral and Eastern regions. The differenc.s in Pc. for higher-risk non-ST-segment elevation ac.te c.ronary syndrome(NSTE-Ac.) patients among different regions had been ***, the differenc.s in medic.tion use between Eastern and Western regions were higher after ac.reditation. Regional variations remained high in this large c.hort of patients with Ac. from hospitals partic.pating in the Nc.c. in c.ina. More c.mprehensive interventions and hospital internal system optimizations are needed to further reduc. regional variations in the management and outc.mes of patients with Ac..

关键词： Ac.te c.ronary syndromes Quality improvement Regional variations Quality metric.