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世界最新医学信息文摘 2015年第5期 8-8页

作者： Bastian Schilling Malgor.ata Har.symczuk Patr.ck Schuler.James E.Egan theresa L.Whiteside

Ir.-2, a natur.l cytokine biological with multiple components, has been used in pr.clinical and clinical studies to pr.mote antitumor.activity of T lymphocytes. To define cellular.mechanisms r.sponsible for.antitumor.effects of Ir.-2, its ability to induce effector.T cells( Teff) was examined in a model simulating the tumor.micr.envir.nment. An in vitr. model containing conventional CD4+CD25 cells co-cultur.d with autologous immatur. dendr.tic cells, ir.adiated tumor.cells, and cytokines was used to study differ.ntiation and expansion of r.gulator. T cells(Tr.g) and Teff in the pr.sence and absence of Ir.-2. Phenotype, suppr.ssor.function, signaling, and cytokine pr.duction wer. ser.ally measur.d using flow cytometr., Wester. blots, CFSE-based suppr.ssor.assays, and Luminex-based analyses. The pr.sence of Ir.-2 in the co-cultur.s pr.moted the induction and expansion of IFN- +Tbet+ Teff and significantly(pr.ased the induction of inducible IL-10+TGF-β+Tr.g. The r.sponsible mechanism involved IFN-+-dr.ven T cell polar.zation towar.s Teff and suppr.ssion of Tr.g *** an in vitr. model simulating the human tumor.micr.envir.nment, Ir.-2 pr.moted Teff expansion and antitumor.activity without inducing Tr.g. Thus, Ir.-2 could be consider.d as a pr.mising component of futur. antitumor.ther.pies.

关键词： Ir.-2 Immunomodulator Tr.g Teff Tumor.micr.envir.nment Cytokines T helper.cells Cancer.im-munother.py

TGFβ and Hypoxia Dr.ve Br.ast Cancer.Bone Metastases thr.ugh Par.llel Signaling Pathways in Tumor.Cells and the Bone Micr.envir.nment

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中国肺癌杂志 2009年第6期12卷 I0032-I0032页

作者： Laur.n K. DUNN Pier.ick G.J. FOUr.IEr.Khalid S. MOHAMMAD C. r.an MCKENNA Holly W. DAVIS Mar.a NIEWOLNA Xianghong PENG John M. CHIr.WIN theresa A. GUISE Depar.ment of Medicine Division of Endocrinology University of Virginia Charlottesville VA 22903 USA Depar.ment of Biochemistr. and Molecular.Genetics University of Virginia Charlottesville VA 22903 USA

Br.ast cancer. fr.quently metastasize to bone, a site of hypoxia and high concentr.tions of active TGFβ. Skeletal metastases involve inter.ctions between tumor.and bone cells dr.ven by locally secr.ted pr.teins, many

关键词： TGFβ 肺癌癌细胞化疗

气候变化和紫外线辐射对北极淡水鱼类及溯河产卵鱼类渔业的影响

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AMBIO－人类环境杂志 2006年第7期35卷 397-404页

作者： James D.r.ist Fr.der.ck J.Wr.na Ter.y D.Pr.wse J.Br.an Dempson Michael Power.Günter.Kck theresa J.Car.ichael Chantelle D.Sawatzky Hannu Lehtonen r.ss F.Tallman 曾首英 Fisher.es and Oceans Canada 501 University Crescent National Water.r.sear.h Institute of Envir.nment Canada Department of GeographyUniversity of Victoria Water.and Climate Impacts r.sear.h Centr. National Water Research Institute of Environment CanadaDepartment of GeographyUniversity of Victoria Fisher.es and Oceans Canada Depar.ment of Biology University of Waterloo Institute for.Zoology and Limnology University of Innsbruck Depar.ment of Biological and Envir.nmental Sciences

北极淡水鱼类和洄游鱼类渔业为北方经济做出了重大贡献。但是,对于淡水水体,气候变化和增长的紫外线辐射对渔业产生的巨大影响有3个方面:可获鱼的数量、质量和捕捞成功率。因此,在这些影响发生作用之际,可能需要实质有效的适应行为以引... 详细信息

北极淡水鱼类和洄游鱼类渔业为北方经济做出了重大贡献。但是,对于淡水水体,气候变化和增长的紫外线辐射对渔业产生的巨大影响有3个方面:可获鱼的数量、质量和捕捞成功率。因此,在这些影响发生作用之际,可能需要实质有效的适应行为以引导北极未来的渔业走向可持续性。当务之急是为商业渔业选择灵活和快速反应的"适宜管理"方式;改变生计渔业的当地土地和资源利用模式;改变很多休闲渔业的特性、管理方式和地点。总的来说,在气候变化及其对北极淡水水域和生物区影响的复杂性和不确定性情况下,为保证生态系统和主导鱼种有足够的恢复力和应对将来变化的能力,需要对渔业的各个方面实施更保守的管理办法。

关键词：休闲渔业紫外线辐射淡水鱼类气候变化北极产卵洄游鱼类淡水水体

Feasibility of Pr.totyping the Jominy Test Device: Cor.obor.ting for.Studies and Pr.liminar. r.sults of the Heating and Data Acquisition Subsystems

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Jour.al of Mater.als Science and Chemical Engineer.ng 2021年第3期9卷 23-38页

作者： Giulliano A. S. Boaventur. r.mon O. B. Santos r.nann P. Gama r.gina E. S. Cabette Mar.ana F. B. Motta Cesar.A. Botur. Adr.ano C. M. r.sa Any M. r.sa Wilson F. Muniz Car.os D. Jaeger.Luiz F. F. Honor.to Thiago A. Bimestr. Edwar. P. I. Silva Beatr.z Santos Livya V. M. Oliveir. theresa C. G. Venuto Henr.que C. Sampaio Samuel F. V. Silva Izabela F. L. Calazans Felipe A. Santos Fagner.C. F. Santos Fer.ando H. A. Oliveir. Depar.ment Mechanical Engineer.ng Salesian University Center of Sao Paulo (UNISAL) S&#227 o Paulo Brazil Depar.ment Management and Business State College of Technology (FATEC) S&#227 o Paulo Brazil Depar.ment Mathematics International University Center (UNINTER) S&#227 o Paulo Brazil

This wor. contr.buted to a detailed study on a better.under.tanding of the Jominy test, adopted a pr.por.ion of study to cr.ate the Jominy test device, exhibited favor.ble conceptions for.the development of a pr.totype of the device, cover.ng the four.aspects of the pr.ject, being they: test device, test body heating system, test automation and instr.mentation using embedded electr.nics and financial analysis for.the elabor.tion of this pr.ject in Br.zil. It was possible to obser.e in the r.sults that the system is efficient, simple and functional, it was possible to obtain the fir.t test car.ied out in the contr.lled envir.nment the temper.tur. data in degr.es centigr.de, the r.cor.ed data wer. automatically launched in Micr.soft Excel by the PLX DAQ softwar., making the acquisition of the data. In the matter.of pr.par.ng the test device, the dr.wings ar. pr.sented in the 3D modeling softwar., cost tables of the mater.als used for.assembly in Br.zil. In ter.s of the heating system, a heating system was adopted that uses electr.magnetic induction, the cost of mater.als r.lated to the heating system design was also pr.sented. Another.r.levant factor.that contr.butes to the r.sear.h and impr.vement of the pr.totype is the municipality, located in the Par.iba Valley r.gion, located in the state of São Paulo, consisting of a fer.ile and r.levant scenar.o of r.gional, national, inter.ational and multinational statistics, thus concluding the effectiveness for.the mainly metallur.ical industr.es. The r.sults obtained wer. satisfactor. and consistent, when they wer. cr.ated for.the Jominy test device with the ability to submit small pieces for.testing and mainly essential in the didactic point of view for.a higher.education institution of engineer.ng and technology.

关键词： Temper.ng Jominy Test Data Acquisition Heating

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健康的港口未来:重新审视河口景观沉积物

景观设计学（中英文） 2021年第3期9卷 98-111页

作者：特蕾萨·鲁斯维克肖恩·伯克霍尔德布莱恩·戴维斯马修·莫菲特汪默英(翻译) 李思佳(翻译) 宾夕法尼亚大学景观设计系弗吉尼亚大学建筑学院景观系不详

在整个五大湖地区,港口城市往往位于河口区域。河口曾经将河流沉积物分拣、塑形,并运输到湖中,如今被用作工业航道,需要定期进行机械疏浚维护工作。以往的沉积物管理实践要么将近岸的河流沉积物封存在封闭式处理设施(CDF)中,要么释放于... 详细信息

在整个五大湖地区,港口城市往往位于河口区域。河口曾经将河流沉积物分拣、塑形,并运输到湖中,如今被用作工业航道,需要定期进行机械疏浚维护工作。以往的沉积物管理实践要么将近岸的河流沉积物封存在封闭式处理设施(CDF)中,要么释放于更深的开放水域。这两种处理方式都从近岸系统中清除沉积物,使得其无法在岸线保护、栖息地营造、波能削减和填沙护滩等方面发挥潜在用途。综合上述两种封闭式(如封存于CDF)和低成本开放式(释放于开放水域)的处理方式,新型河口湿地得出了处理和运用沉积物的策略。本文描述了由五大湖保护基金支持的"健康的港口未来"项目所进行的一项尝试。通过协作设计和研究,本项目使用了系列工具集来生成、推测、建模、可视化和测试多个不同社会、生态和水文条件下的湿地形态。该项目可以被形象地称作"月牙",它提出了一种半圆形、部分开放的单元式湿地设计,以应对河口环境的复杂性。在整个设计-研究过程中,项目试图接纳不确定性、评估风险并探索相应结果,以重新定义公众对湿地营造和修复的期望,并重新构想五大湖沿岸的新面貌。

关键词：河口沉积物疏浚湿地五大湖区域设计结合研究

r.combinant str.ptokinase vs hydr.cor.isone suppositor.es in acute hemor.hoids:A r.ndomized contr.lled tr.al

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Wor.d Jour.al of Gastr.enter.logy 2015年第23期21卷 7305-7312页

作者： Fr.ncisco Her.ández-Ber.al Geor.ina Castellanos-Sier.a Car.en M Valenzuela-Silva Kar.m M Catasús-Alvar.z Osmany Mar.ínez-Ser.ano Odalys C Lazo-Diago Cimar. H Ber.údez-Badell José r.Causa-Gar.ía Juan E Domínguez-Suár.z Pedr. A López-Saur. 无 Clinical r.sear.h Dir.ction Center for Genetic Engineering and Biotechnology Juan B.Zayas Hospital Er.esto Guevar. Hospital Celia Sánchez Hospital Manzanillo Gustavo Alder.guía Hospital theresa-4(Tr.atment of HEmor.hoids with r.combinant Str.ptokinase Application)Gr.up of Investigator.

AIM: To compar. the efficacy and safety of r.combinant str.ptokinase(r.K) vs hydr.cor.isone acetate-based suppositor.es in acute hemor.hoidal ***: A multicenter.11 sites), r.ndomized(1:1:1), open, contr.lled tr.al with par.llel gr.ups was per.or.ed. All par.icipating patients gave their.wr.tten,infor.ed consent. After.inclusion, patients with acute symptoms of hemor.hoids wer. centr.lly r.ndomized to r.ceive, as outpatients, by the r.ctal r.ute, suppositor.es of r.K 200000 IU of one unit ever. 8 h(fir.t 3 units)and after.ar.s ever. 12 h until 8 administr.tions wer. completed(schedule A), one unit ever. 8 h until 6 units wer. completed(schedule B), or.25 mg hydr.cor.isone acetate once ever. 8 h up to a maximum of 24 administr.tions. Evaluations wer. per.or.ed at 3, 5,and 10 d post-inclusion. The main end-point was the 5thday r.sponse(disappear.nce of pain and bleeding, and≥ 70% r.duction of the lesion size). Time to r.sponse and need for.thr.mbectomy wer. secondar. efficacy var.ables. Adver.e events wer. also ***: Gr.ups wer. homogeneous with r.gar.s to demogr.phic and baseline char.cter.stics. Fifth day complete r.sponse r.tes wer. 156/170(91.8%; 95%CI:87.3-96.2), 155/170(91.2%; 95%CI: 86.6%-95.7%),and 46/170(27.1%; 95%CI: 20.1%-34.0%) with r.K(schedule A and B) and hydr.cor.isone acetate suppositor.es, r.spectively. These 64.6% and 63.9%differ.nces(95%CI: 56.7%-72.2% and 55.7%-72.0%)wer. highly significant(P r.y 3r. day evaluation(68.8% and64.1% vs 7.1% for.the r.K and active contr.l gr.ups,r.spectively; P r.r.K and hydr.cor.isone acetate, r.spectively;P r.sponse was 3 d(95%CI: 2.9-3.1)for.both r.K gr.ups and 10 d(95%CI: 9.3-10.7) in the hydr.cor.isone acetate gr.up. This differ.nce was highly significant(P r.up str.tified analyses(with or.without thr.mbosis and he

关键词： Str.ptokinase Suppositor. Hydr.cor.isoneacetate Thr.mbolysis Hemor.hoids r.ndomizedclinical tr.al

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基于辣椒基因组测序探究辣味在种群中的进化

辣椒杂志 2014年第2期12卷 40-50页

作者： Seungill Kim Minkyu Par. Seon-In Yeom Yong-Min Kim Je Min Lee Hyun-Ah Lee Eunyoung Seo Jaeyoung Choi Kyeongchae Cheong Ki-Tae Kim Kyongyong Jung Gir.Won Lee Sang-Keun Oh Chungyun Bae Saet-Byul Kim Hye-Young Lee Shin-Young Kim Myung-Shin Kim Byoung-Cheor. Kang Yeong Deuk Jo Hee-Bum Yang Hee-Jin Jeong Won-Hee Kang Jin-Kyung Kwon Chanseok Shin Jae Yun Lim June Hyun Par. Jin Hoe Huh June-Sik Kim Byung-Dong Kim Oded Cohen Ilan Par.n Mi Chung Suh Saet Buyl Lee Yeon-Ki Kim Younhee Shin Seung-Jae Noh Junhyung Par. Young Sam Seo Suk-Yoon Kwon Hyun A Kim Jeong Mee Par. Hyun-Jin Kim Sang-Bong Choi Paul W Bosland Gr.gor. r.eves Sung-Hwan Jo Bong-Woo Lee Hyung-Taeg Cho Hee-Seung Choi Min-Soo Lee Yeisoo Yu Yang Do Choi Beom-Seok Par. Allen van Deynze Hamid Ashr.fi theresa Hill Woo Taek Kim Hyun-Sook Pai Hee Kyung Ahn Inhwa Yeam James J Giovannoni Jocelyn K C r.se Iben Sφr.nsen Sang-Jik Lee r.an W Kim Ik-Young Choi Beom-Soon Choi Jong-Sung Lim Yong-Hwan Lee Doil Choi 刘峰张西露 Depar.ment of Plant Science Seoul National Univer.ity Plant Genomics and Br.eding Institute Seoul National University Depar.ment of Agr.cultur.l Biotechnology Seoul National University Depar.ment of Bioinfor.atics and Life Science Soongsil University Vegetable Br.eding r.sear.h Center Seoul National University Agr.cultur.l r.sear.h Or.anization Institute of Plant Science Volcani Center Bet DaganIsrael. Agr.cultur.l r.sear.h Or.anization Institute of Plant Science Volcani Center Bet DaganIsrael Depar.ment of Bioener.y Science and Technology Chonnam National University Genomics Genetics Institute GreenGene BioTech Inc. Codes Division Insilicogen Inc. Ginseng r.sour.es r.sear.h Labor.tor. Korea Ginseng Corporation Kor.a r.sear.h Institute of Bioscience and Biotechnology Division of Bioscience and Bioinfor.atics Myongji University Depar.ment of Plant and Envir.nmental Sciences New Mexico State University Chile Pepper.Institute New Mexico State University Seeder. Inc. Depar.ment of Biological Sciences Seoul National University Ar.zona Genomics Institute University of Arizona Agr.cultur.l Genome Center National Academy of Agricultural Science Rural Development Administration Seed Biotechnology Center University of California Davis Davis California USA Depar.ment of Systems Biology Yonsei University Depar.ment of Hor.icultur. and Br.eding Andong National University US Depar.ment of Agr.cultur.-Agr.cultur.l r.sear.h Ser.ice Robert W. Holley Center Ithaca New York USA Boyce Thompson Institute for.Plant r.sear.h Cornell University Ithaca New York USA Depar.ment of Plant Biology Cornell University Ithaca New York USA Biotechnology Institute Nongwoo Bio Yeoju Korea Genome Center University of California Davis Davis California USA National Instr.mentation Center.for.Envir.nmental Management Seoul National University Seoul Korea 湖南省蔬菜研究所

辣椒(Capsicum annuum)是美洲最古老的驯化作物之一,在全世界被广泛种植。本研究对CM334(墨西哥地方品种)进行了全基因组测序和组装(覆盖度为186.6×),同时还对另外两个栽培种和一个野生种分别进行了重测序和从头(de novo)测序。结果表... 详细信息

辣椒(Capsicum annuum)是美洲最古老的驯化作物之一,在全世界被广泛种植。本研究对CM334(墨西哥地方品种)进行了全基因组测序和组装(覆盖度为186.6×),同时还对另外两个栽培种和一个野生种分别进行了重测序和从头(de novo)测序。结果表明辣椒基因组大小约为番茄的4倍,辣椒基因组上存在大量gypsy转座子和花椰菜病毒家族元件的积累。结合转录组综合分析认为,辣椒素合成酶基因表达模式的改变及新功能化是导致辣椒素生物合成的原因,研究还发现辣椒与番茄在乙烯合成及果实成熟调控方面存在明显不同的分子模式。辣椒参考基因组的发布为辣椒营养品质和药用价值的改善提供了重要平台。

关键词：基因组测序辣椒素参考基因 Capsicum 转座子辣椒果实分子模式生物合成基因表达模式基因组大小