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Endogenous leptin fluctuates in hepatic ischemia/reperfusion injury and represents a potential therapeutic target

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World Journal of Gastroenterology 2010年第43期16卷 5424-5434页

作者： Ji Lin, Guang-Tao Yan, Hui Xue, Xiu-Hua Hao, Lu-Huan Wang, Research Laboratory of Biochemistry, Basic Medical Institute, chinese pla general hospital, 28 Fuxing Road, Beijing 100853, China Xiao-Ning Gao, Department of Hematology, Clinical Division of Internal Medicine, chinese pla general hospital, 28 Fuxing Road, Beijing 100853, China Research Laboratory of Biochemistry Basic Medical Institute Chinese PLA General Hospital 28 Fuxing Road Beijing 100853 China.

AIM: To evaluate the role of leptin in the internal disorders during hepatic ischemia/reperfusion injury. METHODS: A rat model of 70% hepatic ischemia/reperfusion injury was established, with groups of shamoperation (Sham), 60 min ischemia/60 min reperfusion (I60'R60'), I60'R150', I60'R240' and I60'R360'. Serum leptin was detected by a self-produced radioimmunoassay; serum glucose, total anti-oxidation capacity, myeloperoxidase, alanine transaminase and diamine oxidase were determined by relevant kits, while histologicalalterations and protein levels of leptin in the lung, liver and duodenum were examined by hematoxylin-eosin staining and immunohistochemistry. Spearman's rank correlation between leptin and other variables or grading of tissue impairment were analyzed simultaneously. RESULTS: Serum leptin in I60'R360' was significantly higher than in Sham and I60'R240' groups (both P < 0.05), serum glucose in I60'R360' was higher than in Sham and I60'R150' (both P < 0.05), and serum total anti-oxidation capacity in I60'R240' and I60'R360' were higher than in Sham (both P < 0.05) and I60'R150' groups (both P < 0.01). Serum myeloperoxidase in groups of I60'R240' and I60'R360' were lower than in I60'R150'group (both P < 0.05), serum alanine transaminase in the four reperfusion groups were higher than in the Sham group (all P < 0.05), while serum DAO in I60'R360' was lower than in I60'R60' (P < 0.05). Histological impairment in the lung, liver and duodenum at the early phase of this injury was more serious, but the impairment at the later phase was lessened gradually. Protein levels of leptin in the lung in the four reperfusion groups were significantly lower than in the Sham group (all P < 0.01), decreasing in the order of I60'R150', I60' R60', I60'R360' and I60'R240'; the levels in the liver in I60'R60' and I60'R240' were higher than in the Sham group (both P < 0.01), while the levels in I60'R240' and I60'R360' were lower than in I60'R60' (both P < 0.01); the levels in

关键词： Leptin Reperfusion injury Liver Lung Duodenum Recovery of function

Effect of gastrectomy on G-cell density and functional activity in dogs

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World Journal of Gastroenterology 2000年第3期6卷 419-420页

作者： Yu Qiang Chen Wen Hu Guo Zheng Ming Chen Lei Shi Yan Xu Chen Department of general Surgery,chinese pla 174th hospital,Xiamen 361003,Fujian Province,China Department of general Surgery,chinese pla Fuzhou general hospital of Nanjing Command Area,Fuzhou 351003,Fujian Province,China State Lab for Tumor Cell Engineering of Xiamen University,Xiamen 361005,Fujian Province,China Department of general Surgery Chinese PLA 174Th Hospital Xiamen 361003 Fujian Province China Xiamen University China chinese pla 174th hospital China Department of general Surgery Chinese PLA 174th Hospital Xiamen 361003 Fujian Province China Department of general Surgery Chinese PLA Fuzhou Gen. Hosp. N. Fuzhou 351003 Fujian Province China State Lab. for Tum. Cell Eng. Xiamen University Xiamen 361005 Fujian Province China

INTRODUCTION Billroth gastrectomy has some advantages ofinhibiting acid secretion,low ulcer recurrence andlow mortality. However, postoperativecomplications,such as dumping syndrome andreflux gastritis,often occurred as a result *** minimize these complications,pylorus-preserving gastrectomy(PPG)had beenperformed for gastric ulcer with satisfied *** correlation was not found betweenulcer recurrence and serum gastrin ***

关键词： gastrectomy pylorus G-cell gastrin: peptic ulcer/surgery

Introduction to a new clinical entity:the multiple organ dysfunction syndrome in the elderly

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Journal of Geriatric Cardiology 2004年第1期1卷 55-57页

作者： Shiwen WANG lnstitute of Geriatric Cardiology Chinese PL4 General HospitalBeing 100853China

Multiple organ dysfunction syndrome in the elderly (MODSE) is an important syndrome in the critical care of elderly patients. MODSE is defined as simultaneous or sequential dysfunction or failure of two or more organs on the top of advanced age and chronic multiple organ dysfunction. MODSE is triggered by precipitating factors such as infection (usually pulmonary infection) trauma,surgery, etc. It occurs in two phases. In the early phase, dysfunction of multiple organs (MODE) occurs,and in the later or severe phase, multiple organ failure (MOFE) occurs. MODSE is the most common cause of mortality in the critically iii elderly patient. It is important to understand its clinical characteristics and elucidate its pathogenesis in order to reduce mortality and improve quality of life for these patients.

关键词： SW MODSE MOFE

Multifactor heart failure in the elderly:a proposal for cooperative research

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Journal of Geriatric Cardiology 2006年第4期3卷 197-198页

作者： Shiwen WANG Institute of Geriatric Cardiology Chinese PLA General Hospital Beijing 100853 China

　　Chronic heart failure (CHF) is a clinical syndrome as a common pathway at the end stage of cardiac diseases of different etiologies, and it is currently the only cardiovascular disease with an increasing prevalence in the developed countries. In the United States, the prevalence of CHF at age 50 years is 1.0%, whereas it reaches 7.5% at age 80years. In the United Kingdom, the prevalence of CHF is5.0% at age 60-70 years, and 10-20% at age 80 years. The situation is similar in Italy and Portugal. Despite being a developing country in Asia, China has experienced rapid progress in acquiring medical knowledge and advancing techniques in recent years. Due to the markedly declined mortality of acute myocardial infarction (AMI) as well as the aging of chinese population, about four million chinese have CHF with a prevalence of 0.9%, most of whom are 60 years of age and older.……

关键词： CHF Multifactor heart failure in the elderly

Cochlear implantation in a child with auditory neuropathy spectrum disorder

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Journal of Otology 2011年第2期6卷 29-37页

作者： JI Fei CHEN Ai-ting HONG Meng-di SHI Wei LI Jia-nan YANG Shi-ming Department of Otolaryngology/Head and Neck Surgery,chinese pla Institute of Otolaryngology,chinese pla general hospital,28 Fuxing Road,Beijing 100853,China Department of Otolaryngology/Head and Neck Surgery Chinese PLA Institute of Otolaryngology Chinese P LA General Hospital 28 Fuxing Road Beijing 100853 China

Objective To report outcomes of cochlear implantation (CI) in a child with auditory neuropathy spectrum disorder (ANSD) and to provide preliminary clinical evidence of the efficacy of CI in ANSD *** A 4-year-old boy with diagnosed auditory neuropathy spectrum disorder (ANSD) received implantation of a Nucleus CI24R after an unsatisfactory trial of ***-implantation performance in both hearing sensitivity and speech recognition was assessed in different *** hearing thresholds were tested by behavioral *** Early Speech Perception Test (MESP),Meaningful Auditory Integration Scale (MAIS),category of auditory performance (CAP) and Speech Intelligibility Rating (SIR) were used to assess the benefits in auditory skills or speech recognition the boy obtained from *** tests were administered before surgery and at 3 months and 7 months after *** The boy demonstrated improved auditory sensitivity by using *** speech recognition and communication,both speech audiometry and questionnaires showed an obvious benefit from *** CI has worked efficiently in this ANSD *** because of limited understanding of ANSD and rehabilitation effect by cochlear implantation in this condition,the clinical decision to implant should be cautious and only after a thorough ***,well controlled and long term studies are needed to confirm the efficacy of cochlear implantation in patients with ANSD.

关键词： Auditory neuropathy spectrum disorder Cochlear implantation

Effect of cyclosporine-A on electrophysiological properties of atria in tachycardia-induced atrial fibrillation

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Journal of Geriatric Cardiology 2008年第3期5卷 175-178页

作者： Lei Gao Wei Yan Yuqi Liu Ya Huang Qi Chen Yuxiao Zhang Peng Liu Caiyi Lu Institute of Geriatric Cardiology, chinese pla general hospital, Beijing 100853, China. Institute of Geriatric Cardiology Chinese PLA General Hospital Beijing 100853 China

Objective To investigate the effects of ciyelosporine-A(CsA).a calcinenrin(CAN)inhibitor,on electrophysiological propertiesof atria in canine tachycardia-induced model of *** Eighteen healthy adult mongrel canines weighing 17.0 to 23.2 kg(rangedfrom 2 to 4 years old)were randomized to 3 groups,Sham group(no pacemaker was implanted),atrial tachypacing group(ATP group)each group at baseline and after 8 weeks' *** included atrial effective refractory period(AERP),conductionvelocity(CV),wave length(WE),atrial fibrillation load and rate-adaptability. Results After 8 weeks' atrial tachypacing,ATP andCsA groups showed significant longer duration of the P wave,shorter AERP,decreased adaptation of AERE slower CV,shorter Wland longer AF duration compared to the shamg roup (all P＜0.05).AERP of the CsA group was longer than that of ATP group (P＜0.05),but there were no differences in rate-adaptability,CV,incidence of induced AF and AF duration between CsA group and ATP *** Our results suggest that calcineurin pathway intervention by CsA have a positive effect on tachycardia-inducedelectrical remodeling of atria,but can not prevent or reverse AF.

关键词： attral fibrillation calcineurin CsA:electrophysiology electrical remodeling

Effects of glutamate on distortion-product otoacoustic emissions and auditory brainstem responses in guinea pigs

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Journal of Otology 2008年第1期3卷 29-34页

作者： SUN Qing1,SUN Jian-he1,SHAN Xi-zheng2, LI Xing-qi1 1 Institute of Otorhinolaryngology, chinese pla general hospital, Beijing 100853, China 2 Department of Otorhinolaryngology, general hospital of chinese People’s Armed Forces Beijing 100039, China Institute of Otorhinolaryngology Chinese PLA General Hospital Beijing 100853 China Department of Otorhinolaryngology General Hospital of Chinese People's Armed Forces Beijing 100039 China

Objectives To investigate changes in evoked potentials and structure of the guinea pig cochleae during whole cochlear perfusion with glutamate. Methods CM, CAP, DPOAE, and ABR were recorded as indicators of cochlear functions during whole cochlear perfusion. The morphology of the cochlea was studied via transmission electron microscopy. Results There were no significant changes in DPOAE amplitude before and after glutamate perfusion. CM I/O function remained nonlinear during perfusion. ABR latencies were delayed following glutamate perfusion. The average CAP threshold was elevated 35 dB SPL following glutamate perfusion.. The OHCs appeared normal, but the IHCs and afferent dendrites showed cytoplasmic blebs after glutamate perfusion. Conclusions While being a primary amino acid neurotransmitter at the synapses between hair cells and spiral ganglion neurons, excessive glutamate is neurotoxic and can destroy IHCs and spiral ganglion neurons. The technique used in this study can also be used to build an animal model of auditory neuropathy.

关键词： glutamate distortion product otoacoustic emission auditory brainstem response auditory neuropathy

EXPERIMENTAL STUDIES OF MEDICAL EQUIPMENT SELECTION BY USING THE MULTI-STAGE WEIGHTING EVALUATION METHOD

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chinese Journal of Biomedical Engineering(English Edition) 1994年第3期3卷 128-134页

作者： Zhang Min Zhang Lei(Medical Engineering Department chinese pla general hospital,Beijing, 100853,China)

As more and more sophiscated medical equipment is being purchased byhospitals, selection is becoming an increasinly complex and important process. But it'sdifficult to compare different products analytically. Therefore personal preferences andbiases will probably be ntroduced. This paper describes a scientific model selectionmethod to quantify a product's value to make comparison easy.

关键词： model selection evaluation multi-stage weighting grading

Expression tendency of nestin and its significance during the dedlfferentiation of mature hepatocyte

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Expression tendency of nestin and its significance during th...