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Reproducible Abnormalities and Diagnostic Generalizability of White Matter in Alzheimer’s Disease

Neuroscience Bulletin 2023年第10期39卷 1533-1543页

作者： Yida Qu Pan Wang Hongxiang Yao Dawei Wang Chengyuan Song Hongwei Yang Zengqiang Zhang Pindong Chen Xiaopeng Kang Kai Du Lingzhong Fan Bo Zhou Tong Han Chunshui Yu Xi Zhang Nianming Zuo Tianzi Jiang Yuying Zhou Bing Liu Ying Han Jie Lu Yong Liu Multi-Center Alzheimer’s Disease Imaging(MCADI)consortium Brainnetome Center and National Laboratory of Pattern Recognition Institute of AutomationChinese Academy of SciencesBeijing 100190China School of Artificial Intelligence University of Chinese Academy of SciencesBeijing 100049China Department of Neurology Tianjin Huanhu HospitalTianjin UniversityTianjin 300222China Department of Radiology Department of Epidemiology and Health StatisticsSchool of Public HealthQilu Hospital of Shandong UniversityJi’nan 250063China Department of Neurology Qilu Hospital of Shandong UniversityJi’nan 250063China Department of Radiology Xuanwu Hospital of Capital Medical UniversityBeijing 100053China Branch of Chinese PLA General HospitalSanya 572022China Department of Neurology The Second Medical CentreNational Clinical Research Centre for Geriatric DiseasesChinese PLA General HospitalBeijing 100089China Department of Radiology Tianjin Huanhu HospitalTianjin 300222China Department of Radiology Tianjin Medical University General HospitalTianjin 300052China Department of Neurology Xuanwu Hospital of Capital Medical UniversityBeijing 100053China Beijing Institute of Geriatrics Beijing 100053China National Clinical Research Center for Geriatric Disorders Beijing 100053China Center of Alzheimer’s Disease Beijing Institute for Brain DisordersBeijing 100053China State Key Lab of Cognition Neuroscience&Learning Beijing Normal UniversityBeijing 100091China School of Artificial Intelligence Beijing University of Posts and TelecommunicationsBeijing 100876China 不详

Alzheimer’s disease(AD)is associated with the impairment of white matter(WM)*** current study aimed to verify the utility of WM as the neuroimaging marker of AD with multisite diffusion tensor imaging datasets[321 patients with AD,265 patients with mild cognitive impairment(MCI),279 normal controls(NC)],a unified pipeline,and independent site *** fiber quantification was used to extract diffusion profiles along ***-effects meta-analyses showed a reproducible degeneration pattern in which fractional anisotropy significantly decreased in the AD and MCI groups compared with *** learning models using tract-based features showed good generalizability among independent site *** diffusion metrics of the altered regions and the AD probability predicted by the models were highly correlated with cognitive ability in the AD and MCI *** highlighted the reproducibility and generalizability of the degeneration pattern of WM tracts in AD.

关键词： Alzheimer’s disease Diffusion tensor imaging White matter tracts Cross-validation

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Comparison of approaches to quantify SARS-CoV-2 in wastewater using RT-qPCR: Results and implications from a collaborative inter-laboratory study in Canada

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Journal of Environmental Sciences 2021年第9期33卷 218-229页

作者： Alex H.S.Chik Melissa B.Glier Mark Servos Chand S.Mangat Xiao-Li Pang Yuanyuan Qiu Patrick M.D’Aoust Jean-Baptiste Burnet Robert Delatolla Sarah Dorner Qiudi Geng John P.Giesy Jr Robert Mike McKay Michael R.Mulvey Natalie Prystajecky Nivetha Srikanthan Yuwei Xie Bernadette Conant Steve E.Hrudey Canadian SARS-CoV-Inter-Laboratory consortium Consultant to Canadian Water Network Inc. KitchenerCanada Presently at Ontario Clean Water Agency MississaugaCanada Environmental Microbiology BC Centre for Disease ControlVancouverCanada Department of Biology University of WaterlooWaterlooCanada National Microbiology Laboratory Public Health Agency of CanadaWinnipegCanada Public Health Laboratory Alberta Precision LaboratoryEdmontonCanada Department of Laboratory Medicine&Pathology Faculty of Medicine and DentistryUniversity of AlbertaEdmontonAB T6G 2G3Canada Faculty of Engineering University of OttawaOttawaCanada Département des génies civil géologique et des minesPolytechnique MontréalMontréalCanada Veterinary Biomedical Sciences University of SaskatchewanSaskatoonCanada Toxicology Centre University of SaskatchewanSaskatoonCanada Great Lakes Institute for Environmental Research University of WindsorWindsorCanada Department of Medical Microbiology University of ManitobaWinnipegCanada Department of Pathology and Laboratory Medicine University of British ColumbiaVancouverCanada Canadian Water Network Inc. WaterlooCanada Group author details below

Detection of SARS-CoV-2 RNA in wastewater is a promising tool for informing public health decisions during the COVID-19 ***,approaches for its analysis by use of reverse transcription quantitative polymerase chain reaction(RT-q PCR)are still far from standardized *** characterize inter-and intra-laboratory variability among results when using various methods deployed across Canada,aliquots from a real wastewater sample were spiked with surrogates of SARS-CoV-2(gamma-radiation inactivated SARS-CoV-2 and human coronavirus strain 229E[HCoV-229E])at low and high levels then provided"blind"to eight *** estimates reported by individual laboratories were consistently within a 1.0-log_(10) range for aliquots of the same spiked *** laboratories distinguished between low-and high-spikes for both *** expected,greater variability was observed in the results amongst laboratories than within individual laboratories,but SARS-CoV-2 RNA concentration estimates for each spiked condition remained mostly within 1.0-log_(10) *** no-spike wastewater aliquots provided yielded non-detects or trace levels(<20 gene copies/mL)of SARS-CoV-2 *** appear linked to methods that included or focused on the solids fraction of the wastewater matrix and might represent in-situ SARS-CoV-2 to the wastewater ***-229E RNA was not detected in the no-spike ***,all methods yielded comparable results at the conditions *** behavior of SARS-CoV-2 and spiked surrogates in wastewater should be considered to evaluate method effectiveness.A consistent method and laboratory to explore wastewater SARS-CoV-2 temporal trends for a given system,with appropriate quality control protocols and documented in adequate detail should succeed.

关键词： COVID-19 Wastewater surveillance Public health Quality assurance Quality control

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亚历山大图书馆

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景观设计 2005年第U4期 16-20页

作者： SnФhetta Hamza consortium 杨鹏鲲（译）唐建（审）

这一85000m^2大小的图书馆建筑占地面积较大．位于该历史城市中心古老的亚历山大港口旁边。图书馆共有11层，它可以同时容纳400万册藏书，在不久的将来通过使用压缩藏书方式．这个数目有望达到800万册。

关键词：图书馆建筑历山城市中心占地面积藏书

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Systematic Cross-biospecimen Evaluation of DNA Extraction Kits for Long-and Short-read Multi-metagenomic Sequencing Studies

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Genomics, Proteomics & Bioinformatics 2022年第2期20卷 405-417页

作者： Jacqueline Rehner Georges Pierre Schmartz Laura Groeger Jan Dastbaz Nicole Ludwig Matthias Hannig Stefan Rupf Berthold Seitz Elias Flockerzi Tim Berger Matthias Christian Reichert Marcin Krawczyk Eckart Meese Christian Herr Robert Bals Soren L.Becker Andreas Keller Rolf Muller The IMAGINE consortium Institute of Medical Microbiology and Hygiene Saarland UniversityD-66421 HomburgGermany Clinical Bioinformatics Saarland UniversityD-66123 SaarbruckenGermany Department of Human Genetics Saarland UniversityD-66421 HomburgGermany Helmholtz Institute for Pharmaceutical Research Saarland D-66123 SaarbruckenGermany Clinic of Operative Dentistry Periodontology and Preventive DentistrySaarland UniversityD-66421 HomburgGermany Department of Ophthalmology Saarland University Medical CenterD-66421 HomburgGermany Department of Medicine Ⅱ Saarland University Medical CenterD-66421 HomburgGermany Department of Internal Medicine V–Pulmonology AllergologyIntensive Care MedicineSaarland UniversityD-66421 HomburgGermany

High-quality DNA extraction is a crucial step in metagenomic *** by different isolation kits impairs the comparison across datasets.A trending topic is,however,the analysis of multiple metagenomes from the same patients to draw a holistic picture of microbiota associated with *** thus collected bile,stool,saliva,plaque,sputum,and conjunctival swab samples and performed DNA extraction with three commercial *** each combination of the specimen type and DNA extraction kit,20-gigabase(Gb)metagenomic data were generated using short-read *** profiles of the specimen types showed close proximity to each other,we observed notable differences in the alpha diversity and composition of the microbiota depending on the DNA extraction *** kit outperformed all selected kits on every *** reached consistently good results using the Qiagen QiAamp DNA Microbiome *** on the specimen,our data indicate that over 10 Gb of sequencing data are required to achieve sufficient resolution,but DNA-based identification is superior to identification by mass ***,longread nanopore sequencing confirmed the results(correlation coefficient>0.98).Our results thus suggest using a strategy with only one kit for studies aiming for a direct comparison of multiple microbiotas from the same patients.

关键词： Whole-genome analysis Comparative genomics Short-read sequencing Long-read sequencing DNA extraction Metagenomics

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三维地震观测方式应用的几点意见

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石油地球物理勘探 1998年第6期33卷 787-795页

作者：阎世信谢文导中国石油天然气集团公司勘探局

笔者通过动、静校正理论计算分析．并以实际勘探资料为佐证，详细论述了三维地震观测排列片和面元属性的选择对勘探效果的影响，提出在复杂地震地质条件下，加强室内论证，采用窄方位角排列片重复接收线观测系统，同时要使面元覆盖次数... 详细信息

笔者通过动、静校正理论计算分析．并以实际勘探资料为佐证，详细论述了三维地震观测排列片和面元属性的选择对勘探效果的影响，提出在复杂地震地质条件下，加强室内论证，采用窄方位角排列片重复接收线观测系统，同时要使面元覆盖次数和炮检距均匀分布，将有利于提高勘探精度和效果。

关键词：三维观测系统地震勘探观测方式

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前列腺癌药物去势治疗随访管理中国专家共识(2024版)

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中华肿瘤杂志 2024年第4期46卷 285-295页

作者：中国前列腺癌研究协作组朱耀叶定伟不详复旦大学附属肿瘤医院泌尿外科复旦大学上海医学院肿瘤学系

随着诊疗技术的进步,前列腺癌患者的5年生存率显著提升,前列腺癌进入慢性疾病管理时代。雄激素剥夺治疗是晚期前列腺癌患者的基石治疗方案,并贯穿患者治疗的各阶段。前列腺癌药物去势治疗后的疾病进展、治疗相关不良反应以及相关并发症... 详细信息

随着诊疗技术的进步,前列腺癌患者的5年生存率显著提升,前列腺癌进入慢性疾病管理时代。雄激素剥夺治疗是晚期前列腺癌患者的基石治疗方案,并贯穿患者治疗的各阶段。前列腺癌药物去势治疗后的疾病进展、治疗相关不良反应以及相关并发症已成为前列腺癌长期管理的一大难题,影响患者的生存及生活质量。除了在诊断和治疗过程中需要注重前列腺癌的疾病管理,更应该密切随访药物去势治疗后患者的整体情况,尤其对于处于疾病治疗关键阶段的患者,应在疾病重要节点(疾病阶段起始点和治疗切换点)监测睾酮或其他指标,避免错过最佳治疗窗口期。前列腺癌随访管理应该兼顾疾病本身治疗阶段特点(疾病分期、既往症状、预后因素及治疗方案)和患者自身诉求,定制个性化的随访策略,更好地提高患者治疗依从性,改善预后。目前中国尚缺乏前列腺癌患者药物去势治疗后随访及生活质量管理的指南或共识,为此,中国前列腺癌研究协作组组织国内相关专家制定了前列腺癌药物去势治疗随访管理中国专家共识(2024版),以期为接受药物去势治疗前列腺癌患者的随访及生活管理提供参考,进一步改善中国前列腺癌患者的预后及生活质量。

关键词：前列腺肿瘤药物去势随访生活质量共识

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Are EPB41 and alpha-synuclein diagnostic biomarkers of sport-related concussion?Findings from the NCAA and Department of Defense CARE consortium

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Journal of Sport and Health Science 2023年第3期12卷 379-387页

作者： Rany Vorn Christina Devoto Timothy B.Meier Chen Lai Sijung Yun Steven P.Broglio Sara Mithani Thomas W.McAllister Christopher C.Giza Hyung-Suk Kim Daniel Huber Jaroslaw Harezlak Kenneth L.Cameron Gerald McGinty Jonathan Jackson Kevin M.Guskiewicz Jason P.Mihalik Alison Brooks Stefan Duma Steven Rowson Lindsay D.Nelson Paul Pasquina Michael A.McCrea Jessica M.Gill the CARE consortium Investigators Johns Hopkins School of Nursing and Medicine BaltimoreMD 21205USA National Institutes of Health BethesdaMD 20892USA Department of Neurosurgery Medical College of WisconsinMilwaukeeWI 53226USA Predictiv Care Inc.Mountain ViewCA 94086USA Michigan Concussion Center University of MichiganAnn ArborMI 48109USA Department of Psychiatry Indiana University School of MedicineIndianapolisIN 46202USA Departments of Pediatrics and Neurosurgery University of California at Los Angeles(UCLA)Los AngelesCA 90024USA Department of Epidemiology and Biostatistics School of Public Health–Bloomington Indiana UniversityBloomingtonIN 47405USA John A.Feagin Sports Medicine Fellowship Keller Army Community HospitalWest PointNY 10996USA United States Air Force Academy Colorado SpringsCO 80840USA Mathew Gfeller Center Department of Exercise and Sport ScienceUniversity of North Carolina at Chapel HillChapel HillNC 27514USA Department of Orthopedics Division of Sports MedicineSchool of Medicine and Public HealthUniversity of WisconsinMadisonWI 53705USA Department of Biomedical Engineering and Mechanics Virginia TechBlacksburgVA 24061USA Center for Neuroscience&Regenerative Medicine Uniformed Services UniversityBethesdaMD 20814USA 不详 Current affiliation:School of Nursing University of Texas Health Science Center San AntonioSan AntonioTX 78229USA

Background:Current protein biomarkers are only moderately predictive at identifying individuals with mild traumatic brain injury or ***,more accurate diagnostic markers are needed for sport-related ***:This was a multicenter,prospective,case-control study of athletes who provided blood samples and were diagnosed with a concussion or were a matched non-concussed control within the National Collegiate Athletic Association-Department of Defense Concussion Assessment,Research,and Education consortium conducted between 2015 and *** blood was collected within 48 h of injury to identify protein abnormalities at the acute and subacute *** with concussion were divided into 6 h post-injury(0-6 h post-injury)and after 6 h postinjury(7-48 h post-injury)*** applied a highly multiplexed proteomic technique that used a DNA aptamers assay to target 1305proteins in plasma samples from athletes with and without sport-related ***:A total of 140 athletes with concussion(79.3%males;aged 18.71±1.10 years,mean±SD)and 21 non-concussed athletes(76.2%males;19.14±1.10 years)were included in this *** identified 338 plasma proteins that significantly differed in abundance(319 upregulated and 19 downregulated)in concussed athletes compared to non-concussed *** top 20 most differentially abundant proteins discriminated concussed athletes from non-concussed athletes with an area under the curve(AUC)of 0.954(95%confidence interval:0.922-0.986).Specifically,after 6 h of injury,the individual AUC of plasma erythrocyte membrane protein band 4.1(EPB41)and alpha-synuclein(SNCA)were 0.956 and 0.875,*** combination of EPB41 and SNCA provided the best AUC(1.000),which suggests this combination of candidate plasma biomarkers is the best for diagnosing concussion in athletes after 6 h of ***:Our data suggest that proteomic profiling may provide novel diagnostic protein markers and that a combina

关键词： Biomarkers College athletes Concussion Mild traumatic brain injury Sport injury

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Convergent Neuroimaging and Molecular Signatures in Mild Cognitive Impairment and Alzheimer’s Disease:A Data-Driven Meta-Analysis with N=3,118

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Neuroscience Bulletin 2024年第9期40卷 1274-1286页

作者： Xiaopeng Kang Dawei Wang Jiaji Lin Hongxiang Yao Kun Zhao Chengyuan Song Pindong Chen Yida Qu Hongwei Yang Zengqiang Zhang Bo Zhou Tong Han Zhengluan Liao Yan Chen Jie Lu Chunshui Yu Pan Wang Xinqing Zhang Ming Li Xi Zhang Tianzi Jiang Yuying Zhou Bing Liu Ying Han Yong Liu The Alzheimer’s Disease Neuroimaging Initiative The Multi-Center Alzheimer’s Disease Imaging(MCADI)consortium School of Artificial Intelligence University of Chinese Academy of SciencesBeijing100049China Brainnetome Center and National Laboratory of Pattern Recognition Institute of AutomationChinese Academy of SciencesBeijing100190China Department of Radiology Qilu Hospital of Shandong UniversityJi’nan250063China Department of Neurology the Second Affiliated Hospital of Air Force Medical UniversityXi’an710032China Department of Radiology Chinese PLA General HospitalBeijing100853China Department of Radiology the Second Medical CentreNational Clinical Research Centre for Geriatric DiseasesChinese PLA General HospitalBeijing100853China School of Artificial Intelligence Beijing University of Posts and TelecommunicationsBeijing100191China Department of Neurology Qilu Hospital of Shandong UniversityJi’nan250063China Department of Radiology Xuanwu Hospital of Capital Medical UniversityBeijing100053China Branch of Chinese PLA General HospitalSanya572013China Department of Neurology the Second Medical CentreNational Clinical Research Centre for Geriatric DiseasesChinese PLA General HospitalBeijing100853China Department of Radiology Tianjin Huanhu HospitalTianjin300222China Department of Psychiatry People’s Hospital of Hangzhou Medical CollegeZhejiang Provincial People’s HospitalHangzhou310014China Department of Radiology Tianjin Medical University General HospitalTianjin300070China Department of Neurology Tianjin Huanhu HospitalTianjin300222China Department of Neurology Xuanwu Hospital of Capital Medical UniversityBeijing100053China Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences&Yunnan Province Kunming Institute of ZoologyChinese Academy of SciencesKunming650201YunnanChina State Key Lab of Cognition Neuroscience&Learning Beijing Normal UniversityBeijing100875China National Clinical Research Center for Geriatric Disorders Beijing100053China Center of Alzheimer’s Disease Beijing Institute for Brain DisordersBeijing1000

The current study aimed to evaluate the susceptibility to regional brain atrophy and its biological mechanism in Alzheimer’s disease(AD).We conducted data-driven meta-analyses to combine 3,118 structural magnetic resonance images from three datasets to obtain robust atrophy *** we introduced a set of radiogenomic analyses to investigate the biological basis of the atrophy patterns in *** results showed that the hippocampus and amygdala exhibit the most severe atrophy,followed by the temporal,frontal,and occipital lobes in mild cognitive impairment(MCI)and *** extent of atrophy in MCI was less severe than that in AD.A series of biological processes related to the glutamate signaling pathway,cellular stress response,and synapse structure and function were investigated through gene set enrichment *** study contributes to understanding the manifestations of atrophy and a deeper understanding of the pathophysiological processes that contribute to atrophy,providing new insight for further clinical research on AD.

关键词： Alzheimer’s disease Structural magnetic resonance imaging Meta-analysis Brain atrophy Gene set enrichment analysis

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Testing the role of genetic variation of the MC4R gene in Chinese population in antipsychotic-induced metabolic disturbance

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Science China(Life Sciences) 2019年第4期62卷 535-543页

作者： Yamin Zhang Hongyan Ren Qiang Wang Wei Deng Weihua Yue Hao Yan Liwen Tan Qi Chen Guigang Yang Tianlan Lu Lifang Wang Fuquan Zhang Jianli Yang Keqing Li Luxian Lv Qingrong Tan Hongyan Zhang Xin Ma Fude Yang Lingjiang Li Chuanyue Wang Dai Zhang Liansheng Zhao Huiyao Wang Xiaojing Li Wanjun Guo Xun Hu Yang Tian Xiaohong Ma Tao Li Chinese Antipsychotics Pharmacogenomics consortium Mental Health Center and Psychiatric Laboratory the State Key Laboratory of BiotherapyWest China Hospital of Sichuan UniversityChengdu 610041China Tianjin Medical University General Hospital Tianjin Medical UniversityTianjin 300070China Hebei Mental Health Center Baoding 71000China Second Affiliated Hospital of Xinxiang Medical University Xinxiang 453002China Department of Psychiatry Xijing HospitalFourth Military Medical UniversityXi'an 710032China Huaxi Biobank West China Hospital of Sichuan UniversityChengdu 610041China West China Brain Research Center West China Hospital of Sichuan UniversityChengdu 610041China Peking University Sixth Hospital(Institute of Mental Health) Beijing 100191China National Clinical Research Center for Mental Disorders & Key Laboratory of Mental Health Ministry of Health(Peking University)Beijing 100191China 5Second Xiangya Hospital Central South UniversityChangsha 410011China Beijing Andi ng Hospital Beijing Institute for Brain DisordersCapital Medical UniversityBeijing 100088China Beijing HuiLongGuan Hospital Beijing 100096China Wuxi Mental Health Center Nanjing Medical UniversityWuxi 214151China Institute of Mental Health Tianjin Anding HospitalTianjin 300070China 不详

Antipsychotic-induced metabolic disturbance(AIMD) is a common adverse effect of antipsychotics with genetics partly underpinning variation in susceptibility among schizophrenia patients. Melanocortin4 receptor(MC4 R) gene, one of the candidate genes for AIMD, has been under-studied in the Chinese patients. We conducted a pharmacogenetic study in a large cohort of Chinese patients with schizophrenia. In this study, we investigated the genetic variation of MC4 R in Chinese population by genotyping two SNPs(rs489693 and rs17782313) in 1,991 Chinese patients and examined association of these variants with the metabolic effects that were often observed to be related to AIMD. Metabolic measures, including body mass index(BMI), waist circumference(WC), glucose, triglyceride, high-density lipoprotein(HDL), and low-density lipoprotein(LDL) levels were assessed at baseline and after 6-week antipsychotic treatment. We found that interaction of SNP×medication status(drug-na?ve/medicated) was significantly associated with BMI, WC, and HDL change %, respectively. Both SNPs were significantly associated with baseline BMI and WC in the medicated group. Moderate association of rs489693 with WC, Triglyceride, and HDL change % were observed in the whole sample. In the drug-na?ve group, we found recessive effects of rs489693 on BMI gain more than 7%, WC and Triglyceride change %, with AA incurring more metabolic adverse effects. In conclusion, the association between rs489693 and the metabolic measures is ubiquitous but moderate. Rs17782313 is less involved in AIMD. Two SNPs confer risk of AIMD to patients treated with different antipsychotics in a similar way.

关键词： MC4R antipsychotics metabolic disturbance

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阿尔茨海默病的血液生物标志物:一项基于中国多中心的横断面和纵向研究

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Science Bulletin 2023年第16期68卷 1800-1808,M0004页

作者：高峰戴林斌王琼刘畅邓克学程昭昭吕心怡吴燕张子伊陶青青袁晶李世平王越苏娅程忻倪俊吴志英张舒婷施炯申勇 China Aging and Neurodegenerative Initiative(CANDI)consortium Department of Neurology Institute on Aging and Brain DisordersThe First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230001China Neurodegenerative Disorder Research Center Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230026China Department of Radiology The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230001China Department of Neurology West China HospitalSichuan UniversityChengdu 610041China Department of Neurology and Research Center of Neurology Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310058China Department of Neurology State Key Laboratory of Complex Severe and Rare DiseasesPeking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100006China Department of Neurology Beijing Tiantan HospitalCapital Medical UniversityBeijing 100070China Department of Neurology National Clinical Research Center for Aging and MedicineHuashan HospitalFudan UniversityShanghai 200040China Anhui Province Key Laboratory of Biomedical Aging Research University of Science and Technology of ChinaHefei 230001China 不详

阿尔茨海默病(AD)的生物标志物在血液中含量可能因种族、老年性疾病与各种环境风险因素等不同而存在差异,尚缺乏系统性的研究来评估AD生物标志物在中国老年及AD患者人群中的变化以及是否具有准确预测脑内淀粉样蛋白沉积的能力.本工作为... 详细信息

阿尔茨海默病(AD)的生物标志物在血液中含量可能因种族、老年性疾病与各种环境风险因素等不同而存在差异,尚缺乏系统性的研究来评估AD生物标志物在中国老年及AD患者人群中的变化以及是否具有准确预测脑内淀粉样蛋白沉积的能力.本工作为一项多中心纵向队列研究,共纳入来自全国各地6个不同临床中心的817个血液样本.研究测量了多个国际上通用的AD生物标志物,包括β-淀粉样蛋白40与42、磷酸化Tau(pTau)蛋白、总Tau蛋白、神经纤维丝轻链(NFL)和胶质纤维酸性蛋白(GFAP),并使用淀粉样斑块PET示踪剂和核磁结构影像对受试者进行综合评估.研究发现,APOE基因型与血浆pTau或血清GFAP组合的预测模型对脑内淀粉样斑块的沉积状态具有较好的区分能力.此外,研究还发现GFAP基线水平越高的患者其神经退行性变的速度越快.本研究结果基于多中心数据,论证了AD血液生物标志物在中国汉族人群中的实用性和应用前景,提示了血液pTau和GFAP是检测AD早期症状的有效指标,为我国AD的早期诊断和治疗提供了参考.

关键词：临床中心 Tau蛋白神经退行性变生物标志物老年性疾病基线水平血液样本示踪剂

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