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Hypoglycemic effect of Astragalus polysaccharide and its effect on PTP1B

Acta Pharmacologica Sinica 2005年第3期26卷 345-352页

作者： Yong WU~(2,3) Jing-ping OU-YANG~(2,5) Ke WU~2 Ya WANG~2 Yun-feng ZHOU~2 Chong-yuan WEN~42 Department of Pathophysiology medical College of Wuhan University,3 Department of Physiology Hubei College of traditional chinese medicine4 Department of Endocrinopathic Sciences,Renmin Hospital,Wuhan University,Wuhan 430060,China Department of Pathophysiology Medical College of Wuhan University Wuhan China Department of Physiology Hubei College of Traditional Chinese Medicine Wuhan China Department of Endocrinopathic Sciences Renmin Hospital Wuhan University Wuhan China

Aim:To examine the effects ofAstragalus polysaccharide (APS),a component ofan aqueous extract of Astragalus membranaceus roots,on protein tyrosine phos-phatase 1B (PTP1B),a negative regulator of insulin-receptor (IR) signaltransduction,and its potential role in the amelioration of insulin ***:Ten-week-old fat-fed streptozotocin (STZ)-treated rats,an animal modelof type Ⅱ diabetes mellitus (TIIDM),were treated with APS (400 mg/kg po) for *** sensitivity was identified by the insulin-tolerance *** analy-ses on the possible changes in insulin signaling occurring in skeletal muscle andliver were performed by immunoprecipitation or Western ***1B activ-ity was measured by an assay ***:The diabetic rats responded to APSwith a significant decrease in body weight,plasma glucose,and improved *** activity and expression of PTP1B were elevated in the skeletalmuscle and liver of TIIDM *** the insulin signaling in target tissues *** reduced both PTP1B protein level and activity in the muscle,but not in the iiver of TIIDM ***-induced tyrosine phosphorylation of theIR β-subunit and insulin receptor substrate-1 (IRS-1) were increased in the muscle,but not in the liver of APS-treated TIIDM *** was no change in the activityor expression of PTP1B in APS-treated normal rats,and blood insulin levels didnot change in TIIDM rats after treatment with ***:APS enablesinsulin-sensitizing and hypoglycemic activity at least in part by decreasing theelevated expression and activity of PTP1B in the skeletal muscles of TIIDM rats.

关键词： Astragalus membranaceus polysaccharides PTP1B type Ⅱdiabetes mellitus insulin resistance streptozotocin

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Participation of opioid system in acupuncture actions on immunosuppression by morphine and trauma

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Acta Pharmacologica Sinica 1999年第5期 77-78页

作者： CAO Xiao-Ding, ZHANG Yu, DU Li-Na, CHENG Xiao-Dong, HE Qiu-Zao, WU Gen-Cheng (national Key Laboratory of medical Neurobiology Institute of Acupuncture Research ( WHO Collaborating Center for traditional medicine ), Shanghai medical University, Shanghai200032, China)

Acupuncture therapy is an effective method in traditional chinese medicine. Substantial studies have shown that acupuncture can ameliorate a diverse collection of ailments that

关键词： Participation of opioid system in acupuncture actions on immunosuppression by morphine and trauma

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何首乌安全用药指南

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Acupuncture and Herbal medicine 2024年第2期4卷 151-158,I0001页

作者：肖小河王伽伯宋海波欧阳冬生邹正升王睿林何婷婷景婧郭玉明柏兆方湛小燕牛明马致洁李春雨中华中医药学会中成药分会中华中医药学会肝胆病分会中国药学会临床中药学专业委员会中国药理学会药源性疾病学专业委员会肝病分委会中国毒理学会临床毒理专业委员会中国人民解放军总医院第五医学中心北京中南大学临床药理研究所长沙国家药品监督管理局药品评价中心北京不详

何首乌为常用中药,在临床治疗和日常保健中使用广泛,但近年来屡见有肝损伤报道,引起国内外广泛关注,部分含何首乌和首乌藤制剂肝损伤风险已被国家食品药品监督管理局多次通报。近年来相关研究已取得实质性进展,揭示了其特异质肝损伤的... 详细信息

何首乌为常用中药,在临床治疗和日常保健中使用广泛,但近年来屡见有肝损伤报道,引起国内外广泛关注,部分含何首乌和首乌藤制剂肝损伤风险已被国家食品药品监督管理局多次通报。近年来相关研究已取得实质性进展,揭示了其特异质肝损伤的基本属性、主要成因、物质基础和分子机制,发现其易感人群的基本特征和生物标志物,表明何首乌仅对极少数特定人群有肝损伤风险,对绝大多数人群是安全的。研究成果为正确客观地认识何首乌致肝损伤、合理制定何首乌及相关制剂安全用药措施提供了科学依据。为此,中华中医药学会组织全国相关领域专家,起草制定了《何首乌安全用药指南》,旨在帮助国内外公众和相关机构,科学认识、评估和规避何首乌肝损伤风险,指导何首乌及相关制剂的合理使用,保障广大消费者的健康权益,同时促进何首乌及相关产业的健康持续发展。该指南已通过中华中医药学会的审核,并进行了发布,编号T/CACM 1328-2019。

关键词：药物安全性肝损伤何首乌合理使用中药

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On bio-diversity, complexity of M-CSF and its receptor

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chinese Science Bulletin 2000年第20期45卷 1918-1920页

作者： WU KefuState Key Laboratory of Experimental Hematology, Institute of Hematology, chinese Academy of medical Sciences & Peking Union medical College, Tianjin 300020, China State Key Laboratory of Experimental Hematology Institute of Hematology Chinese Academy of Medical Sciences & Peking Union Medical College Tianjin China

With the development of science, the methods and the views or scientitic researcn changed from analyses to syntheses. Recently, more attention has been paid to bio-diversity and complexity. According to the study on M-CSF and its receptor for years, the author suggests that, the multi-level of bio-diversity also appears at the bio-macromolecular level. Probability of bio-diversity is one of the bases for bio-complexity. Cellular sociology and topobiology are important aspects in bio-complexity, and should be developed. If taking chinese traditional medicine together with the advantage from Reductionism, joining the study on complexity, chinese scientist would make a chair in the international scientific society.

关键词： bio-diversity complexity macrophage colony-stimulating factor macrophage colony-stimulating factor receptor.

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肝硬化中医诊疗指南

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临床肝胆病杂志 2024年第3期40卷 461-472页

作者：中华中医药学会肝胆病分会王宪波高方媛刘尧李秀惠赵文霞朱英不详首都医科大学附属北京地坛医院首都医科大学附属北京佑安医院河南中医药大学第一附属医院大连医科大学附属第一医院

近年来,随着基础与临床研究的进展,医务工作者对肝硬化的临床诊治有了进一步的认识。同时,国内关于肝硬化的中医证候规律、中西医结合治疗的研究日趋增多,尤其是在抗肝纤维化方面中医中药发挥了重要的作用。本指南在2008版《中医内科常... 详细信息

近年来,随着基础与临床研究的进展,医务工作者对肝硬化的临床诊治有了进一步的认识。同时,国内关于肝硬化的中医证候规律、中西医结合治疗的研究日趋增多,尤其是在抗肝纤维化方面中医中药发挥了重要的作用。本指南在2008版《中医内科常见病诊疗指南》的基础上进行修订,项目组按照中医药标准化、循证医学、技术指导文件的相关要求,通过文献研究、专家访谈、问卷调查、临床问题确定、证据分级、推荐意见形成、征求意见等多种形式最终形成一套可行的中医药诊疗指南以切实、规范地指导临床诊疗。该指南经中华中医药学会批准发布,标准编号:T/CACM1576-2024。

关键词：肝硬化中医诊疗准则

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Clinical practice guideline on traditional chinese medicine in the treatment of influenza (2021)

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Journal of traditional chinese medical Sciences 2021年第4期8卷 280-290页

作者： Specialty Committee of Emergency,China Association of chinese medicine Qingquan Liu Jianping Liu Specialty Committee of Emergency China Association of Chinese MedicineChina Beijing Hospital of traditional chinese medicine Capital Medical University/Beijing Institute of Traditional Chinese MedicineBeijing100010China Centre for Evidence-Based chinese medicine Beijing University of Chinese MedicineBeijing100029China

Influenza is a serious public health problem that endangers the health of the global human *** chinese medicine(TCM)is rich in theory and practical experience regarding the treatment of influenza,and TCM treatments have shown good curative effects,but there is a dearth of standardized clinical *** is necessary to formulate a clinical practice guide based on evidence-based *** this end,the Specialty Committee of Emergency,China Association of chinese medicine(Beijing,China)organized a team of clinical experts,methodological experts,and other multidisciplinary experts to develop a guideline with integrated research methods in the first place of *** guide includes 23 *** prescription section contains 16 recommendations,including 5 recommendations for mild cases,5 recommendations for severe cases,3 recommendations for critical cases,and 4 recommendations for the recovery period;the portion covering proprietary chinese medicines forms a total of 7 *** guide aims to provide the best evidence for clinicians and related practitioners to make decisions about influenza diagnosis and treatment in chinese medicine.

关键词： Influenza traditional chinese medicine Formula chinese patent medicine Guideline

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新疆和内地慢性阻塞性肺疾病中医特点的比较

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中华中医药杂志 2015年第1期30卷 195-198页

作者：高振李风森荆晶徐丹哈木拉提·吾甫尔新疆医科大学附属中医医院国家中医临床研究基地

目的:揭示新疆和内地慢性阻塞性肺疾病(COPD)中医证型、证素、症状等中医特点的异同。方法:采用文献计量学的方法分别研究基于文献的中国内地COPD中医特点和基于流行病学调查的新疆COPD的发病特点,并将二者进行对比研究。结果:对于COPD... 详细信息

目的:揭示新疆和内地慢性阻塞性肺疾病(COPD)中医证型、证素、症状等中医特点的异同。方法:采用文献计量学的方法分别研究基于文献的中国内地COPD中医特点和基于流行病学调查的新疆COPD的发病特点,并将二者进行对比研究。结果:对于COPD内地多发证型依次是痰热蕴肺、痰瘀阻肺、肺脾气虚、肺肾两虚等,新疆多发证型依次是痰浊阻肺、肺气虚、风寒袭肺、西北寒燥等。内地病位证素以肺、脾、肾为主,病性证素以痰、气虚、热、瘀为主;新疆病位为肺、肾、脾;病性以气虚、寒、阳虚、痰为主。内地总体症状依次是咳嗽、咳痰、气喘、喘息等,新疆总体症状依次是气短、咳嗽、气喘、咽干口干等。结论:新疆COPD在中医证型、证素、症状等中医特点上与内地COPD有别,体现出新疆特有的寒、燥特点。

关键词：新疆内地慢性阻塞性肺疾病证型证素中医

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Tetramethylpyrazine protected photoreceptor cells of rats by modulating nuclear translocation of NF-κB

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Acta Pharmacologica Sinica 2005年第7期26卷 887-892页

作者： Jin-nan YANG~(2,3) Jin-mao CHEN~4 Lin LUO~4 Shao-chun LIN~4 Dai LI~4 Shi-xing HU~(4,5,6) 2 School of Pharmacy,Xinxiang medical College,Xinxiang 453003,China 4 Zhongshan Ophthalmic Centre,Sun Yat-sen University,Guangzhou 510060,China 5 Eye Hospital of China,Academy of traditional chinese medicine,Beijing 100040,China School of Pharmacy Xinxiang Medical College Xinxiang China Zhongshan Ophthalmic Centre Sun Yat-sen University Guangzhou China Eye Hospital of China Academy of Traditional Chinese Medicine Beijing China

Aim:To evaluate the effect of tetramethylpyrazine(TMP)injection on retinaldamage induced by N-methyl-N-nitrosourea(MNU)in rats and on nuclear factor-kappa B(NF-κB)family ***:Female Sprague-Dawley(SD)ratswere randomly divided into groups:(i),control group;(ii),model group;and(iii),TMP-injection groups,in which the rats were subdivided into 40 mg/kg,80 mg/kgand 160 mg/kg *** were injected ip into 47-day-old SD rats once a *** 50 days of age,all rats in the model group and drug groups also received asingle ip injection of 60 mg/kg *** in group 1 received ip injection ofphysiological *** rats were killed at different times after MNU or physi-ological saline *** apoptotic index of photoreceptor cells was calcu-lated by TUNEL labeling;retinal damage was evaluated based on retinal thicknessand the expression of NF-κB family members was detected by Western ***:TMP injections,in a dose-dependent manner,suppressed photorecep-tor cell apoptosis and decreased its loss in the peripheral *** comparedwith the MNU-treated group,TMP injection at a dose of 160 mg/kg also time-dependently upregulated the NF-κB/p65 protein level in the nucleus anddownregulated the IκBα protein level in the ***,no protectiveeffect of TMP injection on MNU-induced central retinal damage was ***:TMP injection partially protects against MNU-induced retinal dam-age by upregulating the nuclear translocation of p65 to inhibit photoreceptor cellsapoptosis.

关键词： tetramethylpyrazine photoreceptors methylnitrosourea apoptosis NF-kappa B retinitis pigmentosa

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medical workers in traditional medicine who sacrificed their lives in the battle against COVID-19 deserve to be remembered forever

引用

traditional medicine Research 2020年第3期5卷 122-124页

作者： Editorial Group of traditional medicine Research 不详

China held a national day of mourning on April 4,2020 to commemorate 3,335 victims of the COVID-19 outbreak,including medical workers who sacrificed their lives in the battle against the epidemic[1].April 4 was also Tomb-sweeping Day in China,known as the Qingming Festival,it is an important occasion for the chinese to visit cemeteries,clean tombs,and mourn their ancestors[2].According to data from the official website of the State Administration of traditional chinese medicine,as of February 17,60,107 confirmed cases had been treated with traditional medicine,accounting for 85.2%,while nearly 4,400 medical personnel from more than 600 traditional chinese hospitals were sent to Hubei[3].

关键词： remember who workers

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Effective components of Buyang Huanwu decoction inhibited the thrombin-induced adhesion molecule expression in vascular endothelial cells by downregulating protein kinase C

Effective components of Buyang Huanwu decoction inhibited th...

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湖南省生理科学会2008年度学术年会

作者： Tang Liwen~1,Ou Ming''e~2,Li Hua~3,He Fuyuan~4,Deng Changqing~1 ~1School of Integrated chinese and Western medicine,Hunan University of traditional chinese medicine,Changsha,China ~2Affiliated Hospital of Zhaoqing medical College,Zhaoqing,Guangdong Province,China ~3School of Preclinical medicine,Hunan University of traditional chinese medicine,Changsha, China ~4School of chinese Pharmaceutics,Hunan University of traditional chinese medicine,Changsha, China

＜正＞Buyang Huanwu Decoction（BYHWD）,a classical formula of traditional chinese medicine （TCM）,consists of Astragalus membranaceus,Paeonia veitchii,Angelicae sinensis,Ligusticum chuanxiong hort,Carthamus tinctorius,Pheretima aspergillum,and Prunus *** here evaluate the effects of BYHWD and its major components,alkaloids and glycosides,on thrombin

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