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Comparing different machine learning techniques for predicting COVID-19 severity

Infectious Diseases of Poverty 2022年第1期11卷 97-97页

作者： Yibai Xiong Yan Ma Lianguo Ruan Dan Li Cheng Lu Luqi Huang the national traditional chinese medicine medical team Institute of Basic Research in Clinical medicine China Academy of Chinese Medical SciencesNo.16Nanxiao StreetDongzhimenDongcheng DistrictBeijing100700BeijingChina 不详 national Resource Center for chinese Materia Medica China Academy of Chinese Medical SciencesNo.16Nanxiao StreetDongzhimenDongcheng DistrictBeijing100700BeijingChina

Background Coronavirus disease 2019(COVID-19)is still ongoing spreading globally,machine learning techniques were used in disease diagnosis and to predict treatment outcomes,which showed favorable *** present study aims to predict COVID-19 severity at admission by different machine learning techniques including random forest(RF),support vector machine(SVM),and logistic regression(LR).Feature importance to COVID-19 severity were further *** A retrospective design was adopted in the JinYinTan Hospital from January 26 to March 28,2020,eighty-six demographic,clinical,and laboratory features were selected with LassoCV method,Spearman’s rank correlation,experts’opinions,and literature ***,SVM,and LR were performed to predict severe COVID-19,the performance of the models was compared by the area under curve(AUC).Additionally,feature importance to COVID-19 severity were analyzed by the best performance *** A total of 287 patients were enrolled with 36.6%severe cases and 63.4%non-severe *** median age was 60.0 years(interquartile range:49.0–68.0 years).Three models were established using 23 features including 1 clinical,1 chest computed tomography(CT)and 21 laboratory *** three models,RF yielded better overall performance with the highest AUC of 0.970 than SVM of 0.948 and LR of 0.928,RF also achieved a favorable sensitivity of 96.7%,specificity of 69.5%,and accuracy of 84.5%.SVM had sensitivity of 93.9%,specificity of 79.0%,and accuracy of 88.5%.LR also achieved a favorable sensitivity of 92.3%,specificity of 72.3%,and accuracy of 85.2%.Additionally,chest-CT had highest importance to illness severity,and the following features were neutrophil to lymphocyte ratio,lactate dehydrogenase,and D-dimer,*** Our results indicated that RF could be a useful predictive tool to identify patients with severe COVID-19,which may facilitate effective care and further optimize resources.

关键词： COVID-19 Severity Machine learning Support vector machine Random Forest Logistic regression

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The Effect of Huashibaidu Formula on the blood oxygen saturation status of severe COVID-19:a retrospective cohort study

The Effect of Huashibaidu Formula on the blood oxygen satura...

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中国防痨协会2023年第34届全国学术大会暨结核病诊防治新技术推广应用论坛

作者： Yibai Xiong Yaxin Tian Yan Ma Bin Liu Lianguo Ruan Cheng Lu Luqi Huang the national traditional chinese medicine medical team Institute of Basic Research In Clinical medicine China Academy of Chinese Medical Sciences Department of Infectious Diseases Jinyintan hospital national Resource Center for chinese Materia Medica China Academy of Chinese Medical Sciences

Background Huashibaidu Formula(HSBD) for the COVID-19 treatment has been supported by the China’s Diagnosis and Treatment Protocol for Novel Coronavirus ***,it is not clear whether HSBD can improve blood oxygen satur...

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基于人工智能模型的老年冠心病动态自适应出院评估专家共识

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中西医结合心脑血管病杂志 2024年第20期 3649-3658页

作者： national Cardiology Center national Clinical Research Center for Cardiovascular Diseases chinese Gerontology and Geriatrics Society Committee of Cardiovascular Diseases chinese medical Education, Association of traditional chinese and Western medicine Cardiovascular Professional Committee 国家心脏病中心国家心血管病临床研究中心中国老年学和老年医学学会心血管病专业委员会中国医药教育学会中西医结合心血管专业委员会

我国作为人口大国，心血管疾病呈现高发态势，老年慢性病管理更是面临巨大挑战，老年冠心病是最常见的老年慢性心血管疾病之一，具有高发病率、高死亡率及高致残率的特点。针对老年冠心病的特点，各地医疗机构及科研院所不断研究出适用... 详细信息

我国作为人口大国，心血管疾病呈现高发态势，老年慢性病管理更是面临巨大挑战，老年冠心病是最常见的老年慢性心血管疾病之一，具有高发病率、高死亡率及高致残率的特点。针对老年冠心病的特点，各地医疗机构及科研院所不断研究出适用于老年冠心病群体的基于人工智能的出院评估系统及出院管理策略。本共识目的在于整合最新研究进展及基于人工智能的老年冠心病动态自适应出院评估体系。从而指导临床医生运用人工智能技术进行老年冠心病出院评估及高效的疾病管理。

关键词：老年冠心病人工智能出院评估动态自适应专家共识

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男性雄激素性秃发中西医诊疗专家共识

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临床皮肤科杂志 2024年第5期53卷 305-311页

作者：国家皮肤和性传播疾病专业质控中心毛发专家委员会国家中西医结合医学中心毛发专病医联体中国整形美容协会中医美容分会中华中医药学会皮肤科分会毛发学组北京中西医结合学会皮肤性病专业委员会毛发学组李锘杨顶权不详中日友好医院

雄激素性秃发(AGA)是临床最常见的脱发性疾病,男性AGA发病率更高,严重影响患者的身心健康和生活质量。目前认为该病与遗传易感性和脱发部位毛囊细胞对雄激素的高反应性密切相关。诊断主要依据病史、脱发模式和皮肤镜检查。中医药治疗是... 详细信息

雄激素性秃发(AGA)是临床最常见的脱发性疾病,男性AGA发病率更高,严重影响患者的身心健康和生活质量。目前认为该病与遗传易感性和脱发部位毛囊细胞对雄激素的高反应性密切相关。诊断主要依据病史、脱发模式和皮肤镜检查。中医药治疗是我国AGA防治的优势和特色,为了推广男性AGA的规范化中西医诊治理念,提高我国在该领域的诊治水平,特组织编写了该专家共识。

关键词：雄激素性秃发男性中西医诊疗专家共识

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Synthesis of molecularly imprinted polymers for the application of selective clean-up vinblastine from Catharanthus roseus extract

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中国科学：化学英文版 2010年第12期53卷 2587-2592页

作者： ZHU QuanHong,HUANG DanDan,LI Li & YIN YongGuan College of traditional chinese medicine,Southern medical University,Guangzhou 510515,China College of traditional chinese medicine Southern Medical University Guangzhou China

Molecularly imprinted polymers (MIPs) are synthetic tailor-made polymers with high selectivity towards a particular substance (template).An MIP using vinblastine (VLB) as the template molecule was synthesized and *** presence of monomer-template complexes in a non-covalent way was confirmed by UV-vis spectrometry *** polymerization was performed using methacrylic acid (MAA) as the functional monomer,ethylene glycol dimethacrylate (EGDMA) as the cross-linking agent,and toluene as the porogenic solvent by a thermo-polymerization *** characterization of the obtained MIP was evaluated by scanning electron microscopy (SEM) and Brunauer-Emmett-Teller (BET) *** was observed that the morphology of the MIP was more porous and rough,and the surface area had a significant increase compared with that of the non-imprinted polymer (NIP).This MIP was used as the sorbents of solid-phase extraction (SPE) to assess the selectivity of the MIP after optimization of the SPE *** was specifically adsorbed on the MIP cartridge,while to vincristine (VCR),the chemical analog of VLB,almost no selective binding *** the basis of the results,Catharanthus roseus extract was applied to the MIP cartridge for investigating its capability to extract VLB from the plant extract,and the capacity of the MIP cartridge was also *** was shown that the MIP could effectively enrich VLB from *** extract and the recovery amounted to 93.8%.The solvents dissolving the samples had significant influence on the capacity of the MIP cartridge;it was 750 μg/g in toluene,625 μg/g in chloroform,and 250 μg/g in methanol.

关键词： molecular imprinting polymer vinblastine selective extraction Catharanthus roseus extract

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A Study of the Law of Herbal Administration in Treating Lung-distension by TCM Physicians through History Using Cluster Analysis

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Journal of traditional chinese medicine 2011年第4期31卷 303-307页

作者：高振李风森哈木拉提·吾甫尔 traditional chinese medicine Hospital affiliated with Xinjiang medical University & national Clinical Research Base of traditional chinese medicine Xin Jiang medical University

Objective: To review the herbal drugs used most often for treating lung-distension by determining those used by physicians throughout history; to study their property, taste, and channel tropism; and to explore their compatibility. Methods: Historical prescriptions for treating lung-distension were collected and sorted. Property, taste and channel tropism were determined, and the law of herbal administration was determined by cluster analysis. Results: One hundred and ninety five prescriptions were found, involving 166 herbal drugs, with a total appearance frequency of 1296 drugs. The herbs involved 8 properties (total appearance frequency, 1296), 7 forms of taste (total appearance frequency, 1991) and involved all 12 regular channels (total appearance frequency, 3382). Sixteen herbal drugs were used most often and formed 4 cluster prescriptions: C1: Xing Ren (Semen Armeniacae Amarum), Gan Cao (Radix Glycyrrhizae), and Ban Xia (Rhizoma Pinelliae); C2: Gui Zhi (Ramulus Cinnamomi), Wu Wei Zi (Fructus Schisandrae), and Sheng Jiang (Rhizoma Zingiberis Recens); C3: Da Zao (Fructus Jujubae), Ma Huang (Herba Ephedrae), and Shi Gao (Gypsum Fibrosum); and C4: Chen Pi (Pericarpium Citri Reticulatae), Jie Geng (Radix Platycodi), Fu Ling (Poria), Sang Bai Pi (Cortex Mori), Xi Xin (Herba Asari), Gan Jiang (Rhizoma Zingiberis), and Bai Shao (Radix Paeoniae Alba). Conclusion: In treating lung-distension, phlegm retention has been traditionally considered the underlying pathology, emphasizing regulation of the lung and spleen as key and stressing patient nourishment and mental improvement. Prescriptions for lung-distension should be made with reference to the property, taste, channel tropism, and effectiveness of the chosen herbal drugs.

关键词： ancient medical literature cluster lung-distension property taste and channel tropism the law of herbal administration

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Inhibiting pain with pain——A basic neuromechanism of acupuncture analgesia

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chinese Science Bulletin 2001年第17期46卷 1485-1494页

作者： LIU XiangInstitute of Acupuncture and Moxibustion, China Academy of traditional chinese medicine, Beijing 100700, China Institute of Acupuncture and Moxibustion China Academy of Traditional Chinese Medicine Beijing China

(i) The structure and function of the meridian (channel and collateral) described by ancient medical doctors may correspond to the blood circulation, nerve control and neurohumoral modulation of modern medicine. (ii) The needling, which can injure the tissue, is a noxious stimulation inducing pain. Acupuncture manipulation, such as lifting and thrusting, twisting and twirling, or electroacupuncture (EA) with the sufferable biggest intensity for patients should be a stronger pain stimulation. The needling sensation of soreness, numbness, distension and heaviness is a deep pain. (iii) There is an intrinsic analgesic system in brain, which centers around the periventricular and periaqueductal grey matter, contains endorphins as possible mediators, goes through the descending inhibition system in medulla oblon-gata, and acts on the gating mechanism in spinal cord. Itcould be producing analgesia while the system is activated. (iv) NRM might be a supraspinal center modulating pain, and the R-S neurons could

关键词： acupuncture analgesia Inhibiting pain with pain negative feedback mechanism of pain nucleus raphe magnus afferent C fiber capsaicm.

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中医病证诊断疗效标准·原发性痛经(修订)

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中华中医药杂志 2024年第4期39卷 1884-1887页

作者：《中医病证诊断疗效标准·原发性痛经》项目组杜惠兰梁潇宋亚静不详河北中医药大学 050091

原发性痛经是妇科常见病、多发病,中医治疗特色鲜明,疗效确切。《中医病证诊断疗效标准》(ZY/T001.1—94)由国家中医药管理局于1994年批准发布,已二十余年未修订。本次修订基于循证医学证据并采用系统评价的研究方法确定证据等级和推荐... 详细信息

原发性痛经是妇科常见病、多发病,中医治疗特色鲜明,疗效确切。《中医病证诊断疗效标准》(ZY/T001.1—94)由国家中医药管理局于1994年批准发布,已二十余年未修订。本次修订基于循证医学证据并采用系统评价的研究方法确定证据等级和推荐强度,并通过2轮德尔菲法专家调查问卷形成专家共识,在此基础上起草《中医病证诊断疗效标准·原发性痛经(修订)》,以期为中医药开展诊治原发性痛经的临床及研究工作建立标准化体系。

关键词：原发性痛经中医诊疗标准专家共识法循证医学

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Inflammatory responses of the rat lungs in cold-dryness syndrome in the northwest of China

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Journal of traditional chinese medicine 2012年第2期32卷 234-237页

作者：高振哈木拉提·吾甫尔荆晶廖春燕徐丹李风森 traditional chinese medicine Hospital affiliated with Xinjiang medical University & national Clinical Research Base of traditional chinese medicine Xin Jiang medical University

OBJECTIVE:To examine changes in body weight and the lung inflammation factors interleukin-1β(IL-1β),interleukin-8(IL-8),IL-10 and tumor necrosis factor-α(TNF-α) in a rat model of cold-dryness syndrome in Northwest(Xinjiang) China to provide a reference for treating chronic obstructive pulmonary disease(COPD) with local ***:The rat COPD model was established by intratracheal instillation of porcine pancreatic elastase(PPE) in combination with cigarette smoking(CS).The rat model of cold-dryness syndrome of COPD in the northwest of China was set up by intratracheal instillation of PPE in combination with CS and environmental cold-dryness *** level of IL-1β,IL-8,IL-10 and TNF-α in Bronchoalveolar lavage fluid(BALF) were measured by enzyme-linked immunosorbent assay(ELISA).The data were analyzed using the software SPSS ***:1) Body weight was less in the two model groups than that of control group(P<0.01),PPE plus CS cold-dryness group was less than that of PPE plus CS group(P<0.01).2) IL-1β in BALF significantly increased in PPE plus CS and cold-dryness group than that of control group(P<0.01).3) IL-8 and TNF-α in BALF significantly increased in PPE plus CS and cold-dryness group and PPE plus CS group than that of control group(P<0.01).CONCLUSION:Body weight in COPD model rats was reduced compared with ***-dryness may aggravate such a condition Lung inflammation in the model was mainly manifested by an increase in IL-1β,IL-8 and TNF-α levels,with no change in IL-10 ***-dryness may aggravate lung inflammation of COPD.

关键词： Pulmonary disease Chronic obstructive pulmonary disease Cold-dryness syndrome Northwest China Inflammatory reaction

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Diagnosis and Treatment Protocol for Novel Coronavirus Pneumonia(Trial Version 7)

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chinese medical Journal 2020年第9期133卷 1087-1095页

作者： Wei, Pei-Fang national Health Commission&national Administration of traditional chinese medicine

Since December 2019,multiple cases of novel coronavirus pneumonia(COVID-19)have been identified in Wuhan,*** the spread of the epidemic,such cases have also been found in other parts of China and other *** an acute respiratory infectious disease,COVID-19 has been included in Class B infectious diseases prescribed in the Law of the People’s Republic of China on Prevention and Treatment of Infectious Diseases,and managed as an infectious disease of Class *** taking a series of preventive control and medical treatment measures,the rise of the epidemic situation in China has been contained to a certain extent,and the epidemic situation has eased in most provinces,but the incidence abroad is on the *** increased understanding of the clinical manifestations and pathology of the disease,and the accumulation of experience in diagnosis and treatment,in order to further strengthen the early diagnosis and early treatment of the disease,improve the cure rate,reduce the mortality rate,avoid nosocomial infection as much as possible and pay attention to the spread caused by the imported cases from overseas,we revised the Diagnosis and Treatment Protocol for Novel Coronavirus Pneumonia(Trial Version 6)to Diagnosis and Treatment Protocol for Novel Coronavirus Pneumonia(Trial Version 7).

关键词： diagnosis treatment prescribed

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