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Real-World Treatment Adherence to Smoking cessation Medications and Association with Treatment Outcome—27 Centers,china,2017–2022

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china CDC weekly 2024年第22期6卷 522-529,I0001-I0003页

作者： Anqi Cheng Zhao Liu Xinmei Zhou Zheng Su Dan Xiao Chen Wang the china national tobacco cessation cohort Study(CNTCCS)Study group Department of tobacco Control and Prevention of Respiratory Disease Center of Respiratory MedicineChina-Japan Friendship Hospital/WHO Collaborating Center for Tobacco Cessation and Respiratory Diseases Prevention/National Center for Respiratory Medicine/National Clinical Research Center for Respiratory Diseases/Institute of Respiratory MedicineChinese Academy of Medical SciencesBeijingChina Department of Pulmonary and Critical Care Medicine Center of Respiratory MedicineChina-Japan Friendship Hospital/WHO Collaborating Center for Tobacco Cessation and Respiratory Diseases Prevention/China National Center for Respiratory Medicine/China National Clinical Research Center for Respiratory DiseasesBeijingChina Chinese Academy of Medical Sciences and Peking Union Medical College BeijingChina 不详

What is already known about this topic?Medication non-adherence significantly impedes smoking cessation *** effective smoking cessation medications are accessible in china,realworld adherence and its correlation with treatment outcomes remain largely *** is added by this report?From December 2017 to January 2022,1,120 participants were recruited from 27 centers in all seven geographical regions of *** revealed that only 38.2%of smokers adhered to the prescribed 12-week smoking cessation treatment and those with a higher education level were more likely to be *** addition,smokers with good adherence were more likely to successfully quit *** are the implications for public health practice?The data obtained could enhance our understanding of smoking cessation practices in *** adherence is a crucial strategy to enhance the effectiveness of smoking cessation treatments and management provided to smokers.

关键词： china smoke likely

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Association of physical activity with risk of chronic kidney disease in china:A population-based cohort study

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Journal of Sport and Health Science 2024年第2期13卷 204-211页

作者： Kexiang Shi Yunqing Zhu Jun Lv Dianjianyi Sun Pei Pei Huaidong Du Yiping Chen Ling Yang Bing Han Rebecca Stevens Junshi Chen Zhengming Chen Liming Li Canqing Yu china Kadoorie Biobank collaborative group Department of Epidemiology&Biostatistics School of Public HealthPeking University Health Science CenterBeijing 100191China Peking University Center for Public Health and Epidemic Preparedness&Response Beijing 100191China Key Laboratory of Epidemiology of Major Diseases(Peking University) Ministry of EducationBeijing 100191China Clinical Trial Service Unit&Epidemiological Studies Unit(CTSU) Nuffield Department of Population HealthUniversity of OxfordOxford OX37LFUK Medical Research Council Population Health Research Unit at the University of Oxford Oxford OX37LFUK NCDs Prevention and Control Department Henan Center for Disease Control and PreventionZhengzhou 450016China china national Center for Food Safety Risk Assessment Beijing 100022China 不详

Background:Information on the association between physical activity(PA)and the risk of chronic kidney disease(CKD)is *** aimed to explore the associations of total,domain-specific,and intensity-specific PA with CKD and its subtypes in ***:The study included 475,376 adults from the china Kadoorie Biobank aged 30-79 years during 2004-2008 at *** interviewer-administered questionnaire was used to collect the information about PA,which was quantified as metabolic equivalent of task hours per day(MET-h/day)and categorized into 4 groups based on *** regression was used to analyze the association between PA and CKD ***:During a median follow-up of 12.1 years,5415 incident CKD cases were documented,including 1159 incident diabetic kidney disease(DKD)cases and 362 incident hypertensive nephropathy(HTN)*** PA was inversely associated with CKD risk,with an adjusted hazard ratio(HR,95%confidence interval(95%CI))of 0.83(0.75-0.92)for incident CKD in the highest quartile of total PA as compared with participants in the lowest *** results were observed for risk of DKD and HTN,and the corresponding HRs(95%CIs)were 0.75(0.58-0.97)for DKD risk and 0.56(0.37-0.85)for HTN *** nonoccupational PA,low-intensity PA,and moderate-to-vigorous-intensity PA were significantly associated with a decreased risk of CKD,with HRs(95%CIs)of 0.80(0.73-0.88),0.85(0.77-0.94),and 0.85(0.76-0.95)in the highest quartile,***:PA,including nonoccupational PA,low-intensity PA,and moderate-to-vigorous-intensity PA,was inversely associated with the risk of CKD,including DKD,HTN,and other CKD,and such associations were dose dependent.

关键词： Chronic kidney disease Domain Intensity Physical activity

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Research on stability of the accumulated rock-soil body of reservoir bank under rainfall condition

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Science china(Technological Sciences) 2009年第9期52卷 2528-2535页

作者： GU ChongShi1,2,WU HaiZhen1,2 & SU HuaiZhi1,2 1 College of Water Resources and Hydropower Engineering,Hohai University,Nanjing 210098,china 2 national Engineering Research Center of Water Resources Efficient Utilization and Engineering Safety,Hohai University,Nanjing 210098,china 3 Jiangxi Water Conservancy Research Institute,Nanchang 330029,china College of Water Resources and Hydropower Engineering Hohai University national Engineering Research Center of Water Resources Efficient Utilization and Engineering Safety Hohai University Jiangxi Water Conservancy Research Institute

The shear strength parameters property of rock-soil aggregates in embankment slope of reservoir,that is,the relationship between cohesion and gravel content,between friction angle and gravel content,and the relationship between cohesion and water content,between friction angle and water content,is studied based on the direct shear test results,the shear strength change law of the rock-soil aggregates is given,and the unsaturated shear strength formulation of rock-soil aggregates that could consider suction and saturation degree influence is put forward in this paper,through which the sliding or failure physical mechanism of this type of slope under the condition of rainfall infiltration is studied. Also the 3D unsteady saturated-unsaturated seepage field and its FEM resolving mode are established based on the analysis of the slope rainfall infiltration process. Case study with this method indicates that the minimum safety factor of the accumulated rock-soil aggregates dose not arrive at the moment of rainfall cessation,but appears several hours after the rainfall cessation,this phenomenon is in accordance with the practical slope engineering's failure process and could explain appropriately the slope failure caused by rainfall infiltration. Research results in this paper have an important reference value for the research on stability of the accumulated rock-soil aggregates in embankment slope of reservoir,and can enrich the stability analysis method and relevant theory of reservoir embankment slope.

关键词： reservoir bank slope rock-soil aggregates rainfall infiltration saturated/unsaturated seepage

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中国10个地区老年人长寿影响因素的前瞻性队列研究

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中华流行病学杂志 2024年第1期45卷 26-34页

作者：李烁宇张艺倩肖梦孙点剑一余灿清王月清裴培陈君石陈铮鸣李立明吕筠中国慢性病前瞻性研究项目协作组北京大学公共卫生学院流行病与卫生统计学系北京100191 北京大学公众健康与重大疫情防控战略研究中心北京100191 重大疾病流行病学教育部重点实验室(北京大学) 北京100191 国家食品安全风险评估中心北京100022 牛津大学临床与流行病学研究中心纳菲尔德人群健康系牛津OX37LF 不详

目的分析影响中国人群长寿的社会人口学特征和生活方式相关因素。方法基于中国慢性病前瞻性研究(CKB),排除1938年12月31日之后出生者,纳入分析51870人,将到达年龄定义为研究对象在随访期间死亡时的年龄或截至2018年12月31日的年龄,根据... 详细信息

目的分析影响中国人群长寿的社会人口学特征和生活方式相关因素。方法基于中国慢性病前瞻性研究(CKB),排除1938年12月31日之后出生者,纳入分析51870人,将到达年龄定义为研究对象在随访期间死亡时的年龄或截至2018年12月31日的年龄,根据到达年龄对研究对象进行分组:非长寿组(80岁以前死亡)和长寿组(到达年龄≥80岁),长寿组进一步分组为长寿但死亡、长寿且存活。社会人口学和生活方式信息为2004-2008年基线调查时采集。采用无序多分类logistic回归模型分析暴露因素与结局的关联,以非长寿组为参照组。结果纳入分析的51870人的基线年龄范围为65~79岁,经过(10.2±3.5)年的随访,38841人长寿,其中30354人存活。以男性、农村人群、非在婚者、家庭年收入<10000元者和小学及以下文化程度者为参照,女性、城市人群、在婚者、家庭年收入≥20000元者、大专及以上文化程度者长寿且存活的OR值(95%CI)分别为1.68(1.58~1.78)、1.69(1.61~1.78)、1.15(1.10~1.21)、1.44(1.36~1.53)和1.32(1.19~1.48)。对于生活方式相关因素,总体力活动水平每增加4 MET-h/d,长寿且存活的OR值(95%CI)为1.09(1.08~1.10)。分别以从不或偶尔吸烟者、非每周饮酒者、正常体重者(BMI 18.5~23.9 kg/m2)和腰围<85 cm(男性)/<80 cm(女性)者为参照组,吸烟或因病戒烟者中每日吸烟≥20支者长寿且存活的OR值(95%CI)为0.64(0.60~0.69),每周但非每日饮酒者和每日纯酒精摄入量<30 g者为1.29(1.14~1.46)和1.13(1.01~1.26),低体重、超重和肥胖者依次为0.56(0.52~0.61)、1.27(1.19~1.36)和1.23(1.11~1.36),中心性肥胖者为0.86(0.79~0.93)。进一步按腰围进行分层分析,腰围<85 cm(男性)/<80 cm(女性)者中,BMI每增加5 kg/m2,长寿且存活的OR值(95%CI)为1.80(1.69~1.92);而在腰围≥85 cm(男性)/≥80 cm(女性)者中,对应的OR值(95%CI)为1.02(0.96~1.08),两层关联效应值差异有统计学意义(交互检验P<0.001)。结论本研究发现女性、在婚者、高社会经济水平者、文化程度较高者以及生活方式健康者更有可能长寿。

关键词：长寿生活方式影响因素队列研究中国人

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客观测量身体行为的大型人群队列研究进展与实践

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中华流行病学杂志 2024年第1期45卷 35-40页

作者：陈媛媛柯雅蕾吕筠孙点剑一潘烺裴培杜怀东陈君石陈铮鸣李立明 Aiden Doherty 余灿清中国慢性病前瞻性研究项目协作组北京大学公共卫生学院流行病与卫生统计学系北京100191 北京大学公众健康与重大疫情防控战略研究中心北京100191 重大疾病流行病学教育部重点实验室(北京大学) 北京100191 牛津大学医学研究委员会人口健康研究组牛津OX37LF 牛津大学临床与流行病学研究中心纳菲尔德人群健康系牛津OX37LF 国家食品安全风险评估中心北京100022 牛津大学纳菲尔德人群健康系牛津OX37LF 牛津大学李嘉诚健康信息探索中心大数据研究所牛津OX37LF 不详

受限于传统自我报告问卷测量方法的信、效度,身体行为(身体活动、久坐行为和睡眠)的准确测量受到很大限制。随着科学技术的发展,加速度计等客观测量设备能够更加准确、全面地测量身体行为相关特征,并逐渐为大规模流行病学研究所用。然而... 详细信息

受限于传统自我报告问卷测量方法的信、效度,身体行为(身体活动、久坐行为和睡眠)的准确测量受到很大限制。随着科学技术的发展,加速度计等客观测量设备能够更加准确、全面地测量身体行为相关特征,并逐渐为大规模流行病学研究所用。然而,我国乃至亚洲人群尚缺乏采集身体行为客观测量数据的大型队列研究。中国慢性病前瞻性研究(CKB)项目在第三次重复调查(2020年8月至2021年12月)使用Axivity AX3腕式三轴加速度计测量研究对象的日常活动及睡眠情况,最终共纳入全国10个项目地区20370名研究对象,其中女性占65.2%,年龄(65.4±9.1)岁,不同项目地区研究对象的身体行为活动水平具有较大差异。CKB项目开展的身体行为客观测量数据为描述我国中老年人24 h身体行为特征、探究身体活动、久坐行为、睡眠的健康效应以及其与疾病的深入研究提供了具有重要价值的科研资源。

关键词：身体行为客观测量队列研究

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Pregnancy Loss in Relation to the Risks of Female-Specific Cancers in a Population-Based cohort and Mendelian Randomization Study — china, 2004–2017

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china CDC weekly 2023年第19期5卷 413-418,I0001,I0002页

作者： Yongle Zhan Yawen Wang Yimin Qu Lin Zhang Xuan Liu Ruiyi Liu Peng Xue Jiaxu Wang Dongxu Qin Hexin Yue Canqing Yu Jun Lyu Yu Guo Zhengming Chen Yu Jiang Liming Li china Kadoorie Biobank Collaborative group Department of Epidemiology and Biostatistics School of Population Medicine and Public HealthChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Division of Urology Department of SurgeryLKS Faculty of MedicineThe University of Hong KongHong Kong Special Administrative RegionChina Jockey Club School of Public Health and Primary Care The Chinese University of Hong KongHong Kong Special Administrative RegionChina Melbourne School of Population and Global Health The University of MelbourneVictoriaAustralia Centre of Cancer Research Victorian Comprehensive Cancer CentreMelbourneVictoriaAustralia Department of Epidemiology and Biostatistics School of Public HealthPeking University Health Science CenterBeijingChina Fuwai Hospital Xishan Branch Court Chinese Academy of Medical SciencesBeijingChina Clinical Trial Service Unit&Epidemiological Studies Unit(CTSU) Nuffield Department of Population HealthUniversity of OxfordOxfordUK.&Joint first authors 不详

Summary What is already known about this topic?Limited evidence exists regarding the relationship between pregnancy loss and female-specific cancers within the Chinese population from prospective cohort *** is added by this report?Terminations were associated with a 13%lower risk of endometrial cancer,whereas stillbirths were related to an 18%higher risk of cervical *** residents with a history of pregnancy loss experienced a 19%and 38%increased risk of breast and cervical cancers,respectively,compared to their urban ***,a positive graded relationship between live births and pregnancy loss on cervical cancer was *** are the implications for public health practice?This study has significant implications for identifying women at an increased risk for breast and genital cancers and contributes to the development of effective public health strategies for female cancer *** research on reproductive history,particularly in rural areas,should be given priority in efforts to improve female cancer screening and early detection.

关键词： Population Rural birth

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Lion pride optimizer:An optimization algorithm inspired by lion pride behavior

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Science china(Information Sciences) 2012年第10期55卷 2369-2389页

作者： WANG Bo,JIN XiaoPing & CHENG Bo State Key Laboratory of Automotive Safety and Energy,Tsinghua University,Beijing 100084,china State Key Laboratory of Automotive Safety and Energy Tsinghua University Beijing China

In this paper,we report a novel optimization algorithm,lion pride optimizer(LPO),which is inspired by lion pride *** framework is mainly based on lion prides’ evolution process and group living *** a lion pride,brutal competition of individuals happens among male lions both within and among prides;on the other hand,each member plays an important role in the persistence of a lion *** on this framework,concepts from lion prides behavior,e.g.,the strongest males occupy nearly all mating resources,and if a new cohort of males is able to take over a pride,they will seek to kill young cubs sired by their predecessors,are employed metaphorically to design optimum searching strategies for solving continuous optimization *** the studies of the algorithm property,it is found that the LPO algorithm is not sensitive to most parameters,which shows the robustness of the algorithm and the parameters are not *** tendency of the algorithm is not *** is found that the pride update strategy and brutal competition of individuals are two main factors that contribute to the performance of *** to the test results on 23 famous benchmark functions,the LPO algorithm has better performance than the other seven state-of-the-art algorithms on both unimodal and multimodal benchmark functions;in the test of high-dimensional multimodal problems,LPO outperforms the other five algorithms on all benchmark functions.

关键词： animal behavior evolutionary algorithm lion pride optimization swarm intelligence

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Antioxidative effect of propofol during cardiopulmonary bypass in adults

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Acta Pharmacologica Sinica 2004年第3期25卷 80-86页

作者： Shi-hai ZHANG2,Shou-yong WANG,Shang-long YAO Department of Anesthesiology,Union Hospital,Tongji MedicalCollege,Huazhong Universityof Science & Technology,Wuhan 430022,china Department of Anesthesiology Union Hospital Tongji Medical College Huazhong University of Science & Technology Wuhan 430022 China

AIM: To investigate the antioxidative potential of propofol (an intravenous anesthetic with a chemical structure similarto phenol-basedfree radicalscavengers suchas vitaminE) during cardiopulmonary bypass(CPB). METHODS: Thirty adult patients referred for elective cardiac procedure with CPB were included and randomly allocated to a propofol group or a control group. Patients in the propofol group received propofol (0.1 mg·kg-1·min-1) intrave- nously for anesthesia maintenance, whereas those allocated to the control group received fentanyl 10 μg/kg intrave- nously and inhaled enflurane (1 %-1.5 %). Blood samples were collected at 7 time points: before the start of CPB, at 30 and 60 min of CPB, at the conclusion of CPB, 10 min after the administration of protamine, and 12 and 24 h after the cessation of CPB. Plasma levels of free F2-isoprostanes (sensitive markers of free radicals production) and complement C5a were determined by mass-spectrometricassay and enzyme immunoassay, respectively. Neu- trophil adhesion to endothelial cells was observed at ×200 magnificationunder a light microscope. RESULTS: Levels of F2-isoprostanes, complement C5a and neutrophil adhesion rate increased significantly during and after CPB in both groups. There were significantly higher levels of F2-isoprostanes, C5a, and more neutrophils adhering to endothelial cells in the control group than those in the propofol group, respectively. CONCLUSION: Cardio- pulmonary bypass is associated with a great production of damaging free radicals. Propofol may be beneficial both as an anesthetic and as a potent free radical scavenger in patients presenting pathologies associated with free radical reactions during CPB.

关键词： propofol cardiopulmonary bypass free radicals F2-isoprostanes complement 5a

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Association of fluid balance trajectories with clinical outcomes in patients with septic shock:A prospective multicenter cohort study

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Military Medical Research 2021年第3期8卷 395-404页

作者： Mei-Ping Wang Li Jiang Bo Zhu Bin Du Wen Li Yan He Xiu-Ming Xi china Critical Care Sepsis Trial(CCCST)workgroup Department of Epidemiology and Health Statistics School of Public HealthCapital Medical UniversityNo.10XitoutiaoYou’anmenBeijingFengtai DistrictChina Department of Critical Care Medicine Fuxing HospitalCapital Medical UniversityNo.20Street FuxingmenwaiBeijingXicheng DistrictChina Department of Critical Care Medicine Xuanwu HospitalCapital Medical UniversityBeijing 100053China Medical Intensive Care Unit Peking Union Medical College HospitalPeking Union Medical College and Chinese Academy of Medical SciencesBeijing 100730China

Background:Septic shock has a high incidence and mortality rate in Intensive Care Units(ICUs).Earlier intravenous fluid resuscitation can significantly improve outcomes in septic patients but easily leads to fluid overload(FO),which is associated with poor clinical outcomes.A single point value of fluid cannot provide enough fluid *** aim of this study was to investigate the impact of fluid balance(FB)latent trajectories on clinical outcomes in septic ***:Patients were diagnosed with septic shock during the first 48 h,and sequential fluid data for the first 3 days of ICU admission were included.A group-based trajectory model(GBTM)which is designed to identify groups of individuals following similar developmental trajectories was used to identify latent subgroups of individuals following a similar progression of *** primary outcomes were hospital mortality,organ dysfunction,major adverse kidney events(MAKE)and severe respiratory adverse events(SRAE).We used multivariable Cox or logistic regression analysis to assess the association between FB trajectories and clinical ***:Nine hundred eighty-six patients met the inclusion criteria and were assigned to GBTM analysis,and three latent FB trajectories were detected.64(6.5%),841(85.3%),and 81(8.2%)patients were identified to have decreased,low,and high FB,*** with low FB,high FB was associated with increased hospital mortality[hazard ratio(HR)=1.63,95%CI 1.22–2.17],organ dysfunction[odds ratio(OR)=2.18,95%CI 1.22–3.42],MAKE(OR=1.80,95%CI 1.04–2.63)and SRAE(OR=2.33,95%CI 1.46–3.71),and decreasing FB was significantly associated with decreased MAKE(OR=0.46,95%CI 0.29–0.79)after adjustment for potential ***:Latent subgroups of septic patients followed a similar FB *** latent fluid trajectories were associated with clinical *** decreasing FB trajectory was associated with a decreased risk of hospital mortality and MAKE.

关键词： Septic shock Fluid overload group-based trajectory model Clinical outcomes

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西北区域自然人群队列建设与实践

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中华流行病学杂志 2023年第1期44卷 14-20页

作者：党少农戴江红张毓洪王新华马福昌颜虹西北区域自然人群队列协作组西安交通大学公共卫生学院流行病与卫生统计学系西安710061 新疆医科大学公共卫生学院流行病与卫生统计学系乌鲁木齐830011 宁夏医科大学公共卫生与管理学院流行病与卫生统计学系银川750004 甘肃中医药大学公共卫生学院环境与职业医学教研室兰州730000 青海省疾病预防控制中心慢性非传染病预防控制所西宁810007 西安交通大学环境与疾病相关基因教育部重点实验室西安710061 不详

预防和控制慢性非传染性疾病(慢性病)是我国面临的重要公共卫生问题。西北区域自然环境独特,人群健康状况与疾病特征具有鲜明的地域特色,为了满足深入研究该地区慢性病病因、机制和转归的迫切需求,根据西北区域特殊生态环境、人口规模... 详细信息

预防和控制慢性非传染性疾病(慢性病)是我国面临的重要公共卫生问题。西北区域自然环境独特,人群健康状况与疾病特征具有鲜明的地域特色,为了满足深入研究该地区慢性病病因、机制和转归的迫切需求,根据西北区域特殊生态环境、人口规模和民族分布,于2017-2019年在陕西省、甘肃省、青海省、宁夏回族自治区和新疆维吾尔自治区建立西北区域自然人群队列,招募了117644名35~74岁的多民族(汉族、回族、维吾尔族、哈萨克族和藏族)自然人群,调查队列成员的个体、环境及社会等多方面的基线暴露信息,采集外周血,分离血浆、血清和白膜层,形成各类生物样本90余万份,以-80℃储存于标准生物样本库。已开始用常规监测和主动随访相结合的方式进行长期随访观察。队列成员的平均年龄52.43岁,女性70391名(59.8%),不同民族间的社会经济状况和生活方式存在一定差异,健康状况具有相似性但呈现出各自不同的特点。该队列为深入研究环境、生活方式及遗传因素与重要高发慢性病的关系提供了研究平台,为明确该地区不同民族慢性病的病因及长期健康危害提供重要流行病学证据,为国家制定慢性病防治战略提供西北区域参考。本文简要介绍西北区域自然人群队列的建设概况和实践思考。

关键词：慢性非传染性疾病队列研究自然人群西北

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