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New loci for refractive errors and ocular biometric parameters in young Chinese Han adults

Science China(Life Sciences) 2022年第10期65卷 2050-2061页

作者： Yunyun Sun Zi-Bing Jin Shifei Wei Hongyan Jia Kai Cao Jianping Hu Caixia Lin Wenzai An Jiyuan Guo He LiJing Fu Shi-Ming Li Ningli Wang the anyang university students eye study group the anyang university students eye study group Beijing Tongren eye Center Beijing Tongren HospitalCapital Medical UniversityBeijing Ophthalmology&Visual Sciences Key LaboratoryBejing 100730China Beijing Institute of Ophthalmology Bejing 100730China anyang eye Hospital Anyang 455000China 不详

Myopia has become a major public health issue with an increasing *** are still individuals who experience similar environmental risk factors and,yet,remain ***,there might be genetic factors protecting people from *** the opposite ocular characteristics of primary angle closure glaucoma(PACG)to myopia and possible common pathway between them,we propose that certain risk genes for PACG might act as a protective factor for *** this study,2,678 young adults were genotyped for 37 targeted single nucleotide *** with emmetropia,rs1401999(allele C:OR=0.795,P=0.03;genotype in dominant model:OR=0.759,P=0.02)and rs1258267(allele A:OR=0.824,P=0.03;genotype in dominant model:OR=0.603,P=0.01)were associated with low to moderate myopia and high myopia,*** under recessive model of rs11024102 was correlated with myopia(OR=1.456,P=0.01),low to moderate myopia(OR=1.443,P=0.02)and high myopia(OR=1.453,P=0.02).However,these associations did not survive Bonferroni ***,rs1401999,rs1258267,and rs11024102 showed associations with certain ocular biometric parameters in different *** study suggests that ABCC5,CHAT and PLEKHA7 might be associated with refractive errors by contributing to the regulation of ocular biometry,in terms of uncorrected results and their biological functions.

关键词： candidate gene myopia high myopia ocular biometry primary angle-closure glaucoma

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Strategies to control myopia in children:a review of the findings from the anyang Childhood eye study

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Annals of eye Science 2018年第1期3卷 219-225页

作者： Shi-Ming Li Ningli Wang the anyang Childhood eye study group Beijing Tongren eye Center Beijing Tongren HospitalBeijing Ophthalmology&Visual Science Key LabBeijing Institute of OphthalmologyCapital Medical UniversityBeijing 100000China

Myopia in children remains a major public health problem worldwide,especially in some Asian countries such as China,Singapore and *** many interventions have been attempted,few has been proven to be effective in controlling onset and progression of myopia in *** factors,genetic susceptibility or ethnic differences can affect the efficacy of these ***,many questions remain unclear and even controversial for controlling *** has the biggest population with myopia,especially for children ***,it is of importance to present what achievements Chinese scientists have made in the field of myopia control in *** summarize the current findings on myopia control in children from the anyang Childhood eye study,including epidemiological data,clinical trials,systematic reviews and meta-analyses,and compare them with studies in other countries to find potential clues for controlling myopia in children.

关键词： Children myopia time outdoors near work Chinese eye exercises spectacles

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A combined treatment for patients with dry eye and associated laryngopharyngeal reflux:a real-life approach

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International Journal of Ophthalmology(English edition) 2023年第10期16卷 1616-1622页

作者： Giorgio Ciprandi Stefano Bonini Irene Schiavetti Valerio Damiani study group on Dry-eye Pragmatical Management Allergy Clinic Casa di Cura Villa MontallegroGenoa 16145Italy Ophthalmology Complex Operative Unit University Campus Bio-MedicoRome 00100Italy Health Science Department University of GenoaGenoa 16142Italy Medical Department DMGPomezia 00070Italy 不详

AIM:To evaluate the efficacy and tolerability of administering a combined therapy in patients with dry eye syndrome(DES)and associated laryngopharyngeal reflux(LPR).METHODS:The study was retrospective,open,observational,and conducted in a real-life *** had pathological symptom assessment in dry eye(SANDE)and reflux symptom index(RSI)at *** were re-assessed after 1mo and at the end of *** treatment consisted of a three-month course based on the combined therapy:Gastroftal eye drops,one drop three times a day,and Gastroftal tablets,two tablets after lunch and two tablets after *** break-up-time(TBUT)test,Schirmer test,RSI,and SANDE questionnaire were ***:The study included 253 *** mean age was 58±*** test score and Schirmer’s test significantly increased(both Pstudy shows that combined therapy using Gastroftal eye drops and tablets could represent a valuable option in managing patients with DES associated with LPR.

关键词： dry eye syndrome laryngopharyngeal reflux combined therapy hyaluronic acid alginate Camelia sinensis real-life

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Knowledge-based Convolutional Neural Networks for Transformer Protection

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CSEE Journal of Power and Energy Systems 2021年第2期7卷 270-278页

作者： Zongbo Li Zaibin Jiao anyang He School of Electrical Engineering Xi’an Jiaotong UniversityXi’an 710000China

Deep learning based transformer protection has attracted increasing ***,its poor generalization abilities hinder the application of deep learning in the power system owing to the limited training *** order to improve its generalization abilities,this paper proposes a knowledge-based convolutional neural network(CNN)for the transformer *** general,the power experts can reliably discriminate between faulty transformers and healthy transformers only through the unsaturated parts of equivalent magnetization curve(voltage of magnetizing branch-differential current curve)but deep learning intends to focus on the combined features of saturated and unsaturated *** by the identification process of power experts,CNN adopted a specially designed loss function in this paper which is used to identify the running states of power ***,the presented Restrictive Weight Sparsity substitutes a special regularization term for the common LI *** presented Adaptive Sample Weight Adjustment endows the softmax loss of each sample with the optimizable weight the softmax loss of each sample with the optimizable weights to increase the impact of more-difficult-to-identify cases on the training *** the modified loss function,the knowledge is abstractly introduced into the training process of CNN so as to successfully imitate the identification process of power ***,the proposed knowledge-based CNN will pay more attention to the unsaturated parts of equivalent magnetization curve even if only limited samples are included in the training *** results of simulations and dynamic model experiments reveal that the knowledge-based CNN exhibits an improved generalization ability and the knowledge-based deep learning algorithm is a promising research direction.

关键词： Convolutional neural network equivalent magnetization curve generalization ability,knowledge transformer protection

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Homotopy Coiflets wavelet solution of electrohydrodynamic flows in a circular cylindrical conduit

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Applied Mathematics and Mechanics(English Edition) 2020年第5期41卷 681-698页

作者： anyang WANG Hang XU Qiang YU State Key Lab of Ocean Engineering School of Naval ArchitectureOcean and Civil EngineeringShanghai Jiao Tong UniversityShanghai 200240China College of Ocean Science and Engineering Shanghai Maritime UniversityShanghai 201306China

In previous studies, the nonlinear problem of electrohydrodynamic(EHD)ion drag flows in a circular cylindrical conduit has been studied by several authors. However, those studies seldom involve the computation for large physical parameters such as the electrical Hartmann number and the magnitude parameter for the strength of the nonlinearity due to the existence of strong nonlinearity in these extreme cases. To overcome this faultiness, the newly-developed homotopy Coiflets wavelet method is extended to solve this EHD flow problem with strong nonlinearity. The validity and reliability of the proposed technique are verified. Particularly, the highly accurate homotopy-wavelet solution is obtained for extreme large parameters, which seems to be overlooked *** about the effects of related physical parameters on the axial velocity field is presented.

关键词： homotopy-wavelet method Coiflets electrohydrodynamic(EHD)flow nonlinear boundary value problem(BVP)

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Ocular Trauma in a Rural Population of North China:The Handan eye study

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Biomedical and Environmental Sciences 2015年第7期28卷 495-501页

作者： ZHOU Jun WANG Feng Hua LU Hai LIANG Yuan Bo WANG Ning Li the Handan eye study group Beijing Tongren eye Center Capital Medical University Handan eye Hospital School of Optometry and Ophthalmology Eye Hospital Wenzhou Medical University

Objective To determine the prevalence of ocular trauma and the proportion of blindness and visua impairment due to trauma in a rural population in northern China. Methods The Handan eye study is a population-based cross-sectional study that surveyed 6830 Chinese people aged 30＋ years from 13 randomly selected villages in Yongnian County, city of Handan, Hebei Province, in July, 2006. All participants underwent a standardized interview and extensive examinations. A structured questionnaire was used to collect information on ocular trauma. Results Of the 5837 participants who filled out the questionnaire, 124 subjects [2.1%; 95% confidence interval （CI）, 1.8%-2.5%] reported a history of ocular trauma in either eye, including 19 （0.3%） persons reporting trauma in both eyes. Men were more likely to have an eye injury than women [odds ratio （OR）, 3.3; 2.2-4.9]. In multiple logistic regression models, ocular trauma was significantly more frequent among normotensive participants when compared with hypertensive participants （hypertensive vs. normotensive＂ OR, 0.6; 0.4-0.9） and among participants who had a history of falls （OR, 2.4; 1.2-4.8）. The proportion of unilateral visual impairment and unilateral blindness due to trauma were 10.5% （13 subjects） and 21.0% （26 subjects）, respectively. Conclusion Our study reports the prevalence of severe ocular trauma among adults in rural China, revealing a high proportion of blindness and visual impairment due to trauma. These findings suggest the need for educational strategies to increase eye health awareness in this rural population with focus on providing at least appropriate first aid care to reduce blindness due to trauma.

关键词： Ocular trauma Population-based survey Prevalence Risk factor Handan eye study

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Understanding pitting corrosion behavior of AZ91 alloy and its MAO coating in 3.5%NaCl solution by cyclic potentiodynamic polarization

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Journal of Magnesium and Alloys 2022年第5期10卷 1368-1380页

作者： Yuxiang Liu Zhu Liu anyang Xu Xiaoting Liu National Key Laboratory for Remanufacturing of China 21 DujiakanFengtai DistrictBeijing 100072China School of Materials The University of ManchesterManchester M139PLUK

The pitting corrosion behavior of AZ91 alloy before and after micro-oxidation treatment in 3.5%Na Cl solution was investigated by cyclic potentiodynamic polarization(CPDP)and optical and SEM observations of corroded surfaces at different polarization *** CPDP results show that both the alloy and the MAO-coated alloy suffer from pitting corrosion and it is difficult for pits to stop growth once the pits *** is revealed that the air-formed Mg O film on AZ91 alloy,the MAO coating along with corrosion products(mainly Mg(OH))formed during CPDP can significantly influence the kinetics of the redox reactions of Mg,and further influence the propagation behavior of pitting *** optical and SEM images show that the corrosion products on AZ91 alloy are dense and protective but on the MAO-coated corrosion products are very *** observations support the analyses of CPDP results that pits on AZ91 alloy spread to the width whereas pits on MAO-coated alloy propagate to the ***,pitting corrosion on the MAO-coated alloy can be very severe once the coating ruptures and post-treatments are necessary to provide a promising corrosion protection for the Mg alloys.

关键词： AZ91 alloy MAO coating Pitting corrosion behavior Cyclic potentiodynamic polarization

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A denoising-classification neural network for power transformer protection

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Protection and Control of Modern Power Systems 2022年第1期7卷 801-814页

作者： Zongbo Li Zaibin Jiao anyang He Nuo Xu School of Electrical Engineering Northeast Electric Power UniversityJilinJilinChina School of Electrical Engineering Xi’an Jiaotong UniversityXi’anShaanxiChina

Artificial intelligence(AI)can potentially improve the reliability of transformer protection by fusing multiple ***,owing to the data scarcity of inrush current and internal fault,the existing methods face the problem of poor *** this paper,a denoising-classification neural network(DCNN)is proposed,one which inte-grates a convolutional auto-encoder(CAE)and a convolutional neural network(CNN),and is used to develop a reli-able transformer protection scheme by identifying the exciting voltage-differential current curve(VICur).In the DCNN,CAE shares its encoder part with the CNN,where the CNN combines the encoder and a *** on the inter-action of the CAE reconstruction process and the CNN classification process,the CAE regards the saturated features of the VICur as noise and removes them ***,it guides CNN to focus on the unsaturated features of the *** unsaturated part of the VICur approximates an ellipse,and this significantly differentiates between a healthy and faulty ***,the unsaturated features extracted by the CNN help to decrease the data ergodicity requirement of AI and improve the ***,a CNN which is trained well by the DCNN is used to develop a protection *** simulations and dynamic model experiments verify its superior performance.

关键词： Transformer protection Exciting voltage-differential current curve Convolutional auto-encoder Convolutional neural network Denoising-classification neural network

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The Synthesis of Podophyllotoxin Derivatives with Macrocyclic Dilactone

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Chinese Chemical Letters 1999年第4期10卷 275-276页

作者： Min YANG Ning CHEN Xin Fu PAN Bing Chang QIN(Department of Chemistry. National Laboratory of Applied Organic Chemistry,Lanzhou university, Lanzhou, 730000)(Department of chemistry, anyang Teachers College. anyang 455002) Lanzhou Univ Dept Chem Natl Lab Appl Organ Chem Lanzhou 730000 Peoples R China anyang Teachers Coll Dept Chem Anyang 455002 Peoples R China

Starting from podophyllotoxin, five new derivatives with macrocyclic dilactone 5 similar to 9 have been synthesized,and their structures were confirmed by IR, MS,H-1 NMR as well as HRMS. The key step is cyclization by... 详细信息

关键词： podophyllotoxin derivatives macrocyclic dilactone synthesis

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Modeling and Dynamic Analysis for the Foundation of a Blade-Rotor System

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Transactions of Nanjing university of Aeronautics and Astronautics 2017年第3期34卷 326-332页

作者： Liang anyang Huang Guoyuan Zhang Yuetong Yue Lin College of Mechanical and Electrical Engineering Nanjing University of Aeronautics and Astronautics School of Engineering and Informatics University of Sussex

In order to achieve the model-based fault monitoring and diagnosis,an accurate model for the rotor system is necessary to locate and quantify *** the dynamic characteristics of a blade-rotor system is influenced by foundation flexibility,the modeling and dynamic analyses on the foundation were sequentially ***,the effect of element size on the model convergence was investigated using the forward difference quotient as the slope of the frequency difference,which found that the model converged when the element size refined to ***,a modal analysis and a harmonic response analysis were performed to obtain the dynamic characteristics of the foundation ***,an optimization to the foundation utilizing an additional stiffener was conducted to reduce the foundation response and make the critical speed far away from the working frequency band of 20—50Hz.

关键词： rotor refined sequentially utilizing blade quantify quotient harmonic convergent locate

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