检索结果-南通市图书馆

Abalone sh.ll-derived Mg-doped mesoporous h.droxyapatite microsph.re drug delivery system loaded with.icariin for inducing apoptosis of osteosarcoma cells

引用

Biomaterials Translational 2024年第2期5卷 185-196页

作者： Liu K. Ch.ng M. h.ang h. Yu h. Zh.o S. Zh.u J. Tie D. Wang J. Pan P. Ch.n J. Marine College Shandong University Shandong Province Weihai China State Key Laboratory of Mineral Processing Beijing China College of Biological Science and Tech.ology Fuzhou University Fujian Province Fuzhou China

h.droxyapatite (h.P) porous microsph.res with.very h.gh.specific surface area and drug loading capacity, as well as excellent biocompatibility, h.ve been widely used in tumour th.rapy. Mg2+ is considered to be a key factor in bone regeneration, acting as an active agent to stimulate bone and cartilage formation, and is effective in accelerating cell migration and promoting angiogenesis, wh.ch.is essential for bone tissue repair, anti-cancer, and anti-infection. In th.s study, abalone sh.lls from a variety of sources were used as raw materials, and Mg2+-doped abalone sh.ll-derived mesoporous h.P microsph.res (Mg-h.P) were prepared by h.droth.rmal synth.sis as Mg2+/icariin smart dual delivery system (ICA-Mg-h.P, IMh.). With.increasing of Mg2+ doping, th. surface morph.logy of h.P microsph.res varied from collapsed macroporous to mesoporous to smooth.and non-porous, wh.ch.may be due to Mg2+ substitution or coordination in th. h.P lattice. At 30% Mg2+ doping, th. Mg-h.P microsph.res sh.wed a more h.mogeneous mesoporous morph.logy with.a h.gh.specific surface area (186.06 m2/g). Th. IMh. microsph.res sh.wed h.gh.drug loading (7.69%) and encapsulation rate (83.29%), sustained Mg2+ release for more th.n 27 days, sustained and stable release of icariin for 60 h.urs, and good responsiveness to ph.(ph.6.4 > ph.5.6). In addition, th. IMh. delivery system stimulated th. rapid proliferation of bone marrow mesench.mal stem cells and induced apoptosis in MG63 cells by blocking th. G2 ph.se cycle of osteosarcoma cells and stimulating th. h.gh.expression of apoptotic genes (Bcl-2, caspase-3,-8,-9). Th.s suggests th.t th. abalone sh.ll-based IMh. may h.ve potential applications in drug delivery and tumour th.rapy. © 2024, Ch.nese Medical Multimedia Press Co Ltd. All righ.s reserved.

关键词： abalone sh.ll drug delivery h.droxyapatite microsph.res magnesium doping osteosarcoma

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Discrete Boltzmann model with.split collision for nonequilibrium reactive flows

引用

Communications in Th.oretical Ph.sics 2024年第8期76卷 164-186页

作者： Ch.andong Lin Kai h.Luo h.ilin Lai Sino-French.Institute of Nuclear Engineering and Tech.ology Sun Yat-sen UniversityZhuhai 519082China Key Laboratory for Th.rmal Science and Power Engineering of Ministry of Education Department of Energy and Power EngineeringTsinghua UniversityBeijing 100084China Department of Mech.nical Engineering National University of Singapore10 Kent Ridge Crescent119260Singapore Department of Mech.nical Engineering University College LondonTorrington PlaceLondon WC1E 7JEUnited Kingdom Sch.ol of Math.matics and Statistics Key Laboratory of Analytical Mathematics and Applications(Ministry of Education)Fujian Key Laboratory of Analytical Mathematics and Applications(FJKLAMA)Center for Applied Mathematics of Fujian Province(FJNU)Fujian Normal University350117 FuzhouChina

A multi-relaxation-time discrete Boltzmann model(DBM) with.split collision is proposed for both.subsonic and supersonic compressible reacting flows, wh.re ch.mical reactions take place among various components. Th. ph.sical model is based on a unified set of discrete Boltzmann equations th.t describes th. evolution of each.ch.mical species with.adjustable acceleration, specific h.at ratio, and Prandtl number. On th. righ.-h.nd side of discrete Boltzmann equations, th. collision,force, and reaction terms denote th. ch.nge rates of distribution functions due to self-and crosscollisions, external forces, and ch.mical reactions, respectively. Th. source terms can be calculated in th.ee ways, among wh.ch.th. matrix inversion meth.d possesses th. h.gh.st ph.sical accuracy and computational efficiency. Th.ough.Ch.pman-Enskog analysis, it is proved th.t th. DBM is consistent with.th. reactive Navier-Stokes equations, Fick's law and th. Stefan-Maxwell diffusion equation in th. h.drodynamic limit. Compared with.th. one-step-relaxation model, th. split collision model offers a detailed and precise description of h.drodynamic, th.rmodynamic, and ch.mical nonequilibrium effects. Finally, th. model is validated by six bench.arks, including multicomponent diffusion, mixture in th. force field, Kelvin-h.lmh.ltz instability, flame at constant pressure, opposing ch.mical reaction, and steady detonation.

关键词： discrete Boltzmann meth.d reactive flow detonation nonequilibrium effect

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Assessment of Appropriateness of Diagnostic Lymph.Node Tissue Collection from th. Operating Th.ater and by Interventional Radiologist. A Clinical Audit

引用

Advances in Infectious Diseases 2024年第3期14卷 541-548页

作者： Kowth.r Salman h.ssan Divya Deodh.r Abdullah.T. Al-Rawah. Mah.ood h. Al Abri Department of Medicine Infectious Diseases Sultan Qaboos University Hospital Muscat Oman Department of Infection Control Sultan Qaboos University Hospital Muscat Oman Department of Radiology and Molecular Imaging Sultan Qaboos University Hospital Muscat Oman

Background: Appropriate sample requesting, collecting and timely dispatch.to th. appropriate laboratory is essential in establish.ng diagnosis of path.logies with.lesions. Much.time and effort may be wasted if th.s is not done according to certain standards. We conducted th.s study to assess th. route of lymph.node samples from requests to reach.ng th. laboratories. Meth.ds: We conducted an audit over a period from 4th.June until 10th.Aug 2023. Data for all th. procedures performed over th.s period on lymph.node samples (was entered into and analysed using Excel. Results: A total of eigh.een samples for sixteen patients were obtained during th.s period. Median age of th. patients was 34 years (19 - 73) with.a M:F ratio of 5:11. Among th. IR samples, nine samples were from th. neck, th.ee from inguinal area and one from axilla. Seven samples (53.8%) were tru-cut biopsies, six samples (46.15%) were FNA. All samples were sent to th. path.logy laboratory fixed in formalin. Samples for TB were sent only for five cases (31.25%) and for only two cases (12.5%) were samples sent for bacterial culture. For th. OR samples, none were sent for eith.r bacterial culture or TB. Overall, eigh. patients (50%) were not investigated for any infectious etiologies like brucella, toxoplasmosis, CMV, EBV plus oth.r possible causes. Repeat sampling was required for 25% of patients (with.n and out of th. audit period). Conclusions: to avoid delays in making diagnoses, it is paramount to consider infectious etiologies as possible diagnosis for lymph.denopath. and request appropriate investigations. Th.s requires liaising with.infectious diseases/clinical microbiology experts to guide regarding types of samples, types of media and timely dispatch.to th. correct laboratory.

关键词： Clinical Audit Clinical Samples Biopsies Lymph.Nodes Saline Formalin Quality Improvement

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

h.patitis B virus genotypes in precision medicine of h.patitis Brelated h.patocellular carcinoma:Wh.re we are now

引用

World Journal of Gastrointestinal Oncology 2024年第4期16卷 1097-1103页

作者： Caecilia h.C Sukowati Sri Jayanti Turyadi Turyadi David h.Muljono Claudio Tiribelli Eijkman Research.Center for Molecular Biology Research Organization for HealthNational Research and Innovation Agency of IndonesiaJakarta 10340Indonesia Liver Cancer Unit Fondazione Italiana Fegato ONLUSTrieste 34149Italy Faculty of Medicine Hasanuddin UniversityMakassar 90245South SulawesiIndonesia Faculty of Medicine and h.alth University of SydneySydney 2050Australia

h.patitis B virus(h.V)infection is a major player in ch.onic h.patitis B th.t may lead to th. development of h.patocellular carcinoma(h.C).h.V genetics are diverse wh.re it is classified into at least 9 genotypes(A to I)and 1 putative genotype(J),each.with.specific geograph.cal distribution and possible different clinical outcomes in th. *** diversity may be associated with.th. precision medicine for h.V-related h.C and th. success of th.rapeutical approach.s against h.C,related to different path.genicity of th. virus and h.st *** Editorial discusses recent updates on wh.th.r th. classification of h.V genetic diversity is still valid in terms of viral oncogenicity to th. h.C and its precision medicine,in addition to th. recent advances in cellular and molecular biology tech.ologies.

关键词： h.patitis B virus h.patocellular carcinoma Genotypes Path.genesis Precision medicine

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Tungsten-based nanocatalysts with.different structures for visible ligh. responsive ph.tocatalytic degradation of bisph.nol A

引用

Journal of Environmental Sciences 2024年第5期139卷 569-588页

作者： h.i Bang Truong Th. Th. Loan Doan Nguyen Tien h.ang Nguyen van Tam Minh.Kim Nguyen Le Gia Trung Jin Seog Gwag Nguyen Tien Tran Optical Materials Research.Group Science and Technology Advanced InstituteVan Lang UniversityHo Chi Minh CityViet Nam Faculty of Applied Tech.ology School of TechnologyVan Lang UniversityHo Chi Minh CityViet Nam Th. University of Da Nang University of Science and Technology54 Nguyen Luong BangDa NangViet Nam Th. University of Da Nang University of Science and Education459 Ton Duc Thang St.Lien ChieuDa Nang 550000Viet Nam Institute of Veterinary Science and Tech.ology 31ha zoneTrau QuyGia LamHa Noi 12400Viet Nam Department of Ph.sics Yeungnam UniversityGyeongsanGyeongbuk 38541Republic of Korea Center for Advanced Ch.mistry Institute of Research and DevelopmentDuy Tan University03 Quang TrungDa Nang 550000Viet Nam Faculty of Natural Sciences Duy Tan University03 Quang TrungDa Nang 550000Viet Nam

Environmental pollution,such.as water contamination,is a critical issue th.t must be absolutely ***,th.ee different morph.logies of tungsten-based ph.tocatalysts(WO_(3)nanorods,WO_(3)/WS_(2)nanobricks,WO_(3)/WS_(2)nanorods)are made using a simple h.droth.rmal meth.d by ch.nging th. solvents(h.(2)O,DMF,aqueous h.l solution).Th. as-prepared nanocatalysts h.ve excellent th.rmal stability,large porosity,and h.gh.*** results sh.w all materials h.ve good ph.tocatalytic activity in aqueous media,with.WO_(3)/WS_(2)nanorods(NRs)h.ving th. best activity in th. ph.todegradation of bisph.nol A(BPA)under visible-ligh. *** may originate from increased migration of ch.rge carriers and effective prevention of electron–h.le recombination in WO_(3)/WS_(2)NRs,wh.reby th.s ph.tocatalyst is able to generate more reactive·Oh.and·O_(2)^(–)species,leading to greater ph.tocatalytic *** 99.6% of BPA is ph.todegraded with.n 60 min wh.n using 1.5 g/L WO_(3)/WS_(2)NRs and 5.0 mg/L BPA at ph.***,th. optimal conditions(ph.catalyst dosage,initial BPA concentration)for WO_(3)/WS_(2)NRs are also elaborately *** rod-like h.terostructures are expressed as potential catalysts with.excellent ph.tostability,efficient reusability,and h.gh.y active effectivity in different types of *** particular,th. removal efficiency of BPA by WO_(3)/WS_(2)NRs reduces by only 1.5% after five recycling runs and even reach.s 89.1%in contaminated lake *** study provides promising insigh.s for th. nearly complete removal of BPA from wastewater or different water resources,wh.ch.is advantageous to various applications in environmental remediation.

关键词： Ph.todegradation Bisph.nol A Tungsten-based nanocatalyst Structure Nanorod

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Fish.on-Ch.ps:unveiling neural processing of ch.micals in small animals th.ough.precise fluidic control

引用

Neural Regeneration Research 2024年第11期19卷 2351-2353页

作者： Samuel K.h.Sy h. Ko Division of Neurology Department of Medicine and TherapeuticsFaculty of MedicineThe Chinese University of Hong KongShatinNew TerritoriesHong Kong Special Administrative RegionChina Li Ka Sh.ng Institute of h.alth.Sciences Faculty of MedicineThe Chinese University of Hong KongShatinNew TerritoriesHong Kong Special Administrative RegionChina Department of Electrical and Electronic Engineering Faculty of EngineeringThe University of Hong KongPok Fu LamHong Kong IslandHong Kong Special Administrative RegionChina Advanced Biomedical Instrumentation Center Hong Kong Science ParkPak Shek KokNew TerritoriesHong Kong Special Administrative RegionChina Margaret K.L.Ch.ung Research.Center for Management of Parkinsonism Faculty of MedicineThe Chinese University of Hong KongShatinNew TerritoriesHong Kong Special Administrative RegionChina Lau Tat-ch.en Research.Center of Brain Degenerative Diseases in Ch.nese Faculty of MedicineThe Chinese University of Hong KongShatinNew TerritoriesHong Kong Special Administrative RegionChina Gerald Ch.a Neuroscience Institute The Chinese University of Hong KongShatinNew TerritoriesHong Kong Special Administrative RegionChina

Precise ch.mical cue presentation alongside advanced brainwide imaging tech.iques is important to th. study of ch.mosensory processing in ***,th. dynamic nature of ch.mical-carrying media,such.as water or air,poses a significant ch.llenge for delivering h.gh.y-controlled ch.mical flow to an animal ***,contact-based cue manipulation and delivery easily sh.ft th. position of th. animal subject,wh.ch.is often undesirable for h.gh.quality brain ***,more advanced interfacing tools th.t align with.th. diverse range of body part sizes of an animal,ranging from micrometer-scale neurons to meter-long limbs,are much.*** is particularly crucial wh.n dealing with.dimensions th.t are beyond th. reach.of conventional experimental tools.

关键词： dealing precise sizes

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Function and dysfunction of GEMIN5:understanding a novel neurodevelopmental disorder

引用

Neural Regeneration Research 2024年第11期19卷 2377-2386页

作者： Ch.rles h.Nelson Udai B.Pandey Department of Pediatrics Division of Child NeurologyChildren’s Hospital of PittsburghUniversity of Pittsburgh Medical CenterPittsburghPAUSA Ch.ldren’s Neuroscience Institute Children’s Hospital of PittsburghUniversity of Pittsburgh Medical CenterPittsburghPAUSA

Th. recent identification of a neurodevelopmental disorder with.cerebellar atroph. and motor dysfunction(NEDCAM)h.s resulted in an increased interest in GEMIN5,a multifunction RNA-binding *** th. largest member of th. survival motor neuron complex,GEMIN5 plays a key role in th. biogenesis of small nuclear ribonucleoproteins wh.le also exh.biting translational regulatory functions as an independent *** many questions remain regarding both.th. path.genesis and path.ph.siology of th.s new disorder,considerable progress h.s been made in th. brief time since its *** th.s review,we examine GEMIN5 with.n th. context of NEDCAM,focusing on th. structure,function,and expression of th. protein specifically in regard to th. disorder ***,we explore th. current animal models of NEDCAM,as well as potential molecular path.ays for treatment and future directions of *** review provides a compreh.nsive overview of recent advances in our understanding of th.s unique member of th. survival motor neuron complex.

关键词： cerebellar atroph. GEMIN5 neurodevelopmental disorder neurological disease SMN complex

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Spontaneous Recovery in Directed Dynamical Networks

引用

Engineering 2024年第6期37卷 208-214页

作者： Xueming Liu Xian Yan h.Eugene Stanley Sch.ol of Artificial Intelligence and Automation&Th. MOE Engineering Research.Center of Autonomous Intelligent Unmanned Systems&th. Key Laboratory of Image Processing Huazhong University of Science and TechnologyWuhan 430074China Center for Polymer Studies Department of PhysicsBoston UniversityBostonMA 02215USA

Complex networked systems,wh.ch.range from biological systems in th. natural world to infrastructure systems in th. h.man-made world,can exh.bit spontaneous recovery after a failure;for example,a brain may spontaneously return to normal after a seizure,and traffic flow can become smooth.again after a *** studies on th. spontaneous recovery of dynamical networks h.ve been limited to undirected ***,most real-world networks are *** fill th.s gap,we build a model in wh.ch.nodes may alternately fail and recover,and we develop a th.oretical tool to analyze th. recovery properties of directed dynamical *** find th.t th. tool can accurately predict th. final fraction of active nodes,and th. prediction accuracy decreases as th. fraction of bidirectional links in th. network increases,wh.ch.emph.sizes th. importance of directionality in network *** to different initial states,directed dynamical networks may sh.w alternative stable states under th. same control parameter,exh.biting h.steresis *** addition,for networks with.finite sizes,th. fraction of active nodes may jump back and forth.between h.gh.and low states,mimicking repetitive failure-recovery *** findings could h.lp clarify th. system recovery mech.nism and enable better design of networked systems with.h.gh.resilience.

关键词： Network resilience Directed dynamical networks Spontaneous recovery

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Deformable microlaser force sensing

引用

Ligh.(Science & Applications) 2024年第6期13卷 1196-1209页

作者： Eleni Dalaka Joseph.Sh.ll Jonath.n h.h.Booth.Anna Popczyk Stefan R.Pulver Malte C.Gath.r Marcel Sch.bert Centre of Bioph.tonics SUPASchool of Physics and AstronomyUniversity of St AndrewsNorth HaughSt AndrewsUK h.mboldt Centre for Nano-and Bioph.tonics Department of ChemistryUniversity of CologneKölnGermany Sch.ol of Psych.logy and Neuroscience University of St AndrewsSt Mary’s QuadSouth StreetSt AndrewsUK Institute for Bioengineering of Catalonia BarcelonaSpain

Mech.nical forces are key regulators of cellular beh.vior and function,affecting many fundamental biological processes such.as cell migration,embryogenesis,immunological responses,and path.logical *** force sensors and imaging tech.iques h.ve been developed to quantify th.se oth.rwise invisible forces in single cells and in ***,current tech.iques rely h.avily on h.gh.resolution microscopy and do not allow interrogation of optically dense tissue,reducing th.ir application to 2D cell cultures and h.gh.y transparent biological ***,we introduce DEFORM,deformable microlaser force sensing,a spectroscopic tech.ique th.t detects sub-nanonewton forces with.unprecedented spatio-temporal *** is based on th. spectral analysis of laser emission from dye-doped oil microdroplets and uses th. force-induced lifting of laser mode degeneracy in th.se droplets to detect nanometer *** validation by atomic force microscopy and development of a model th.t links ch.nges in laser spectrum to applied force,DEFORM is used to measure forces in 3D and at depth. of h.ndreds of microns with.n tumor sph.roids and late-stage Drosoph.la *** furth.rmore sh.w continuous force sensing with.single-cell spatial and millisecond temporal resolution,th.s paving th. way for non-invasive studies of biomech.nical forces in advanced stages of embryogenesis,tissue remodeling,and tumor invasion.

关键词： invasion oth.rwise h.ndreds

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Proton-neutron symplectic model description of ^(106)Cd

引用

Ch.nese Ph.sics C 2024年第3期48卷 169-179页

作者： h.G.Ganev Joint Institute for Nuclear Research DubnaRussia Institute of Mech.nics Bulgarian Academy of SciencesSofiaBulgaria

In th.s study,a microscopic sh.ll-model description of th. low-lying collective states in th. weakly deformed nucleus ^(106)Cd with.n th. recently proposed microscopic version of th. Boh.-Mottelson model is provided.A good description of th. excitation energies of th. lowest ground,γ,andβquasibands is obtained with.ut th. adjustable kinetic energy ***,γdegrees of freedom are sh.wn to play a crucial role in th. description of spectroscopy of th.s nucleus.A modified SU(3)SU(3)preserving h.gh.order interaction is used to produce aγ-unstable type of odd-even staggering,observed experimentally between th. states of th. quasi-γ*** current approach.enables th. ch.racterization of observed intraband and interband quadrupole *** findings of th.s study propose an alternative interpretation of th. fundamental question regarding th. nature of low-energy vibrations,as well as th. emergence of deformation and collectivity in weakly deformed atomic nuclei.

关键词： sh.ll-model version of th. Boh.-Mottelson model proton-neutron symplectic model Sp(12,R)dynamical algebra quadrupole dynamics

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：