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Built Heritage 2023年第2期7卷 3-14页

作者： Zachary m.Jones théodora Pappas dASTU Politecnico di MilanoMilanItaly

Resilience has become an increasingly important concept in the cultural heritage feld,particularly in the aftermath of the unprecedented challenges the COVId-19 global pandemic ***,on a conceptual and practical level,resilience remains closely linked to the technical conservation of built heritage,and there remains a need to develop broader approaches inclusive of cultural and socioeconomic *** article investigates the potential applicability of theoretical concepts linked to identity and identities in heritage planning to help fll these gaps and develop approaches that consider resilience and are better able to address a range of unanticipated *** frst review the literature and policy documents to defne and identify the potential for identities-based *** then examine the case of matera,an extremely fragile world heritage site in southern Italy that has been continuously inhabited for more than 8000 years and provides a relevant example of *** explore the trends and efects of globalised tourism development before the pandemic and the post pandemic emergence of more local/regional and slow tourism patterns,largely based on cultural solutions to local development challenges and knowledge *** this comparison,we analyse the potential and limitations of introducing identities-based concepts into heritage planning as a more robust way to enhance resilience and prepare cities for unexpected future crises.

关键词： identity heritage management plans matera resilience locally based development mode

G6Pd deficiency and COVId-19 in Burkina Faso: A Possible Link?

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Journal of Biosciences and medicines 2023年第1期11卷 57-69页

作者： Abdoul Karim Ouattara Lassina Traoré Tégwendé Rebeca Compaoré théodora.m.houkèdè zohoncon Jacques Simporé Université Norbert Zongo/Centre Universitaire de manga Koudougou Burkina Faso Laboratoire de Biologie moléculaire et de Génétique (LABIOGENE) UFR/SVT Université Joseph Ki-Zerbo Ouagadougou Burkina Faso Centre de Recherche Biomoléculaire Pietro Annigoni (CERBA) Ouagadougou Burkina Faso département Biomédical et de Santé Publique Institut de Recherche en Sciences de la Santé (CNRST/IRSS) Ouagadougou Burkina Faso Faculté de médecine Université Saint Thomas d’Aquin (USTA) Ouagadougou Burkina Faso

Burkina Faso is a malaria-endemic country, with a high incidence of G6Pd deficiency (G6Pdd), which recorded its first case of COVId-19 in march 2020. G6Pdd leads to a decrease in the efficiency of erythrocytes to combat oxidative stress, while SARS-CoV-2 infection induces massive production of Reactive Oxygen Species (ROS) in patients. In the present review, we discuss a possible link between G6Pdd and SARS-CoV-2 infection. the mean prevalence of G6Pdd in Burkina Faso is estimated at 16.6% among males and 6.5% among females. A total of 21,128 cases of COVId-19 have been recorded in Burkina Faso with 387 deaths reported (with a mortality rate of 1.15% among diagnosed cases) as of August 30, 2022. To our knowledge, no association study between G6Pdd and SARS-CoV-2 infection has been conducted to date in Burkina Faso. However, several case reports around the world have described elevated risks of hemolysis and thrombosis, and other complications among G6Pd-deficient patients infected with SARS-CoV-2. the use of Hydroxychloroquine (HCQ) has also been deemed unsafe by some authors for the treatment of COVId-19 among patients with G6Pdd. Although HCQ has been shown to be well tolerated in COVId-19 patients in Burkina Faso, the drug could induce hemolytic crises in people with G6Pd deficiency. G6Pd is important in regulating ROS and maintaining erythrocyte homeostasis. In view of its high prevalence in Burkina Faso, determination of the G6Pd status is required in COVId-19 patients for adequate management such as identifying a subset of COVId-19 patients for whom close monitoring and supportive care may be essential and to restrict treatment with HCQ.

关键词： G6Pd deficiency COVId-19 CQ/HCQ Hemolysis Burkina Faso

Cytotoxic Properties on Cervical and Liver Cancer Cells of Two Plant Recipes from Burkina Faso

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Journal of Biosciences and medicines 2024年第6期12卷 216-229页

作者： Estelle Ouédraogo Bagora Bayala théodora.m.houkèdè zohoncon Samiratou Ouédraogo Olga mélanie Lompo Essi Etonam dovo Jean-marie Compaoré Albert théophane Yonli Jacques Simpore Laboratory of molecular Biology and Genetics (LABIOGENE) Joseph KI-ZERBO University Ouagadougou Burkina Faso Center of Biomolecular Research Pietro Annigoni (CERBA) Ouagadougou Burkina Faso Ecole Normale Suprieure Koudougou Burkina Faso Hspital Saint Camille of Ouagadougou (HOSCO) Ouagadougou Burkina Faso Faculty of Health University Saint Thomas dAquin (USTA) Ouagadougou Burkina Faso Chair Research and Action against Cancer Department of Public Health Training and Research Unit in Health Sciences Joseph KI-ZERBO University Ouagadougou Burkina Faso National Population Health Observatory National Institute of Public Health Ouagadougou Burkina Faso the department of Epidemiology Biostatistics and Occupational Health School of Population and Global Health Montral Canada Laboratory of Pathological Anatomy and Cytology University Joseph KI-ZERBO Ouagadougou Burkina Faso TIIG LA TIIm Ouagadougou Burkina Faso

Cancer is one of the deadliest diseases in developing countries. In recent years, natural plant-based compounds have been used in the search for drugs to combat numerous diseases, including cancer. In this study, we evaluate the cytotoxic properties of paanfo tiben 1 and paanfo tiben 2, two traditional herbal formulations from Burkina Faso used in the treatment of cancer in Burkina Faso. To this end, the recipes were infused and freeze-dried. the dry extracts obtained were used to determine total phenolics and flavonoids content, assess antioxidant activity using the dPPH, ABTS and FRAP methods, evaluate anti-inflammatory properties by inhibiting 15-LOX, COX 1 and 2, and assess cytotoxic activity on HeLa cervical cancer and HePG2 liver cancer cell lines using the mTT test. the paanfo tiben 1 recipe showed the highest levels of total phenolics and flavonoids, as well as the best antioxidant activities, with IC50 values of 21.020 ± 0.6 µg/ml and 22.94 ± 0.57 µg/ml for dPPH and ABTS, and 165.15 mm EAA/mg dry extract for FRAP. It also exhibited the best cytotoxic activity with IC50 values of 112.02 ± 0.025 µg/ml on HeLa cells and 80.67 ± 6.08 µg/ml on HepG2 cells. On the other hand, paanfo tiben 2 exhibited the best anti-inflammatory activities through inhibition of 15-LOX and COX 1, with inhibition percentages at 100 µg/ml of 32.523% and 24.717 % respectively. these results could justify the traditional use of these two recipes by traditional health practitioners in the treatment of cancer sufferers in Burkina Faso.

关键词： Antioxidant Anti-Inflammatory Cytotoxicity Paanfo Tiben Burkina

Evolution of HBV Viral Load during Clinical and Biological Follow-Up of Chronic Hepatitis B Patients at the Saint Camille Hospital in Ouagadougou

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Advances in Infectious diseases 2023年第4期13卷 550-563页

作者： théodora.m.houkèdè zohoncon T. Rose Clémence Ido da Nicaise Zagre Pauline Belemkoabga denise P. Ilboudo Abdoul Karim Ouattara Paul Ouedraogo Jacques Simpore department of molecular Biology H&#244pital Saint Camille de Ouagadougou (HOSCO) Ouagadougou Burkina Faso Faculté de médecine Université Saint Thomas d’Aquin (USTA) Ouagadougou Burkina Faso Laboratoire de Biologie moléculaire et de Génétique (LABIOGENE) Université Joseph KI-ZERBO Ouagadougou Burkina Faso Centre de Recherche Biomoléculaire Pietro Annigoni (CERBA) Ouagadougou Burkina Faso

Hepatitis B virus (HBV) infection is a major public health problem worldwide. the aim of this study was to document the dynamics of HBV viral load during the follow-up of chronic hepatitis B patients at the Saint Camille Hospital in Ouagadougou (HOSCO) from 2017 to 2021. this descriptive retrospective study was carried out in the Hepato-Gastro-Enterology department of HOSCO and focused on patients who were undergoing treatment for chronic viral hepatitis B. A total of 260 cases of chronic hepatitis B were included in the study. the most affected age group was 21 to 30 years, accounting for 48.08% of the cases. Lifestyle factors included alcohol consumption (3.08%) and tobacco use (2.69%). major risk factors for transmission included lack of vaccination (98.46%), family history of HBV infection (68.00%) and engagement in high-risk activities (28.00%). Patients requiring treatment were prescribed Tenofovir 300 mg tablets. FibroScan® showed the presence of stage F3-F4 fibrosis (2.14%) and S3 steatosis (13.33%). After one year of follow-up, 6.92% of patients achieved an undetectable viral load with normalized transaminase levels. the majority of other patients had a detectable viral load but below 20,000 IU/mL. the prevalence of viral hepatitis B remains significant worldwide. Although effective and well-monitored treatment can lead to undetectable viremia, prevention remains the most effective strategy for successful management of this disease.

关键词： Chronic Viral Hepatitis B Viral dNA Follow-Up Evolution of Viral Load

Frequency of Antibiotic Resistance of Escherichia coliand Klebsiella pneumoniaeby Production of TOHO-Type β-Lactamases at Saint Camille Hospital, Ouagadougou (Burkina Faso)

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Advances in microbiology 2021年第12期11卷 713-722页

作者： Serge Sougué Amana mètuor-dabiré djénéba Ouermi Yasmine Rahimatou Wend-Kouni Tiemtoré Bénao Stéphanie Lynseh Carine Sita théodora.m.houkèdè zohoncon Yasmine Aminata Bangré Elie Kabré Jacques Simporé department of Biochemistry and microbiology Faculty of Applied Science and Technology Biomolecular Research Centre (CERBA/LABIOGENE) UFR-SVT Joseph KI-ZERBO University Ouagadougou Burkina Faso National Public Health Laboratory of Ouagadougou Ouagadougou Burkina Faso University of dedougou Dedougou Burkina Faso Saint thomas Aquinas University (USTA) Saint Camille Hospital of Ouagadougou Ouagadougou Burkina Faso

Extended-spectrum β-lactamase (ESBL) appeared some years after the introduction in hospital environment of unhydrolysable or extended-spectrum cephalosporins. Several studies have been reported on the blaTEm, blaCTX-m and blaSHV genes in ESBL producing Enterobacteria, however, very few studies reported in the literature were related to blaCTX-m subgroup blaTOHO. TOHO enzymes were responsible for healthcare-associated infections in hospitals and in the community. In Burkina Faso, data related to these types of enzymes were scarce. the purpose of this study was to detect TOHO enzymes in Escherichia coli and Klebsiella pneumoniae in order to know the prevalence of infections related to bacterial resistance due to TOHO enzymes at Saint Camille Hospital of Ouagadougou (Burkina Faso). the study was conducted firstly by microbiological identification of ESBLs-producing by Escherichia coli and Klebsiella pneumoniae using API 20 E gallery;secondly the antibiogram was performed by the diffusion method and finally the molecular characterization was made by conventional PCR to search for the blaTOHO gene. the visualization of the specific bands was made using the ultraviolet lamp (Gene Flash) for the photography of the gels. data were entered and analyzed using Excel 2013 and EPI Info version 6.0 software. A p-value dered as significant. We obtained at all 39 strains constituted by 21 (53.8%) Escherichia coli and 18 (46.2%) Klebsiella pneumoniae. molecular characterization showed the presence of the blaTOHO gene in 25 bacterial strains (64.1%). It was therefore established in this study the existence of blaTOHO gene at Saint Camille Hospital in Ouagadougou in Burkina Faso. Our study made it possible to know the distribution of the blaTOHO gene in Escherichia coli and Klebsiella pneumoniae.

关键词： Antibiotic Resistance Bacteria ESBL Genes TOHO

detection of Human Papillomavirus dNA and E6/E7 mRNA from HPV Genotypes 16, 18, 31 and 33 in Histologically Confirmed Cases of Cervical Cancer and Precancerous Lesions in Burkina Faso

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American Journal of molecular Biology 2023年第4期13卷 276-290页

作者： théodora.m.houkèdè zohoncon Shoukrat Ohuwa Toyin Bello Prosper Bado Rogomenoma Alice Ouédraogo Estelle Ouédraogo Ina marie Angèle Traoré Abdoul Karim Ouattara Florencia Wenkunni djigma Albert théophane Yonli Assita Sanou-Lamien Olga mélanie Lompo Jacques Simpore Laboratoire de Biologie moléculaire et de Génétique (LABIOGENE) Université Joseph KI-ZERBO Ouagadougou Burkina Faso Centre de Recherche Biomoléculaire Pietro Annigoni (CERBA) Ouagadougou Burkina Faso Faculté des Sciences de la Santé Université Saint Thomas d’Aquin (USTA) Ouagadougou Burkina Faso Centre Hospitalo-Universitaire Yalgado Ouedraogo Ouagadougou Burkina Faso Pathological Anatomy and Cytology Laboratory Université Joseph Ki-Zerbo Ouagadougou Burkina Faso

Introduction: Cervical cancer, caused by persistent high-risk human papillomavirus (HPV) infection, remains a global public health problem. the cellular transformation and maintenance of the malignant phenotype of these HPVs are attributed to the viral oncoproteins E6 and E7. Objective: this study aims to detect the presence of human papillomavirus dNA and E6/E7 oncoprotein mRNA of HPV genotypes 16, 18, 31 and 33 in cases of cervical cancer and precancerous lesions, histologically confirmed in Burkina Faso. methods: this descriptive cross-sectional study focused on cases of cervical cancer and high-grade intraepithelial neoplasia (CIN) and was conducted from June to december 2022. One hundred (100) samples of fixed and paraffin-embedded tissues were collected from the pathological anatomy and cytology laboratories of hospitals in the capital of Burkina Faso. High-risk human papillomavirus (HR-HPV) dNA was detected using multiplex real-time PCR, while the presence of E6 and E7 mRNA in cervical cancer and high-grade CIN samples was determined using real-time Reverse Transcriptase-PCR (RT-PCR) with Taqman probes. Results: the mean age of women diagnosed with cervical cancer and high-grade CIN was 50.81 ± 13.65 years, ranging from 22 to 82 years. Cervical cancer and high-grade CIN were positive for at least one high-risk human papillomavirus (HR-HPV) in 80% of cases. the most prevalent genotypes observed were HPV16, 18, 31, and 33, collectively accounting for 70.08% of cases. Of the 89 samples that tested positive for HR-HPV genotypes 16, 18, 31, and 33, 88 (98.88%;95% CI: [94.58 - 99.94]) were also positive for the presence of mRNA encoding the E6 and E7 oncoproteins of HPV16, 18, 31, and 33. Conclusion: In the presence of HPV dNA, testing for E6 and E7 oncoprotein mRNA could serve as a promising biomarker and valuable tool for improved assessment of the progression to cervical cancer.

关键词： HPV E6/E7 Cervical Cancer Precancerous Lesions Burkina Faso

distribution of High-Risk Human Papillomavirus Genotypes in Precancerous Cervical Lesions in Ouagadougou, Burkina Faso

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Open Journal of Obstetrics and Gynecology 2016年第4期6卷 196-204页

作者： Charlemagne Ouédraogo théodora.m.houkèdè zohoncon Esther m. A. Traoré Souleymane Ouattara Prosper Bado Clarisse T. Ouedraogo Florencia W. djigma djénéba Ouermi dorcas Obiri-Yeboah Olga Lompo Simon A. Akpona Jacques Simpore Pietro Annigoni Biomolecular Research Center (CERBA) Ouagadougou Burkina Faso UFR/SdS University of Ouagadougou Ouagadougou Burkina Faso Laboratory of molecular Biology and Genetics (LABIOGENE) University of Ouagadougou Ouagadougo Burkina Faso Teaching and Research Unit in Biochemistry and molecular Biology Faculty of Medicine University of Parakou Parakou Republic of Benin Faculty of medicine Université Saint Thomas d’Aquin Ouagadougou Burkina Faso University of Cape Coast School of Medical Sciences Microbiology Department University Post Office Cape Coast Ghana Yalgado Ouédraogo University Hospital (CHU/YO) Ouagadougou Burkina Faso

Aims: We aimed at identifying the high-risk HPV genotypes associated with high-grade dysplastic cervical lesions in Burkina Faso. the available vaccines to Burkina Faso only protect against two high risk HPV genotypes: HPV 16 and 18. Are the genotypes identified in the high-grade precan-cerous lesions in this survey covered by the available vaccines? methods: the detection and genotyping of high-risk HPV have been conducted based on 118 formalin-fixed and paraffin-embedded archived tissues using the “HPV Genotypes 14 Real-Tm Quant” (Sacace biotechnologies®, Italy) kit allowing for the detection of fourteen high-risk HPV genotypes: HPV 16, 31, 18, 39, 45, 59, 33, 35, 56, 68, 51, 52, 58 and 66. Results: the prevalence of high-risk HPV infections was 48.8% based on the appropriate PCR results (21/43). the most common HPV genotypes were HPV 39 (21.7%), HPV 35 (13.0%) and HPV 45 (13.0%). Two cases of multiple infections between HPV 39 - 45 and HPV 39 - 59 have been observed. HPV 16 was not detected in this study. Conclusions: We noted a high prevalence rate for HPV 39, HPV 35 and HPV 45, which are not covered by the commercial vaccines. We also found that the prevalence of HPV 18 was very low in this study and HPV 16 was not detected.

关键词： HPV Cancer CIN Cervix Burkina Faso

Association between Polymorphisms of Glutathione S-Transferase and Progression to Cervical Cancer in Women from Burkina Faso and mali

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Journal of Biosciences and medicines 2020年第4期8卷 12-25页

作者： Teega-Wendé Clarisse Ouedraogo Florencia Wendkuuni djigma théodora.m.houkèdè zohoncon Boureima Idani Abdoul Karim Ouattara Pegdwendé Abel Sorgho dorcas Obiri-Yeboah Prosper Bado mah Alima Esther Traore Birama diarra Albert théophane Yonli Charlemagne Ouedraogo Jacques Simpore Laboratory of molecular Biology and Genetics (LABIOGENE) University Joseph Ki-Zerbo Ouagadougou Burkina Faso Pietro Annigoni Biomolecular Research Centre (CERBA) Ouagadougou Burkina Faso University Saint thomas d’Aquin Faculty of Medicine Ouagadougou Burkina Faso department of microbiology and Immunology School of Medical Sciences University of Cape Coast PMB Cape Coast Ghana University Joseph Ki-Zerbo UFR/SDS Ouagadougou Burkina Faso

Although persistence of high-risk human papillomavirus infection is the main risk factor, Glutathione S-Transferase highly polymorphic enzyme involved in the metabolism of xenobiotics, is a good candidate gene. the objective of this study was to compare the polymorphisms of Glutathione S-Transferase m1-null in women with cancerous lesions and without lesions. this study consisted of 322 uterine cervix samples of women from mali and Burkina Faso with Cervical Intra-epithelial Neoplasia 2 and 3, adenocarcinoma and squamous cell carcinoma and 100 women with no lesions. Human Papillomavirus genotyping was performed by Real-time multiplex Polymerase Chain Reaction. Glutathione S-Transferase gene polymorphisms were determined using conventional Polymerase Chain Reaction followed by migration on agarose gel. A statistically significant association with high relative risks of 10.77 for the development of High grade Superficial or Squamous Intra-epithelial Lesion (95% CI = 5.59 - 20.72;p d 13.20 for cancer development (95% CI = 6.79 - 25.63;p d in women with the null genotype of Glutathione S-Transferase m1 in the study population. In Burkina Faso and mali, Glutathione S-Transferase m1-null presented relative risks of 9 and 11.05 for high-grade lesions, 15 and 11.40 for cancer. Similarly, significant results had been observed in women with human papillomavirus positive and human papillomavirus negative. the results of the present study support the idea that the deletion of Glutathione S-Transferase m1 plays a crucial role in the progression of high-grade lesions and cervical cancer.

关键词： Glutathione S-Transferase m1-Null Cervical Cancer Burkina Faso mali

State of the HIV, Hepatitis B and C Virus Pandemic from 2003 to 2022 in Burkina Faso: Evolution of Prevalence Trends and Strategic Recommendations to Achieve the WHO’s Goal for their Eradication by 2030

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Advances in Infectious diseases 2024年第3期14卷 628-643页

作者： Abdou Azaque Zouré Christelle Nadembega djénéba Ouermi Abdoul Karim Ouattara Lassina Traoré Adama Tiemtoré Olivier Sawadogo théodora m. zohoncon Florencia W. djigma Jacques Simpore Cerba-Labiogene Group Centre de Recherche Biomolculaire Pietro Annigoni (CERBA) Ouagadougou Burkina Faso Laboratoire de Biologie molculaire et de Gntique (LABIOGENE) Universit Joseph KI-ZERBO Ouagadougou Burkina Faso Institute for Research in Health Sciences (IRSS/CNRST) Ouaga Burkina Faso department of Biomedical Hpital Saint Camille de Ouagadougou (HOSCO) Ouagadougou Burkina Faso department of Biology Universit Norbert Zongo/Centre Universitaire de Manga Koudougou Burkina Faso department of mathematic Universit de Ouahigouya Ouahigouya Burkina Faso Faculty of medicine University Saint Thomas dAquin (USTA) Ouagadougou Burkina Faso

Background: the World Health Organization (WHO) has set a goal to eradicate or at least significantly reduce the prevalence the human immunodeficiency virus (HIV), hepatitis B Virus (HBV) and Hepatitis C Virus (HCV) by 2030. the main objective was to provide an evolving overview of the prevalence of HIV, HBV and HCV infection between 2003 and 2022 in Burkina Faso. methods: It was a retrospective cross-sectional study based on data from 2003 to 2022. the data were collected using information available in the databases of the HOSCO and CERBA laboratories and included all individuals who underwent HIV and/or HBV and/or HCV testing. data analysis was performed using SPSS version 20.0, EpiInfo 7, and R version 4.1.0. Results were considered statistically significant if p Results: the study recorded 7432 samples and the mean age of the subjects was 27.98 ± 8.50 years. during this period, the respective prevalence of HIV, HBV, and HCV were 4.66% (346/7432), 8.77% (582/6636) and 5.54% (322/5816). However, from 2003 to 2022, there was a significant decrease (P y=−1.75x+12.59;y=−0.24x+10.01and y=−0.11x+6.02, with “y” corresponding to prevalence and “x” to the years. Conclusion: Burkina Faso needs to rigorously apply prevention and control strategies recommended by the WHO by 2030.

关键词： HIV Viral Hepatitis B and C WHO’s 2030 Goal Burkina Faso

HPV/HBV or HPV/HCV Co-Infections in Women Treated for Chronic Hepatitis at Hôpital Saint Camille in Ouagadougou, Burkina Faso

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American Journal of molecular Biology 2024年第1期14卷 1-12页

作者： Estelle Ouédraogo théodora.m.houkèdè zohoncon Bagora Bayala Prosper Bado Rose P. Clémence da Rogomenoma Alice Ouedraogo Ina marie Angèle Traoré Punya Akouélé Kuassi-Kpede Samiratou Ouédraogo Essi Etonam dovo Lassina Traoré Albert théophane Yonli Florencia Wendkuuni djigma Olga mélanie Lompo Jacques Simpore Laboratory of molecular Biology and Genetics (LABIOGENE) University Joseph KI-ZERBO Ouagadougou Burkina Faso Centre of Biomolecular Research Pietro Annigoni (CERBA) Ouagadougou Burkina Faso Hô spital Saint Camille of Ouagadougou (HOSCO) Ouagadougou Burkina Faso Faculty of Health University Saint Thomas d’Aquin (USTA) Ouagadougou Burkina Faso Ecole Normale Supérieure Koudougou Burkina Faso Chair “Research and Action Against Cancer” Département de Santé Publique Training and Research Unit in Health Sciences University Joseph KI-ZERBO Ouagadougou Burkina Faso Observatoire National de la Santé de la Population Institut National de Santé Publique Ouagadougou Burkina Faso the department of Epidemiology Biostatistics and Occupational Health School of Population and Global Health Montreal Canada Laboratory of Pathological Anatomy and Cytology University Joseph KI-ZERBO Ouagadougou Burkina Faso

Introduction: Cervical cancer is a public health concern and is mainly caused by Human papillomaviruses (HPV). In many parts of the world, studies are being carried out to understand the different genotypes to better tackle this issue. We conducted a study to determine the prevalence of HPV genotypes in women with chronic hepatitis B or C infection, co-infected or not with HIV, treated at the Hôpital Saint Camille in Ouagadougou (Burkina Faso). methods: this study was conducted from April to July 2023, including 100 women in gastroenterology at Hôpital Saint Camille. A questionnaire on their socio-demographic and life style was administrated;and endocervical samples were collected using sterile swabs and then sent to Centre of Biomolecular Research Pietro Annigoni (CERBA). HPV molecular detection and genotyping were performed by PCR and hybridization using the HPV direct Flow Chips kit. data were analysis using chi square test or Fischer’s exact test with a significance threshold for p Results: the prevalence of HPV infection was 28% (28/100) on the sample of women tested. the most frequent genotypes were HPV 52 (8.33%), followed by HPV 18 and 68 (6.25% each) for high-risk HPVs, and HPV 6, 44/55 and 62/81 (8.33% each) for low-risk HPVs. Conclusion: this study, the first of its kind in Burkina Faso on this group of the population, reveals that the most frequent genotypes found in this study are not included in the vaccine available in Burkina Faso (Gardasil®4).

关键词： Human Papillomavirus Cervical Cancer Hepatitis Human Immunodeficiency Virus Burkina Faso