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The effect of optimism bias and governmental action on siltation management within Japanese reservoirs surveyed via artificial neural network

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Big Earth Data 2020年第1期4卷 68-89页

作者： Tobias Landwehr Sameh Ahmed Kantoush Claudia Pahl-Wostl tetsuya Sumi Mitsuteru Irie Institute for Environmental Systems Research Osnabrück UniversityOsnabrückGermany Water Resources Research Center Disaster Prevention Research InstituteKyoto UniversityKyotoJapan Department of Civil and Environmental Engineering Faculty of EngineeringMiyazaki UniversityMiyazakiJapan

Reservoirs are installed as long-term assets to guarantee water and energy security for decades,if not ***,the effect of siltation undermines reservoirs’sustainability because it significantly reduces the reservoirs’original *** present paper attempts to evaluate the global reservoir siltation problem with the optimism bias theorem introduced by Kahneman and Tversky and applied to infrastructural mega-projects by Flyvbjerg and Ansar using artificial neural networks(ANNs)algorithms for large Japanese *** possesses suitable long-term data and a legal directive concerning the sediment capacity siltation duration,which serves as a valid guide to check whether,over the past 100 years,engineers,planners and managers were capable of judging the sediment input *** ANN models were established to emulate Japanese reservoir siltation *** networks demonstrate that reservoirs in Japan suffer from optimism *** contrast to the law,the dead storage volume of an average dam is supposed to reach capacity after 52 *** finding joins the overall observation that mega-projects generally and globally suffer from optimism *** emulations were subsequently screened for a presumed influence of governance actions,namely,indicating plus monitoring and the change in the market competition *** reservoir siltation appears to continue regardless of the level of competition in public procurement,monitoring directives appear to have a considerable impact on improved siltation management,which demonstrates that dedicated governance action can significantly strengthen the sustainable behavior of key infrastructure elements such as reservoirs.

关键词： Neural networks optimism bias governance Japan sustainability reservoirs sedimentation infrastructure

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Degradation of dibromophenols by UV irradiation

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Journal of Environmental Sciences 2014年第6期26卷 1284-1288页

作者： Keiko Katayama-Hirayama Naoki Toda Akihiko Tauchi Atsushi Fujioka tetsuya Akitsu Hidehiro Kaneko Kimiaki Hirayama Interdisciplinary Graduate School of Medicine and Engineering University of Yamanashi 4-3-11 Takeda Kofu 400-8511 Japan Technology Development Division Toshiba Lighting and Technology Corporation Asahimachi 5-2-1 Imabari Ehime 794-8510 Japan

We examined the degradation of dibromophenols （DBPs）, i.e. 2,4-DBP, 2,6-DBP and 3,5-DBP by ultraviolet （UV） irradiation and estimated the relationship between degradability and molecular orbital properties of each dibromopbenol. The removal of DBPs under a UV lamp system was successfully performed in an aqueous solution. After 5 min of irradiation, the initial DBPs concentration of 20 mg/L was decreased to below 1 mg/L, and about 60% of bromide ion was released. A decrease in the concentration of dissolved organic carbon （DOC） suggested the mineralization of DBPs, The mineralization may occur after release of bromide ions because the decrease of DOC was slower than the release of bromide ions. The degradability of 3,5-DBP was slightly lower than 2,6-DBP and 2,4-DBE Molecular orbital calculation suggested that the electrophilic frontier density and the highest occupied molecular orbital （HOMO） energy may be related to the degradability of DBPs.

关键词： bromide ion dibromophenol DOC mineralization UV irration

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Safety and effectiveness of propofol sedation during and after outpatient colonoscopy

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World Journal of Gastroenterology 2012年第26期18卷 3420-3425页

作者： Akira Horiuchi Yoshiko Nakayama Masashi Kajiyama Naoyuki Kato tetsuya Kamijima Yasuyuki Ichise Naoki Tanaka Digestive Disease Center Showa Inan General HospitalKomagane 399-4117Japan Department of Pediatrics Shinshu University School of MedicineMatsumoto 390-8621Japan Department of Metabolic Regulation Shinshu University Graduate School of MedicineMatsumoto 390-8621Japan

AIM:To study the safety and effectiveness of propofol sedation for outpatient ***:Propofol was given by bolus injection with an age-adjusted standard protocol consisting of 60 mg for patients < 70 years old,40 mg for patients age 70-89 years,and 20 mg for those ≥ 90 years,and additional injections of 20 mg propofol were given up to a maximum of 200 *** principal parameters were the occurrence of adverse events within 24 h after colonoscopy and overall satisfaction for this *** parameters included successful procedure,respiratory depression,and other ***:Consecutive patients were entered prospectively and all 2101 entered successfully completed outpatient *** mean dose of propofol used was 96.4 mg(range 40-200 mg).Younger patients required higher doses of propofol than older patients(20-40 years vs ≥ 61 years:115.3 ± 32 mg vs 89.7 ± 21 mg,P < 0.001).Transient supplemental oxygen supply was needed by five patients(0.2%);no other complications *** questionnaires were completed by 1820(87%) of 2101 patients and most rated their overall satisfaction as excellent(80%) or good(17%).The majority(65%) of patients drove home or to their office after their ***(99%) were willing to repeat the same *** incidents occurred within 24 h after ***:Propofol sedation using a dose < 200 mg proved both safe and practical for outpatient colonoscopy.

关键词：结肠镜异丙酚安全性检查门诊镇静标准协议不良反应

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Acquisition of LURE-Binding Activity at the Pollen Tube Tip of Torenia fournieri

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Molecular Plant 2013年第4期6卷 1074-1090页

作者： Satohiro Okuda Takamasa Suzuki Masahiro M. Kanaoka Hitoshi Moric Narie Sasaki tetsuya Higashiyama Division of Biological Science Graduate School of Science Nagoya University Furo-cho Chikusa-ku Nagoya Aichi 464-8602 Japan JST ERATO Higashiyama Live-Holonics Project Nagoya University Furo-cho Chikusa-ku Nagoya Aichi 464-8602 Japan Department of Bioengineering Sciences Graduate School of Bioagricultural Sciences Nagoya University Furo-cho Chikusa-ku Nagoya Aichi 464-8602 Japan WPI-ITbM Nagoya University Furo-cho Chikusa-ku Nagoya Aichi 464-8602 Japan

Pollen tube guidance is controlled by multiple complex interactions with the female tissues. Here, we show that pollen tubes of Torenia fournieri are regulated by a stylar tissue in a length-dependent manner to receive and respond to attractant LURE peptides secreted from synergid cells. We developed an immunostaining method to visualize LURE peptides bound at the plasma membrane of the tip region of the pollen tube. Using this method, we found that LURE peptides bound specifically to pollen tubes growing through a cut style. The peptides also bound to pollen tubes growing through a shorter style, which were not competent to respond to these peptides. These observations suggested a possibility that acquisition of the LURE peptide reception ability and acquisition of full competency are separable pro- cesses. RNA-Seq suggested that the transcription profile of pollen tubes was affected by both the length of the style and the cultivation period, consistently with physiological changes in binding activity and LURE response ability. The data- base generated from de novo RNA-Seq of Torenia pollen tubes was shown to be useful to identify pollen tube proteins by mass spectrometry. Our studies provide insight and an effective platform for protein identification to understand pollen tube guidance.

关键词： pollen tube guidance attractants pollen tube de novo transcriptome proteome.

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Characteristics of Sleep and Autonomic Activity in Active Older Adults Based on Metabolic Age: A Comparative Case Study

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Open Journal of Psychiatry 2023年第4期13卷 229-245页

作者： Miki Sato Ryuichi Tanioka Feni Betriana Kyoko Osaka Yueren Zhao tetsuya Tanioka Akira Takahashi Department of Clinical Nursing Kochi Medical School Kochi University Kochi Japan Faculty of Health Sciences Department of Rehabilitation Hiroshima Cosmopolitan University Hiroshima Japan Faculty of Nursing Prince of Songkla University Hat Yai Thailand Department of Psychiatry Fujita Health University Aichi Japan Institute of Biomedical Sciences Graduate School Tokushima University Tokushima Japan

Background: The balance of autonomic nervous system activity and its relationship with body composition, sleep quality, and activities of daily living among older people is still unclear. Purpose: This comparative case study examined the characteristics of body composition, sleep quality, and autonomic nerve activity in active older adults with a younger body age-calculated from age trends in body composition and basal metabolic rate. Methods: We selected two cases with a metabolic age younger than their actual age. They had good sleep quality, no sarcopenia, strong muscle and grip strength, and balanced autonomic nervous system activity. They were compared with two other age- and gender-matched cases, who had poor sleep quality, unbalanced autonomic nervous system activity, and had a physical age closer to their actual age. Results: Older adults with more muscle mass and higher basal metabolism were younger than their actual age, had a better sleep status, and had a good balance of autonomic nervous activity during exercise stimulation. They also had lower percentages of body and visceral fat and higher percentages of body water. Conclusion: Two cases had a metabolic age younger than their actual age were found to be much younger than their actual age. However, the older adults with normal muscle mass and basal metabolic rate had poor sleep status and no sympathetic hyperactivity during exercise simulation.

关键词： Healthy Aging Autonomic Nervous Activities Heart Rate Variability Sleep Status Well-Being

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Development of a competitive enzyme-linked immunosorbent assay for therapeutic drug monitoring of afatinib

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Journal of Pharmaceutical Analysis 2019年第1期9卷 49-54页

作者： Rintaro Sogawa tetsuya Saita Yuta Yamamoto Sakiko Kimura Yutaka Narisawa Shinya Kimura Masashi Shin Department of Pharmacy Saga University Hospital Applied Life Science Department Faculty of Biotechnology and Life Science Sojo University Division of Hematology Respiratory Medicine and Oncology Department of Internal Medicine Faculty of Medicine Saga University

Afatinib is an oral tyrosine kinase inhibitor(TKI) approved for treating advanced non-small cell lung cancer. It is necessary to develop a simple quantification method for TKIs in order to facilitate therapeutic drug monitoring(TDM) in clinical settings. This study sought to develop a simple and sensitive competitive enzyme-linked immunosorbent assay(ELISA) to quantify afatinib in plasma for routine pharmacokinetic applications. An anti-afatinib antibody was obtained using(S)-N-4-(3-chloro-4-fluorophenyl)-7-(tetrahydrofuran-3-yloxy)-quinazoline-4,6-diamine(CTQD), which has the same substructure as afatinib, as a hapten. Enzyme labeling of afatinib with horseradish peroxidase was similarly performed using CTQD. A simple competitive ELISA for afatinib was developed based on the principle of direct competition between afatinib and the enzyme marker for the anti-afatinib antibody, which had been immobilized on the plastic surface of a microtiter plate. Plasma afatinib concentrations below the limit of quantification of 30 pg/mL were reproducibly measurable. Also, the values of plasma afatinib levels measured from 20 patients were comparable with those measured by high-performance liquid chromatography, and there was a strong correlation between the values determined by both methods(Y=0.976 X – 0.207, r=0.975). As indicated by its specificity and sensitivity, this newly developed ELISA for afatinib is an important tool for TDM and studies of the pharmacokinetics of afatinib.

关键词： Afatinib Enzyme-linked immunosorbent assay Therapeutic drug monitoring Tyrosine-kinase inhibitor

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Mercury removal and recovery by immobilized Bacillus megaterium MB1

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Frontiers of Chemical Science and Engineering 2012年第2期6卷 192-197页

作者： Meifang CHIEN Ryo NAKAHATA tetsuya ONO Keisuke MIYAUCHI Ginro ENDO Faculty of Engineering Tohoku-Gakuin University Miyagi 985-8537 Japan

From several mercury removing microorgan- isms, we selected Bacillus megaterium MB 1, which is non- pathogenic, broad-spectrum mercury resistant, mercuric ion reducing, heat tolerant, and spore-forming, as a useful bacterium for bioremediation of mercury pollution. In this study, mercury removal performance of the immobilized B. megaterium MB1 was investigated to develop safe, efficient and stable catalytic bio-agent for mercury bioremediation. The results showed that the alginate gel immobilized B. megaterium MB 1 cells efficiently removed 80% of mercury from the solution containing 10mg/L mercuric chloride within 24 h. These cells still had high activity of mercury removal even after mercuric ion loading was repeated for nine times. The analysis of mercury contents of the alginate beads with and without immobilized B. megaterium MB1 suggested that a large portion of reduced metallic mercury was trapped in the gel beads. It was concluded that the alginate gel immobilized B. megaterium MB 1 cells have potential to remove and recover mercury from mercury-containing water.

关键词： mercury removal immobilized bacteria alginate gel bioremediation

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Photothermal therapy of tumors in lymph nodes using gold nanorods and near-infrared laser light with controlled surface cooling

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Nano Research 2015年第12期8卷 3842-3852页

作者： Tessai Sugiura Daisuke Matsuki Junnosuke Okajima Atsuki Komiya Shiro Mori Shigenao Maruyama tetsuya Kodama Department of Mechanical Systems and Design Graduate School of Engineering Tohoku University Sendai 980-8579 Japan Laboratory of Biomedical Engineering for Cancer Department of Biomedical Engineering Graduate School of Biomedical Engineering Tohoku University Sendai 980-8575 Japan Institute of Fluid Science Tohoku University 2-1-I Katahira Aoba Ward Sendai 980-8577 Japan Department of Oral and Maxillofacial Surgery Tohoku University Hospital Sendai 980-8575 Japan

Photothermal 治疗(PTT ) 用在红外线附近(NIR ) 激光光和金 nanorods (GNR ) 作为一种新奇癌症治疗形式显示出诺言。然而，要求破坏肿瘤房间的激光紧张在皮肤下面定位了比阀值紧张大那原因皮肤损坏；因此，有激光光的照耀损坏皮肤以及... 详细信息

Photothermal 治疗(PTT ) 用在红外线附近(NIR ) 激光光和金 nanorods (GNR ) 作为一种新奇癌症治疗形式显示出诺言。然而，要求破坏肿瘤房间的激光紧张在皮肤下面定位了比阀值紧张大那原因皮肤损坏；因此，有激光光的照耀损坏皮肤以及肿瘤。这里，我们证明一个温度控制系统允许变形淋巴节点(行) 被 PTT 用 NIR 激光光和 GNR 对待，没有皮肤损坏。行转移的一个老鼠模型被肿瘤房间的注射开发，并且忍受肿瘤的合适的腋的行在 GNR 的注射以后与 NIR 激光光被对待。皮肤温度在 45 点被维持。潮湿转移能力索引(h D A/P ) 最大因为 30essure (BP ) ，心率(HR ) 和官方补给的症状在 270min 上被估计。

关键词：温度控制系统近红外激光肿瘤细胞癌症治疗表面冷却淋巴结纳米棒光热

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Pathogenesis of childhood idiopathic nephrotic syndrome:a paradigm shift from T-cells to podocytes

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World Journal of Pediatrics 2015年第1期11卷 21-28页

作者： Kazunari Kaneko Shoji Tsuji Takahisa Kimata tetsuya Kitao Sohsaku Yamanouchi Shogo Kato Department of Pediatrics Kansai Medical University2-5-1 Shin-machiHirakataOsaka 573-1010Japan

Background:Nephrotic syndrome is the most common cause of kidney disease in children,but its pathogenesis remains *** article reviews the novel aspects of the mechanisms underlying massive proteinuria in minimal-change disease,which is the most common form of childhood nephrotic *** sources:This article integrates the findings of a PubMed database search for English language articles published in the past 40 years(from September 1974 to February 2014)using the key words"pathogenesis","minimal change nephrotic syndrome"or"idiopathic ne phrotic syndrome".Results:Unknown humoral factors associated with T-cell dysfunction have been thought to play an important role in the pathogenesis of minimal-change ***,recent findings are changing this paradigm,i.e,visceral glomerular epithelial cells(podocytes)may be involved via expression of molecules such as CD80 and angiopoietin-like ***:Recent evidence suggests that minimal-change disease results from interactions between humoral factors and dysfunctional *** addition to immunosuppressant drugs that target lymphocytes,a biological agent such as an antibody against the abnormal molecule(S)expressed by podocytes may provide novel drug treatment for minimal-change disease.

关键词： angiopoietin-like 4 CD80 cytokine minimal change nephrotic syndrome podocyte

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Isolation and Structure Elucidation of New Glycosides From the Leaves of Oplopanax Elatus NAKAI (Ⅲ)

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Chinese Science Bulletin 1994年第23期39卷 1969-1972页

作者：王广树徐景达 tetsuya Murayama Junzo Shoji Bethune University of Medical Sciences Changchun 130021 PRC School of Pharmaceutical Sciences Showa UniversityTokyo 142Japan

The roots of oplopanax elatus NAKAI (Chinese name, Cirensen) (Araliaceae) have been used as a medicine in China for tonica,antitussis, eliminating fever,regulating blood pressure and so *** chemical studies of the lea... 详细信息

关键词： oplopanax elatus triterpenoid saponin cirensenoside oleanene-type trilerpenoid saponin.

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