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Association between ADAMTS13 activity-VWF antigen imbalance and the therapeutic effect of HAIC in patients with hepatocellular carcinoma

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World Journal of Gastroenterology 2020年第45期26卷 7232-7241页

作者： Hiroaki Takaya Tadashi Namisaki Kei Moriya Naotaka Shimozato Kosuke kaji Hiroyuki Ogawa Koji Ishida Yuki Tsuji Daisuke Kaya Hirotestu Takagi Yukihisa Fujinaga Norihisa Nishimura Yasuhiko Sawada Hideto Kawaratani Takemi Akahane Masanori Matsumoto Hitoshi Yoshiji Department of Gastroenterology Nara Medical UniversityKashiharaNara 634-8522Japan Department of Blood Transfusion Medicine Nara Medical UniversityKashiharaNara 634-8522Japan

BACKGROUND Prediction of HAIC treatment response is important for improving the prognosis in patients with hepatocellular carcinoma(HCC).The progression of HCC is related to hypercoagulability and *** is known that ADAMTS13 and von Willebrand factor(VWF)are related to *** addition,previous study reported that the association between ADAMTS13 and VWF,and angiogenesis via vascular endothelial growth factor(VEGF).Recently,ADAMTS13 and VWF have been associated with the prognosis in patients with various kinds of cancer undergoing *** To investigate whether ADAMTS13 and VWF become useful biomarkers of treatment response in HCC patients before the initiation of HAIC *** Seventy-two patients were enrolled in this ***13 activity(ADAMTS13:AC),VWF antigen(VWF:Ag)and VEGF levels were determined via enzyme-linked immunosorbent *** and multivariable analyses were performed to determine the predictive factors of treatment response in patients with HCC undergoing HAIC *** ADAMTS13:AC levels in HCC patients with stable disease(SD)+partial response(PR)of HAIC treatment were significantly higher than those with progressive disease(PD)(P2.7)had higher VEGF levels than those with low ratio(≤2.7).Multivariable analysis revealed that VWF:Ag/ADAMTS13:AC ratio was a predictive factor of HAIC treatment *** VWF:Ag/ADAMTS13:AC ratio may become a useful biomarker of treatment response in HCC patients before the initiation of HAIC treatment.

关键词： ADAMTS13 Von Willebrand factor Vascular endothelial growth factor Biomarkers Hepatocellular carcinoma HAIC

Inversion and Isomerization of an Aspartyl Residue Affect the Properties of Peptides

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Inversion and Isomerization of an Aspartyl Residue Affect th...

作者： N.Fujii Y.kaji N.Fujii Department of Ophthalmology University of Tsukuba

IINTRODUCTION:Proteins have been considered to consist exclusively of L-amino acids in living tissues. However,our previous studies showed that two specific aspartyl(Asp) residues inαA- and ctB-crystallins,respectively, from human eye lenses invert to the D-isomers to a high degree during *** reaction is also accompanied by isomerization into a form containingβ-Asp(isoaspartate) *** appearance of Dandβ-Asp in protein potentially induces large changes to the higher order structure of the protein as well as its

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丙烯酸在聚酯纤维上的辐射引发接枝

国外纺织技术 1986年第6期 1-6页

作者： Kanako kaji 岑红

一、引言作者同 Sakwrada 及其合作者们一道,进行了一系列用辐射引发接枝的方法对合成纤维进行改性的研究。合成纤维大多数为疏水性的,它们的吸湿性、上染率、热稳定性和阻燃能力都比较差。这些不足之处可通过合适

关键词：接枝 PET 回潮率织物丙烯酸接枝率辐射引发溶胀剂纤维阻聚剂

Analysis of Thin Monocrystalline Silicon Solar Cell by Photographic Surveying

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Analysis of Thin Monocrystalline Silicon Solar Cell by Photo...

第十五届国际光伏科学与工程大会

作者： Yu Takahashi Yasue kaji Akiyoshi Ogane Yukiharu Uraoka Takashi Fuyuki Graduate School of Materials Science Nara Institute of Science and Technology8916-5 Takayama Ikoma Nara 630-0192 Japan

We propose new evaluation technique of rear passivation effect and rear structure in thin monocrystalline silicon (c-Si) solar cells. Light emission from the solar cell was detected by a charge coupled device (CCD) camera. We have found that the intensity distribution of light emission correlate closely with the number of minority carriers in p-type layer. The number of minority carriers was affected by rear surface recombination velocity (S), which was estimated from the emission intensity in thin c-Si solar cells with larger minority carrier diffusion length (L) than cell thickness. The several kinds of rear passivation layers and rear structures evaluated for same forward current density. The difference in emission intensity was detected. We could demonstrate that the emission intensity had the correlation with S and Rear structure of thin c-Si solar cell

关键词： Evaluation Recombination Passivation

Characterization of Polycrystalline Silicon Solar Cells by Electroluminescence

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Characterization of Polycrystalline Silicon Solar Cells by E...

第十五届国际光伏科学与工程大会

作者： Yasue kaji Yu Takahashi Akiyoshi Ogane Yukiharu Uraoka Takashi Fuyuki Graduate School of Materials Science Nara Institute of Science and Technology（NAIST） 8916-5 Takayama Ikoma Nara 630-0192 Japan Graduate School of Materials Science Nara Institute of Science and Technology（NAIST） 8916-5 Takayama Ikoma Nara 630-0192 Japan Graduate School of Materials Science Nara Institute of Science and Technology（NAIST） 8916-5 Takayama Ikoma Nara 630-0192 Japan Graduate School of Materials Science Nara Institute of Science and Technology（NAIST） 8916-5 Takayama Ikoma Nara 630-0192 Japan Graduate School of Materials Science Nara Institute of Science and Technology（NAIST） 8916-5 Takayama Ikoma Nara 630-0192 Japan

＜正＞ The novel detection method of the spatial distribution of minority carrier diffusion length has been proposed utilizing the photographic surveying of electroluminescence emitted from polycrystalline Si solar cells. Under the forward bias condition, the cell emits infrared light （wavelength: 1000 - 1300 nm）, which intensity reflects the minority carrier diffusion length quantitatively . Quantitative analysis of the correlation between this emission intensity and forward current was carried.

关键词： c-Si Diffusion length Evaluation Electroluminescence

Analysis of the risk of ovarian torsion in 49 consecutive pediatric patients treated at a single institution

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World Journal of Pediatric Surgery 2019年第2期2卷 1-5页

作者： Koshiro Sugita Takafumi Kawano Mukai Motoi Toshihiro Muraji Shun Onishi Tomoe Moriguchi Koji Yamada Waka Yamada Ryuta Masuya Seiro Machigashira Kazuhiko Nakame Tatsuru kaji Satoshi Ieiri Department of Pediatric Surgery Kagoshima University Graduate School of Medicine and Dental SciencesKagoshimaJapan Department of Pediatric Surgery Kirishima Medical CenterKirishimaJapan

Purpose An early diagnosis of ovarian torsion is sometimes difficult due to variable clinical symptoms and non-specific imaging *** retrospectively reviewed patients with pediatric ovarian masses manifesting *** Fifty-eight ovarian masses(55 episodes)in 49 non-neonatal patients treated from April 1984 to March 2017 were retrospectively *** Mann-Whitney U test and Fisher’s exact test were used for the statistical *** The median age of these 55 episodes was 10.5 years old(range 1.0-23.0).Thirty-three patients presented with abdominal ***-five tumors and 13 cystic masses were resected and diagnosed pathologically(50 benign and 8 malignant).Torsion was identified in 15 cases(25.9%)at *** torsion masses were all benign,and 8 ovaries(53.3%)were successfully *** the torsion cases with the non-torsion cases,only the white cell count was significantly higher in the torsion cases(p=0.0133)and in the patients presented with abdominal pain(p=0.0068).The duration of abdominal pain was significantly shorter in ovary preserved cases than in oophorectomy *** The white blood cell may be a helpful indicator of the presence of torsion as well as the need for surgery.

关键词： torsion analysis. white

New Multi-Component Photoinitiating Systems based on Bisimidazole Derivative

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New Multi-Component Photoinitiating Systems based on Bisimid...

RadTech Asia 2005

作者： Xavier Allonas Jean-Pierre Fouassier Houssam Obeid Makoto kaji Yasuhisa Ichihashi Département Département Département Hitachi Chemical Co. Ltd. Research and Development Center 13-1 Higashi-cho 4-chome Hitachi-shi Ibaraki-ken 317-8555 JAPAN Hitachi Chemical Co. Ltd. Research and Development Center 13-1 Higashi-cho 4-chome Hitachi-shi Ibaraki-ken 317-8555 JAPAN

＜正＞ The comparative efficiency of selected multi-component photoinitiating systems （PIS） based on Cl-HABl （2- Chlorohexaarylbiimidazole） in the presence of coumarins or ketocoumarines or ketones or/and hydrogen donors is investigated through Real Time FT-IR. The results of the polymerization kinetics and complementary data on the processes obtained through steady state analytical techniques allows the elaboration of a general picture for the mechanisms encountered in the different PIS and a discussion on their relative efficiency.

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Alpha-fetoprotein-producing colon cancer with atypical bulky lymph node metastasis

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World Journal of Gastroenterology 2006年第47期12卷 7715-7716页

作者： Kuangi Fu Akihiro Kobayashi Norio Saito Yasushi Sano Shigeharu Kato Hiroaki Ikematsu Takahiro Fujimori Yasushi kaji Shigeaki Yoshida Department of Radiology Dokkyo University School of Medicine 880 Kitakobaysashi Mibu Shimotuga Tochigi 321-0293 Japan Department of Gastrointestinal Oncology and Digestive Endoscopy National Cancer Center Hospital East Kashiwa Chiba 277-8577 Japan Department of Surgery National Cancer Center Hospital East Kashiwa Chiba 277-8577 Japan Department of Gastrointestinal Oncology and Digestive Endoscopy National Cancer Center Hospital East Kashiwa Chiba 277-8577 Japan Department of Surgical and Molecular Pathology Dokkyo University School of Medicine 880 Kitakobaysashi Mibu Shimotuga Tochigi 321-0293 Japan Department of Radiology Dokkyo University School of Medicine 880 Kitakobaysashi Mibu Shimotuga Tochigi 321-0293 Japan

Alpha-fetoprotein (AFP)-producing colorectal cancer is extremely rarely reported until now. All of the reported cases harboring synchronous hematogenous spread including liver and/or lung metastasis had a poor prognosis and died within 12 mo. We here describe a 71-year old man with AFP-producing colon cancer who presented with an unusual bulky lymph node metastasis instead of hematogenous spread. He underwent adjuvant chemotherapy in addition to curative surgical resection, which prolonged his survival.

关键词：结肠癌淋巴细胞胎蛋白 X线断层摄影术

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日本东京圈的铁路网与公共交通指向型开发

城市轨道交通研究 2016年第11期19卷 6-10页

作者：鍛冶智也日本明治学院大学法学部东京108-8636

东京圈的铁路网由一种缺少竞争的地域分业体制组成。连接开发空间较大的郊区与市中心的近距离铁路,主要是由私营铁路公司来建设的。因此,私营铁路公司在建设铁路的同时,还通过推进地域的开发和促进人口增长的策略来提高人们乘坐铁路列... 详细信息

东京圈的铁路网由一种缺少竞争的地域分业体制组成。连接开发空间较大的郊区与市中心的近距离铁路,主要是由私营铁路公司来建设的。因此,私营铁路公司在建设铁路的同时,还通过推进地域的开发和促进人口增长的策略来提高人们乘坐铁路列车的机会,并且实行公共交通指向型开发来扩充铁路运输事业。

关键词：东京铁路公共交通指向型开发都市圈蔓延互连互通运输节点交通