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The increase in surface CXCR4 expression on lung extravascular neutrophils and its effects on neutrophils during endotoxin-induced lung injury

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Cellular & Molecular Immunology 2011年第4期8卷 305-314页

作者： Mitsuhiro Yamada Hiroshi Kubo Seiichi Kobayashi Kota Ishizawa Mei He Takaya Suzuki Naoya Fujino Hiroyuki Kunishima Masamitsu Hatta Katsushi Nishimaki tetsuji aoyagi Kouichi Tokuda Miho Kitagawa Hisakazu Yano Hirokazu Tamamura Nobutaka Fujii Mitsuo Kaku Department of Regional Cooperation for Infectious Diseases Tohoku University Graduate School of MedicineSendaiMiyagiJapan Department of Advanced Preventive Medicine for Infectious Disease Tohoku University Graduate School of MedicineSendaiMiyagiJapan Department of Respiratory Medicine Japanese Red-Cross Ishinomaki HospitalIshinomakiMiyagiJapan Department of Infection Control and Laboratory Diagnostics Tohoku University Graduate School of MedicineSendaiMiyagiJapan Department of Clinical Microbiology with Epidemiological Research&Management and Analysis of Infectious Diseases Tohoku University Graduate School of MedicineSendaiMiyagiJapan Institute of Biomaterials and Bioengineering Tokyo Medical and Dental UniversityChiyoda-kuTokyoJapan Graduate School of Pharmaceutical Sciences Kyoto UniversityKyotoJapan

Inflammatory stimuli,such as a microbes or lipopolysaccharides,induce a rapid release of neutrophils from the bone marrow and promote neutrophil migration into inflamed sites to promote host ***,an excess accumulation and retention of neutrophils in inflamed tissue can cause severe tissue injuries in the later stages of *** studies have reported that both CXCL12 levels in injured lungs and its receptor,CXCR4,on accumulated neutrophils in injured lungs,increased;furthermore,these studies showed that the CXCL12/CXCR4 signaling pathway participated in neutrophil accumulation in the later stages of lipopolysaccharide(LPS)-induced lung ***,the mechanisms underlying this increase in surface CXCR4 expression in neutrophils remain *** this study,we found that surface CXCR4 expression increased in extravascular,but not intravascular,neutrophils in the lungs of LPS-induced lung injury model ***,ex vivo studies revealed that CXCL12 acted not only as a chemoattractant,but also as a suppressor of cell death for the lung neutrophils expressing ***,one of the native ligands for L-selectin,induced the increase of surface CXCR4 expression on isolated circulating neutrophils,suggesting that the activation of L-selectin may be involved in the increase in surface *** findings show that surface CXCR4 levels on neutrophils increase after extravasation into injured lungs,possibly through the activation of *** CXCL12/CXCR4 signaling pathway plays an important role in the modulation of neutrophil activity during acute lung injury,not only by promoting chemotaxis but also by suppressing cell death.

关键词： CXCL12 CXCR4 lipopolysaccharides lung injury neutrophils

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Evaluation of excavation damaged zones(EDZs)in Horonobe Underground Research Laboratory(URL)

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第2期16卷 365-378页

作者： Koji Hata Sumio Niunoya Kazuhei aoyagi Nobukatsu Miyara Obayashi Corporation Technology Research InstituteTechnology DivisionKiyoseTokyo204-8558Japan Obayashi Corporation Nuclear Facilities DivisionSinagawaTokyo108-8502Japan Japan Atomic Energy Agency Horonobe Underground Research CenterHoronobeHokkaido098-3224Japan

Excavation of underground caverns,such as mountain tunnels and energy-storage caverns,may cause the damages to the surrounding rock as a result of the stress *** this influenced zone,new cracks and discontinuities are created or propagate in the rock ***,it is effective to measure and evaluate the acoustic emission(AE)events generated by the rocks,which is a small elastic vibration,and permeability *** authors have developed a long-term measurement device that incorporates an optical AE(O-AE)sensor,an optical pore pressure sensor,and an optical temperature sensor in a single multi-optical measurement probe(MOP).Japan Atomic Energy Agency has been conducting R&D activities to enhance the reliability of high-level radioactive waste(HLW)deep geological disposal *** a high-level radioactive disposal project,one of the challenges is the development of methods for long-term monitoring of rock mass ***,in January 2014,the long-term measurements of the hydro-mechanical behavior of the rock mass were launched using the developed MOP in the vicinity of 350 m below the surface at the Horonobe Underground Research *** measurement results show that AEs occur frequently up to 1.5 m from the wall during *** addition,hydraulic conductivity increased by 2e4 orders of *** analysis revealed that the hydraulic behavior of the rock mass affected the pore pressure fluctuations and caused *** on this,a conceptual model is developed to represent the excavation damaged zone(EDZ),which contributes to the safe geological disposal of radioactive waste.

关键词： Excavation damaged zone(EDZ) Optical sensor Long-term monitoring Acoustic emission(AE) Shaft sinking

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Swimmer with submerged SiO_(2)/Al/LiNbO_(3) surface acoustic wave propulsion system

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Biomimetic Intelligence & Robotics 2024年第2期4卷 71-77页

作者： Deqing Kong Ryo Tanimura Fang Wang Kailiang Zhang Minoru Kuribayashi Kurosawa Manabu aoyagi Department of Engineering Muroran Institute of TechnologyMuroran 050-8585Japan Tianjin Key Laboratory of Film Electronic and Communication Devices School of Integrated Circuit Science and EngineeringTianjin University of TechnologyTianjin 300384China School of Engineering Tokyo Institute of TechnologyYokohama 226-8501Japan

Acoustic propulsion system presents a novel underwater propulsion approach in small scale *** study introduces a submerged surface acoustic wave(SAW)propulsion system based on the SiO_(2)/Al/LiNbO_(3) *** 19.25 MHz,the SAW propulsion system is proposed and investigated by the propulsion force calculation,PIV measurements and propulsion measurements.3.3 mN propulsion force is measured at 27.6 V_(pp).To evaluate the miniature swimmer,the SAW propulsion systems with multiple frequencies are *** 2.2 W,the submerged SAW propulsion system at 38.45 MHz demonstrates 0.83 mN/mm^(2) propulsion *** 96.13 MHz and 24 V_(pp),the movements of miniature swimmer with a fully submerged SAW propulsion system are recorded and analyzed to a maximum of 177 mm/*** of miniaturization,high power density,and simple structure,the SAW propulsion system can be expected for some microrobot applications,such as underwater drone,pipelinerobotand intravascularrobot.

关键词： Acoustofluidics Surface acoustic wave Swimmer Underwater propulsion system

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Effects of estradiol and progesterone on the proinflammatory cytokine production by mononuclear cells from patients with chronic hepatitis C

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World Journal of Gastroenterology 2008年第14期14卷 2200-2207页

作者： Ying Yuan Ichiro Shimizu Mi Shen Eriko aoyagi Hidetaka Takenaka Tatuzo Itagaki Mari Urata Katsutaka Sannomiya Nao Kohno Katsuyoshi Tamaki Masayuki Shono tetsuji Takayama Jiangsu Key Laboratory of Neuroregeneration Nantong University Nantong 226001 Jiangsu Province China Department of Digestive and Cardiovascular Medicine Institute of Health Biosciences Tokushima 7708503 Japan Support Center for Advanced Medical Sciences University of Tokushima Graduate School Tokushima 7708503 Japan

AIM:To investigate the effects of estradiol (E2) and progesterone on the unstimulated and oxidative stressstimulated production of tumor necrosis factor (TNF)-α, interleukin (IL)-1β, IL-8, and macrophage chemotactic protein (MCP)-1 by peripheral blood mononuclear cells (PBMCs) from patients with chronic hepatitis C and healthy controls. METHODS:The PBMCs were separated from agematched 72 males and 71 females with and without chronic hepatitis C, who were divided into two groups based on a mean menopausal age of 50 years. Oxidative stress was induced by hydrogen peroxide in the cells incubated in serum-free media. Cytokines in the culture supernatant were measured by an enzyme-linked immunosorbent assay. RESULTS:The highest levels of the spontaneous production of TNF-α, IL-1β, IL-8, and MCP-1 by the unstimulated PBMCs were in the older male patients with chronic hepatitis C and the lowest levels were in the premenopausal female healthy controls. E2 inhibited the cytokine production by the unstimulated PBMCs from the older male and post-menopausal female patients, which was further stimulated by progesterone. The exposure to hydrogen peroxide in the PBMCs from the younger male and pre-menopausal female healthy subjects induced the production of cytokines. The change rates of the hydrogen peroxide-stimulated cytokine production were suppressed by E2 and enhanced by progesterone. CONCLUSION:These findings suggest that E2 may play a favorable role in the course of persistent liver injury by preventing the accumulation of monocytes-macrophages and by inhibiting proinflammatory cytokine production, whereas progesterone may counteract the favorable E2 effects.

关键词： Estradiol Progesterone Mononuclear cell Proinflammatory cytokine Chemokine

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Effect of mechanical ball milling on the electrical and powder bed properties of gas-atomized Ti-48Al-2Cr-2Nb and elucidation of the smoke mechanism in the powder bed fusion electron b eam melting process

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Journal of Materials Science & Technology 2023年第6期137卷 36-55页

作者： Seungkyun Yim Kenta aoyagi Keiji Yanagihara Huakang Bian Akihiko Chiba Institute for Materials Research Tohoku University2-1-1 KatahiraSendaiMiyagi 980-8577Japan

Smoke is unexpected powder-splashing caused by electrostatic force and is one of the main problems hindering the process stability and applicability of the powder bed fusion electron beam(PBF-EB)*** this study,mechanical stimulation was suggested to suppress smoke of gas-atomized(GA)Ti-48Al-2Cr-2Nb powder using Al_(2)O_(3) and WC ball *** deformation mechanism of the GA powder depending on the ball milling media was discussed based on the developed particle morphology distribu-tion map and contact mechanics *** was revealed that the rapid decrement of flowability and packing density after WC ball milling owing to the formation of angular fragments by the brittle *** variation of surface and electrical properties by mechanical stimulation was investigated via XPS,TEM,and Impedance *** electrical resistivity of the ball-milled powders gradually decreased with increasing milling duration,despite the increased oxide film thickness,and the capacitive response disappeared in Al-60 and WC-30 via metal-insulator *** could be due to the accumulation of strain and defects on the oxide film via mechanical *** smoke mechanism of ball-milled powders was discussed based on the percolation *** the smoke experiment,smoke was more suppressed for WC-10 and WC-20 than that for Al-40 and Al-50,respectively,despite the longer charge dissipation *** could be due to the high probability of contact with conductive *** the Al-60 and WC-30 powders,smoke was further restricted by the formation of a percolation cluster with metal-like electrical *** believe that this study will contribute to a better understanding of the smoke mechanism and process optimization of the PBF-EB.

关键词： Metal-insulator transition Electron beam melting additive manufacturing Packing density Flowability Smoke mechanism Percolation theory

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Isothermal γ →ε phase transformation behavior in a Co-Cr-Mo alloy depending on thermal history during electron beam powder-bed additive manufacturing

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Journal of Materials Science & Technology 2020年第15期47卷 162-170页

作者： Yufan Zhao Yuichiro Koizumi Kenta aoyagi Kenta Yamanaka Akihiko Chiba Department of Materials Processing Graduate School of EngineeringTohoku UniversityAoba-yama 02Aoba-kuSendai980-8579Japan Institute for Materials Research Tohoku University2-1-J KatahiraAoba-kuSendai980-8577Japan

Powder bed fusion with electron beam(PBF-EB),allows Co-Cr-Mo(CCM) implants with patientcustomization to be fabricated with high quality and complex ***,the variability in the properties of PBF-EB-built CCM alloy,mainly due to the lack of understanding of the mechanisms that govern microstructural heterogeneity,brings limitations in extensive *** this study,the microstructural heterogeneity regarding the γ-fcc→ε-hcp phase transformation was *** phase transformation during PBF-EB was analyzed depending on the thermal history that was elucidated by the numerical *** revealed that isothermal γ→ε transformation occurred during the ***,the difference in γ/ε phase distribution was a result of the thermal history determining which method phase transformation was taking place,which can be influenced by the PBF-EB process *** the sample with a low energy input(Earea=2.6 J/mm2),the martensitic transformation was *** the building height increased from the bottom,the e phase fraction *** the other hand,in the sample with a higher energy input(Earea=4.4 J/mm2),the ε phase fo rmed via diffusional-massive transformation and only appea red in a short range of the lower part away from the bottom.

关键词： Powder bed fusion with electron beam Phase transformation Thermal history Numerical simulation

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Effects of the aluminum concentration on twin boundary motion in pre-strained magnesium alloys

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Journal of Materials Science & Technology 2021年第14期73卷 116-127页

作者： Yujie Cui Kenta aoyagi Huakang Bian Yuichiro Hayasaka Akihiko Chiba Institute for Materials Research Tohoku UniversitySendai 980-8577Japan The Electron Microscopy Center Tohoku UniversitySendai 980-8577Japan

We investigated the effects of Al concentration on the reciprocated motion of twin boundaries in pre-strained Mg-Al-Zn alloys through a combination of applied compression and tension,in-situ electron-backscattering diffraction observations,and high-angle annular dark-field scanning transmission electron microscopy *** twin growth was restricted by increased Al concentration,which resulted in the occurrence of smaller-sized *** reverse motion of twin boundaries was also restricted,resulting in the formation of higher fractions of secondary twins and 2–5°boundaries during reverse *** secondary twins and 2–5°boundaries mainly contributed to the increased ultimate tensile strength of the pre-strained Mg *** effect is more significant in Mg alloys with larger ***,the increased amount of the Al solute atoms,rather than the precipitates,mainly contributed to the increased strengthening effect on the twin boundary *** research contributes to development of high-strength Mg alloys by stabilizing twin boundaries.

关键词： Hexagonal close packed Magnesium alloy Twinning Dislocations Strength Solute atoms

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Regulation of CTNNB1 signaling in gastric cancer and stem cells

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World Journal of Gastrointestinal Oncology 2016年第8期8卷 592-598页

作者： Shihori Tanabe Kazuhiko aoyagi Hiroshi Yokozaki Hiroki Sasaki Division of Risk Assessment Biological Safety Re-search Center National Institute of Health ScienceTokyo Department of Translational Oncology National Cancer Center Research InstituteTokyo Department of Pathology Kobe University of Graduate School of Medicine

Recent research has shown that the alteration of combinations in gene expression contributes to cellular phenotypic changes. Previously, it has been demonstrated that the combination of cadherin 1 and cadherin 2 expression can identify the diffuse-type and intestinal-type gastric cancers. Although the diffuse-type gastric cancer has been resistant to treatment, the precise mechanism and phenotypic involvement has not been revealed. It may be possible that stem cells transform into gastric cancer cells, possibly through the involvement of a molecule alteration and signaling mechanism. In this review article, we focus on the role of catenin beta 1 (CTNNB1 or β-catenin) and describe the regulation of CTNNB1 signaling in gastric cancer and stem cells.

关键词： CTNNB1 signaling &beta -catenin Epithelial-mesenchymal transition Gastric cancer Stem cell

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Nitrifiers activity and community characteristics under stress conditions in partial nitrification systems treating ammonium-rich wastewater

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Journal of Environmental Sciences 2018年第11期30卷 1-8页

作者： Jia Miao Qidong Yin Tomoyuki Hori Tomo aoyagi Hiroshi Habe Guangxue Wu Guangdong Province Engineering Research Center for Urban Water Recycling and Environmental Safety Graduate School at ShenzhenTsinghua University Environmental Management Research Institute National Institute of Advanced Industrial Science and Technology(AIST)

Long-term exposure of nitrifiers to high concentrations of free ammonia （FA） and free nitrous add （FNA） may affect nitrifiers activity and nitrous oxide （N2O） emission. Two sequencing batch reactors （SBRs） were operated at influent ammonium nitrogen （NH4-N） concentrations of 800 mg/L （SBRH） and 33S mg/L （SBRL）, respectively. The NH4-N removal rates in SBRH and SBRL were around 2.4 and 1.0 g/L/day with the nitritation efficiencies of 99.3% and 95.7%, respectively. In the simulated SBR cycle, the N20 emission factors were 1.61% in SBRH and 2.30% in SBRL. N2O emission was affected slightly by FA with the emission factor of 0.22%-0.65%, while N2O emission increased with increasing FNA concentrations with the emission factor of 0.22%～3.96%. The dominant ammonia oxidizing bacteria （AOB） were Nitrosomonas spp. in both reactors, and their relative proportions were 38.89% in SBRH and 13.36% in SBRL. Within the AOB genus, a species （i.e., operational taxonomic unit [OTU] 76） that was phylogenetically identical to Nitrosomonas europaea accounted for 99.07% and 82.04% in SBRH and SBRL, respectively. Additionally, OTU 215, which was related to Nitrosomonas stercoris, accounted for 16.77% of the AOB in SBRL.

关键词： Ammonium-rich wastewater Free ammonia Free nitrous acid N2O emission Partial nitrification

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Autoantibodies in primary biliary cirrhosis:Recent progress in research on the pathogenetic and clinical significance

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World Journal of Gastroenterology 2014年第10期20卷 2606-2612页

作者： Satoshi Yamagiwa Hiroteru Kamimura Masaaki Takamura Yutaka aoyagi Division of Gastroenterology and Hepatology Niigata University Graduate School of Medical and Dental Sciences Niigata 951-8510 Japan

Primary biliary cirrhosis(PBC)is a chronic progressive cholestatic liver disease characterized by immunemediated destruction of the small-and medium-sized intrahepatic bile ducts and the presence of antimitochondrial antibodies(AMA)in the *** are detected in over 90%of patients with PBC,whereas their prevalence in the general population is extremely low,varying from 0.16%to 1%.Previous studies have shown that the unique characteristics of biliary epithelial cells undergoing apoptosis may result in a highly direct and very specific immune response to mitochondrial ***,recent studies have demonstrated that serum from AMA-positive PBC patients is reactive with a number of xenobiotic modified E2 subunits of the pyruvate dehydrogenase complex,which is not observed in the serum of normal *** findings indicate that chemicals originating from the environment may be associated with a breakdown in the tolerance to mitochondrial *** it is currently generally accepted that AMA are the most specific serological markers of PBC,more than 60 au-toantibodies have been investigated in patients with PBC,and some have previously been considered specific to other autoimmune *** review covers the recent progress in research on the pathogenetic and clinical significance of important autoantibodies in *** the pathogenic role of those autoantibodies in PBC remains a priority of basic and clinical research.

关键词： Primary biliary cirrhosis Autoantibodies Anti-mitochondrial antibodies Anticentromere antibodies Anti-gp210 antibodies

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