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Effect of acupuncture at acupoint of Shenshu (BL 23) on the bones of ovariectomized rats

Journal of Traditional Chinese Medicine 2018年第1期38卷 54-60页

作者： Atsushi Takeda teruhiko koike Shigeru Urata Torao Ishida Yoshiharu Oshida School of Medicine Nagoya Uni- versity Showa-ku 466-8550 Japan Department of Acupuncture Medicine Suzuka University of Medical Science Suzuka 510-0293 Japan Research Center of Health Physical Fitness and Sports Nagoya University Fu- rou-cho Chikusa-ku Nagoya 464-8601 Japan Institute of Traditional Chinese Medicine Suzuka University of Medical Science Suzuka 510-0226 Japan

OBJECTIVE： To investigate the effect of acupuncture at acupoint of Shenshu （BL 23） in ovariectomized rats and sham-operated rats. METHODS： Female Sprague-Dawley rats were divided into the following four groups （n = 12 each）： sham operation only （Sham）, sham operation with acupuncture （Sham ＋ ACP）, ovariectomy only （OVX）, and ovariectomy with acupuncture （OVX ＋ ACP）. Operations were performed at the 9th week of age. Acupuncture of Shenshu （BL 23） was started at the 1 lth week of age and conducted 3 times per week until the 26th week of age. RESULTS： Among ovariectomized rats, the acupuncture-treated rats had significantly lower body weights and cross-linked N-telopeptide of type 1 collagen levels in the urine after 3 weeks of acu- puncture treatment, higher bone mineral density of the lumbar vertebra after 7 weeks, and smaller trabecular separation of the sixth lumbar vertebra, measured by micro-computed tomography, after 17 weeks than control rats. These effects were not observed in sham-operated rats. Blood concentrations of estradiol were significantly higher in the OVX ＋ ACP group than in the untreated group. Acupuncture treatment increased plasma testosterone levels in sham-operated rats, while this increase was not observed in OVX rats. CONCLUSION： Acupuncture of Shenshu （BL 23） prevents bone loss and structural changes by sup- pressing bone resorption.

关键词： Acupuncture Point BL23 (Shenshu) Es- trogens Osteoporosis Ovariectomy

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The evolution of cancer genomic medicine in Japan and the role of the National Cancer Center Japan

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Cancer Biology & Medicine 2024年第1期21卷 29-44页

作者： teruhiko Yoshida Yasushi Yatabe Ken Kato Genichiro Ishii Akinobu Hamada Hiroyuki Mano Kuniko Sunami Noboru Yamamoto Takashi Kohno Department of Genetic Medicine and Services National Cancer Center HospitalTokyo 104-0045Japan Department of Diagnostic Pathology National Cancer Center HospitalTokyo 104-0045Japan Clinical Research Support Offce Clinical Research Coordinating SectionBiobank Translational Research Support SectionNational Cancer Center HospitalTokyo 104-0045Japan Department of Pathology and Clinical Laboratories National Cancer Center Hospital EastChiba 277-8577Japan Division of Molecular Pharmacology National Cancer Center Research InstituteTokyo 104-0045Japan National Cancer Center Research Institute Tokyo 104-0045Japan Department of Laboratory Medicine National Cancer Center HospitalTokyo 104-0045Japan Department of Experimental Therapeutics National Cancer Center HospitalTokyo 104-0045Japan Division of Genome Biology National Cancer Center Research InstituteTokyo 104-0045Japan

The journey to implement cancer genomic medicine(CGM)in oncology practice began in the 1980s,which is considered the dawn of genetic and genomic cancer *** the time,a variety of activating oncogenic alterations and their functional significance were unveiled in cancer cells,which led to the development of molecular targeted therapies in the 2000s and *** CGM is still a relatively new discipline and it is difficult to predict to what extent CGM will benefit the diverse pool of cancer patients,the National Cancer Center(NCC)of Japan has already contributed considerably to CGM advancement for the conquest of *** back at these past achievements of the NCC,we predict that the future of CGM will involve the following:1)A biobank of paired cancerous and non-cancerous tissues and cells from various cancer types and stages will be *** quantity and quality of these samples will be compatible with omics *** biobank samples will be linked to longitudinal clinical information.2)New technologies,such as whole-genome sequencing and artificial intelligence,will be introduced and new bioresources for functional and pharmacologic analyses(e.g.,a patient-derived xenograft library)will be systematically deployed.3)Fast and bidirectional translational research(bench-to-bedside and bedside-to-bench)performed by basic researchers and clinical investigators,preferably working alongside each other at the same institution,will be implemented;4)Close collaborations between academia,industry,regulatory bodies,and funding agencies will be established.5)There will be an investment in the other branch of CGM,personalized preventive medicine,based on the individual's genetic predisposition to cancer.

关键词： Cancer genomic medicine biobank patient-derived xenograft multi-gene panel test whole genome sequencing

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Genomic medicine in clinical practice:national genomic medicine program in Japan

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Cancer Biology & Medicine 2024年第1期21卷 4-9页

Cancer statistics in Japan Cancer is the most common cause of death in Japan based on Statistics 2021~*** statistics were first gathered,infectious diseases,such as tuberculosis,and cerebrovascular disease have been the main causes of death in *** surpassed cerebrovascular disease as the main cause of death in 1981,and the number of cancer deaths has *** 38,000 people died of cancer in *** National Cancer Center(NCC)reported that the 5-year survival rate for patients with cancer was improving(62%for males and 66.9%for females)in a population-based cancer registry.

关键词： Cancer cancer death

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Design of Bridge Expansion Joints with Perforated Dowels Under Impact Loading

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Transactions of Tianjin University 2008年第5期14卷 340-343页

作者： YODA teruhiko AYASHI Mamiko Department of Civil and Environmental Engineering Waseda University

The expansion joints are expected to have movement capacity, bearing capacity for static and dynamic loading, water-tightness, low noise emission and traffic safety. In particular, the failure due to impact loading is the main reason for the observed damages. The problem of dynamic behavior of the expansion joints is so complex that we shall focus our attention on the impact factor for vehicle load that is governed by traffic impact. In order to overcome this difficulty, the cantilever-toothed aluminum joint (finger joint) is one of the promising joints under impact loading. In this study, from the viewpoint of design methodology, numerical studies for impact behavior were conducted for aluminum alloy expansion joints with perforated dowels. The design impact factor for the expansion joints with the perforated dowels against traffic impact loading was examined by using numerical simulations.

关键词： bridge expansion joints traffic impact loading perforated dowel

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Durability of Bridge Expansion Joints with Perforated Dowels Under Traffic Impact Loading

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Transactions of Tianjin University 2006年第B9期12卷 42-45页

作者： YODA teruhiko YOSHIDA Tetsuya SETA Makoto Department of Civil and Environmental Engineering Waseda UniversityTokyo 169-8555Japan Kyouryou Maintenance Co.Ltd Tokyo 115-0055Japan

In design phases, expansion joints are required to have movement capacity, bearing capacity for static and dynamic loading, watertight, low noise emission and traffic safety. On the basis of the fact that failure due to dynamic loading is the main reason for the observed damages, attention is focused on the bearing capacity for dynamic loading governed by impact, because it differs from the static loading. In this study, from the viewpoint of durability, experimental studies for dynamic behavior were conducted for aluminium alloy expansion joints with perforated dowels. The validity of the perforated dowels against traffic impact loading was confirmed by both experimental and numerical studies.

关键词： bridge expansion joints traffic impact loading durability aluminium alloy

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Histological observation of trabecular meshwork in a patient with Axenfeld-Rieger syndrome——a new theory for the mechanism of ectropion uvea in congenital glaucoma

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International Journal of Ophthalmology(English edition) 2020年第7期13卷 1167-1169页

作者： Satoru Kase Shinki Chin teruhiko Hamanaka Yasuhiro Shinmei Takeshi Ohguchi Susumu Ishida Department of Ophthalmology Faculty of Medicine and Graduate School of MedicineHokkaido UniversitySapporo CityHokkaido 060-8638Japan Department of Ophthalmology Japan Red Cross Medical CenterTokyo 150-8935Japan

Dear Editor,I am *** Kase,from the Department of Ophthalmology,Faculty of Medicine and Graduate School of Medicine,Hokkaido University.I write to present the case of clinicopathological findings in Axenfeld-Rieger syn... 详细信息

关键词： Medicine Rieger congenital

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Comparison of Studs and Perfo-Bond Strips on Mechanical Behavior of Composite Girders under Negative Bending

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Journal of Civil Engineering and Architecture 2013年第6期7卷 677-685页

作者： Weiwei Lin teruhiko Yoda Department of Civil and Environmental Engineering Waseda University Tokyo 169-8555 Japan

The purpose of the present study is to investigate the influence of different types of shear connectors on mechanical behavior of composite steel and concrete girders under negative bending moment. Two overturned simply supported steel-concrete composite girders with different shear connectors including studs and PBLs （perfo-bond strips） were tested under point load in the mid-span. Based on the experimental observations, a three-dimensional FE （finite element） model capable of analyzing the composite girders subjected to negative bending moment was built. Load and deformation response, concrete initial cracking and composite girder ultimate load bearing capacity, strain development process of reinforcing bars before and after concrete cracking were observed in the test and compared with the numerical values. Results predicted by this modeling method are in good agreement with those obtained from the tests. Furthermore, the %rack closure＂ or ＂through crack＂ load were recorded by π-ganges in the tests and compared with the code-specified ultimate load.

关键词： Composite steel and concrete girder negative bending moment studs PBLs.

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Self-care practices and health-seeking behavior among older persons in a developing country:Theories-based research

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International Journal of Nursing Sciences 2016年第1期3卷 11-23页

作者： Andi Masyitha Irwan Mayumi Kato Kazuyo Kitaoka teruhiko Kido Yoshimi Taniguchi Miho Shogenji School of Nursing Hasanuddin UniversityTamalanreaMakassarIndonesia Gerontological Rehabilitation Nursing Department Division of Health SciencesGraduate School of Medical SciencesKanazawa UniversityIshikawaJapan Division of Health Sciences Graduate School of Medical SciencesKanazawa UniversityIshikawaJapan

Purpose:The aim of this study was to examine the self-care practices and health-seeking behaviours of older adults in urban ***:The cross-sectional study was performed from January to March 2014 in the Tammua sub-district of *** the time of the study,273 older adults resided in Tammua,and half of them(51.2%)participated in this *** collection was carried out including self-care practices,health literacy,self-efficacy and basic conditioning ***:It was found that most respondents(124;88.6%)always ate various protein sources ***,many participants never limited consumption of sugar(55;39.3%)or salt(40;28.6%),and more than half of respondents(96;68.6%)did not regularly visit *** status(p<0.05),health maintenance(p<0.01)and salt limitation(p<0.05)were all significantly associated with salt *** was found that respondents with higher selfefficacy,those who did not want to get information,and those of younger ages are less likely to visit MHCs ***:An understanding of self-care practices and self-efficacy is needed to improve health care in developing *** self-efficacy should be promoted along with adequate health *** persons should learn the importance of regular health examinations to promote health,prevent diseases,and slow the progress of chronic *** number of respondents who never limit their sugar and salt intake was especially *** intervention program should be developed to limit salt and sugar intake of Indonesian elderly and to motivate older persons to use primary health services.

关键词： Health-seeking behavior Monthly health checkups Older adults Primary health care Self-care practices

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Identifying MicroRNA and mRNA Expression Profiles in Embryonic Stem Cells Derived from Parthenogenetic,Androgenetic and Fertilized Blastocysts

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Journal of Genetics and Genomics 2013年第4期40卷 189-200页

作者： Xiang-Shun Cui Xing-Hui Shen Shao-Chen Sun Sun-Wha Cho Young-Tae Heo Yong-Kook Kang teruhiko Wakayama Nam-Hyung Kim Department of Animal Science Chungbuk National UniversityGaeshin-dongCheongjuChungbuk 361-763South Korea Department of Histology and Embryology Harbin Medical UniversityHarbin 150081China College of Animal Science and Technology Nanjing Agricultural UniversityNanjing 210095China Laboratory of Development and Differentiation Korea Research Institute of Bioscience and BiotechnologyDaejeon 305-806South Korea Center for Developmental Biology RIKEN KobeKobe 650-0047Japan

MicroRNAs（miRNAs） are a class of highly conserved small non-coding RNA molecules that play a pivotal role in several cellular *** this study,miRNA and messenger RNA（mRNA） profiles were examined by Illumina microarray in mouse embryonic stem cells（ESCs） derived from parthenogenetic,androgenetic,and fertilized *** global analysis of miRNA-mRNA target pairs provided insight into the role of miRNAs in gene *** showed that a total of 125 miRNAs and 2394 mRNAs were differentially expressed between androgenetic ESCs（aESCs） and fertilized ESCs（fESCs）,a total of 42 miRNAs and 87 mRNAs were differentially expressed between parthenogenetic ESCs（pESCs） and fESCs,and a total of 99 miRNAs and 1788 mRNAs were differentially expressed between aESCs and *** addition,a total of 575,5 and 376 miRNA-mRNA target pairs were observed in aESCs ***,pESCs ***,and aESCs ***,***,15 known imprinted genes and 16 putative uniparentally expressed miRNAs with high expression levels were confirmed by both microarray and real-time ***,transfection of miRNA inhibitors was performed to validate the regulatory relationship between putative maternally expressed miRNAs and target mRNAs. Inhibition of miR-880 increased the expression of Peg3,Dyrklb,and Prrg2 mRNA,inhibition of miR-363 increased the expression of Nfat5 and Soatl mRNA,and inhibition of miR-883b-5p increased Nfat5,Tacstd2,and Ppapdc1 *** results warrant a functional study to fully understand the underlying regulation of genomic imprinting in early embryo development.

关键词： Embryonic stem cell Parthenogenetic Androgenetic Fertilized Microarray miRNA-mRNA network

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Effect of Soy Bean Isoflavon on Lipid Accumulation in 3T3-L1 Adipocytes

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Journal of Biosciences and Medicines 2015年第9期3卷 52-54页

作者： teruhiko Matsushima Noriko Yoshimura Yuumi Koseki Department of Human Life Science Jissen Women’s University Tokyo Japan

Several nutrition and food ingredients are supposed to have beneficial effects, but precise cell biological mechanism has not been elucidated. Among food ingredients, polyphenols such as soy bean isoflavon genistein and wine resveratrol have been reported to have effects on lipid metabolism and cardiovacular diseases (1). In order to elucidate the effect of genistein on obesity, we cultured adipocyte and observed of genisten to lipid accumulation in cells. Triglyceride accumulation was suppressed by genistein when it was added at the time of differentiation but not when added after differentiation. Genistein is considered to suppress lipid accumulation by suppressing the differtiation of adipocytes.

关键词： Obesity Adipocyte Genistein Resveratrol

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