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The 2<sup>nd</sup>Step by Step International Spinal Cord Repair—Combining research Step by Step into multi-pronged approaches for spinal cord repair

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j.urnal of Biomedical Science and Engineering 2013年第7期6卷 21-32页

作者： Maria teresa Moreno-Flores Francois Ferón Victor Arvanian Armin Blesch Armin Curt David j. Fink Marina Mata Kinichi Nakashima Xavier Navarro Francisco j.vier Rodríguez Michal Schwartz Mikael Svensson Erik Sundstrom j.an Romero Filip Lim Department of Biotechnology University Francisco de Vitoria Pozuelo de Alarcón Spain Department of Cell Biology Physiology and Immunology University Autonoma de Barcelona Barcelona Spain Department of Medicine University Hospital Balgrist Zurich Switzerland Department of Molecular Biology University Autónoma de Madrid Madrid Spain Department of Neurobiology Care Sciences and Society Karolinska Institute Stockholm Sweden Department of Neurobiology Weizmann Institute of Science Rehovot Israel Department of Neurology University of Michigan Ann Arbor USA Department of Stem Cell Biology and Medicine Kyushu University Fukuoka Japan Faculty of Medicine Aix Marseille University Marseille France National Paraplegics Hospital Toledo Spain Northport Veterans Affairs Medical Center Northport USA Spinal Cord Inj.ry Center University Hospital Heidelberg Germany Step by Step Foundation Barcelona Spain

On April 26-27, 2013, the Step by Step Foundation hosted the Second International Spinal Cord Repair Meeting at the Fira Barcelona Convention Center in Hospitalet de Llobregat, Spain, highlighting some of the exciting research including clinical trials which show promise for treatments for this devastating disorder. This meeting brought together clinicians, clinical scientists and molecular biologists from more than 10 countries to evaluate current knowledge on clinical, cellular, and biomolecular aspects of spinal cord inj.ry. A maj.r goal of the conference in advancing the translation of research data to the clinic was to promote multi-pronged approaches for therapy of this complex problem.

关键词： Spinal Cord Inj.ry Immunomodulation Glial Scar Nerve Grafts Neurotrophins Neural Stem Cells Electromagnetic Stimulation HSV-1 Vectors Cholecalciferol Vitamin D3 Wnt Proteins Neuroregeneration

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丰中子核^(113)Ru集体转动带的识别

高能物理与核物理 2003年第8期27卷 688-691页

作者：张征朱胜江 j.H.Hamilton A.V.Ramayya j.K.Hwang 许瑞清姜卓肖树冬 I.Y.Lee j.O.rasmussen W.C.Ma 清华大学物理系 Department of Physics Vanderbilt University Nashville TN37235 USA Lawrence Berkeley National Laboratory Berkeley CA94720 USA Department of Physics Mississippi State University MS39762 USA

通过对重核^(252)Cf自发裂变产生的瞬发γ谱的测量,对非常丰中子核^(113)Ru的能级结构进行了研究,建立了较高自旋态的能级纲图,识别了基于中子h_(11/2)轨道激发产生的集体转动带,最高自旋态达31/2h.还发现了另一个可能基于9/2^-能级的... 详细信息

通过对重核^(252)Cf自发裂变产生的瞬发γ谱的测量,对非常丰中子核^(113)Ru的能级结构进行了研究,建立了较高自旋态的能级纲图,识别了基于中子h_(11/2)轨道激发产生的集体转动带,最高自旋态达31/2h.还发现了另一个可能基于9/2^-能级的集体转动带,对新建立的^(113)Ru的集体带的一些重要特性进行了讨论。

关键词：丰中子核 ^113Ru 集体转动带较高自旋态能级纲图自发裂变原子核结构瞬发γ谱钌

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Pulmonary arterial hypertension related to human immunodeficiency virus infection:A case series

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World j.urnal of Cardiology 2014年第6期6卷 495-501页

作者： Inês Araúj. Cristina Enj.anes-Grau Carmen j.menez Lopez-Guarch Dariusz Narankiewicz Maria j.Ruiz-Cano teresa Velazquez-Martin j.an Delgado Pilar Escribano 3~(rd) Medicine Department S?o Francisco Xavier HospitalCHLO1449-005 LisboaPortugal Cardiology Department University Hospital of Canarias38320 La LagunaTenerifeSpain teresa Velazquez-Martin Juan DelgadoPilar EscribanoPulmonary Hypertension UnitUniversity Hospital of 12 de Octubre28041 MadridSpain Internal Medicine Department Carlos Haya Hospital29010 MálagaSpain Pulmonary Hypertension Unit University Hospital of 12 de Octubre28041 MadridSpain

AIM: To present 18 new cases of human immunodeficiency virus(HIV)-related pulmonary arterial hypertension(PAH) with presenting features,treatment options and follow-up ***: This is a single-centre,retrospective,observational study that used prospectively collected data,conducted during a 14-year period on HIV-related PAH patients who were referred to a pulmonary hy-pertension unit. All patients infected with HIV were consecutively admitted for an initial evaluation of PAH during the study period and included in our study. Right heart catheterisation was used for the diagnosis of PAH. Specific PAH treatment was started according to the physician's j.dgment and the recommendations for idiopathic PAH. The data collected included demographic characteristics,parameters related to both HIV infection and PAH and disease ***: Eighteen patients were included. Intravenous drug use was the maj.r risk factor for HIV infection. Risk factors for PAH,other than HIV infection,were present in 55.5% patients. The elapsed time between HIV infection and PAH diagnoses was 12.2 ± 6.9 years. At PAH diagnosis,94.1% patients had a CD4 cell count > 200 cells/μL. Highly active antiretroviral therapy(present in 47.1% patients) was associated with an accelerated onset of PAH. Survival rates were 93.8%,92.9% and 85.7% at one,two and three years,respectively. Concerning specific therapy,33.3% of the patients were started on a prostacyclin analogue,and the rest were on oral drugs,mainly phosphodiesterase-5 inhibitors. During the follow-up period,specific therapy was de-escalated to oral drugs in all of the living ***: The survival rates of HIV-related PAH patients were higher,most likely due to new aggressive specific therapy. The maj.rity of patients were on oral specific therapy and clinically stable. Moreover,sildenafil appears to be a safe therapy for less severe HIVrelated PAH.

关键词： Human immunodeficiency virus infection Pulmonary arterial hypertension Treatment

Split liver transplantation in adults

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World j.urnal of Gastroenterology 2016年第33期22卷 7500-7506页

作者： koj. hashimoto masato fuj.ki cristiano quintini federico n aucej. teresa diago uso dympna m kelly bij.n eghtesad j.hn j.fung charles m miller department of general surgery digestive disease institutecleveland clinicCleveland OH 44 195 United States

Split liver transplantation(SLT),while widely accepted in pediatrics,remains underutilized in adults. Advancements in surgical techniques and donor-recipient matching,however,have allowed expansion of SLT from utilization of the right trisegment graft to now include use of the hemiliver graft as well. Despite less favorable outcomes in the early experience,better outcomes have been reported by experienced centers and have further validated the feasibility of SLT. Importantly,more than two decades of experience have identified key requirements for successful SLT in adults. When these requirements are met,SLT can achieve outcomes equivalent to those achieved with other types of liver transplantation for adults. However,substantial challenges,such as surgical techniques,logistics,and ethics,persist as ongoing barriers to further expansion of this highly complex procedure. This review outlines the current state of SLT in adults,focusing on donor and recipient selection based on physiology,surgical techniques,surgical outcomes,and ethical issues.

关键词： Split liver transplantation Adults Graft survival Graft size Donor and recipient selection Surgical technique Ethical issues

Pathophysiology of cerebral oedema in acute liver failure

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World j.urnal of Gastroenterology 2013年第48期19卷 9240-9255页

作者： teresa R Scott Victoria T Kronsten Robin D Hughes Debbie L Shawcross Institute of Liver Studies King’s College London School of Medicine at King’s College Hospital King’s College Hospital London SE5 9RS United Kingdom

Cerebral oedema is a devastating consequence of acute liver failure(ALF)and may be associated with the development of intracranial hypertension and *** ALF,some patients may develop cerebral oedema and increased intracranial pressure but progression to lifethreatening intracranial hypertension is less frequent than previously described,complicating less than one third of cases who have proceeded to coma since the advent of improved clinical *** rapid onset of encephalopathy may be dramatic with the development of asterixis,delirium,seizures and *** and vasogenic oedema mechanisms have been implicated with a preponderance of experimental data favouring a cytotoxic *** swelling is the most consistent neuropathological finding in humans with ALF and ammonia plays a definitive role in the development of cytotoxic brain *** mechanism(s)by which ammonia induces astrocyte swelling remains unclear but glutamine accumulation within astrocytes has led to the osmolyte *** evidence also supports an alternate‘Troj.n horse’hypothesis,with glutamine as a carrier of ammonia into mitochondria,where its accumulation results in oxidative stress,energy failure and ultimately astrocyte *** a complete breakdown of the blood-brain barrier is not evident in human ALF,increased permeation to water and other small molecules such as ammonia has been demonstrated resulting from subtle alterations in the protein composition of paracellular tight *** present,there is no fully efficacious therapy for cerebral oedema other than liver transplantation and this reflects our incomplete knowledge of the precise mechanisms underlying this process which remain largely unknown.

关键词： Cerebral oedema Acute liver failure Ammonia Hepatic encephalopathy Intracranial pressure Intracranial hypertension Cerebral blood flow

Expanding the genetic landscape of Rett syndrome to include lysine acetyltransferase 6A(KAT6A)

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j.urnal of Genetics and Genomics 2020年第10期47卷 650-654页

作者： Simranpreet Kaur Nicole j.Van Bergen Bruria Ben-Zeev Emanuela Leonardi Tiong Y.Tan David Coman Benj.min Kamien Susan M.White Miya St j.hn Dean Phelan Kristin Rigbye Sze Chern Lim Michelle C.Torres Melanie Marty Elena Savva teresa Zhao Sean Massey Alessandra Murgia Wendy A.Gold j.hn Christodoulou Brain and Mitochondrial Research Group Murdoch Children's Research InstituteMelbourneAustralia Department of Paediatrics University of MelbourneMelbourneAustralia Paediatric Neurology Institute The Edmond and Lily Safra Paediatric HospitalSheba Medical CenterTel HaShomerIsrael Sackler School of Medicine Tel Aviv UniversityIsrael Molecular Genetics of Neurodevelopment Department of Woman and Child HealthUniversity of PadovaItaly Fondazione Istituto di Ricerca Pediatrica(IRP) Citta della SperanzaPadovaItaly Victorian Clinical Genetics Services Murdoch Children's Research InstituteMelbourneAustralia Department of Paediatrics The Wesley HospitalBrisbaneBrisbaneAustralia Queensland Children's Hospital BrisbaneAustralia School of Medicine University of QueenslandBrisbaneAustralia Genetic Services of Western Australia Western AustraliaAustralia Faculty of Health and Medical Sciences University of Western AustraliaAustralia Speech and Language Murdoch Children's Research InstituteParkvilleVictoriaAustralia Department of Audiology and Speech Pathology University of MelbourneParkvilleVictoriaAustralia The University of Sydney School of Medical Sciences and Discipline of Child and Adolescent HealthFaculty of Medicine and HealthSydneyAustralia Molecular Neurobiology Lab Kids ResearchWestmead Children's HospitalWestmeadSydneyAustralia Kids Neuroscience Centre Kids ResearchChildren's Hospital at WestmeadWestmeadSydneyAustralia

Pathogenic variants in methyl-Cp G protein 2(MECP2;OMIM300005)result in an X-linked,severe,and progressive epigenetic disorder,Rett syndrome(RTT,OMIM:312750),that predominantly affects females(Rett,1966).Using Neul’s revised diagnostic criteria,affected individuals can be clinically classified as classic or atypical RTT(Neul et al.,2010).

关键词： Rett al. landscape

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塞维利亚1992世界博览会,西班牙

世界建筑 1992年第5期 40-41页

作者： j.j.askelainen P.Rouhiainen. j.Tirkkonen j.P.Viguier. j.F.j.dry N.Grimshaw j.Sondergaard. H.rasmussen I.Makovecz 安藤忠雄 H.MuhIberger

1 芬兰馆设计 j. j.askelainen, P. Rouhiainen, j. Tirkkonen 2 法国馆设计 j. P. Viguier, j. F. j.dry 3 英国馆设计 N. Grimshaw 4 丹麦馆设计 j. Sonder gaard, H. rasmussen 5 匈牙利馆设计 I. Makovecz 6.7 日本馆设计安藤忠雄 8... 详细信息

1 芬兰馆设计 j. j.askelainen, P. Rouhiainen, j. Tirkkonen 2 法国馆设计 j. P. Viguier, j. F. j.dry 3 英国馆设计 N. Grimshaw 4 丹麦馆设计 j. Sonder gaard, H. rasmussen 5 匈牙利馆设计 I. Makovecz 6.7 日本馆设计安藤忠雄 8 步行道上,凉雾袭人

关键词：世界博览会日本馆塞维利亚安藤忠雄步行道

丰中子奇A核^(145,147)Ce的集体带结构

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高能物理与核物理 2000年第11期24卷 1018-1023页

作者： M.萨哈伊朱胜江甘翠云朱凌燕杨利明许瑞清全明吉姜卓张征 j. H. Hamilton A. V. Ramayya B. R. S. Babu j. K. Hwang W. C. Ma j. Komicki j. D. Cole R. Aryaeinej.d M. W. Drigert j. O. rasmussen M. A. Stoyer S. Y. Chu K E. Gregorich M. F. Mohar S. G. Prussi 清华大学物理系北京100084 Department of Physics Vanderbilt University Department of Physics Mississippi State University IdahoNationalEngineering Laboratory Lawrence Berkeley Laboratory j.int Institute for Nuclear Research

通过对２５２Ｃｆ自发裂变产生的瞬发γ谱的测量，对丰中子奇Ａ核１４５，１４７Ｃｅ的高自旋态进行了研究，首次识别了１４５Ｃｅ的集体带结构，扩展了１４７Ｃｅ的集体带结构，扩展了１４７Ｃｅ的能级，并新识别了３个边带，粒子－转... 详细信息

通过对２５２Ｃｆ自发裂变产生的瞬发γ谱的测量，对丰中子奇Ａ核１４５，１４７Ｃｅ的高自旋态进行了研究，首次识别了１４５Ｃｅ的集体带结构，扩展了１４７Ｃｅ的集体带结构，扩展了１４７Ｃｅ的能级，并新识别了３个边带，粒子－转子模型的计算指出，１４５，１４７Ｃｅ的晕带可能来自于νｉ１３／２轨道的耦合，１４５Ｃｅ基态起源于（νｈ９／２νｆ７／２）组态混合，而１４７Ｃｅ基态则起源于νｈ９／２轨道．在这两个核中未观测到明显的八极形变带，然而，在１４７Ｃｅ中观测到的一个边带，可能显露出八极关联的迹象．

关键词：核结构集体带结构丰中子奇A核铈

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Impact of an acute hemodynamic response-guided protocol for primary prophylaxis of variceal bleeding

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World j.urnal of Clinical Cases 2018年第13期6卷 611-623页

作者： j.sé Ignacio Fortea ángela Puente Patricia Ruiz Iranzu Ezcurra j.vier Vaquero Antonio Cuadrado María teresa Arias-Loste j.aquín Cabezas Susana Llerena Paula Iruzubieta Carlos Rodríguez-Lope Patricia Huelin Fernando Casafont Emilio Fábrega j.vier Crespo Servicio de Aparato Digestivo Hospital Universitario Marques? de Valdecilla Instituto de Investigación Sanitaria Marqués de Valdecilla Centro de Investigación Biomédica Red de Enfermedades Hepáticas y Digestivas Laboratorio de Investigación en Hepatología y Gastroenterología Hospital General Universitario Gregorio Mara?ón-Instituto de Investigación Sanitaria Gregorio Mara?ón

AIM To evaluate the long-term outcome of an acute hemodynamic response-guided protocol in which acute responders to intravenous propranolol received traditional nonselective beta-blockers(NSBBs) and acute nonresponders received *** Retrospective review of a protocol for primary prophylaxis of variceal bleeding guided by the acute hemodynamic response to intravenous propranolol. Fifty-two acute responders treated with traditional NSBB(i.e. propranolol or nadolol) were compared with 24 acute nonresponders receiving carvedilol. A second hemodynamic study was performed in 27 and 13 patients, respectively. The primary endpoint was development of first or further decompensation. Secondary endpoints included death from any cause, association between acute and chronic hemodynamic response, and baseline clinical and laboratory variables related to the acute hemodynamic *** Acute responders and acute nonresponders presented similar 1, 2, and 3-year probabilities of first decompensation(NSBB: 0%, 13.7%, 26.1% vs carvedilol: 0%, 20%, 20%, P = 0.968) or further decompensation(21.2%, 26.1%, 40.9% vs 21.2%, 50.0%, 50.0%, P = 0.525). A previous episode of hepatic encephalopathy was the only independent predictor of decompensation [hazard ratio(95% confidence interval): 8.03(2.76-23.37)]. Mortality rates were similar in acute responders and acute nonresponders with compensated(P = 0.428) or decompensated cirrhosis(P = 0.429). No clinical, laboratory, endoscopic or hemodynamic parameter predicted the acute hemodynamic response. In patients receiving traditional NSBB, the acute and chronic changes of hepatic venous pressure gradient were correlated(r = 0.59, P = 0.001). Up to 69.2% of acute nonresponders gained chronic response with *** Early identification and treatment with carvedilol of acute nonresponders to intravenous propranolol improves the clinical outcome of this high-risk group of patients, probably due to its greater effects fo

关键词： Gastrointestinal hemorrhage Propranolol Carvedilol Liver cirrhosis Portal hypertension