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Synthesis, Electrochemistry and Antitumor Activity of 1’H, 3’H(Me)-spiro-[(aza)benzimidazoline-2’, 3-(1,2-diferrocenylcyclopropenes)], 2-(1,2-Diferrocenylvinyl)benz- and Azabenzimidazoles

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Open j.urnal of Synthesis Theory and Applications 2014年第4期3卷 44-56页

作者： j.ssica j. Sánchez García Luis Ortiz-Frade Elena Martínez-Klimova j.an C. García Ramos Marcos Flores-Alamo teresa Ramírez Apan Elena I. Klimova Faculty of Chemistry University National Autonomous of México México City México Centre of Investigation and Development Technology in Electrochemistry S.C. Queretaro México Departament of Bioengineering South Kensington Imperial College London London UK Institute of Chemistry University National Autonomous of México México City México

A new method of synthesis of 2-(1,2-diferrocenylvinyl)benz- and azabenzimidazoles (3a-f), (4a-f) and 1’H,3’H(Me)-spiro-[(aza)benzimidazoline-2’,3-(1,2-diferrocenylcyclopropenes)] (5a-f) via reactions of diferrocenyl(methylsulfanyl)cyclopropenylium iodide (1) with aromatic o-diamines (2a-f) in the presence of Et3N (80°C - 82°C) is described. The structures of the resultant compounds are established using IR, 1H and 13C NMR spectroscopy, mass spectrometry and elemental analysis. The structure of one compound, cis-2-(1,2-diferrocenylvinyl)-1-methylbenzimidazole (3b), is confirmed by X-ray diffraction analysis. The electrochemical properties of compounds 3a, 3b, 3d and 5f are investigated using cyclic square wave voltammetry. Two electrochemical processes (I-II), attributed to oxidation of the ferrocene moieties, and the values of E0’(I), E0’(II), DE0’(II-I) and comporportionation constant Kcom are reported. The bioactivities of seven compounds 3a, 3c-f, 5d, 5f are evaluated. Compound 5f is the most active compound with a modest cytotoxic activity against six human cancer cell lines: U-251 (glioma), PC-3 (prostate cancer), K-562 (leukemia), HCT-15 (colon cancer), MCF-7 (breast cancer) and SKLU-1 (lung cancer).

关键词： Diferrocenyl(methylthio)cyclopropenylium 2-(1 2-Diferrocenylvinyl)(aza)benzimidazoles 1’H 3’H(Me)-spiro-[(aza)benzimidazoline-2’ 3-(1 2-diferrocenylcyclopropenes)] Electrochemistry Antitumor Activity

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英语自学 2006年第12期 7-9页

作者： Deborah j.rasmussen 李荷卿

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丰中子Ru奇A核能级结构的进一步研究

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高能物理与核物理 2005年第1期29卷 23-27页

作者：朱胜江张征 j.H.Hamilton A.V.Ramayya j.K.Hwang 肖树冬车兴来禹英男李明亮郑然成 I.Y.Lee j.O.rasmussen W.C.Ma 清华大学物理系 Department of Physics Vanderbilt UniversityNashvilleTN 37235USA Lawrence Berkeley National Laboratory BerkeleyCA 94720USA Department of Physics Mississippi State UniversityMS 39762USA

通过对重核2 52 Cf自发裂变产生的瞬发γ谱的高精度测量数据的分析 ,扩展了丰中子奇A核10 9,111Ru的高自旋态 ,对不同延迟符合矩阵的数据分析 ,得到了10 7,10 9,111,113Ru低激发态多个能级的寿命 ,发现10 9Ru核中的 96 .4keV的能级为一... 详细信息

通过对重核2 52 Cf自发裂变产生的瞬发γ谱的高精度测量数据的分析 ,扩展了丰中子奇A核10 9,111Ru的高自旋态 ,对不同延迟符合矩阵的数据分析 ,得到了10 7,10 9,111,113Ru低激发态多个能级的寿命 ,发现10 9Ru核中的 96 .4keV的能级为一寿命约为 130 0ns的同质异能态 .对10 9,111Ru转动带的转动惯量随转动频率变化的分析表明 ,在相邻偶偶核110 Ru中观测到的集体回弯现象确实起源于一对h11/ 2 中子的角动量顺排 .用粒子转子模型对10 7,10 9,111,113Ru的集体带的部分能级及跃迁几率进行了计算 ,得到与实验较为满意的符合 ,指出在这几个核中的中子h11/ 2 闯入带尼尔逊轨道的起源 .

关键词：奇A核能级结构中子低激发态偶偶核同质异能态转动频率寿命实验分析

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Deep data analytics for genetic engineering of diatoms linking genotype to phenotype via machine learning

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npj.Computational Materials 2019年第1期5卷 580-587页

作者： Artem A.Trofimov Alison A.Pawlicki Nikolay Borodinov Shovon Mandal teresa j.Mathews Mark Hildebrand Maxim A.Ziatdinov Katherine A.Hausladen Paulina K.Urbanowicz Chad A.Steed Anton V.Ievlev Alex Belianinov j.shua K.Michener Rama Vasudevan Olga S.Ovchinnikova Center for Nanophase Materials Sciences Oak Ridge National LaboratoryOak RidgeTN 37831USA Environmental Sciences Division Oak Ridge National LaboratoryOak RidgeTN 37830USA Scripps Institute of Oceanography University of CaliforniaSan DiegoLa JollaCA 92093USA Computer Science and Mathematics Division Oak Ridge National LaboratoryOak RidgeTN 37830USA Biosciences Division Oak Ridge National LaboratoryOak RidgeTN 37830USA

Genome engineering for materials synthesis is a promising avenue for manufacturing materials with unique properties under ambient *** in diatoms,unicellular algae that use silica to construct micron-scale cell walls with nanoscale features,is an attractive candidate for functional synthesis of materials for applications including photonics,sensing,filtration,and drug ***,controllably modifying diatom structure through targeted genetic modifications for these applications is a very promising *** this work,we used gene knockdown in Thalassiosira pseudonana diatoms to create modified strains with changes to structural morphology and linked genotype to phenotype using supervised machine *** artificial neural network(NN)was developed to distinguish wild and modified diatoms based on the SEM images of frustules exhibiting phenotypic changes caused by a specific protein(Thaps3_21880),resulting in 94% detection *** activation maps visualized physical changes that allowed the NNs to separate diatom strains,subsequently establishing a specific gene that controls pores.A further NN was created to batch process image data,automatically recognize pores,and extract pore-related *** interrelationship of the extracted paraments was visualized using a multivariate data visualization tool,called CrossVis,and allowed to directly link changes in morphological diatom phenotype of pore size and distribution with changes in the genotype.

关键词： pores walls linking

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Study on New Band Structures in Neutron-Rich 104Zr and 152Nd Nuclei

Study on New Band Structures in Neutron-Rich 104Zr and 152Nd...

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第十三届全国核结构研讨会暨第九次全国“核结构与量子力学”专题讨论会

作者： E.Y.Yeoh j.H.Hamilton A.V.Ramayya j.O.rasmussen I.Y.Lee Department of Physics Tsinghua UniversityBeijing 100084People’s Republic of China Department of Physics Vanderbilt UniversityNashvilleTennessee 37235USA Lawrence Berkeley National Laboratory BerkeleyCalifornia 94720USA

The neutron-rich Zr and Nd nuclei are located at A～100 and A～140 *** on the high spin states for these nuclei can provide valuable information of the nuclear *** previous publications,some levels and band structures have been reported in Zr and *** comparing to the neighboring nuclei,the information of the high spin states for these nuclei is still *** we report some new results of the high spin band structures of Zr and Nd.

关键词： spontaneous fission neutron-rich nuclei quasiparticle band

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Review of natural products with hepatoprotective effects

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World j.urnal of Gastroenterology 2014年第40期20卷 14787-14804页

作者： Eduardo Madrigal-Santillán Eduardo Madrigal-Buj.idar Isela álvarez-González María teresa Sumaya-Martínez j.sé Gutiérrez-Salinas Mirandeli Bautista ángel Morales-González Manuel García-Luna y González-Rubio j.Leopoldo Aguilar-Faisal j.sé A Morales-González Laboratorio Medicina de Conservación Escuela Superior de Medicina Instituto Politécnico Nacional Plan de San Luis y Díaz Mirón Col. Casco de Santo Tomás Del. Miguel Hidalgo México DF 11340 México Laboratorio de Genética Escuela Nacional de Ciencias Biológicas Instituto Politécnico Nacional Unidad profesional Adolfo López Mateos Col. Lindavista Delegación Gustavo A. Madero México DF 07738 México Secretaria de Investigación y Estudios de Posgrado Universidad Autónoma de Nayarit "Ciu-dad de la Cultura Amado Nervo" Nayarit 28000 México Laboratorio de Bioquímica y Medicina Experimental División de Investigación Biomédica Centro Médico Nacional "20 de Noviembre" ISSSTE México DF 03100 México área Académica de Farmacia Instituto de Ciencias de la Salud UAEH Pachuca Hidalgo 42000 México Escuela Superior de Cómputo Instituto Politécnico Nacional Av. Juan de Dios Bátiz s/n esquina Miguel Othón de Mendizabal Unidad Profesional Adolfo López Mateos México DF 07738 Mexico Facultad de Odontología UNAM México DF 04510 Mexico

The liver is one of the most important organs in the body,performing a fundamental role in the regulationof diverse processes,among which the metabolism,secretion,storage,and detoxification of endogenous and exogenous substances are *** to these functions,hepatic diseases continue to be among the main threats to public health,and they remain problems throughout the *** enormous advances in modern medicine,there are no completely effective drugs that stimulate hepatic function,that offer complete protection of the organ,or that help to regenerate hepatic ***,it is necessary to identify pharmaceutical alternatives for the treatment of liver diseases,with the aim of these alternatives being more effective and less *** use of some plants and the consumption of different fruits have played basic roles in human health care,and diverse scientific investigations have indicated that,in those plants and fruits so identified,their beneficial effects can be attributed to the presence of chemical compounds that are called *** present review had as its obj.ctive the collecting of data based on research conducted into some fruits(grapefruit,cranberries,and grapes)and plants[cactus pear(nopal)and cactus pear fruit,chamomile,silymarin,and spirulina],which are consumed frequently by humans and which have demonstrated hepatoprotective capacity,as well as an analysis of a resin(propolis)and some phytochemicals extracted from fruits,plants,yeasts,and algae,which have been evaluated in different models of hepatotoxicity.

关键词： Hepatoprotection Grapefruit Vaccinium spp Vitis vinifera L Opuntia ficus-indica Spirulina Propolis Glucans Alcoholic liver disease

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脚手架系统几何缺陷及节点刚度研究

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钢结构(中英文) 2011年第4期 85-86页

作者： Tayakorn Chandrangsu Kim j.R.rasmussen

介绍了脚手架系统几何缺陷的现场测量结果,包括柱子、框架的几何缺陷及荷载偏心。在浇筑混凝土前,测量现场脚手架系统的实际初始几何缺陷和荷载偏心。对随机抽取的构件进行试验,研究节点刚度,获得绕水平轴及竖轴的转角。对节点构造(双... 详细信息

介绍了脚手架系统几何缺陷的现场测量结果,包括柱子、框架的几何缺陷及荷载偏心。在浇筑混凝土前,测量现场脚手架系统的实际初始几何缺陷和荷载偏心。对随机抽取的构件进行试验,研究节点刚度,获得绕水平轴及竖轴的转角。对节点构造(双向、三向及四向节点)、弯曲轴、荷载方向进行试验。对数据进行统计分析,使其能应用于脚手架系统模拟和概率评估中。

关键词：几何缺陷荷载偏心节点试验碗扣式节点脚手架系统

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Octupole Deformation and Signature Inversion in ^(145)Ba

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Chinese Physics Letters 1999年第10期16卷 715-717页

作者： ZHU Sheng-j.ang M.Sakhaee j.H.Hamilton A.V.Ramayya GAN Cui-yun ZHU Ling-yan YANG Li-ming LONG Gui-lu PAU San-li B.R.S.Babu j.K.Hwang W.C.Ma j.Komicki X.Q.Zhang E.F.j.nes j.D.Cole R.Aryaeinej.d M.W.Drigert j.O.rasmussen M.A.Stoyer S.Y.Chu K.E.Gregorich M.F.Mohar S.G.Prussin I.Y.Lee Yu.Ts.Oganessian M.Ter-Akopian A.V.Daniel Department of Physics Tsinghua UniversityBeijing 100084 Department of Physics Vanderbilt UniversityNashvilleTN 37235USA Department of Physics Mississippi State UniversityMS 39762USA Idaho National Engineering Laboratory Idaho FallsID 83415USA Lawrence Berkeley Laboratory BerkeleyCA 94720USA j.int Institute for Nuclear Research Dubna 141980Russia

High spin states in neutron-rich odd-N ^(145)Ba nucleus have been investigated from study of promptγ-rays in spontaneous fission of^(252)*** alternating parity bands are identified indicating octupole deformation with simplex quantum number s=-*** ground state band shows signature splitting and inversion at low *** collective band structures exhibit the competition and co-existence between symmetric and asymmetric shapes.

关键词： Inversion collective signature

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Intercultural Competence Development of Chinese Students After a Short-Term Study Abroad Experience

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Sino-US English Teaching 2019年第5期16卷 177-196页

作者： Shuangmei Gao teresa j. Kennedy Quj.ng Normal University Qujing China University of Texas at Tyler Tyler USA

This study investigated Chinese students’ intercultural competence and linguistic growth during a six-week study abroad program. The students and their professor participated in pre- and post-tests covering written and oral language competency as well as intercultural competence. The Global Scale of English assessed student language development to determine linguistic growth and the Assessment of Intercultural Competence of Chinese College Students (AIC-CCS) was used to determine student growth of intercultural competence skills, specifically related to cultural knowledge, skills, attitudes, and awareness as a result of their experiences in a non-Western context. Results indicated that students experienced a change in the salience of intercultural knowledge themes over their period abroad, as well as improved their individual language abilities. This study provides suggestions for future programming focused on the development of Chinese student intercultural competencies during short-term study abroad experiences in Western university environments.

关键词： English language development linguistic growth Global Scale of English second language (L2) intercultural communicative competence (ICC) Chinese college students Chinese context

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Conversion of Rapid Prototyping Models into Metallic Tools by Ceramic Moulding—an Indirect Rapid Tooling Process

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厦门大学学报(自然科学版) 2002年第S1期41卷 218-218页

作者： teresa P DUARTE j.M FERREIRA F j.rge LINO A BARBEDO Rui NETO FEUP-Faculdade de Engenharia da Universidade do Porto DEMEGI-Departamento de Engenharia Mecanica e Gestāo IndustrialPortugal Departamento de Engenharia Cermica e do Vidro CICECOUniversidade de AveiroPortugal INEGI-Instituto de Engenharia Mecanica e Gestāo Industrial CETECOFF-Fundicāo e Novas TecnologiasPortugal

A process to convert models made by rapid prototypi ng techniques like SL(stereolitography)and LOM(laminated obj.ct manufacturing)or by conventional techniques(silicones,resins,wax,etc.)into metallic mould s or tools has been *** main purpose of this technique is to rapidly obtain the first prototypes of parts,for plastics inj.ction,forging or any oth er manufacturing process using the tools produced by casting a metal into a cera mic ***,it can be said that the ceramic moulds are produced by mixing in variab le proportions,depending on the type of ceramics employed,strength and roughne ss desired,a ceramic mixture composed by alumina and/or zirconium silicates bon ded with silica coming from a liquid binder,based on ethyl silicate.A catalyst is added to the slurry in order to produce a sol-gel *** liquid slur ry is poured into the box containing the mould to be *** a short p eriod of time,controlled by the amount of gelling agent,the ceramic mixture ac quires a rubber *** pattern is removed from the ceramic mould,whic h is fired to stop the gelation *** this stabilization the ceramic m ould is sintered at high temperatures in order to generate an inert mould wi th the desired strength in which almost all metallic alloys can be *** effect of ceramic materials(shape,granulometric distribution,chemical com position,etc.),processing parameters(proportion binder/ceramic/catalyst,sint ering conditions,etc.)and casting conditions(mould pre-heating temperature a nd pouring temperature)were studied in order to obtain metallic moulds or tools with tailored properties(high dimensional accuracy,low roughness and high mec hanical strength).

关键词： Conversion of Rapid Prototyping Models into Metallic Tools by Ceramic Moulding an Indirect Rapid Tooling Process

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