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Procoagulant activity of circulating microparticles is associated with the presence of moderate calcified plaque burden detected by multislice computed tomography

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Journal of Geriatric Cardiology 2014年第1期11卷 13-19页

作者： Serena Del Turco Giuseppina Basta Alessandro Mazzarisi Debora Battaglia teresa navarra Michele Coceani Massimiliano Bianchi Mathis Schlueter Paolo Marraccini Institute of Clinical Physiology CNR San Cataldo Research Area Via Moruzzi 1 56124 Pisa Italy Fondazione G. Monasterio CNR-Regione Toscana Via Moruzzi 1 56124 Pisa Italy

Background Circulating microparticles （MPs） have been reported to be associated with coronary artery disease （CAD）. In this study, we explored the relationship between MPs procoagulant activity and characteristics of atherosclerotic plaque detected by 64-slice computed tomography angiography （CTA）. Methods In 127 consecutive patients with CAD but without acute coronary syndrome and who under went 64-slice CTA, MPs procoagulant activity in plasma Coy a thrombin generation test）, soluble form of lectin-like oxidized low-density lipoprotein receptor-1 （sLOX-1） and N（epsilon）-（carboxymethyl） lysine （CML） circulating levels （by ELISA） were measured. A quantitative volumetric analysis of the lumen and plaque burden of the vessel wall （soft and calcific components）, for the three major coronary vessels, was performed. The patients were classified in three groups according to the presence of calcium volume： non-calcified plaque （NCP） group （calcium volume （%） = 0）, moderate calcified plaque （MCP） group （0 〈 calcium volume （%）〈 1）, and calcified plaque （CP） group （calcium volume （%）〉 1）. Results MPs procoagulant activity and CML levels were higher in MCP group than in CP or NCP group （P = 0.009 and P = 0.027, respectively）. MPs procoagulant activity was positively associated with CML （r = 0.317, P 〈 0.0001） and sLOX-1 levels （r = 0.216, P = 0.0025）. Conclusions MPs procoagulant activity was higher in the MCP patient group and correlated positively with sLOX-1 and CML levels, suggesting that it may characterize a state of blood vulnerability that may locally precipitate plaque instability and increase the risk of subsequent major cardiovascular events.

关键词： Computed tomograpby Micropanicles Low density lipoprotein Lysine Coronary artery disease

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以食物为基础的膳食模式与慢性疾病预防

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英国医学杂志中文版 2021年第3期24卷 133-138页

作者： Matthias B Schulze Miguel A Martínez-González teresa T Fung Alice H Lichtenstein Nita G Forouhi 陈夏燕(译) 王燕芳(译) 武阳丰(校) Department of Molecular Epidemiology German Institute of Human Nutrition Potsdam-RehbrueckeNuthetalGermany University of Potsdam Institute of Nutritional SciencesNuthetalGermany NutriAct—Competence Cluster Nutrition Research Berlin-Potsdam Germany Department of Preventive Medicine and Public Health University of Navarra-ⅠdiSNAPamplonaSpain CIBER Fisiopatología de la Obesidad y Nutrición(CIBERobn) Instituto de Salud Carlos III(ISCIII)Spain Department of Nutrition Harvard T H Chan School of Public HealthBostonUSA Department of Nutrition Simmons CollegeBostonUSA Friedman School of Nutrition Science and Policy Tufts UniversityBostonUSA Cardiovascular Nutrition Laboratory Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts UniversityBostonUSA Medical Research Council Epidemiology Unit University of CambridgeCambridgeUK 北京大学临床研究所

Matthias B Schulze及其同事讨论了目前已知的膳食模式与癌症、冠心病、卒中及2型糖尿病的关联,重点在仍不确定的领域和未来的研究方向。

关键词：膳食模式 2型糖尿病慢性疾病冠心病

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Proposed Protocol for Risk Assessment and Stratification

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Occupational Diseases and Environmental Medicine 2020年第3期8卷 99-110页

作者： Teófila Vicente-Herrero Victoria Ramírez Iñiguez de la Torre teresa del Campo Balsa Luis Reinoso Barbero Alejandro Fernández Montero Juan Carlos Rueda Garrido Asociación Españ ola de Especialistas en Medicina del Trabajo Madrid Spain Occupational Health and Safety Services of Correos Valencia Spain Occupational Health and Safety Services of Correos Albacete Spain Department of Occupational and Prevention at University Hospital Fundación Jiménez Díaz Universidad Autónoma de Madrid Madrid Spain Occupational Medicine Service Grupo Banco Santander Madrid Spain Faculty of Health Sciences Universidad International de la Rioja La Rioja Spain Department of Occupational Medicine Universidad de Navarra Navarra Spain SABIC Medical Services Cartagena Spain

Introduction: COVID-19 disease is a highly contagious viral infection caused by the SARS-CoV-2 coronavirus. There is growing interest in Public Health and Occupational Health in identifying the COVID-19 prognostic factors, needed to stratified patients by risk being necessary to consider occupational variables as well as individual and clinical factors of the workers. Objective: The aim of this study was to perform a tool to identify the more vulnerable workers for COVID-19 that will be useful to value their work limitations. Methods: A review of medical literature about the vulnerability for COVID-19 is taken into account occupational risks and occupational preventive measures. Results: It is proposed an index of vulnerability criteria for COVID-19 in workers based on quantifying individual characteristics, pre-existing medical conditions and its control, high risk of occupational exposure, and prevention and protection strategies in the workplace. The final result is stratified into three degrees of vulnerability that will serve to propose the most appropriate preventive measures. Conclusion: This proposal protocol assesses about the vulnerability for COVID-19 infection in workers to help decide the preventive management at workplace in this pandemic situation.

关键词： COVID-19 Vulnerability Occupational Health Occupational Medicine

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An Important Pool of Sucrose Linked to Starch Biosynthesis is Taken up by Endocytosis in Heterotrophic Cells

An Important Pool of Sucrose Linked to Starch Biosynthesis i...

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The Second International Symposium on Plant Neurobiology

作者： Edurne Baroja-Fernandez Ed Etxeberria Francisco José Muoz María teresa Morán-Zorzano Nora Alonso-Casajús Pedro Gonzalez Javier Pozueta-Romero Agrobioteknologia Instituta Nafarroako Unibertsitate Publikoa Gobierno de Navarra and Consejo Superior de Investigations CientificasMutiloako etorbidea zenbaki gabe31192 MutiloabetiNafarroaSpain University of Florida IFAS Citrus Research and Education Center700 Experiment Station RoadLake Alfred FL33850USA Agrobioteknologia Instituta Nafarroako Unibertsitate Publikoa Gobierno de Navarra and Consejo Superior de Investigations CientificasMutiloako etorbidea zenbaki gabe31192 MutiloabetiNafarroaSpain Agrobioteknologia Instituta Nafarroako Unibertsitate Publikoa Gobierno de Navarra and Consejo Superior de Investigations CientificasMutiloako etorbidea zenbaki gabe31192 MutiloabetiNafarroaSpain Agrobioteknologia Instituta Nafarroako Unibertsitate Publikoa Gobierno de Navarra and Consejo Superior de Investigations CientificasMutiloako etorbidea zenbaki gabe31192 MutiloabetiNafarroaSpain University of Florida IFAS Citrus Research and Education Center700 Experiment Station Road Lake Alfred FL33850USA Agrobioteknologia Instituta Nafarroako Unibertsitate Publikoa Gobierno de Navarra and Consejo Superior de Investigaciones CientificasMutiloako etorbidea zenbaki gabe31192 MutiloabetiNafarroaSpain

＜正＞We have recently shown the occurrence of endocytic sucrose uptake in heterotrophic cells （Etxeberria et al. Plant Cell Physiol. 46, 474-481）. Whether this mechanism is involved in the sucrose-starch conversion process was investigated by comparing the rates of starch accumulation in sycamore cells cultured in the presence or absence of the endocytic inhibitors wortmannin and LY294002. These analyses revealed a two-phase process involving an initial 120 min wortmannin- and

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Aplastic anemia and severe pancytopenia during treatment with peg-interferon,ribavirin and telaprevir for chronic hepatitis C

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World Journal of Gastroenterology 2015年第17期21卷 5421-5426页

作者： Sabela Lens Jose L Calleja Ana Campillo Jose A Carrion teresa Broquetas Christie Perello Juan de la Revilla Zoe Marino Maria-Carlota Londono Jose M Sanchez-Tapias Alvaro Urbano-Ispizua Xavier Forns Liver Unit Hospital ClinicIDIBAPSCIBERehd08036 BarcelonaSpain Liver Unit Hospital Puerta del HierroIDIPHIMCIBERehd28222 MajadahondaMadridSpain Gastroenterology Department Hospital Reina Sofia31500 TudelaNavarraSpain Liver Unit Hospital Del MarIMIMCIBERehd08003 BarcelonaSpain Hematology Unit Hospital Clinic08036 BarcelonaSpain

Telaprevir and Boceprevir are the first direct acting antivirals approved for chronic hepatitis C in combination with peg-interferon alfa and *** due to myelotoxicity caused by these drugs may occur,but severe hematological abnormalities or aplastic anemia(AA) have not been *** collected all cases of severe pancytopenia observed during triple therapy with telaprevir in four Spanish centers since approval of the drug in *** 142 cirrhotic patients receiving treatment,7 cases of severe pancytopenia(5%) were identified and three were consistent with the diagnosis of *** age was 59 years,five patients had compensated cirrhosis and two patients had severe hepatitis C recurrence after liver *** pancytopenia was diagnosed a median of 10 wk after the initiation of *** patients had pre-treatment hematological abnormalities related to *** six patients,antiviral treatment was interrupted at the onset of hematological *** patients died due to septic complications and one patient due to acute alveolar *** remaining patients *** pancytopenia and especially AA,are not rare during triple therapy with telaprevir in patients with advanced liver *** monitoring is imperative in this setting to promptly detect serious hematological disorders and to prevent further complications.

关键词： Aplastic anemia Hepatitis C Telaprevir Interferon Protease inhibitors

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Acceptance of living liver donation among medical students: A multicenter stratified study from Spain

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World Journal of Gastroenterology 2016年第25期22卷 5800-5813页

作者： Antonio Ríos Ana Isabel López-Navas Ana Isabel López-López Francisco Javier Gómez Jorge Iriarte Rafael Herruzo Gerardo Blanco Francisco Javier Llorca Angel Asunsolo Pilar Sánchez-Gallegos Pedro Ramón Gutiérrez Ana Fernández María teresa de Jesús Laura Martínez-Alarcón Alberto Lana Lorena Fuentes Juan Ramón Hernández Julio Virseda José Yelamos José Antonio Bondía Antonio Miguel Hernández Marco Antonio Ayala Pablo Ramírez Pascual Parrilla International Collaborative Donor Project ('Proyecto Colaborativo Internacional Donante' 30007 Casillas Murcia Spain Department of Surgery Paediatrics Obstetrics and Gynaecology University of Murcia Avenida de las Fuerzas Armadas 30800 Espinardo Murcia Spain Transplant Unit Surgery Service IMIB - Virgen de la Arrixaca University Hospital Carretera Madrid-Cartagena s/n 30120 El Palmar Murcia Spain Regional Transplant Centre Consejeria de Sanidad y Consumo de la Region de Murcia 30008 Ronda de Levante Murcia Spain Hospital Clinico Universitario Virgen de la Arrixaca Departamento de Cirugia General y del Aparato Digestivo Unidad de Trasplantes 30007 Casillas Murcia Spain Department of Psychology Universidad Catolica San Antonio (UCAM) Avenida de los Jeronimos 30107 Guadalupe Murcia Spain Department of Urology San Juan University Hospital of Alicante 03010 Calle Pintor Baeza Alicante Spain Universidad de Granada Avenida del Hospicio s/n 18010 Granada Spain Universidad de navarra Campus Universitario 31080 Pamplona Navarra Spain Universidad Autonoma de Madrid Ciudad Universitaria de cantoblanco 28049 Madrid Spain Servicio de Cirugia HBP y Trasplante Hepatico Complejo Hospitalario Universitario de Badajoz Hospital Infanta Cristina Avenida Elvas s/n 06006 Badajoz Spain Universidad de Cantabria Avenida los Castros s/n 39005 Santander Cantabria Spain Departamento de Cirugia Ciencias Medicas y Sociales Facultad de Medicina y Ciencias de la Salud Universidad de Alcala Campus Cientifico-Tecnologico Plaza de San Diego s/n 28801 Alcala de Henares Madrid Spain Facultad de Medicina Universidad de Malaga 29071 Avenida de Cervantes Malaga Spain Servicio de Urologia (Complejo Hospitalario Universitario de Canarias CHUC) y Departamento de Cirugia (Universidad de La Laguna ULL) Calle Molinos de Agua s/n 38207 San Cristobal de La Laguna Santa Cruz de Tenerife Spain Departamento de Ciencias Biomedicas Basicas Facultad de Ciencias Biomedicas Universidad Europea de

AIM: To analyze the attitude of Spanish medical students toward living liver donation (LLD) and to establish which factors have an influence on this ***: Study type: A sociological, interdisciplinary, multicenter and observational study. Study population: Medical students enrolled in Spain (n = 34000) in the university academic year 2010-2011. Sample size: A sample of 9598 students stratified by geographical area and academic year. Instrument used to measure attitude: A validated questionnaire (PCID-DVH RIOS) was self-administered and completed anonymously. Data collection procedure: Randomly selected medical schools. The questionnaire was applied to each academic year at compulsory sessions. Statistical analysis: Student´s t test, χ2 test and logistic regression ***: The completion rate was 95.7% (n = 9275). 89% (n = 8258) were in favor of related LLD, and 32% (n = 2937) supported unrelated LLD. The following variables were associated with having a more favorable attitude: (1) age (P = 0.008); (2) sex (P < 0.001); (3) academic year (P < 0.001); (4) geographical area (P = 0.013); (5) believing in the possibility of needing a transplant oneself in the future (P < 0.001); (6) attitude toward deceased donation (P < 0.001); (7) attitude toward living kidney donation (P < 0.001); (8) acceptance of a donated liver segment from a family member if one were needed (P < 0.001); (9) having discussed the subject with one’s family (P < 0.001) and friends (P < 0.001); (10) a partner’s opinion about the subject (P < 0.001); (11) carrying out activities of an altruistic nature; and (12) fear of the possible mutilation of the body after donation (P < 0.001).CONCLUSION: Spanish medical students have a favorable attitude toward LLD.

关键词： Attitude Living liver donation Medical students Transplantation Organ donation Psychosocial variables Spain

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Twelve-month efficacy and safety of the conversion to everolimus in maintenance heart transplant recipients

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World Journal of Transplantation 2015年第4期5卷 310-319页

作者： Nicolás Manito Juan F Delgado María G Crespo-Leiro José María Arizón Javier Segovia Francisco González-Vílchez Sònia Mirabet Ernesto Lage Domingo Pascual-Figal Beatriz Díaz Jesús Palomo Gregorio Rábago Marisa Sanz teresa Blasco Eulàlia Roig Heart Failure and Transplant Unit Department of CardiologyHospital de Bellvitge Heart Failure and Transplant Unit Department of CardiologyHospital 12 de Octubre Department of Cardiology Complejo Hospitalario Universitario A Coru?a Department of Cardiology Hospital Universitario Reina Sofía Heart Failure Transplant and Pulmonary Hypertension UnitHospital Universitario Puerta de Hierro Department of Cardiology Hospital Universitario Marqués de Valdecilla Department of Cardiology Hospital de la Santa Creu i Sant Pau Department of Cardiology Hospital Universitario Virgen del Rocío Department of Cardiology Hospital Virgen de la Arrixaca Department of Cardiology Hospital Universitario Central de Asturias Department of Cardiology Hospital General Universitario Gregorio Mara?ón Department of Cardiovascular Surgery Clínica Universitaria de Navarra Department of Cardiology Hospital Miguel Servet Department of Cardiology Hospital Clínic i Provincial

AIM: To determine the clinical reasons for conversion to everolimus(EVL) and long-term outcomes in heart transplant(HT) ***: A retrospective 12-mo study has been carried out in 14 Spanish centres to assess the efficacy and safety of conversion to EVL in maintenance HT ***: Two hundred and twenty-two patients were included(mean age: 53 ± 10.5 years; mean time from HT: 8.1 ± 4.5 years). The most common reasons for conversion were nephrotoxicity(30%), chronic allograft vasculopathy(20%) and neoplasms(17%). The doses and mean levels of EVL at baseline(conversion to EVL) and after one year were 1.3 ± 0.3 and 1.2 ± 0.6 mg/d and 6.4 ± 3.4 and 5.6 ± 2.5 ng/mL, respectively. The percentage of patients receiving calcineurin inhibitors(CNIs) at baseline and on the final visit was 95% and 65%, respectively. The doses and mean levels of CNIs decreased between baseline and month 12 from 142.2 ± 51.6 to 98.0 ± 39.4 mg/d(P < 0.001) and from 126.1 ± 50.9 to 89.2 ± 47.7 ng/mL(P < 0.001), respectively, for cyclosporine, and from 2.9 ± 1.8 to 2.6 ± 1.9 mg/d and from 8.3 ± 4.0 to 6.5 ± 2.7 ng/mL(P = 0.011) for tacrolimus. In the subgroup of patients converted because of nephrotoxicity, creatinine clearance increased from 34.9 ± 10.1 to 40.4 ± 14.4 mL/min(P < 0.001). There were 37 episodes of acute rejection in 24 patients(11%). The most frequent adverse events were oedemas(12%), infections(9%) and gastrointestinal problems(6%). EVL was suspended in 44 patients(20%). Since the database was closed at the end of the study, no further followup data is ***: Conversion to EVL in maintenance HT recipients allowed minimisation or suspension of the CNIs, with improved kidney function in the patients with nephrotoxicity, after 12 mo.

关键词： Everolimus Mammalian target of rapamycin inhibitors Heart transplantation Nephrotoxicity Renal failure

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