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STAT1对人肾透明细胞癌放射敏感性的影响

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中华放射肿瘤学杂志 2009年第3期18卷 238-242页

作者：惠周光骆爱萍毕楠张烨雷明芳麦伟源 teh bin-tean teh bin-sing 中国医学科学院北京协和医学院肿瘤医院放疗科北京100021 中国医学科学院北京协和医学院分子肿瘤国家重点实验室北京100021 美国贝勒医学院放射及放疗科休斯顿77054 美国Van Andel研究所癌症基因实验室 Grand Rapids49503

目的研究人肾透明细胞癌信号传递和转录活化因子1（STAT1）表达情况及抑制STAT1对该肿瘤细胞放射敏感性的影响。方法采用免疫组织化学染色技术对比检测34例人肾透明细胞癌标本和12例正常肾组织标本的STAT1表达。用Western blotting法检... 详细信息

目的研究人肾透明细胞癌信号传递和转录活化因子1（STAT1）表达情况及抑制STAT1对该肿瘤细胞放射敏感性的影响。方法采用免疫组织化学染色技术对比检测34例人肾透明细胞癌标本和12例正常肾组织标本的STAT1表达。用Western blotting法检测离体培养人肾透明细胞癌细胞（CRL-1932）、纤维母细胞（CCL-116）和Wilm’s瘤细胞（CRL-1441）的STAT1表达。用氟达拉滨和siRNA抑制CRL-1932细胞STAT1表达，并通过成克隆法和台盼蓝染色计数法研究抑制STAT1对CRL-1932细胞放射敏感性的影响。结果人肾透明细胞癌标本的总STAT1和磷酸化STAT1表达均明显高于正常肾组织。Western blotting法显示CRL-1932细胞STAT1表达比CRL-1441、CCL-116细胞明显增高；药物氟达拉滨能显著抑制CRL-1932细胞磷酸化STAT1的表达，并显著增加CRL-1932细胞的放射敏感性，且放射增敏程度与药物浓度呈正相关。经STAT1 siRNA处理后CRL-1932细胞总STAT1和磷酸化STAT1的表达均被有效抑制，且细胞在照射后的存活分数显著下降。结论肾透明细胞癌STAT1呈高表达，抑制STATI对该细胞有放射增敏作用。

关键词：细胞系,肾肿瘤照射信号传递和转录活化因子放射增敏剂

A Two-layer Framework for Mitigating the Con-gestion of Urban Power Grids Based on Flexible Topology with Dynamic Thermal Rating

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Protection and Control of Modern Power Systems 2024年第4期9卷 83-95页

作者： Yi Su Jiashen teh Qian Luo Kangmiao Tan Jiaying Yong the School of Automation and Electronic In-formation Xiangtan Universityxiangtan 411100China IEEE the School of Electrical and Electronic Engineering Universiti Sains Malaysia(USM)Penang 11800Malaysia the School of Computer Sciences Universiti Sains Malaysia(USM)Penang 11800Malaysia the Institute of Power Engineering College of EngineeringUniversiti Tenaga Nasional(UNITEN)Kajang 43000Malaysia

The urban power grid(UPG)combines transmission and distribution *** studies on UPG congestion mitigation have primarily focused on relieving local congestion while ignoring large-scale energy transfer with safety margins and load *** situation is expected to worsen with the proliferation of renewable energy and electric *** this paper,a two-layer congestion mitigation framework is proposed,one which considers the congestion of the UPG with flexible *** the upper-layer,the particle swarm optimization algorithm is employed to optimize the power supply distribution(PSD)of substation *** is known as the upper-layer *** lower-layer model recalculates the new PSD,known as the lower-layer PSD,based on the topology candidates.A candidate topology is at an optimum when the Euclidean distance mismatch between the upper-and lower-layer PSDs is the *** optimum topology is tested by standard power flow to ascertain its *** optimum transitioning sequence between the initial and optimum topologies is also determined by the two-layer framework to minimize voltage deviation and line overloading of the UPG considering dynamic thermal *** proposed framework is tested on a 56-node test *** show that the proposed framework can significantly reduce congestion,maintain safety margins,and determine the optimum transitioning sequence.

关键词： Congestion mitigation urban power grid two-layer framework transitioning sequence dynamic thermal rating

Impact of Large Language Models on Scholarly Publication Titles and Abstracts:A Comparative Analysis

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Journal of Social Computing 2024年第2期5卷 105-121页

作者： Phoey Lee teh Chukwudi Festus Uwasomba the Department of Cyber and Computing Wrexham UniversityWrexhamLL112AWUK the School of Computing and Computing STEM FacultyThe Open UniversityMilton KeynesMK76AAUK

Artificial Intelligence(AI)tools become essential across industries,distinguishing AI-generated from human-authored text is increasingly *** study assesses the coherence of AI-generated titles and corresponding abstracts in anticipation of rising AI-assisted document *** main goal is to examine the correlation between original and AI-generated titles,emphasizing semantic depth and similarity measures,particularly in the context of Large Language Models(LLMs).We argue that LLMs have transformed research focus,dissemination,and citation patterns across five selected knowledge areas:Business Administration and Management(BAM),Computer Science and Information Technology(CS),Engineering and Material Science(EMS),Medicine and Healthcare(MH),and Psychology and Behavioral Sciences(PBS).We collected 15000 titles and abstracts,narrowing the selection to 2000 through a rigorous multi-stage screening process adhering to our study’s *** shows that there is insufficient evidence to suggest that LLM outperforms human authors in article title generation or articles from the LLM era demonstrates a marked difference in semantic richness and readability compared to those from the ***,it asserts that LLM is a valuable tool and can assist researchers in generating *** LLM’s assistance,the researcher ensures that the content is reflective of the finalized abstract and core research themes,potentially increasing the impact and accessibility and readability of the academic work.

关键词： semantic alignment cosine similarity patterns large language models technology impact

Predictive factors for percutaneous nephrolithotomy bleeding risks

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Asian Journal of Urology 2024年第1期11卷 105-109页

作者： U Phun Loo Chun Hou Yong Guan Chou teh Urology Department Sarawak General HospitalKuchingMalaysia

Objective:This study aimed to identify predictive factors for percutaneous nephrolithotomy(PCNL)bleeding *** better risk stratification,bleeding in high-risk patient can be anticipated and facilitates early ***:A prospective observational study of PCNL performed at our institution was *** adults with radio-opaque renal stones planned for PCNL were included except those with coagulopathy,planned for additional *** including gender,co-morbidities,body mass index,stone burden,puncture site,tract dilatation size,operative position,surgeon's seniority,and operative duration were studied using stepwise multivariate regression analysis to identify the predictive factors associated with higher estimated hemoglobin(Hb)***:Overall,4.86%patients(n=7)received packed cells *** mean estimated Hb deficiency was 1.3(range 0-6.5)g/dL and the median was 1.0 g/*** multivariate regression analysis revealed that absence of hypertension(p=0.024),puncture site(p=0.027),and operative duration(p=0.023)were significantly associated with higher estimated Hb ***,the effect sizes are rather small with partial eta-squared of 0.037,0.066,and 0.038,*** power obtained was 0.621,0.722,and 0.625,*** factors studied did not correlate with Hb ***:Hypertension,puncture site,and operative duration have significant impact on estimated Hb deficiency during ***,the effect size is rather small despite adequate study power ***,operative position(supine or prone),puncture number,or tract dilatation size did not correlate with Hb *** mainstay of reducing bleeding in PCNL is still meticulous operative *** study findings also suggest that PCNL can be safely done by urology trainees under supervision in suitably selected patient,without increasing risk of bleeding.

关键词： Percutaneous nephrolithotomy Predictive factor Risk factor Bleeding Blood loss

Accelerated partial breast irradiation:advances and controversies

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Chinese Journal of Cancer 2016年第4期35卷 163-170页

作者： Mani Akhtari bin S.teh Department of Radiation Oncology Houston Methodist HospitalCancer Center and Research InstituteWeil Cornell Medical College Department of Radiation Oncology The University of Texas Medical Branch at Galveston

The management of localized breast cancer has changed dramatically over the past three to four *** therapy,which involved lumpectomy followed by adjuvant irradiation,is now widely considered the standard of care in women with early-stage breast *** partial breast irradiation(APBI),which involves focal irradiation of the lumpectomy cavity over a short period of time,has developed over the past two decades as an alternative to whole breast irradiation(WBI).Multiple APBI modalities have been developed including brachytherapy,external beam irradiation,and intraoperative *** new technigues have provided early-stage breast cancer patients with shorter treatment duration and more focused irradiation,delivering very high biological doses to the region at a high risk of failures over a much shorter treatment course as compared with conventional ***,the advantages of APBI over conventional radiotherapy are controversial,including a higher risk of complications reported in retrospective literature and shorter follow-up duration in the intraoperative APBI ***,APBI presents a valuable alternative to WBI for a selected population of women with early-stage breast cancer.

关键词： Accelerated partial breast irradiation Brachytherapy Breast cancer

Prevalence of Malnutrition and Anaemia in Children ≤ 5 Years of Age in Some Conflict Hit Areas of Meme Division of the South West Region of Cameroon

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Food and Nutrition Sciences 2024年第4期15卷 235-244页

作者： Asoba Gillian Nkeudem Ebong Fidelis Sameh Samuel Metuge teh Rene Ning Ngede Laura Senge Sumbele Irene Ngole Department of Social Economy and Family Management Higher Technical Teachers’ Training College University of Buea Kumba Cameroon Department of Zoology and Animal Physiology Faculty of Science University of Buea Buea Cameroon

Malnutrition refers to the deficiency, imbalances, or excesses in a person’s intake of energy or nutrients [1]. Khan defines anaemia as below level of Haemoglobin in red blood shown by a lower number of functioning red blood cells [2]. The crisis in the North West and South West Regions of Cameroon has led to several negative effects on children’s living conditions. There has been an increase in malnutrition and anaemia in the South West Region and Kumba in particular. The main objective of this study was “to examine the prevalence of malnutrition and anaemia in children ≤ 5 years of age in some conflict-hit areas of Meme Division”. A descriptive cross-sectional study was conducted in 2023 from March to June. We recruited 200 children ≤ 5 years into the study from three hospitals. The regional hospital annex in Kumba, Presbyterian General Hospital Kumba and the Ntam Hospital in Kumba. Socio-demographic factors were assessed using questionnaire, nutritional status was assessed by the use anthropometric measurements and an auto haematology analyser was used to determine anaemia. The overall prevalence of malnutrition in the study area was 40.5%. The prevalence of malnutrition varied significantly (P < 0.001) with the study sites. The overall prevalence of anaemia in the study area was 70.5%. The prevalence of anaemia was not significantly associated with the study sites. The prevalence of Malnutrition and Anaemia in children ≤ 5 years of age is very high in the Kumba municipalities. This could be attributed to the ongoing crisis which has caused a lot of social migrations from rural areas to Urban areas which are safer.

关键词： Malnutrition Anaemia Prevalence Conflict Hit Areas

The Effects of Different Feeding Practices on the Nutritional Status of Infants below 12 Months Old in the Kumba 1 Sub-Division

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Food and Nutrition Sciences 2024年第5期15卷 336-350页

作者： Gillian Nkeudem Asoba Fidelis Sameh Ebong Samuel Metuge Etchu Kaptai Tabe teh Rene Ning Sumbele Irene Ngole Department of Social Economy and Family Management Higher Technical Teachers&#8217 Training College University of Buea Kumba Cameroon Department of Zoology and Animal Physiology Faculty of Science University of Buea Buea Cameroon

Appropriate feeding practices are important during infancy for good health, growth and development of infants and children. WHO revised its earlier recommendation of Exclusive Breastfeeding (EBF) of infants from 4 to 6 months of age to EBF until about 6 months of age, with the addition of complementary foods thereafter. This recommendation confirms that breast milk alone is sufficient to meet infants’ nutritional requirements for the first 6 months of life. The main objective of this study was to investigate the effect of various feeding practices on the Nutritional status of infants 0 - 12-month-old in the Kumba 1 Sub-Division. A descriptive cross-sectional study was conducted from December 2019 to August 2020. A total of 341 nursing mothers and their infants 0 - 12 months of age were recruited. Socio-demographic factors and the different feeding habits of the children were assessed using a semi-structured questionnaire. Nutritional status was assessed using anthropometric measurements. The overall proportion of infants who exclusively breastfed for 6 months was 69.2% and those who were mix-fed were 30.8% in the study area. The overall prevalence of malnutrition in the population was 61.0%. Among the malnourished children, 53.1% were underweight, 19.6% were wasted and 10.0% were stunted. Though not significant, the prevalence of wasting (21.0%) and underweight (58.3%) was higher among Mix-Fed (MF) children when compared to their EBF counterparts. Feeding practices affected the nutritional status of the infants. Underweight and wasting were observed among infants on Complementary Feeding (CF), although some exclusively breast-fed infants were stunted. Hence, nursing mothers should try as much as possible to practice EBF as recommended by WHO and can practice CF when the child is above six months.

关键词： Exclusive Breastfeeding Complementary Feeding Feeding Practices Infants Malnutrition Nutritional Status Underweight Wasted Stunting

Chemotherapy in non-small cell lung cancer: opportunities for advancement

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Chinese Journal of Cancer 2016年第9期35卷 438-440页

作者： Mani Akhtari Eric H.Bernicker bin S.teh Department of Radiation Oncology Houston Methodist Hospital Cancer Center and Research Institute Weil Cornell Medical College Department of Radiation Oncology The University of Texas Medical Branch at Galveston Cancer Center Thoracic Medical Oncology Houston Methodist Hospital

Locally advanced non-small cell lung cancer(NSCLC) continues to be a challenging disease to treat. With high rates of both local and distant failures, there is signiicant interest in inding more biologically active chemotherapy regimens that can contribute to reduce both failures. The phase III PROCLAIM trial, recently published in the Journal of Clinical Oncology entitled "PROCLAIM: randomized phase III trial of pemetrexed–cisplatin or etoposide–cisplatin plus thoracic radiation therapy followed by consolidation chemotherapy in locally advanced nonsquamous non-small-cell lung cancer", compared two diferent chemotherapy regimens given concurrently with radiotherapy in patients with stage III non-squamous lung cancer: pemetrexed plus cisplatin versus cisplatin plus etoposide. Both groups received consolidation chemotherapy. After enrolling 598 of planned 600 patients, the study was stopped early due to futility as no diference was seen in the primary end-point of overall survival. Since PROCLAIM was designed as a superiority trial, these results suggest that pemetrexed regimens do not ofer a clinical advantage over standard cisplatin plus etoposide. There are some subpopulations who might still beneit from pemetrexed, especially if clinicians are concerned about myelosuppression-related adverse events. Future trials are needed to investigate novel biologic agents and irradiation techniques that can result in more durable local and distant disease control in locally advanced NSCLC.

关键词：非小细胞肺癌化疗放射治疗临床医生疾病控制 III 生物活性生物制剂

Visualizing Photodynamic Therapy in Transgenic Zebrafish Using Organic Nanoparticles with Aggregation-Induced Emission

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Nano-Micro Letters 2018年第4期10卷 61-69页

作者： Purnima Naresh Manghnani Wenbo Wu Shidang Xu Fang Hu Cathleen teh bin Liu Department of Chemical and Biomolecular Engineering National University of Singapore 4 Engineering Drive 4 Institute of Molecular and Cell Biology Proteos BuildingBiopolis Drive

Photodynamic therapy(PDT) employs accumulation of photosensitizers(PSs) in malignant tumor tissue followed by the light-induced generation of cytotoxic reactive oxygen species to kill the tumor cells. The success of PDT depends on optimal PS dosage that is matched with the ideal power of light. This in turn depends on PS accumulation in target tissue and light administration time and *** theranostic nanomedicine is driven by multifunctional therapeutics that aim to achieve targeted tissue delivery and image-guided therapy, fluorescent PS nanoparticle(NP)accumulation in target tissues can be ascertained through fluorescence imaging to optimize the light dose and administration parameters. In this regard, zebrafish larvae provide a unique transparent in vivo platform to monitor fluorescent PS bio-distribution and their therapeutic efficiency. Using fluorescent PS NPs with unique aggregation-induced emission characteristics, we demonstrate for the first time the real-time visualization of polymeric NP accumulation in tumor tissue and, more importantly, the best time to conduct PDT using transgenic zebrafish larvae with inducible liver hyperplasia as an example.

关键词： Nanomedicine Photodynamic therapy Transgenic zebrafish Aggregation-induced emission Organic nanoparticles