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Cochlear implantation in patients with Meniere’s disease:A systematic review

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2021年第4期7卷 303-311页

作者： Vincent M.Desiato Jaimin J.Patel Shaun A.Nguyen ted a.meyer Paul R.Lambert Department of Otolaryngology-Head and Neck Surgery Medical University of South CarolinaCharlestonSCUSA

Background:Meniere’s disease(MD)is an idiopathic disorder of the inner ear,which manifests as cochleo-vestibular *** loss will progress to a profound levelin a subset of patients with MD,and vestibular interventions can independently cause loss of *** aim of this study was to systematically review the published literature describing the safety and efficacy of CI in patients with *** and methods:A systematic literature review was conducted in accordance PRISMA guidelines to identify articles that assessed at least one functional outcome in patients with MD who underwent *** information,disease history,MD symptoms,outcomes measures,and complications related to CI were extracted from included ***:In total,17 studies were included,and 182 patients with MD underwent *** weighted-mean age was 61.9 years(range 27-85).Study objective and methodology varied,and there was significant heterogeneity in CI outcome measures *** total,179(98.3%)of 182 patients reported objective improvements in at least one hearing metric after CI.A total of 69 patients(37.9%)reported vertigo or severe dizziness prior to CI,compared to 22 patients(15.4%)*** studies reported significant reductions in postoperative Tinnitus Handicap Inventory score(THI).Quality of life assessments varied between *** rates were low with only nine patients(4.9%)reporting a serious CI-related ***:This systematic review evaluated 17 studies describing the safety and efficacy of CI in patients with MD and encountered many challenges due to small sample sizes,and heterogeneity in study design and outcomes *** these limitations,this study of 182 patients is to the best of our knowledge the largest systematic review evaluating the safety and efficacy of CI in *** results of this study support the need for a standardized approach to evaluating outcomes of CI in patients with MD in future s

关键词： Cochlear implantation Meniere’s disease

Opioid prescribing patterns within otolaryngology

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2019年第2期5卷 112-116页

作者： Alexander W.Murphey Suqrat Munawar Shaun A.Nguyen ted a.meyer Ashli K.O'Rourke Department of Otolaryngology-Head and Neck Surgery Medical University of South Carolina135 Rutledge AvenueMSC 550CharlestonSC29425USA

Objective:Determine current opioid prescribing patterns for adult procedures within an academic Otolaryngology-Head and Neck Surgery training program in order to establish a general guideline and more uniform approach to narcotic prescribing ***:The is a prospective,single-center pilot *** online,anonymous survey was sent to all members of the Otolaryngology-Head and Neck Surgery training program at Medical University of South Carolina including residents,fellows,and attending surgeons,and advanced practice providers (APP).The survey consisted of questions including demographics,most commonly prescribed analgesic and the average number of opioid tablets prescribed postoperatively for eleven of the most common adult procedures within ***:Forty-two participants responded to the *** the 42 respondents,20 were attending surgeons,11 junior level residents (year 1-3),6 senior level residents (year 4-5),and 5 *** most commonly prescribed narcotic was hydrocodone-acetaminophen with 83.3% (35/42) of respondents prescribing this *** or uvulopalatopharyngoplasty had the highest average number of tablets prescribed at 32.3 (Range:5 to 90).Neck dissection,parotidectomy,and thyroidectomy procedures all averaged over 20 *** laryngoscopy opioid dose was the lowest at 4.8 tablets (range 0-20).Opioid prescriptions by surgery were broken down by provider class with only septoplasty showing a significant difference with attending physicians prescribing an average of 20 tablets vs 14.1 tablets for residents (P =0.034).Conclusion:We believe there remains an unacceptably high variability in current opioid prescribing patterns within otolaryngology especially within more painful *** of standardized post-operative narcotic guidelines is warranted.

关键词： Opioids Narcotics Otolaryngology

The outcomes of hypoglossal nerve stimulation in the management of OSA: A systematic review and meta-analysis

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2019年第1期5卷 41-48页

作者： Anvesh R.Kompelli Jonathan S.Ni Shaun A.Nguyen Eric J.Lentsch David M.Neskey ted a.meyer Department of Otolaryngology-Head and Neck Surgery Medical University of South CarolinaCharlestonSCUSA

Objectives:Obstructive sleep apnea (OSA) is a prevalent disease with significant health *** first line therapy is CPAP,long-term compliance is low and device misuse is common,highlighting the need for alternative *** airway surgery is one alternative,but substantial side effects hamper efficacy.A new alternative is an implantable hypoglossal nerve stimulator (HNS).These devices utilize neuromodulation to dilate/reinforce the airway and reduce side effects associated with traditional *** recent trials investigated the efficacy of these *** purpose of this study was to perform meta-analysis of available HNS studies investigating treatment of OSA to analyze objective and subjective outcomes and side ***:A comprehensive literature search of PubMed and Scopus was *** independent reviewers examined clinical trials investigating HNS in treatment of sleep apnea in *** with objective and subjective endpoints in sleep were included for *** events from trials were also ***:Across 16 studies,381 patients were *** 6 months (p =0.008),mean SAQLI improved by 3.1 (95%CI,2.6-3.7).At 12 months (p < 0.0001),mean AHI was reduced by 21.1 (95%Cl,16.9-25.3),mean ODI was reduced by 15.0 (95%CI,12.7-17.4),mean ESS was reduced by 5.0 (95%CI,4.2-5.8),mean FOSQ improved by 3.1 (95%CI,2.6-3.4).Pain (6.2%:0.7-16.6),tongue abrasion (11.0%:1.2-28.7),and internal (3.0%:0.3-8.4)/external device (5.8%:0.3-17.4) malfunction were common adverse ***:HNS is a safe and effective treatment for CPAP refractory *** study comparing HNS to other therapies is required.

关键词： Surgical treatment of obstructive sleep apnea Sleep medicine Obstructive sleep apnea

The influence of obesity on operating room time and perioperative complications in cochlear implantation

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2017年第4期3卷 231-234页

作者： Jonathan L.Hatch Isabel M.Boersma Forest W.Weir Michael J.Bauschard Meredith A.Holcomb Paul R.Lambert ted a.meyer Department of Otorhinolaryngology Head and Neck Surgery Medical University of South Carolina SC 29425 USA

Objective:The rising incidence of obesity in the United States is associated with increased healthcare expenditures and resource *** has been associated with prolonged operating times during surgical *** primary objective of this study is to compare body mass index (BMI) to length of surgery during cochlear ***:A retrospective case control study from a tertiary academic referral center was *** included were adults who underwent primary,single-sided cochlear implantation with documented BMI and operating room (OR) times from January 2009 to July *** following data were collected:BMI,total operating room time (TORT),surgical operating room time (SORT),ASA status,perioperative and postoperative complications,age,and ***:Two hundreds and thirty-four patients were included and stratified into obese (BMI ＞30)and non-obese (BMI ＜ 30) *** analysis was performed comparing TORT against the obesity category along with other *** sample t-test demonstrated that obesity increases TORT and SORT by 16.8 min (P ＝ 0.0002) and 9.3 min (P ＝ 0.03),respectively,compared to the non-obese *** linear regression analysis demonstrated no statistically significant impact of gender,or ASA status on total operating or surgical *** was associated with increased perioperative complications (odds ratio [OR],6.21;95％ CI,1.18-32.80;P ＝ 0.03) and postoperative complications (OR,3.97;95％ CI,1.29-12.26;P ＝ 0.02).Conclusions:Obesity leads to longer TORT and SORT during primary cochlear implant *** is also associated with increased perioperative and postoperative complications compared to non-obese *** data have implications with utilization of operating room resources.

关键词： Cochlear implant Body mass index Operating time Perioperative complications

Cistrome Data Browser and Toolkit:analyzing human and mouse genomic data using compendia of ChlP-seq and chromatin accessibility data

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Quantitative Biology 2020年第3期8卷 267-276页

作者： Rongbin Zheng Xin Dong Changxin Wan Xiaoying Shi Xiaoyan Zhang Clifford a.meyer Clin ical Tran slati onal Research Center Shan ghai Pulmonary HospitalSchool of Life Science and Tech no logyTbngji UniversityShanghai 200433China Department of Bioinformatics School of Life Science and TechnologyTongji UniversityShanghai 200092China Department of Data Science Dana-Farber Cancer Institute and Harvard T.H.Chan School of Public HealthBostonMA 02215USA Center for Functional Cancer Epigenetics Dana-Farber Cancer InstituteBostonMA 02215USA

The Cistrome Data Browser(DB)at the website(***/db)provides about 56,000 published human and mouse ChlP-seq,DNase-seq,and ATAC-seq chromatin profiles,which we have processed using uniform analysis and quality control *** Cistrome DB Toolkit at the website(***)was developed to allow users to investigate fundamental questions using this data *** this tutorial,we describe how to use the Cistrome DB to search for publicly available chromatin profiles,to assess sample quality,to access peak results,to visualize signal intensities,to explore DNA sequence motifs,and to identify putative target genes・We also describe the use of the Toolkit module to seek the factors most likely to regulate a gene of interest,the factors that bind to a given genomic interval(enhancer,SNP,etc.),and samples that have significant peak overlaps with user-defined peak *** tutorial guides biomedical researchers in the use of Cistrome DB resources to rapidly obtain valuable insights into gene regulatory questions.

关键词： ChlP-seq chromatin accessibility gene regulatory analysis transcription factor

Social and geographical disparities in Twitter use during Hurricane Harvey

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International Journal of Digital Earth 2019年第11期12卷 1300-1318页

作者： Lei Zou Nina S.N.Lam Shayan Shams Heng Cai Michelle a.meyer Seungwon Yang Kisung Lee Seung-Jong Park Margaret A.Reams Department of Geography College StationTXUSA Department of Environmental Sciences Louisiana State UniversityBaton RougeLAUSA Division of Computer Science and Engineering Center for Computation and TechnologyLouisiana State UniversityBaton RougeLAUSA Department of Sociology Louisiana State UniversityBaton RougeLAUSA Department of Landscape Architecture and Urban Planning Texas A&M UniversityCollege StationTXUSA School of Library and Information Science Center for Computation and TechnologyLouisiana State UniversityBaton RougeLAUSA

Socialmedia such as Twitter is increasingly beingused as an effective platform to observe human behaviors in disastrous ***,uneven social media use among different groups of population in different regions could lead to biased consequences and affect disaster *** paper studies the Twitter use during 2017 Hurricane Harvey in 76 counties in Texas and *** seek to answer a fundamental question:did socialgeographical disparities of Twitter use exist during the three phases of emergency management(preparedness,response,recovery)?We employed a Twitter data mining framework to process the data and calculate two indexes:Ratio and *** analyses between the Ratio indexes and the social-geographical characteristics of the counties at the three phrases reveal significant social and geographical disparities in Twitter use during Hurricane *** with higher disasterrelated Twitter use in Harvey generally were communities having better social and geographical *** results of Twitter use patterns can be used to compare with future similar studies to see whether the Twitter use disparities have increased or *** research is also needed to examine the effects of Twitter use disparities on disaster resilience and to test whether Twitter use can predict community resilience.

关键词： Social media Twitter Hurricane Harvey emergency management digital divide social and geographical disparities

风险技术在压力容器和管道上的应用张鹏讲师,1964年1月生,1987年毕业于西南石油学院机械系力学专业,现从事教学和科研工作,为在职博士生。

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油气储运 1996年第5期15卷 54-59页

作者： Theodre a.meyer 张鹏西南石油学院

风险技术已被广泛用于电力、石油、化工和许多工业领域的压力容器和管道中。这些技术包括经常性的采纳专家意见进行风险评估及其相关的几种最新方法:1.基于决策科学和贝叶斯概率理论的决策分析方法;2.利用事件树和故障树的概率风险评估... 详细信息

风险技术已被广泛用于电力、石油、化工和许多工业领域的压力容器和管道中。这些技术包括经常性的采纳专家意见进行风险评估及其相关的几种最新方法:1.基于决策科学和贝叶斯概率理论的决策分析方法;2.利用事件树和故障树的概率风险评估;3.从应力-强度叠加到蒙特卡洛模拟方法的结构可靠性和风险评估。本文对各种风险技术在压力容器和管道中应用的技术和经济价值进行了工业评论,包括一些分析工具和应用实例,还讨论了风险技术与工程运用之间的相互关系,展望了各种风险技术的发展前景,使工程技术人员了解和掌握风险技术在各领域应用中的重要性。

关键词：压力罐管道风险分析经济评价压力容器

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CSS权威指南

2001年

作者：（美）Eric a.meyer 许勇齐宁译

本书是一本将CSS与当前浏览器支持结合起来描述的读物。它提供了对CSS1和CSS定位的完整描述，同时也给出了CSS2的概述，并对CSS的每个属性都做了详细的研究。

ISBN: (纸本)7508305604

关键词：工业技术自动化技术、计算机技术计算技术、计算机技术

来源：汇雅图书（南通市图书馆... 评论

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