检索结果-南通市图书馆

水基Ag-SiO纳米流体分频光伏/光热集热器功能单元性能实验研究

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

新能源进展 2024年

作者：刘仙萍田东 taylor robert a 湖南科技大学土木工程学院新南威尔士大学机械与制造工程学院

以纳米流体分频的光伏/光热（PV/T）集热器能使光伏和光热模块的工作温度解耦，从而获得更高的太阳能综合利用效率。以水基Ag-SiO2纳米流体为分频液和集热工质，设计新型的分频PV/T集热器结构，研究在Ag-SiO2纳米流体4种质量浓度和运行... 详细信息

以纳米流体分频的光伏/光热（PV/T）集热器能使光伏和光热模块的工作温度解耦，从而获得更高的太阳能综合利用效率。以水基Ag-SiO2纳米流体为分频液和集热工质，设计新型的分频PV/T集热器结构，研究在Ag-SiO2纳米流体4种质量浓度和运行条件下，分频PV/T集热器功能单元的热、电性能。结果表明：Ag-SiO2纳米流体的质量浓度显著影响PV/T集热器功能单元的性能，质量浓度为0.025%时，综合效率约为63.21%，比水为分频流体时的综合效率提升约38.04%；得出水基Ag-SiO2纳米流体分频时PV/T集热器功能单元的热、电效率和综合效率与不同纳米颗粒质量浓度的拟合关系式，为通过控制纳米流体质量浓度参数从而调节PV/T集热器的热、电输出提供理论依据。

关键词：太阳能纳米流体光谱分频光伏/光热系统质量浓度

The First Approved “Deuterated” Drug: A Short Review of the Concept

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Pharmacology & Pharmacy 2018年第10期9卷 440-446页

作者： robert B. Raffa Joseph V. Pergolizzi robert taylor Neumentum Inc. Palo Alto CA USA Colleges of Pharmacy University of Arizona Tucson AZ USA Temple University School of Pharmacy Philadelphia PA USA NEMA Research Inc. Naples FL USA

The first “deuterated” drug has recently been approved by the U.S. FDA (Food & Drug Administration). A “deuterated” drug is a drug in which the hydrogen atom in one or more of the carbon-hydrogen bonds in its chemical structure is replaced by deuterium (“heavy hydrogen”, a hydrogen isotope that has a neutron, i.e., one neutron instead of the usual no neutrons). A carbon-deuterium (C-D) bond is more stable in the body than a carbon-hydrogen (C-H) bond. If the deuterium is strategically located in a drug’s chemical structure, the extra stability of the bond will be more resistant to metabolic breakdown, and the duration of drug action will be prolonged. We review the general concept of deuterated drugs, historical examples of the classes of application, and the new approval.

关键词： Deuterium Drug Structure Chemical Bonds Drug Metabolism Duration of Action

Nanofluid-based optical filter optimization for PV/T systems

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Light(Science & Applications) 2012年第1期1卷 24-30页

作者： robert A taylor Todd Otanicar Gary Rosengarten University of New South Wales SydneyNSWAustralia University of Tulsa TulsaOKUSA RMIT University MelbourneVic.Australia

Optical filters are essential in a wide range of applications,including optical communications,electronics,lighting,optical sensors and *** article presents recent work which indicates that optical filters can be created from specialized nanoparticle ***,this article describes a theoretical optimization process for designing nanofluid-based filters for hybrid solar photovoltaic/thermal(PV/T)*** particular application is suitable because nanofluids can be utilized as both volumetric solar absorbers and flowing heat transfer *** nanofluid filters described in this work compare favorably with conventional optical filters for five photovoltaic(PV)cell alternatives:InGaP,CdTe,InGaAs,Si,and *** study demonstrates that nanofluids make efficient,compact and potentially low-cost,spectrally selective optical filters.

关键词： Hybrid nanofluid optical filter photovoltaic solar energy solar thermal

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

中国产业调整和外贸策略

江西社会科学 2005年第8期25卷 219-229页

作者： robert taylor 郭宇冈英国谢菲尔德大学新加坡国立大学

自1978改革开放以来,中国在世界贸易中扮演着越来越重要的角色。本文分析中国外贸的发展,试图证明:中国商品通过外贸的方式进入国际市场,对中国经济不仅是必需的手段,而且可以达到调整产业结构和促进改革的目的。国际市场的变化已经影... 详细信息

自1978改革开放以来,中国在世界贸易中扮演着越来越重要的角色。本文分析中国外贸的发展,试图证明:中国商品通过外贸的方式进入国际市场,对中国经济不仅是必需的手段,而且可以达到调整产业结构和促进改革的目的。国际市场的变化已经影响和冲击了中国外贸出口的结构和产品竞争力。一些影响中国外贸的因素(例如国际市场上的进出口区域差异、供求关系和价格弹性)引起了越来越多的关注。改革开放初期,中国基本上是以出口原材料和初级产品为主;随着中国经济的发展,制造业在出口中所占的比重越来越大;如今高科技产品的贸易在外贸中的重要性上升,而同时中国对能源进口的需求已经对世界能源供应链产生了压力。2001年,中国加入WTO可以被看作是一个分水岭。加入WTO以后,随着关税和非关税壁垒的消失,产品更容易进入外国市场。作者着重讨论中国的外贸策略的选择:充分利用WTO的特别保护和过渡保护期的规定,特别是保护一些处于起步阶段的行业,并分析了一些具体的行业。另外,世界经济对中国外贸的影响也体现在组成区域经济共同体以及形成全球化生产网络等方面。由于中国对美国和欧盟的贸易顺差,双方的贸易摩擦一直在增长。随着大量的外国直接投资(FDI)进入中国,中国成为跨国公司全球化生产网络一个重要组成部分。而要求中国参与组织东亚,甚至包括ASEAN(东南亚国家联盟)自由贸易区的呼声也越来越高。这些都反映了中国经济的影响和实力。文章由此得出结论:中国产业结构的调整和外贸策略的相互作用对于中国经济的进一步发展和中国国力的增强将产生至关重要的影响。

关键词：产业调整外贸策略

Persistence of Healthcare-Associated (Nosocomial) Infections Due to Inadequate Hand Hygiene: Part 1—Biological and Treatment Factors

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Pharmacology & Pharmacy 2018年第8期9卷 293-309页

作者： robert B. Raffa Joseph V. Pergolizzi robert taylor Sanjib Choudhuri robert Rodenbeck University of Arizona College of Pharmacy Tucson AZ USA Professor Emeritus Temple University School of Pharmacy Philadelphia PA USA Neumentum Inc. Palo Alto CA USA NEMA Research Inc. Naples FL USA Delta Faucet Co. Indianapolis IN USA

The most frequent adverse event in the healthcare delivery system is acquisition of an infection within a healthcare facility. Since infection control measures are known, simple, and low-cost, we examine why the problem of healthcare-associated infections persists. Hundreds of millions of patients each year are affected by a healthcare-associated infection, with negative medical outcome and financial cost. It is a major public health problem even in countries with advanced healthcare systems. This is a bit perplexing, given that hygienic practices have been known and actively promoted. The objective is to address the question: doesn’t the use of disinfection, sterilization, handwashing, and alcohol rubs prevent the spread of pathogenic organisms? We conclude that the persistent high prevalence of nosocomial infections despite known hygienic practices is attributable to two categories of factors: biological and inherent shortcomings of some practices (considered in Part 1), and human factors (considered in Part 2). A new approach is presented in Part 3.

关键词： Infection Nosocomial Hospital Healthcare-Associated Hygiene Handwashing

The Place of Community Rescue Naloxone in a Public Health Crisis of Opioid Overdose

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Pharmacology & Pharmacy 2019年第2期10卷 61-81页

作者： Joseph V. Pergolizzi Jo Ann LeQuang robert taylor robert B. Raffa NEMA Research Naples FL USA Neumentum Palo Alto CA USA LeQ Medical Angleton TX USA University of Arizona College of Pharmacy Tucson AZ USA Temple University School of Pharmacy Philadelphia PA USA

The recent large increase in deaths involving opioids (whether prescription or illicit, pure or adulterated, alone or in combination with other drugs) is the manifestation of a complex, and multifaceted problem consisting of psychological, psychosocial, medical, legal, regulatory, economic, cultural, and political components, among others. Because the problem involves issues related to both supply and demand, the solution is not obvious, simple, or quick. There is no easy fix. Preventing and treating opioid misuse and abuse requires a comprehensive, time-intensive, and expensive intervention supported by public policy and support through coordinated medical, regulatory, legal, and financial guidelines and practice. But until the long-term problems can be fixed, the immediate crisis of overdose deaths can be ameliorated by making available an opioid receptor antagonist to reverse the respiratory depression that is the cause of death to those who are in the best position to administer it in time (professionals, untrained bystanders, and even fellow drug abusers). The statistics overwhelmingly demonstrate that this is a life-saving medical intervention. Yet, there is still uncertainty about this intervention, and even some opposition to it. We describe the scientific basis for the approach and the issues surrounding its use to treat accidental or intentional overdose by pain patients, recreational opioid users, and addicts. We also describe the calls to limit the number of times it should be available to a user and the limitations of its effectiveness—mainly that it only addresses the acute death crisis, not the underlying problems that led to it.

关键词： Opioid Crisis Opioid Abuse Opioid Antagonist Community Naloxone

Differences in the Receptor Binding Profile of Lofexidine Compared to Clonidine

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Pharmacology & Pharmacy 2019年第1期10卷 1-10页

作者： robert B. Raffa Joseph V. Pergolizzi robert taylor robert P. James Mark Pirner Neumentum Inc. Palo Alto CA USA University of Arizona College of Pharmacy Tucson AZ USA Temple University School of Pharmacy Philadelphia PA USA NEMA Research Inc. Naples FL USA US WorldMeds LLC Louisville KY USAs

Lucemyra? (lofexidine hydrochloride) has recently been approved by the US FDA for the mitigation of withdrawal symptoms to facilitate abrupt discontinuation of opioids in adults. Lofexidine is an alpha-2 adrenoceptor agonist. However, the clinical attributes of lofexidine differ in advantageous ways from the classical alpha-2 adrenoceptor agonist clonidine. In the present study, we measured the receptor binding profile of lofexidine and clonidine in an effort to gain an insight into the clinical difference(s).

关键词： Lofexidine Clonidine Opioid Withdrawal Receptor Affinity Alpha-2 Agonist

Designing General Anesthetics That Have a Better Safety Profile

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Pharmacology & Pharmacy 2019年第10期10卷 407-415页

作者： robert B. Raffa Joseph V. Pergolizzi Jr. robert taylor Jr. Neumentum Inc.，Palo Alto CAUSA College of Pharmacy University of Arizona Tucson AZ USA Temple University School of Pharmacy Philadelphia PA USA NEMA Research Inc. Naples FL USA.

General anesthetics constitute some of the most important and widely-used therapeutic drugs in the pharmacotherapeutic armamentarium. They are routinely used effectively and with adequate precaution-safety throughout the world for a multitude of clinical applications, predominantly as adjunctive agents for surgical procedures. Nevertheless, they have potential adverse effects (such as a drop in blood pressure and the inhibition of steroid production), particularly in vulnerable populations such as the very young and the frail elderly. It would be desirable therefore to have alternative agents that are just as efficacious, but have a better safety profile in a broader spectrum of patients. Toward this end, an anesthetic based on a unique chemical core (viz., an N-arylpyrrole derivative) has been reported in preclinical models to produce anesthetic effects without hemodynamic suppression. This lead could pave the way for new general anesthetics that are safer and easier to use.

关键词： General Anesthetic Intravenous Drug Discovery GABAA Receptor Molecular Modeling

“Atropisomeric” Drugs: Basic Concept and Example of Application to Drug Development

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Pharmacology & Pharmacy 2020年第1期11卷 1-8页

作者： robert B. Raffa Joseph V. Pergolizzi Jr. robert taylor Jr. Neumentum Inc. Palo Alto CA USA College of Pharmacy University of Arizona Tucson AZ USA School of Pharmacy Temple University Philadelphia PA USA NEMA Research Inc. Naples FL USA

Many therapeutic drugs are racemates;i.e. they are chiral molecules consisting of “left”- and “right-handed” enantiomers (stereoisomers that are mirror images of each other, and are non-superimposable). In some cases, both enantiomers of the drug contribute to some extent (or equally) to the therapeutic effect;in other cases they contribute not at all. The same is true for the adverse effects of racemate drugs: the adverse effects of a racemate drug can be greater-than, less-than, or equal to one or the other enantiomer. An unusual situation arises when a drug consists of “atropisomers”, stereoisomers arising because of hindered rotation about a single chemical bond. We summarize the concept of atropisomerism, and give examples.

关键词： Atropisomer Chirality Pharmacotherapy Drug Development NaV1.7 Inhibitor