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Genome and clonal hematopoiesis stability contrasts with immune,cfDNA,mitochondrial,and telomere length changes during short duration spaceflight

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Precision Clinical Medicine 2024年第1期7卷 1-13页

作者： J.sebastian Garcia-Medina Karolina sienkiewicz s.Anand Narayanan Eliah G.Overbey Kirill Grigorev Krista A.Ryon Marissa Burke Jacqueline Proszynski Braden Tierney Caleb M.schmidt Nuria Mencia-Trinchant Remi Klotz Veronica Ortiz Jonathan Foox Christopher Chin Deena Najjar Irina Matei Irenaeus Chan Carlos Cruchaga Ashley Kleinman JangKeun Kim Alexander Lucaci Conor Loy Omary Mzava Iwijn De Vlaminck Anvita singaraju Lynn E.taylor Julian C.schmidt Michael A.schmidt Kelly Blease Juan Moreno Andrew Boddicker Junhua Zhao Bryan Lajoie Andrew Altomare semyon Kruglyak shawn Levy Min Yu Duane C.Hassane susan M.Bailey Kelly Bolton Jaime Mateus Christopher E.Mason Department of Physiology and Biophysics Weill Cornell MedicineCornell UniversityNew YorkNY 10021USA The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine Weill Cornell MedicineNew YorkNY 10021USA Department of Immunology Weill Cornell MedicineCornell UniversityNew YorkNY 10021USA Department of stem Cell Biology and Regenerative Medicine Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCA 90033USA space Exploration Technologies Corporation HawthomeCA 90250USA sovaris Aerospace BoulderCO 80302USA Advanced Pattern Analysis&Human Performance Group BoulderCO 80302USA Children's Cancer and Blood Foundation Laboratories Departments of Pediatrics and Cell and Developmental BiologyDrukier Institute for Children's HealthMeyer Cancer CenterWeill Cornell MedicineNew YorkNY 10021USA Meyer Cancer Center Weill Cornell MedicineNew YorkNY 10065USA Department of Nutrition and Integrative Physiology Florida State UniversityTallahasseeFL 32306USA Department of systems Engineering Colorado State UniversityFort CollinsCO 80523USA Element Biosciences San DiegoCA 10055USA Department of Environmental and Radiological Health sciences Colorado State UniversityFort CollinsCO 80523USA Cell and Molecular Biology Program Colorado State UniversityFort CollinsCO 80523USA BioAstra Inc New YorkNYUSA Washington University st Louis Oncology Division St.LouisMO 63100USA Meinig school of Biomedical Engineering Cornell UniversityIthacaNY 14853USA The Feil Family Brain and Mind Research Institute Weill Cornell MedicineNY 10021USA WorldQuant Initiative for Quantitative Prediction Weill Cornell MedicineNew YorkNY 10021USA

Background The Inspiration4(I4)mission,the first all-civilian orbital flight mission,investigated the physiological effects of short-duration spaceflight through a multi-omic *** advances,there remains much to learn about human adaptation to spaceflight's unique challenges,including microgravity,immune system perturbations,and radiation *** To provide a detailed genetics analysis of the mission,we collected dried blood spots pre-,during,and post-flight for DNA *** length was measured by quantitative PCR,while whole genome and cfDNA sequencing provided insight into genomic stability and immune adaptations.A robust bioinformatic pipeline was used for data analysis,including variant calling to assess mutational *** Telomere elongation occurred during spaceflight and shortened after return to ***-free DNA analysis revealed increased immune cell signatures *** significant clonal hematopoiesis of indeterminate potential(CHIP)or whole-genome instability was *** long-term gene expression changes across immune cells suggested cellular adaptations to the space environment persisting months *** Our findings provide valuable insights into the physiological consequences of short-duration spaceflight,with telomere dynamics and immune cell gene expression adapting to spaceflight and persisting after return to *** sequencing data will serve as a reference point for studying the early development of CHIP in astronauts,an understudied phenomenon as previous studies have focused on career *** study will serve as a reference point for future commercial and non-commercial spaceflight,low Earth orbit(LEO)missions,and deep-space exploration.

关键词： genomes clonal hematopoiesis stability immune mitochondria ribosomes spaceflight

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Enhanced photoluminescence quantum yield of MAPbBr3 nanocrystals by passivation using graphene

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Nano Research 2020年第4期13卷 932-938页

作者： Youngsin Park Atanu Jana Chang Woo Myung Taeseung Yoon Geungsik Lee Claudius C.Kocher Guanhua Ying Vitaly Osokin Robert A.taylor Kwang s.Kim school of Natural science Ulsart National Institute of Science and TechnologhUlsan 44919Republic of Korea 2 Clarendon LaboratoryDepartment of PhysicsUniversity of OxfordParks RoadOxford0X13PUUK

Diminishing surface defect states in perovskite nancx^rystals is a highly challenging subject for enhancing optoelectronic device *** synthesized organic/inorganic lead-halide perovskite MAPbBr3(MA=methylammonium)clusters comprising nanocrystals with diameters ranging between 20 and 30 nm and characterized an enhanced photoluminescence(PL)quantum yield(as much as^7 times)by encapsulating the MAPbBr3 with graphene(Gr).The optical properties of MAPbBr3 and Gr/MAPbBr3 were investigated by temperature-dependent micro-PL and time-resolved PL *** functional theory calculations show that the surface defect states in MAPbBr3 are removed and the optical band gap is reduced by a 0.15 eV by encapsulation with graphene due to partial restoration of lattice distortions.

关键词： perovskite nanocluster photoluminescence surface passivation graphene density functional theory calculations

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Pharmaceutical amorphous solid dispersion: A review of manufacturing strategies

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Acta Pharmaceutica sinica B 2021年第8期11卷 2505-2536页

作者： sonal V.Bhujbal Biplob Mitra Uday Jain Yuchuan Gong Anjali Agrawal shyam Karki Lynne s.taylor sumit Kumar Qi(Tony)Zhou Department of Industrial and Physical Pharmacy College of PharmacyPurdue University Oral Product Development Bristol Myers Squibb Material science and Engineering Bristol Myers Squibb

Amorphous solid dispersions(AsDs)are popular for enhancing the solubility and bioavailability of poorly water-soluble *** approaches have been employed to produce AsDs and novel techniques are *** review provides an updated overview of manufacturing techniques for preparing *** physical stability is a critical quality attribute for AsD,the impact of formulation,equipment,and process variables,together with the downstream processing on physical stability of AsDs have been *** strategies are proposed to identify suitable manufacturing methods,which may aid in the development of AsDs with satisfactory physical stability.

关键词： Amorphous solid dispersions stability Drug delivery Manufacturing solvent evaporation Melting process Co-precipitation Downstream processing selection criteria

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Anterior glenohumeral instability:Current review with technical pearls and pitfalls of arthroscopic soft-tissue stabilization

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World Journal of Orthopedics 2021年第1期12卷 1-13页

作者： John M Apostolakos Joshua Wright-Chisem Lawrence V Gulotta samuel A taylor Joshua s Dines Department of sports Medicine and shoulder surgery Hospital for Special SurgeryNew YorkNY 10021United States

The glenohumeral joint(GHJ)allows for a wide range of motion,but is also particularly vulnerable to episodes of *** GHJ instability is especially frequent among young,athletic populations during contact sporting *** first time dislocators can be managed non-operatively with a period of immobilization and rehabilitation,however certain patient populations are at higher risk for recurrent instability and may require surgical intervention for adequate *** of the optimal treatment strategy should be made on a case-by-case basis while weighing both patient specific factors and injury patterns(i.e.,bone loss).The purpose of this review is to describe the relevant anatomical stabilizers of the GHJ,risk factors for recurrent instability including bony lesions,indications for arthroscopic vs open surgical management,clinical history and physical examination techniques,imaging modalities,and pearls/pitfalls of arthroscopic soft-tissue stabilization for anterior glenohumeral instability.

关键词： Arthroscopic soft-tissue Anterior instability Glenohumeral Functional anatomy Recurrent instability

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Calcium signaling and T-type calcium channels in cancer cell cycling

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World Journal of Gastroenterology 2008年第32期14卷 4984-4991页

作者： James T taylor Xiang-Bin Zeng Jonathan E Pottle Kevin Lee Alun R Wang stephenie G Yi lennifer A s scruggs suresh s sikka Ming Li Department of Pharmacology Tulane University Health Sciences Center New Orleans LA 70112 United States Department of Urology Tulane University Health Sciences Center New Orleans LA 70112 United States Department of Physiology Tulane University Health Sciences Center New Orleans LA 70112 United States Department of Pathology Tulane University Health Sciences Center New Orleans LA 70112 United States

Regulation of intracellular calcium is an important signaling mechanism for cell proliferation in both normal and cancerous cells. In normal epithelial cells, free calcium concentration is essential for cells to enter and accomplish the s phase and the M phase of the cell cycle. In contrast, cancerous cells can pass these phases of the cell cycle with much lower cytoplasmic free calcium concentrations, indicating an alternative mechanism has developed for fulfilling the intracellular calcium requirement for an increased rate of DNA synthesis and mitosis of fast replicating cancerous cells. The detailed mechanism underlying the altered calcium loading pathway remains unclear; however, there is a growing body of evidence that suggests the T-type Ca2+ channel is abnormally expressed in cancerous cells and that blockade of these channels may reduce cell proliferation in addition to inducing apoptosis. Recent studies also show that the expression of T-type Ca2+ channels in breast cancer cells is proliferation state dependent, i.e. the channels are expressed at higher levels during the fast-replication period, and once the cells are in a non-proliferation state, expression of this channel isminimal. Therefore, selectively blocking calcium entry into cancerous cells may be a valuable approach for preventing tumor growth. since T-type Ca2+ channels are not expressed in epithelial cells, selective T-type Ca2+ channel blockers may be useful in the treatment of certain types of cancers.

关键词： T-type calcium channels Cancer Cellcycle Calcium

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Three-Dimensional Modeling of shallow shear-Wave Velocities for Las Vegas, Nevada, Using sediment Type

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Journal of China University of Geosciences 2009年第3期20卷 555-562页

作者： Barbara Luke Helena Murvosh Wanda taylor Jeff Wagoner University of Nevada Las Vegas Las Vegas NV USA stanley Consultants Inc. Las Vegas NV USA Lawrence Livermore National Laboratory Livermore CA USA

A three-dimensional model of near-surface shear-wave velocity in the deep alluvial basin underlying the metropolitan area of Las Vegas, Nevada （UsA）, is being developed for earthquake site response projections. The velocity dataset, which includes 230 measurements, is interpolated across the model using depth-dependent correlations of velocity with sediment type. The sediment-type database contains more than 1 400 well and borehole logs. sediment sequences reported in logs are assigned to one of four units. A characteristic shear-wave velocity profile is developed for each unit by analyzing closely spaced pairs of velocity profiles and well or borehole logs. The resulting velocity model exhibits reasonable values and patterns, although it does not explicitly honor the measured shear-wave velocity profiles. site response investigations that applied a preliminary version of the velocity model support a two-zone ground-shaking hazard model for the valley. Areas in which clay predominates in the upper 30 m are predicted to have stronger ground motions than the rest of the basin.

关键词： shear-wave velocity earthquake site response site amplification microzonation sediment type.

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Owner-Intruder contests with correlated resource values

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International Journal of Biomathematics 2021年第4期14卷 121-129页

作者： Polina A.Bukina Mehtab s.Khara Haider H.Nadhem Patrick L.Woolley Jan Rychtár Dewey taylor Department of Biology Virginia Commonwealth University RichmondVA 23284-2012USA Department of Mathematics and Applied Mathematics Virginia Commonwealth University Richmond VA 23284-2014USA

We study a conflict of two individuals over a valuable *** construct a sequential game where the first individual,the Owner,decides whether to defend the resource and the other individual,the Intruder,decides whether to attack and try to steal the *** know the value of the resource to *** provides the individuals an estimate of the value of the resource to the *** build a mathematical model that allows us to quantify and vary the accuracy of this *** study how the outcomes of the game depend on the *** show that,in our setting,the accuracy does not matter to the Intruder but it does to the *** resources of a large value,the Owner benefits from a smaller ***,for resources of a small value,the Owner benefits from a bigger accuracy.

关键词： Kleptoparasitism Owner-Intruder resource valuation game theory incom-plete information

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Gait analysis in swine,sheep,and goats after neurologic injury:a literature review

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Neural Regeneration Research 2023年第9期18卷 1917-1924页

作者： Jacob W.sveum Raveena R.Mishra taylor L.Marti Jalon M.Jones Daniel J.Hellenbrand Amgad s.Hanna Department of Neurological surgery University of Wisconsin School of Medicine and Public Health(UWSMPH)MadisonWIUSA

Medical research on neurologic ailments requires representative animal models to validate treatments before they are translated to human clinical *** are the predominant animal model used in neurological research despite limited anatomic and physiologic similarities to *** a result,functional testing designed to assess locomotor recovery after neurologic impairment is well established in rodent ***,large r,more clinically relevant models have not been as well *** achieve similar locomotor testing standardization in larger animals,the models must be accessible to a wide array of ***-human primates are the most relevant animal model fo r translational research,however ethical and financial barriers limit their *** review focuses on swine,sheep,and goats as large animal alternatives for transitional studies between rodents and non-human *** objective of this review is to compare motor testing and data collection methods used in swine,sheep,and goats to encourage testing standardization in these larger animal *** PubMed database was analyzed by searching combinations of swine,sheep,and goats,neurologic injuries,and functional *** were categorized by animal model,data collection method,and assessment *** and sheep were used in the majority of the studies,while only two studies were found using *** functional assessments included open pen analysis,treadmill walking,and guided free *** collection methods included subjective behavioral rating scales and objective tools such as pressure-sensitive mats and image-based analysis ***,swine and sheep were well-suited for a variety of assessment designs,with treadmill walking and guided free walking offering the most consistency across multiple *** collection methods varied,but image-based gait analysis software provided the most robust *** studies should be conducted to stan

关键词： functional testing gait analysis goats large animals neurologic injury sheep spinal cord injury swine

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Heating demand and economic feasibility analysis for year-round vegetable production in Canadian Prairies greenhouses

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Information Processing in Agriculture 2019年第1期6卷 81-90页

作者： Md shamim Ahamed Huiqing Guo Lisa taylor Karen Tanino Department of Farm Power and Machinery Bangladesh Agricultural UniversityBangladesh Department of Mechanical Engineering University of SaskatchewanCanada Department of Plant sciences University of SaskatchewanCanada

Greenhouse vegetable production in Canadian Prairies is important for creating a sustainable regional food economy,especially in northern *** study included the estimation of heating demand for year-round production and evaluation of the economic feasibility of greenhouse vegetable production(tomato,cucumber,and pepper)in a conceptually designed greenhouse(0.6 ha)located in remote northern communities in saskatchewan,*** heating simulation was based on a greenhouse heating simulation model(GREENHEAT)developed by the authors *** simulation results showed that the annual heating requirement for the production of tomato,cucumber,and pepper are 1486 MJ m^2,1657 MJ m^2,and 1754 MJ m^2,*** economic analysis indicates the net return(NR)from the production of tomato,cucumber,and pepper,are C$69.2/m^2(in Canadian dollar,CAD),C$41.5/m^2,and C$43.8/m^2,respectively,based on the market price C$3.5/kg,C$2.7/kg,and C$8.0/kg,and yields of 55.0 kg m^-2,65.0 kg m^-2,and 23.0 kg m^-*** net present value(NPV)for the tomato,cucumber,and pepper production are C$1.9 M,C$1.2 M,and C$1.1 M,respectively,and the benefit-cost ratio(BCR)are 1.38,1.21,and *** economic feasibility analysis indicates the year-round production of vegetables in a greenhouse at remote northern saskatchewan would be economically profitable.

关键词： Northern latitudes Heating requirement Economic analysis sensitivity analysis Year-round production

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Imaging of liver cancer

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World Journal of Gastroenterology 2009年第11期15卷 1289-1300页

作者： Ben Ariff Claire R Lloyd sameer Khan Mohamed shariff Andrew V Thillainayagam Devinder s Bansi shahid A Khan simon D taylor-Robinson Adrian KP Lim Department of Imaging Imperial College Healthcare NHS Trust Charing Cross Hospital Campus Fulham Palace Road London W6 8RF United Kingdom Department of Hepatology and Gastroenterology Division of Medicine Imperial College London St Mary's Hospital Campus South Wharf Road London W2 1NY United Kingdom

Improvements in imaging technology allow exploitation of the dual blood supply of the liver to aid in the identif ication and characterisation of both malignant and benign liver lesions. Imaging techniques available include contrast enhanced ultrasound, computed tomography and magnetic resonance imaging. This review discusses the application of several imaging techniques in the diagnosis and staging of both hepatocellular carcinoma and cholangiocarcinoma and outlines certain characteristics of benign liver lesions. The advantages of each imaging technique are highlighted, while underscoring the potential pitfalls and limitations of each imaging modality.

关键词： Hepatic cell carcinoma Cholangiocarcinoma Contrast enhanced ultrasound Computed tomography Magnetic resonance imaging

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